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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids
Open accessAbstract
The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption. In addition, GF mice conventionalized with high-fat diet-induced jejunal microbiota exhibit increased lipid absorption even when fed a low-fat diet. Conditioned media from specific bacterial strains directly upregulate lipid absorption genes in murine proximal small intestinal epithelial organoids. These findings indicate that proximal gut microbiota play key roles in host adaptability to dietary lipid variations through mechanisms involving both the digestive and absorptive phases and that these functions may contribute to conditions of over- and undernutrition.
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Cites
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES
Folch, J., Lees, M., & Stanley, G. H. S. (1957) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64849-5 · Cited by 65,189
QIIME allows analysis of high-throughput community sequencing data
Caporaso, J. G., Kuczynski, J., Stombaugh, J., Bittinger, K., Bushman, F. D., Costello, E. K., Fierer, N., Peña, A. G., Goodrich, J. K., Gordon, J. I., et al. (2010) · Nature Methods · doi:10.1038/nmeth.f.303 · Cited by 34,887
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M., Barker, N., Stange, D. E., van Es, J. H., Abo, A., Kujala, P., Peters, P. J., et al. (2009) · Nature · doi:10.1038/nature07935 · Cited by 7,204
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058
Mechanisms underlying the resistance to diet-induced obesity in germ-free mice
Bäckhed, F., Manchester, J. K., Semenkovich, C. F., & Gordon, J. I. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605374104 · Cited by 2,615
Gut biogeography of the bacterial microbiota
Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904
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Items 101–200 of 675
Yang, Y., Liu, P., & Mei, L. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122850 · Cited by 64
The small intestine: dining table of host–microbiota meetings
Delbaere, K., Roegiers, I. H., Bron, A., Durif, C., de Wiele, T. V., Blanquet‐Diot, S., & Marinelli, L. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad022 · Cited by 73
“…ole in host fatty acid absorption mainly via some Clostridiaceae tr ains suc h as Clostridium bifermentans , able to affect the gene xpr ession of trigl ycerides r e-esterification enzymes, diacylgl ycr ol O-acyltr ansfer ases (Dgat1 and Dgat2) in mice small intestine Martinez-Guryn et al. 2018 ).”
InfluentialInterplay of CD36, autophagy, and lipid metabolism: insights into cancer progression
Yang, Y., Liu, X., Yang, D., Li, L., Li, S., Lu, S., & Li, N. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155905 · Cited by 68
Metabolic implications of circadian disruption
Fatima, N., & Rana, S. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02381-6 · Cited by 74
“Furthermore, GF mice were partially protected from high fat diet-induced obesity due to decreased dietary lipid digestion and absorption [87].”
BackgroundNutritional and lifestyle management of the aging journey: A narrative review
Kassis, A. N., Fichot, M., Horcajada, M.-N., Horstman, A. M. H., Duncan, P. I., Bergonzelli, G. E., Preitner, N., Zimmermann, D., Bosco, N., Vidal, K., et al. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1087505 · Cited by 81
“Indeed, intestinal microbiota were reported to play a key role in macronutrient digestion and absorption (118, 119).”
BackgroundWu, Q., Wu, S., Yang, C., Zhang, Z., Mao, G., Li, S., Yang, Y., Zhang, X., Wu, M., & Tong, H. (2021) · Food & Function · doi:10.1039/d0fo03329d · Cited by 68
The Role of The Tumor Microbiome in Tumor Development and Its Treatment
Chen, Y., Wu, F., Wu, P., Xing, H., & Ma, T. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.935846 · Cited by 68
Shaw, C. A., Hess, M., & Weimer, B. C. (2023) · Microorganisms · doi:10.3390/microorganisms11071825 · Cited by 73
“Host cells of the large intestine, goblet cells and enterocytes, produce mucosa and digestive enzymes for the further breakdown of food matter from the small intestine [7].”
