Cited by 675Gut microbiota and healthGastrointestinal motility and disordersAnimal Nutrition and Physiology

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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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Martinez-Guryn, Kristina, Hubert, Nathaniel, Frazier, Katya, Urlass, Saskia, Musch, Mark W., Ojeda, Patricia, Pierre, Joseph F., Miyoshi, Jun, Sontag, Timothy J., Cham, Candace M., Reardon, Catherine A., Leone, Vanessa, Chang, Eugene B.·2018·Cell Host & Microbe

DOI 10.1016/j.chom.2018.03.011PMC PMC5912695

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Abstract

The gut microbiota play important roles in lipid metabolism and absorption. However, the contribution of the small bowel microbiota of mammals to these diet-microbe interactions remains unclear. We determine that germ-free (GF) mice are resistant to diet-induced obesity and malabsorb fat with specifically impaired lipid digestion and absorption within the small intestine. Small bowel microbes are essential for host adaptation to dietary lipid changes by regulating gut epithelial processes involved in their digestion and absorption. In addition, GF mice conventionalized with high-fat diet-induced jejunal microbiota exhibit increased lipid absorption even when fed a low-fat diet. Conditioned media from specific bacterial strains directly upregulate lipid absorption genes in murine proximal small intestinal epithelial organoids. These findings indicate that proximal gut microbiota play key roles in host adaptability to dietary lipid variations through mechanisms involving both the digestive and absorptive phases and that these functions may contribute to conditions of over- and undernutrition.

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Additional file 10 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462965
Additional file 9 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715103
Additional file 7 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463037
Additional file 5 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463028
Additional file 1 of Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
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Additional file 3 of Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
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Additional file 10 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715046
Additional file 1 of Functional enrichment of gut microbiome by early supplementation of Bacillus based probiotic in cage free hens: a field study
Khan, S., & Chousalkar, K. K. (2021) · Figshare · doi:10.6084/m9.figshare.15064468
Additional file 4 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463022
Additional file 8 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463040
Additional file 6 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715094
Additional file 12 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462977
Additional file 11 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462971
Additional file 9 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463043
Additional file 2 of Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
Essock-Burns, T., Lawhorn, S., Wu, L., McClosky, S., Moriano‐Gutierrez, S., Ruby, E. G., & McFall‐Ngai, M. (2024) · Figshare · doi:10.6084/m9.figshare.26579489
Additional file 6 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463034
Additional file 17 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462998
Additional file 4 of Endogenous small intestinal microbiome determinants of transient colonisation efficiency by bacteria from fermented dairy products: a randomised controlled trial
Zaccaria, E., Klaassen, T., Alleleyn, A. M. E., Boekhorst, J., Smokvina, T., Kleerebezem, M., & Troost, F. J. (2023) · Figshare · doi:10.6084/m9.figshare.22617545
Additional file 4 of Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
Essock-Burns, T., Lawhorn, S., Wu, L., McClosky, S., Moriano‐Gutierrez, S., Ruby, E. G., & McFall‐Ngai, M. (2024) · Figshare · doi:10.6084/m9.figshare.26579495
Additional file 6 of Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
Essock-Burns, T., Lawhorn, S., Wu, L., McClosky, S., Moriano‐Gutierrez, S., Ruby, E. G., & McFall‐Ngai, M. (2024) · Figshare · doi:10.6084/m9.figshare.26579501
Additional file 1 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463004
Additional file 1 of Oligofructose improves small intestinal lipid-sensing mechanisms via alterations to the small intestinal microbiota
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Additional file 5 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715091
Additional file 4 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715088
Additional file 11 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715049
Additional file 8 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715100
Additional file 3 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12463016
Additional file 16 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462995
Additional file 20 of Joint contributions of the gut microbiota and host genetics to feed efficiency in chickens
Wen, C., Yan, W., Mai, C., Duan, Z., Zheng, J., Sun, C., & Yang, N. (2021) · Figshare · doi:10.6084/m9.figshare.14715076
Additional file 1 of Gut microbiota in a mouse model of obesity and peripheral neuropathy associated with plasma and nerve lipidomics and nerve transcriptomics
Guo, K., Figueroa‐Romero, C., Noureldein, M. H., Hinder, L. M., Sakowski, S. A., Rumora, A. E., Petit, H. J., Savelieff, M. G., Hur, J., & Feldman, E. L. (2023) · Figshare · doi:10.6084/m9.figshare.22621370
Additional file 13 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462983
Additional file 15 of Eggshell and environmental bacteria contribute to the intestinal microbiota of growing chickens
Maki, J. J., Bobeck, E. A., Sylte, M. J., & Looft, T. P. (2020) · Figshare · doi:10.6084/m9.figshare.12462992
Additional file 5 of Maturation state of colonization sites promotes symbiotic resiliency in the Euprymna scolopes-Vibrio fischeri partnership
Essock-Burns, T., Lawhorn, S., Wu, L., McClosky, S., Moriano‐Gutierrez, S., Ruby, E. G., & McFall‐Ngai, M. (2024) · Figshare · doi:10.6084/m9.figshare.26579498
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Exploring the Prevention and Treatment of Simple Obesity through the Liver, Spleen, and Kidney Based on Gut Microbiota
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Authors: Martinez-Guryn, K., Hubert, N., Frazier, K., Urlass, S., Musch, M. W., Ojeda, P., Pierre, J. F., Miyoshi, J., Sontag, T. J., Cham, C. M., Reardon, C. A., Leone, V., & Chang, E. B.
Affiliations: University of Chicago (US)
Corresponding author: Chang, Eugene B.
ORCID: Hubert, Nathaniel
Frazier, Katya
Urlass, Saskia
Musch, Mark W.
Pierre, Joseph F.
Miyoshi, Jun
Cham, Candace M.
Reardon, Catherine A.
Leone, Vanessa
Chang, Eugene B.
Venue: Cell Host & Microbe
Publisher: Elsevier BV
Published: 2018-04
Volume: 23
Issue: 4
Pages: 458-469.e5
ISSN: 1931-3128 (ISSN-L)
DOI: 10.1016/j.chom.2018.03.011
PMC: PMC5912695
OpenAlex: W2796527107
Cited by: 663
References: 53
Citations by year: 2026: 54 · 2025: 85 · 2024: 101 · 2023: 98 · 2022: 88 · 2021: 93 · 2020: 82 · 2019: 43 · 2018: 18
FWCI: 21.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 375 d)
Locations: Cell Host & Microbe (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK42086)
Digestive Diseases Research Core Center, University of Chicago (DK097268, T32DK007074)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
Keywords: small intestinal microbiota, dietary fat absorption, lipid digestion, germ-free mice, diet-induced obesity, fat malabsorption, high-fat diet, jejunal microbiota, overnutrition, malnutrition
MeSH terms: Gastrointestinal Microbiome, Animals, Diet, Intestine, Small, Lipid Metabolism, Mice

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Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

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