Cited by 192Chromatography in Natural ProductsTraditional Chinese Medicine AnalysisAnalytical Chemistry and Chromatography

Role of counter-current chromatography in the modernisation of Chinese herbal medicines

Sutherland, Ian A., Fisher, Derek·2009·Journal of Chromatography A

Abstract

This review focuses on the growing popularity of using counter-current chromatography (CCC), with its liquid stationary phase, as one of the prime methods for isolating compounds from Chinese herbal medicines (CHMs). 198 publications are reviewed covering 108 different plant species from 56 plant families. These describe the isolation of 354 different molecules across a wide range of polarities, chemical classes and molecular weights (in the range 100-1000 Da). The suitability of CCC for the separation of active compounds from CHM, the phase systems used, how CCC has developed in China, compounds isolated, CCC instrumentation, performance, operational issues and innovations, all supported by detailed cross-referencing, are described. It is concluded that CCC is making an increasingly important contribution to the modernisation of Chinese herbal medicines.

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Crossref · 10.1016/j.chroma.2008.11.095

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Authors
Sutherland, I. A., & Fisher, D.
Affiliations
Brunel University of London (GB)
Corresponding author
Sutherland, Ian A.
Venue
Journal of Chromatography A
Publisher
Elsevier BV
Published
2009-01
Volume
1216
Issue
4
Pages
740-753
ISSN
0021-9673 (ISSN-L)
OpenAlex
W2160635294
Cited by
192
References
202
Citations by year
2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 13 · 2014: 21 · 2013: 13 · 2012: 15
FWCI
1.95
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Chromatography A (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • International Plant Nutrition Institute
  • Imperial College London
  • Royal Botanical Gardens, Kew
Topics
  • Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
  • Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
  • Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
Keywords
countercurrent chromatography, Chinese herbal medicine, liquid stationary phases, natural product separation
MeSH terms
Countercurrent Distribution, Drugs, Chinese Herbal

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