The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation
Open accessAbstract
N6-methyladenosine (m 6 A) modification plays important roles in various cellular responses by regulating mRNA biology. However, how m 6 A modification is involved in innate immunity via affecting the translation of immune transcripts remains to be further investigated. Here we report that RNA methyltransferase Mettl3-mediated mRNA m 6 A methylation promotes dendritic cell (DC) activation and function. Specific depletion of Mettl3 in DC resulted in impaired phenotypic and functional maturation of DC, with decreased expression of co-stimulatory molecules CD40, CD80 and cytokine IL-12, and reduced ability to stimulate T cell responses both in vitro and in vivo. Mechanistically, Mettl3-mediated m 6 A of CD40, CD80 and TLR4 signaling adaptor Tirap transcripts enhanced their translation in DC for stimulating T cell activation, and strengthening TLR4/NF-κB signaling-induced cytokine production. Our findings identify a new role for Mettl3-mediated m 6 A modification in increasing translation of certain immune transcripts for physiological promotion of DC activation and DC-based T cell response.
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Dominissini, D., Moshitch-Moshkovitz, S., Schwartz, S., Salmon-Divon, M., Ungar, L., Osenberg, S., Cesarkas, K., Jacob-Hirsch, J., Amariglio, N., Kupiec, M., et al. (2012) · Nature · doi:10.1038/nature11112 · Cited by 4,884
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility
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Self-citationN6-methyladenosine Modulates Messenger RNA Translation Efficiency
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Miao, L., Zhang, Y., & Huang, L. (2021) · Molecular Cancer · doi:10.1186/s12943-021-01335-5 · Cited by 934
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He, P. C., & He, C. (2021) · The EMBO Journal · doi:10.15252/embj.2020105977 · Cited by 786
The RNA modification N6-methyladenosine as a novel regulator of the immune system
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Tailoring mRNA Vaccine to Balance Innate/Adaptive Immune Response
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Metadata
- Authors
- Wang, H., Hu, X., Huang, M., Liu, J., Gu, Y., Ma, L., Zhou, Q., & Cao, X.
- Venue
- Nature Communications
- Published
- 2019-04-23
- Volume
- 10
- Issue
- 1
- Pages
- 1898-1898
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W2941121518
- Cited by
- 503
- References
- 60
- FWCI
- 17.19
- Type
- journal article
- Language
- en
- Open access
- gold
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