BackgroundHost-microbial interactions in the metabolism of different dietary fats
Chadaideh, K. S., & Carmody, R. N. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.04.011 · Cited by 63
“Modern human diets source anywhere from 10% to 58% of daily energy from fats (Cordain, 2006; Cordain et al., 2002; Eaton, 1992; German and Dillard, 2004; Linseisen et al., 2009; Mennen et al., 2000), with reported saturated fat consumption ranging from as little as 3% to as high as 31% of calories across populations (…”
BackgroundBastiaanssen, T. F. S., Quinn, T. P., & Loughman, A. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00148-3 · Cited by 71
“The small intestine is more difficult to study, however it has established roles in carbohydrate metabolism, bile acid deconjugation and micronutrient storage (Martinez-Guryn et al., 2018).”
BackgroundWhen fat meets the gut—focus on intestinal lipid handling in metabolic health and disease
Wit, M., Viera, J. T., Strohmeyer, A., Klingenspor, M., Hankir, M. K., & Sumara, G. (2022) · EMBO Molecular Medicine · doi:10.15252/emmm.202114742 · Cited by 63
Environmental enteric dysfunction: gut and microbiota adaptation in pregnancy and infancy
Cowardin, C. A., Syed, S., Iqbal, N. T., Jamil, Z., Sadiq, K., Iqbal, J., Ali, A., & Moore, S. R. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00714-7 · Cited by 71
Treatment of Dyslipidemia through Targeted Therapy of Gut Microbiota
Flaig, B., Garza, R., Singh, B., Hamamah, S., & Covașă, M. (2023) · Nutrients · doi:10.3390/nu15010228 · Cited by 65
The Role of Bacteriophages in the Gut Microbiota: Implications for Human Health
Emencheta, S. C., Olovo, C. V., Eze, O. C., Kalu, C. F., BEREBON, D. P., Onuigbo, E. B., Vila, M. M. D. C., Balcão, V. M., & Attama, A. A. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15102416 · Cited by 68
Roles of Milk Fat Globule Membrane on Fat Digestion and Infant Nutrition
Chai, C., Oh, S., & Imm, J. (2022) · Food Science of Animal Resources · doi:10.5851/kosfa.2022.e11 · Cited by 61
“Martinez-Guryn et al. (2018) demonstrated 191 that small intestinal microbiota regulates host adaptation in response to dietary lipids.”
BackgroundGregory, A., Gerhardt, K., Zhong, Z.-P., Bolduc, B., Temperton, B., Konstantinidis, K. T., & Sullivan, M. B. (2022) · Microbiome · doi:10.1186/s40168-022-01231-0 · Cited by 68
Liu, S., Wang, Z., Xiang, Q., Wu, B., Lv, W., & Xu, S. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114031 · Cited by 63
Gut microbial profiles and the role in lipid metabolism in Shaziling pigs
Ma, J., Duan, Y., Li, R., Liang, X., Li, T., Huang, X., Yin, Y., & Yin, J. (2022) · Animal nutrition · doi:10.1016/j.aninu.2021.10.012 · Cited by 63
Gut Health and Influencing Factors in Pigs
Szabó, C., Lugata, J. K., & Ortega, A. D. S. V. (2023) · Animals · doi:10.3390/ani13081350 · Cited by 71
DeLeon, O., Mocanu, M., Tan, A., Sidebottom, A. M., Koval, J., Ceccato, H. D., Kralicek, S. E., Colgan, J. J., George, M. M. S., Lake, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.014 · Cited by 64
Self-citationPostbiotic-Enabled Targeting of the Host-Microbiota-Pathogen Interface: Hints of Antibiotic Decline?
Puccetti, M., Xiroudaki, S., Ricci, M., & Giovagnoli, S. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12070624 · Cited by 59
“revealed altered butyrate levels in high fat diet models [219,220].”
BackgroundRegulation of Gastrointestinal Immunity by Metabolites
Gu, B., Kim, M., & Yun, C. (2021) · Nutrients · doi:10.3390/nu13010167 · Cited by 57
“However, the impaired lipid metabolism in GF mice was recovered by transplantation of high-fat-diet-induced jejunal microbiota with increased abundance of Clostridiaceae and decreases in Bifidobacteriaceae and Bacteroidaceae [58].”
