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Cited by 244

The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.

Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing

Open access
Paharik, Alexandra E., Parlet, Corey P., Chung, Nadjali, Todd, Daniel A., Rodriguez, Emilio I., Van Dyke, Michael J., Cech, Nadja B., Horswill, Alexander R.·2017·Cell Host & Microbe
DOI 10.1016/j.chom.2017.11.001
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Abstract

Summary Coagulase-negative staphylococci (CoNS) and Staphylococcus aureus are part of the natural flora of humans and other mammals. We found that spent media from the CoNS species Staphylococcus caprae can inhibit agr-mediated quorum sensing by all classes of S. aureus. A biochemical assessment of the inhibitory activity suggested that the S. caprae autoinducing peptide (AIP) was responsible, and mass spectrometric analysis identified the S. caprae AIP as an eight-residue peptide (YSTCSYYF). Using a murine model of intradermal MRSA infection, the therapeutic efficacy of synthetic S. caprae AIP was evident by a dramatic reduction in both dermonecrotic injury and cutaneous bacterial burden relative to controls. Competition experiments between S. caprae and MRSA demonstrated a significant reduction in MRSA burden using murine models of both skin colonization and intradermal infection. Our findings indicate that important interactions occur between commensals that can impact disease outcomes and potentially shape the composition of the natural flora.

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Metadata

Authors
Paharik, A. E., Parlet, C. P., Chung, N., Todd, D. A., Rodriguez, E. I., Van Dyke, M. J., Cech, N. B., & Horswill, A. R.
Venue
Cell Host & Microbe
Publisher
Elsevier BV
Published
2017-12
Volume
22
Issue
6
Pages
746-756.e5
ISSN
1931-3128 (ISSN-L)
DOI
10.1016/j.chom.2017.11.001
OpenAlex
W2771650241
Cited by
244
References
8
FWCI
6.89
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing. https://app.cochat.ai/papers/10.1016/j.chom.2017.11.001
The paper
Paharik, A. E., Parlet, C. P., Chung, N., Todd, D. A., Rodriguez, E. I., Van Dyke, M. J., Cech, N. B., & Horswill, A. R. (2017). Coagulase-Negative Staphylococcal Strain Prevents Staphylococcus aureus Colonization and Skin Infection by Blocking Quorum Sensing. Cell Host & Microbe. https://doi.org/10.1016/j.chom.2017.11.001

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.