The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Comparative metabolomic study of transgenic versus conventional soybean using capillary electrophoresis-time-of-flight mass spectrometry
Open accessAbstract
In this work, capillary electrophoresis-time-of-flight mass spectrometry (CE-TOF-MS) is proposed to identify and quantify the main metabolites found in transgenic soybean and its corresponding non-transgenic parental line both grown under identical conditions. The procedure includes optimization of metabolites extraction, separation by CE, on-line electrospray-TOF-MS analysis and data evaluation. A large number of extraction procedures and background electrolytes are tested in order to obtain a highly reproducible and sensitive analytical methodology. Using this approach, a large number of metabolites were tentatively identified based on the high mass accuracy provided by TOF-MS analyzer, together with the isotopic pattern and expected electrophoretic mobility of these compounds. In general, the same metabolites and in similar amounts were found in the conventional and transgenic variety. However, significant differences were also observed in some specific cases when the conventional variety was compared with its corresponding transgenic line. The selection of these metabolites as possible biomarkers of transgenic soybean is discussed, although a larger number of samples need to be analyzed in order to validate this point. It is concluded that metabolomic procedures based on CE-MS can open new perspectives in the study of transgenic foods in order to corroborate (or not) the equivalence with their conventional counterparts.
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“Independent studies have shown the compositional equivalence of the current generation of GE crops (Cheng et al., 2008; Garcia-Villalba et al., 2008; Herman and Price, 2013; Hollingworth et al., 2003)”
From Prevalence and impacts of genetically engineered feedstuffs on livestock populations1 (2014) · cites this paper as Garcia-Villalba et al., 2008
Citations
Cites
Mass spectrometry in the structural analysis of flavonoids
Cuyckens, F., & Claeys, M. (2004) · Journal of Mass Spectrometry · doi:10.1002/jms.585 · Cited by 1,086
Yield effects of genetically modified crops in developing countries
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Iwashina, T. (2000) · Journal of Plant Research · doi:10.1007/pl00013940 · Cited by 488
Fungal pathogen protection in potato by expression of a plant defensin peptide
Gao, A.-G., Hakimi, S. M., Mittanck, C. A., Wu, Y., Woerner, B. M., Stark, D. M., Shah, D. M., Liang, J., & Rommens, C. M. T. (2000) · Nature Biotechnology · doi:10.1038/82436 · Cited by 472
Molecular basis for the herbicide resistance of Roundup Ready crops
Funke, T., Han, H., Healy-Fried, M. L., Fischer, M. J., & Schönbrunn, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603638103 · Cited by 383
Anklam, E., Gadani, F., Heinze, P., Pijnenburg, H. C. H., & den Eede, G. V. (2002) · European Food Research and Technology · doi:10.1007/s002170100415 · Cited by 296
The Composition of Glyphosate-Tolerant Soybean Seeds Is Equivalent to that of Conventional Soybeans
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Research works printed but not linked: 1
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Metabolomic analysis in food science: a review
Cevallos‐Cevallos, J. M., Reyes-De-Corcuera, J. I., Etxeberria, E., Danyluk, M. D., & Rodrick, G. E. (2009) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2009.07.002 · Cited by 545
Foodomics: MS‐based strategies in modern food science and nutrition
Herrero, M., Simó, C., García‐Cañas, V., Ibáñez, E., & Cifuentes, A. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20335 · Cited by 397
Self-citationRecent advances in the application of metabolomics for food safety control and food quality analyses
Li, S., Tian, Y., Jiang, P., Lin, Y., Liu, X., & Yang, H. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1761287 · Cited by 405
Ramautar, R., Somsen, G. W., & de Jong, G. J. (2008) · Electrophoresis · doi:10.1002/elps.200800512 · Cited by 282
Achievements and Challenges in Legume Breeding for Pest and Disease Resistance
Rubiales, D., Fondevilla, S., Chen, W., Gentzbittel, L., Higgins, T. J. V., Castillejo, M. Á., Singh, K. B., & Rispail, N. (2014) · Critical Reviews in Plant Sciences · doi:10.1080/07352689.2014.898445 · Cited by 265
Metadata
- Authors
- García-Villalba, R., León, C., Dinelli, G., Segura-Carretero, A., Fernández-Gutiérrez, A., Garcia-Cañas, V., & Cifuentes, A.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- University of Bologna (IT)
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 1195
- Issue
- 1-2
- Pages
- 164-173
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W1966413091
- Cited by
- 129
- References
- 55
- Citations by year
- 2025: 2 · 2023: 7 · 2022: 4 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 9
- FWCI
- 12.50
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Institutional Repository of the University of Granada (University of Granada) (submittedVersion, cc-by-nc-nd)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Genetically Modified Organisms Research
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Keywords
- transgenic soybean, metabolomics, metabolite extraction, supporting electrolyte
- MeSH terms
- Glycine max, Electrophoresis, Capillary, Spectrometry, Mass, Electrospray Ionization, Plant Preparations, Plants, Genetically Modified
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