InfluentialShanahan, E. R., McMaster, J. J., & Staudacher, H. M. (2021) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12868 · Cited by 61
Yin, J., Li, Y., Tian, Y., Zhou, F., Ma, J., Xia, S., Yang, T., Ma, L., Zeng, Q., Liu, G., et al. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100486 · Cited by 58
“Germ-free mice are characterized by impaired fat digestion and absorption within the small intestine, while lipid transport is re-established after conventionalization with microbiota.(20) Therefore, we proposed that by fecal microbiota transplantation, gut microbial cues in this regionmay have a great impact on thema…”
BackgroundIdowu, P. A., Mpofu, T. J., Magoro, A. M., Modiba, M. C., Nephawe, K. A., & Mtileni, B. J. (2025) · Frontiers in Animal Science · doi:10.3389/fanim.2025.1562527 · Cited by 57
Higher-Order Interactions Dampen Pairwise Competition in the Zebrafish Gut Microbiome
Sundarraman, D., Hay, E. A., Martins, D. M., Shields, D. S., Pettinari, N. L., & Parthasarathy, R. (2020) · mBio · doi:10.1128/mbio.01667-20 · Cited by 61
Romualdo, G. R., Valente, L. C., dos Santos, A. C. S., Bacil, G. P., de Souza, I. P., Rodrigues, J., Rodrigues, M. A. M., Vinken, M., Cogliati, B., & Barbisan, L. F. (2022) · Nutrition · doi:10.1016/j.nut.2022.111836 · Cited by 56
Kashyap, P., Moayyedi, P., Quigley, E. M. M., Simrén, M., & Vanner, S. J. (2024) · Neurogastroenterology & Motility · doi:10.1111/nmo.14817 · Cited by 66
“74 These effects vary according to dietary fat com - position; a diet high in milk-fat favored expansion of bile-tolerant Bilophila wadsworthia , which was associated with the development of colitis in genetically susceptible mice.”
BackgroundHuman Gut Microbiome: A Connecting Organ Between Nutrition, Metabolism, and Health
Valencia, S., Zuluaga, M., Pérez, M. C. F., Montoya-Quintero, K. F., Candamil-Cortés, M. S., & Robledo, S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26094112 · Cited by 87
“For example, in the small intestine it has been shown to regulate nutrient absorption and metabolism performed by the host [66].”
Small intestinal microbiota: the neglected stepchild needed for fat digestion and absorption
Chang, E. B., & Martinez, K. (2018) · Gut Microbes · doi:10.1080/19490976.2018.1502539 · Cited by 58
“Our recently published paper “Small Intestine Microbiota Regulate Digestive and Absorptive Adaptive Responses to Dietary Lipids” in Cell Host & Microbe identified mechanisms by which microbes regulate lipid digestion and absorption and also demonstrated that high fat diets affect this process, particularly through alt…”
BackgroundSelf-citationThe impact of maternal and early life malnutrition on health: a diet-microbe perspective
Forgie, A. J., Drall, K. M., Bourque, S. L., Field, C. J., Kozyrskyj, A. L., & Willing, B. P. (2020) · BMC Medicine · doi:10.1186/s12916-020-01584-z · Cited by 59
“changes in fat intake later in life, thereby contributing to metabolic disorders [87].”
BackgroundDey, P., Chaudhuri, S. R., Efferth, T., & Pal, S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.09.026 · Cited by 59
Nugrahapraja, H., Sugiyo, P. W. W., Putri, B. Q., Ni’matuzahroh, N., Fatimah, F., Huang, L. F., Hafza, N., Götz, F., Santoso, H., Wibowo, A. T., et al. (2022) · Environments · doi:10.3390/environments9110140 · Cited by 58
“In the digestive system, gut microbiota modulate fat digestion and adsorption, as well as complex carbohydrates’ catabolism [28,29]; they are essential for human health [30].”
BackgroundCao, W., Guan, S., Yuan, Y., Wang, Y., Yiasmin, M. N., Liu, Y., Tong, Y., Yu, S., & Hua, X. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2253547 · Cited by 59
“A previous study has suggested that the presence of microbiota in the terminal ileum can degrade glycans, but there are few recent studies (Martinez-Guryn et al. 2018).”
