The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection
Open accessAbstract
The RNA modification N6 -methyladenosine (m 6 A) post-transcriptionally regulates RNA function. The cellular machinery that controls m 6 A includes methyltransferases and demethylases that add or remove this modification, as well as m 6 A-binding YTHDF proteins that promote the translation or degradation of m 6 A-modified mRNA. We demonstrate that m 6 A modulates infection by hepatitis C virus (HCV). Depletion of m 6 A methyltransferases or an m 6 A demethylase, respectively, increases or decreases infectious HCV particle production. During HCV infection, YTHDF proteins relocalize to lipid droplets, sites of viral assembly, and their depletion increases infectious viral particles. We further mapped m 6 A sites across the HCV genome and determined that inactivating m 6 A in one viral genomic region increases viral titer without affecting RNA replication. Additional mapping of m 6 A on the RNA genomes of other Flaviviridae , including dengue, Zika, yellow fever, and West Nile virus, identifies conserved regions modified by m 6 A. Altogether, this work identifies m 6 A as a conserved regulatory mark across Flaviviridae genomes.
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Cites
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Cited by
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The Architecture of SARS-CoV-2 Transcriptome
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Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
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m6A modification controls the innate immune response to infection by targeting type I interferons
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Metadata
- Authors
- Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E., & Horner, S. M.
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 20
- Issue
- 5
- Pages
- 654-665
- ISSN
- 1931-3128 (ISSN-L)
- OpenAlex
- W2538543247
- Cited by
- 477
- References
- 56
- FWCI
- 17.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Gokhale, N. S., McIntyre, A. B. R., McFadden, M. J., Roder, A. E., Kennedy, E. M., Gandara, J. A., Hopcraft, S. E., Quicke, K. M., Vazquez, C., Willer, J., Ilkayeva, O. R., Law, B. A., Holley, C. L., Garcia-Blanco, M. A., Evans, M. J., Suthar, M. S., Bradrick, S. S., Mason, C. E., & Horner, S. M. (2016). N6 -Methyladenosine in Flaviviridae Viral RNA Genomes Regulates Infection. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2016.09.015
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
