Cited by 675Gut microbiota and healthGastrointestinal motility and disordersAnimal Nutrition and Physiology

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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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Martinez-Guryn, Kristina, Hubert, Nathaniel, Frazier, Katya, Urlass, Saskia, Musch, Mark W., Ojeda, Patricia, Pierre, Joseph F., Miyoshi, Jun, Sontag, Timothy J., Cham, Candace M., Reardon, Catherine A., Leone, Vanessa, Chang, Eugene B.·2018·Cell Host & Microbe

DOI 10.1016/j.chom.2018.03.011PMC PMC5912695

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Abstract

The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption. In addition, GF mice conventionalized with high-fat diet-induced jejunal microbiota exhibit increased lipid absorption even when fed a low-fat diet. Conditioned media from specific bacterial strains directly upregulate lipid absorption genes in murine proximal small intestinal epithelial organoids. These findings indicate that proximal gut microbiota play key roles in host adaptability to dietary lipid variations through mechanisms involving both the digestive and absorptive phases and that these functions may contribute to conditions of over- and undernutrition.

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Authors: Martinez-Guryn, K., Hubert, N., Frazier, K., Urlass, S., Musch, M. W., Ojeda, P., Pierre, J. F., Miyoshi, J., Sontag, T. J., Cham, C. M., Reardon, C. A., Leone, V., & Chang, E. B.
Affiliations: University of Chicago (US)
Corresponding author: Chang, Eugene B.
ORCID: Hubert, Nathaniel
Frazier, Katya
Urlass, Saskia
Musch, Mark W.
Pierre, Joseph F.
Miyoshi, Jun
Cham, Candace M.
Reardon, Catherine A.
Leone, Vanessa
Chang, Eugene B.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2018-04
Volume: 23
Issue: 4
Pages: 458-469.e5
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2018.03.011
PMC: PMC5912695
OpenAlex: W2796527107
Cited by: 663
References: 53
Citations by year: 2026: 54 · 2025: 85 · 2024: 101 · 2023: 98 · 2022: 88 · 2021: 93 · 2020: 82 · 2019: 43 · 2018: 18
FWCI: 21.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK42086)
Digestive Diseases Research Core Center, University of Chicago (DK097268, T32DK007074)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: small intestinal microbiota, dietary fat absorption, lipid digestion, germ-free mice, diet-induced obesity, fat malabsorption, high-fat diet, jejunal microbiota, overnutrition, malnutrition
MeSH terms: Gastrointestinal Microbiome, Animals, Diet, Intestine, Small, Lipid Metabolism, Mice

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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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