Gut microbiome therapy: fecal microbiota transplantation vs live biotherapeutic products
Kim, D.-Y., Lee, S.-Y., Lee, J., Whon, T. W., Lee, J., Jeon, C. O., & Bae, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2412376 · Cited by 62
Vonaesch, P., Araújo, J. R., Gody, J., Mbecko, J., Sanke‐Waîgana, H., Andrianonimiadana, L., Naharimanananirina, T., Ningatoloum, S. N., Vondo, S. S., Gondje, P. B., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209589119 · Cited by 55
Host-microbiota interaction in intestinal stem cell homeostasis
Wu, H., Mu, C., Xu, L., Yu, K., Shen, L., & Zhu, W. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2353399 · Cited by 62
“157 Supplementation with long-chain saturated fatty acids led to increased relative abundances of total Lactobacillus species and Lactobacillus rhamnosus , which reduced alcohol-induced liver injury in mice.”
BackgroundThe microbiota: a key regulator of health, productivity, and reproductive success in mammals
Khan, I. M., Nassar, N., Chang, H., Khan, S., Cheng, M., Wang, Z., & Xiang, X. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1480811 · Cited by 61
Prescott, S. L., Wegienka, G., Logan, A. C., & Katz, D. L. (2018) · BioPsychoSocial Medicine · doi:10.1186/s13030-018-0126-z · Cited by 53
“tryptophan the serotonin precursor) to polyphenols (producing bioactive metabolites) which are directly and indirectly capable of influencing mood [49, 50].”
BackgroundXie, C., Teng, J., Wang, X., Xu, B., Niu, Y., Ma, L., & Yan, X. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.10.010 · Cited by 55
“Gut microbiota and the microbial metabolites in mammals play a crucial role in lipid metabolism and fat storage (Martinez-Guryn et al., 2018; Suarez-Zamorano et al., 2015).”
BackgroundGut-on-a-chip for disease models
Xian, C., Zhang, J., Zhao, S., & Li, X. (2023) · Journal of Tissue Engineering · doi:10.1177/20417314221149882 · Cited by 53
Anti-infective activities of long-chain fatty acids against foodborne pathogens
Borreby, C., Lillebæk, E. M. S., & Kallipolitis, B. H. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad037 · Cited by 53
“2018 , Martinez-Guryn et al. 2018 , Saika et al. 2019 , Chadaideh nd Carmody 2021 , Mirzaei et al. 2022 ).”
Gut microbes and the liver circadian clock partition glucose and lipid metabolism
Frazier, K., Manzoor, S. S., Carroll, K., DeLeon, O., Miyoshi, S., Miyoshi, J., George, M. S., Tan, A., Chrisler, E. A., Izumo, M., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci162515 · Cited by 58
“Environmental changes, such as diet, can rapidly affect microbial composition and functions that affect the host (13, 17).”
BackgroundSelf-citationThe gut microbiota in retinal diseases
Bringer, M.-A., Gabrielle, P., Bron, A. M., Creuzot-Garcher, C. P., & Acar, N. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2021.108867 · Cited by 52
“…through regulation of several aspects of lipid metabolism, such as de novo biosynthesis or intestinal absorption, transport, and storage in host tissue (Backhed et al., 2004; Ghazalpour et al., 2016; Kindt et al., 2018; Martinez-Guryn et al., 2018; Velagapudi et al., 2010; Villette et al., 2020).”
BackgroundZhang, M.-L., Li, M., Sheng, Y., Tan, F., Chen, L., Cann, I., & Du, Z. (2020) · mSystems · doi:10.1128/msystems.00303-20 · Cited by 53
“It is known that Dgat2 is a critical enzyme for triglyceride synthesis and storage, and Clostridiaceae could upregulate the expression level of Dgat2 to facilitate lipid absorption (8).”
BackgroundInfluentialGut-liver axis: Pathophysiological concepts and medical perspective in chronic liver diseases
Rodrigues, S. G., der Merwe, V., Krag, A. A., & Wiest, R. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2023.101859 · Cited by 51
Qiu, Y., Liu, S., Hou, L., Li, K., Wang, L., Gao, K., Yang, X., & Jiang, Z. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa331 · Cited by 57
Zhu, L., Fu, J., Xiao, X., Wang, F., Jin, M., Fang, W., Wang, Y., & Zong, X. (2021) · Microbial Biotechnology · doi:10.1111/1751-7915.13951 · Cited by 50
“and an increased risk of insulin resistance and type 2 diabetes (Kahn et al., 2006; Martinez-Guryn et al., 2018).”
BackgroundInfluentialZhang, Q., Guo, W., Chen, G.-M., Qian, M., Han, J., Lv, X., Chen, L., Rao, P., Ai, L., & Ni, L. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.04.009 · Cited by 50
Microbiota of the gastrointestinal tract: Friend or foe?
Senchukova, M. A. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i1.19 · Cited by 56
Wheeler, R., Bastos, P. A. D., Disson, O., Rifflet, A., Gabanyi, I., Spielbauer, J., Berard, M., Lecuit, M., & Boneca, I. G. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2209936120 · Cited by 50
“Microbiota and mature lacteal vessels are necessary for absorption of triglyceride, cholesterol, and free fatty acids (51, 52).”
Zheng, Z.-Y., Cao, F., Wang, W., Yu, J., Chen, C., Chen, B., Liu, J., Firrman, J., Renye, J. A., & Ren, D. (2020) · BMC Microbiology · doi:10.1186/s12866-020-01922-4 · Cited by 50
The gut microbiota as a versatile immunomodulator in obesity and associated metabolic disorders
Liébana-García, R., Olivares, M., Bullich‐Vilarrubias, C., López‐Almela, I., Romaní‐Pérez, M., & Sanz, Y. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101542 · Cited by 51
The gut microbiota-artery axis: A bridge between dietary lipids and atherosclerosis?
Zhang, Q., Zhang, L., Chen, C., Li, P., & Lu, B. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101209 · Cited by 50
Chemical Metabolism of Xenobiotics by Gut Microbiota
Nakov, R., & Velikova, T. V. (2020) · Current Drug Metabolism · doi:10.2174/1389200221666200303113830 · Cited by 52
van Trijp, M. P. H., Rösch, C., An, R., Keshtkar, S., Logtenberg, M. J., Hermes, G. D. A., Zoetendal, E. G., Schols, H. A., & Hooiveld, G. J. E. J. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000455 · Cited by 48
Chikina, A. S., & Vignjevic, D. M. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203712 · Cited by 52
Zhang, Y., Pan, H., Ye, X., & Chen, S. (2022) · Food & Function · doi:10.1039/d1fo04147a · Cited by 48
How Food Affects Colonization Resistance Against Enteropathogenic Bacteria
Kreuzer, M., & Hardt, W. (2020) · Annual Review of Microbiology · doi:10.1146/annurev-micro-020420-013457 · Cited by 45
Exploring the Gut Microbiota and Cardiovascular Disease
Murphy, K., O’Donovan, A. N., Caplice, N. M., Ross, R. P., & Stanton, C. (2021) · Metabolites · doi:10.3390/metabo11080493 · Cited by 48
“showed that GF mice exhibit decreased plasma triglyceride and LDL-C compared to control mice [72].”
BackgroundZhao, H., Bai, H., Deng, F., Zhong, R., Liu, L., Chen, L., & Zhang, H. (2022) · Antibiotics · doi:10.3390/antibiotics11020132 · Cited by 53
“Small intestinal microbiota plays an important role in affecting intestinal development and physiological functions, including the digestion and absorption of nutrients and the production of short chain fatty acids (SCFA) [30,31], although the populations of small intestinal microbiota (≈104–108 microbial cells) are v…”
BackgroundKastl, A., Zong, W., Gershuni, V. M., Friedman, E. S., Tanes, C., Boateng, A., Mitchell, W. J., O’Connor, K., Bittinger, K. L., Terry, N. A., et al. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2083417 · Cited by 49
Microbiota in cancer: molecular mechanisms and therapeutic interventions
Chen, Z., Guan, D., Wang, Z., Li, X., Dong, S., Huang, J., & Zhou, W. (2023) · MedComm · doi:10.1002/mco2.417 · Cited by 47
Lachance, G., Robitaille, K., Laaraj, J., Gevariya, N., Varin, T. V., Feldiorean, A., Gaignier, F., Bourdeau‐Julien, I., Xu, H. W., Hallal, T., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45332-w · Cited by 55
“Fatty acid assimilation in humans is regulated by the commensal gut bacteria 12,13 .”
Hu, H., Zhang, Y., Zhao, F., Chen, K., Wu, T., Liu, Q., Huang, S., Zhang, A., & Jia, Z. (2021) · iScience · doi:10.1016/j.isci.2021.102077 · Cited by 47
Consistent changes in the intestinal microbiota of Atlantic salmon fed insect meal diets
Li, Y., Gajardo, K., Jaramillo-Torres, A., Kortner, T. M., & Krogdahl, Å. (2022) · Animal Microbiome · doi:10.1186/s42523-021-00159-4 · Cited by 45
“585 Interaction between microbiota and lipid metabolism in the 586 intestine has also been documented (84, 85).”
BackgroundYang, N., Lan, T., Han, Y., Zhao, H., Wang, C., Xu, Z. C., Zhao, C., Tao, M., Li, H., Song, Y., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0289364 · Cited by 50
“As the diversity and abundance of bacteria decrease, the mice’s gut digestion slows down [36], so they eat less and lose weight.”
Physiology of Electrolyte Transport in the Gut: Implications for Disease
Rao, M. C. (2019) · Comprehensive physiology · doi:10.1002/cphy.c180011 · Cited by 54
Impacts of food additives on gut microbiota and host health
Li, P., Qu, R., Li, M., Sheng, P., Jin, L., Huang, X., & Xu, Z. Z. (2024) · Food Research International · doi:10.1016/j.foodres.2024.114998 · Cited by 45
Ruigrok, R. A. A. A., Collij, V., Sureda, P. F., Klaassen, M. A. Y., Bolte, L. A., Jansen, B. H., Voskuil, M. D., Fu, J., Wijmenga, C., Zhernakova, A., et al. (2021) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjab020 · Cited by 42
Zuo, J., Zhang, Y., Wu, Y. H., Liu, J., Wu, Q., Shen, Y., Li, J., Wu, M., Ma, Z., & Tong, H. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.07.184 · Cited by 44
Byndloss, M. X., Devkota, S., Duca, F. A., Niess, J. H., Nieuwdorp, M., Orho‐Melander, M., Sanz, Y., Tremaroli, V., & Zhao, L. (2024) · Diabetologia · doi:10.1007/s00125-024-06198-1 · Cited by 47
“…small intestine epithelium also plays an essential role in glucose and fat uptake and metabolism, protecting the host from features of metabolic dysfunction [162, 163], and the small intestine microbiota is a regulator of EEC function and nutrient absorption, metabolism, and secretion [164, 165].”
BackgroundMicrobiota on biotics: probiotics, prebiotics, and synbiotics to optimize growth and metabolism
Edwards, P. T., Kashyap, P., & Preidis, G. A. (2020) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00028.2020 · Cited by 43
Xu, Q., Zhang, J., Lu, Y., & Wu, L. Y. (2024) · iScience · doi:10.1016/j.isci.2024.108783 · Cited by 43
“90 Additionally, PCOS stool microbiota exhibits reduced diversity and an altered phylogenetic profile, contributing to reproductive and metabolic issues.”
BackgroundMajor Lipids, Apolipoproteins, and Alterations of Gut Microbiota
Yun, K. E., Kim, J., Kim, M.-H., Park, E., Kim, H., Chang, Y., Ryu, S., & Kim, H. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051589 · Cited by 40
“Most studies on lipid markers were animal studies [9], the supplementation of specific strains of bacteria [10], or human studies with a small sample size [11].”
BackgroundThe Immunological Role of Milk Fat Globule Membrane
Cavaletto, M., Givonetti, A., & Cattaneo, C. (2022) · Nutrients · doi:10.3390/nu14214574 · Cited by 39
“It has been demonstrated that the microbiota of the small intestine tunes the host’s adaptation in response to dietary lipids; this synergism could be exploited in the preparation of infant formula with probiotics and MFGM to improve lipid digestion [35].”
BackgroundLuo, X., Liu, W., Zhao, M., Huang, Y. S., & Feng, F. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.05.017 · Cited by 38
Probiotics and Gut Microbiota in Obesity: Myths and Realities of a New Health Revolution
Aguilera, X. L., Manzano, A., Pírela, D., & Bermúdez, V. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081282 · Cited by 45
“Therefore, a reduction in these protein’s expression via SCFA levels decrease alters the integrity gut epithelial barrier, causing bacterial translocation and expression of inflammatory cytokines [71] such as TNFα and interleukin-1 [72], increasing Gram-negative bacteria adherence to the intestinal epithelium [73], le…”
BackgroundUnveiling the Human Gastrointestinal Tract Microbiome: The Past, Present, and Future of Metagenomics
Athanasopoulou, K., Adamopoulos, P. G., & Scorilas, A. (2023) · Biomedicines · doi:10.3390/biomedicines11030827 · Cited by 43
Wen, X., Feng, X., Xin, F., An, R. F., Huang, H., Mao, L., Liu, P., Zhang, J., Huang, H., Liu, X., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2423040 · Cited by 38
“14,15 Compared to specific pathogen-free (SPF) mice, HFD-fed germ-free (GF) mice have higher levels of fecal lipid, indicating the impact of gut microbiota on lipid metabolism.”
Wilson, M. H., Ekker, S. C., & Farber, S. A. (2021) · eLife · doi:10.7554/elife.66393 · Cited by 38
Su, Y., Ge, Y., Xu, Z., Zhang, D., & Li, D. (2021) · Poultry Science · doi:10.1016/j.psj.2021.101422 · Cited by 38
“Animal phenotypic variation is non-negligibly affected not only by host genetics but also by numerous complex microorganisms and the environment (Nicholson et al., 2012; Martinez-Guryn et al., 2018).”
BackgroundWeninger, S. N., Herman, C., Meyer, R. K., Beauchemin, E. T., Kangath, A., Lane, A. I., Martinez, T. M., Hasneen, T., Jaramillo, S. A., Lindsey, J., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01590-2 · Cited by 37
He, L., Li, J., Sun, M., Wang, X., Zhao, J., Zhang, W., Lv, G., Wang, Y., & Lin, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128538 · Cited by 37
Gaudino, S. J., Singh, A., Huang, H., Padiadpu, J., Jean-Pierre, M., Kempen, C. G., Bahadur, T., Shiomitsu, K. P., Blumberg, R. S., Shroyer, K. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45568-6 · Cited by 37
“4.”
Miller, C. A., Holm, H., Horstmann, L. A., George, J. C., Fredricks, H. F., Mooy, B. A. S. V., & Apprill, A. M. (2019) · The ISME Journal · doi:10.1038/s41396-019-0549-y · Cited by 39
Cho, S., Cho, Y., & Park, J. (2021) · The Journal of Microbiology · doi:10.1007/s12275-022-1614-1 · Cited by 41
“High-fat diet (HFD)-induced changes in microbial composition in the small intestine promote lipid absorption (Martinez-Guryn et al., 2018).”
BackgroundGut Microbiota and Aging: Traditional Chinese Medicine and Modern Medicine
Li, J., Li, D., Chen, Y., Chen, W., Xu, J., & Gao, L. (2023) · Clinical Interventions in Aging · doi:10.2147/cia.s414714 · Cited by 37
Xie, Z., Li, Y., Xiong, K., Tu, Z., Waiho, K., Yang, C., Deng, Y., Li, S., Fang, J. K., Hu, M., et al. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121921 · Cited by 36
Celastrol functions as an emerging manager of lipid metabolism: Mechanism and therapeutic potential
Gu, J., Shi, Y., Zhu, N., Li, H., Zhang, C., & Li, Q. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114981 · Cited by 36
Outside the liver box: The gut microbiota as pivotal modulator of liver diseases
Wahlstrom, A. M. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.07.004 · Cited by 35
Guo, K., Figueroa‐Romero, C., Noureldein, M. H., Hinder, L. M., Sakowski, S. A., Rumora, A. E., Petit, H. J., Savelieff, M. G., Hur, J., & Feldman, E. L. (2023) · Microbiome · doi:10.1186/s40168-022-01436-3 · Cited by 34
The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling
Lai, T.-T., Tsai, Y.-H., Liou, C.-W., Fan, C., Hou, Y.-T., Yao, T.-H., Chuang, H.-L., & Wu, W. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00477-w · Cited by 40
Bernard, M., Lecoeur, A., Coville, J., Bruneau, N., Jardet, D., Lagarrigue, S., Meynadier, A., Calenge, F., Pascal, G., & Zerjal, T. (2024) · Scientific Reports · doi:10.1038/s41598-024-58374-3 · Cited by 38
“The efficiency of digestion and energy harvesting from feed has been associated with the activity and composition of the gut microbiota 35,36 .”
BackgroundThe Role of Diet, Additives, and Antibiotics in Metabolic Endotoxemia and Chronic Diseases
Park, J., Park, H., Kim, Y., & Park, M. (2024) · Metabolites · doi:10.3390/metabo14120704 · Cited by 41
Huang, Z., Ye, Y., Long, Z., Qin, H., Liu, L., Xu, A., & Li, Z. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125122 · Cited by 36
Zaccaria, E., Klaassen, T., Alleleyn, A. M. E., Boekhorst, J., Smokvina, T., Kleerebezem, M., & Troost, F. J. (2023) · Microbiome · doi:10.1186/s40168-023-01491-4 · Cited by 34
“This is exemplified by recent rodent studies that established prominent roles of the SI microbiota in whole body glucose homeostasis [7, 8], lipid digestion and absorption [9], and bile acid metabolism [10].”
BackgroundAraújo, M., Beekman, J. K., Mapa, M. S. T., MacMahon, S., Zhao, Y., Flynn, T. J., Flannery, B. M., Mossoba, M. E., & Sprando, R. L. (2020) · Toxicology in Vitro · doi:10.1016/j.tiv.2020.104887 · Cited by 34
Albouery, M., Bretin, A., Buteau, B., Gregoire, S., Martine, L., Gambert, S., Bron, A. M., Acar, N., Chassaing, B., & Bringer, M.-A. (2021) · Nutrients · doi:10.3390/nu13031037 · Cited by 36
“Indeed, comparisons of germ-free (GF) mice with conventional or conventionalized mice have shown that gut microbes are required for proper digestion and absorption of dietary lipids and further fat storage [31,32].”
BackgroundThe Role of Gut Microbiota in Hypertension Pathogenesis and the Efficacy of Antihypertensive Drugs
Xiong, Y., Xiong, Y., Zhu, P., Wang, Y., Yang, H., Zhou, R., Shu, Y., Zhou, H., & Li, Q. (2021) · Current Hypertension Reports · doi:10.1007/s11906-021-01157-2 · Cited by 35
Metadata
- Authors
- Martinez-Guryn, K., Hubert, N., Frazier, K., Urlass, S., Musch, M. W., Ojeda, P., Pierre, J. F., Miyoshi, J., Sontag, T. J., Cham, C. M., Reardon, C. A., Leone, V., & Chang, E. B.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Chang, Eugene B.
- ORCID
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2018-04
- Volume
- 23
- Issue
- 4
- Pages
- 458-469.e5
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC5912695
- OpenAlex
- W2796527107
- Cited by
- 663
- References
- 53
- Citations by year
- 2026: 54 · 2025: 85 · 2024: 101 · 2023: 98 · 2022: 88 · 2021: 93 · 2020: 82 · 2019: 43 · 2018: 18
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Host & Microbe (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK42086)
- Digestive Diseases Research Core Center, University of Chicago (DK097268, T32DK007074)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- small intestinal microbiota, dietary fat absorption, lipid digestion, germ-free mice, diet-induced obesity, fat malabsorption, high-fat diet, jejunal microbiota, overnutrition, malnutrition
- MeSH terms
- Gastrointestinal Microbiome, Animals, Diet, Intestine, Small, Lipid Metabolism, Mice
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