Role of counter-current chromatography in the modernisation of Chinese herbal medicines
Abstract
This review focuses on the growing popularity of using counter-current chromatography (CCC), with its liquid stationary phase, as one of the prime methods for isolating compounds from Chinese herbal medicines (CHMs). 198 publications are reviewed covering 108 different plant species from 56 plant families. These describe the isolation of 354 different molecules across a wide range of polarities, chemical classes and molecular weights (in the range 100-1000 Da). The suitability of CCC for the separation of active compounds from CHM, the phase systems used, how CCC has developed in China, compounds isolated, CCC instrumentation, performance, operational issues and innovations, all supported by detailed cross-referencing, are described. It is concluded that CCC is making an increasingly important contribution to the modernisation of Chinese herbal medicines.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
HSCCC eliminates irreversible adsorption of analytes on the solid phase in conventional column chromatography and offers full recovery of target compounds.
“High-speed counter-current chromatography (HSCCC), being a kind of liquid–liquid partition chromatography, eliminates the irreversible adsorption of analytes on the solid phase in conventional column chromatography and offers full recovery of target compounds.”
Cites
G.U.E.S.S.—A Generally Useful Estimate of Solvent Systems for CCC
Friesen, J. B., & Pauli, G. F. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500225234 · Cited by 298 · see citing works
Chen, L., Games, D. E., & Jones, J. J. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(02)01954-4 · Cited by 200 · see citing works
Recent advances in analysis of Chinese medical plants and traditional medicines
Drašar, P., & Moravcová, J. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.09.037 · Cited by 199 · see citing works
Li, H., & Chen, F. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.088 · Cited by 185 · see citing works
Si, W., Gong, J., Tsao, R., Kalab, M., Yang, R., & Yin, Y. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.05.061 · Cited by 184 · see citing works
Separation methods used for Scutellaria baicalensis active components
Li, H., Jiang, Y., & Chen, F. (2004) · Journal of Chromatography B · doi:10.1016/j.jchromb.2004.06.045 · Cited by 162 · see citing works
Peng, J., Fan, G., Hong, Z., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.067 · Cited by 159 · see citing works
Lifting the Veil on Traditional Chinese Medicine
Stone, R. (2008) · Science · doi:10.1126/science.319.5864.709 · Cited by 148 · see citing works
Communesins G and H, New Alkaloids from the Psychrotolerant Fungus Penicillium rivulum
Dalsgaard, P. W., Blunt, J. W., Munro, M. H. G., et al. (2005) · Journal of Natural Products · doi:10.1021/np049646l · Cited by 132 · see citing works
Chen, L., Zhang, Q., Yang, G., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.09.098 · Cited by 126 · see citing works
Chu, X., Sun, A., & Liu, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.08.008 · Cited by 126 · see citing works
Hatano, T., Yasuhara, T., Fukuda, T., et al. (1989) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.37.3005 · Cited by 124 · see citing works
Gu, M., Ouyang, F., & Su, Z. G. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.09.038 · Cited by 123 · see citing works
Li, L., Tsao, R., Liu, Z., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.11.024 · Cited by 121 · see citing works
Zhou, X. G., Peng, J., Fan, G., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.064 · Cited by 116 · see citing works
Liu, R., Li, A., & Sun, A. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.101 · Cited by 108 · see citing works
Wang, X., Wang, Y., Geng, Y., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.02.073 · Cited by 103 · see citing works
Wei, Y., & Ito, Y. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.081 · Cited by 102 · see citing works
Yang, F., Zhang, T., Zhang, R., et al. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00776-6 · Cited by 100 · see citing works
Cao, X., Tian, Y., Zhang, T., et al. (1999) · Journal of Chromatography A · doi:10.1016/s0021-9673(99)00715-3 · Cited by 99 · see citing works
Isolation of dammarane saponins from Panax notoginseng by high-speed counter-current chromatography
Du, Q., Jerz, G., Waibel, R., et al. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(03)00988-9 · Cited by 97 · see citing works
Yang, F., Zhang, T., Tian, G., et al. (1999) · Journal of Chromatography A · doi:10.1016/s0021-9673(99)00827-4 · Cited by 96 · see citing works
Ha, Y. W., Lim, S. S., Ha, I. J., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.01.038 · Cited by 94 · see citing works
Ling, J. Y., Zhang, G. Y., Cui, Z., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.01.080 · Cited by 93 · see citing works
Gu, M., Zhang, G., Su, Z. G., & Ouyang, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.04.030 · Cited by 92 · see citing works
Chen, L., Han, Y., Yang, F., et al. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00960-2 · Cited by 92 · see citing works
Yao, S., Li, Y., & Kong, L. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.071 · Cited by 92 · see citing works
Gu, M., Zhang, S., Su, Z. G., Chen, Y., & Ouyang, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.145 · Cited by 91 · see citing works
Shen, S., Chang, Z., Liu, J., et al. (2006) · Separation and Purification Technology · doi:10.1016/j.seppur.2006.07.003 · Cited by 89 · see citing works
Lei, L., Yang, F., Zhang, T., et al. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00583-0 · Cited by 85 · see citing works
Liu, R., Sun, Q., Sun, A., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.023 · Cited by 85 · see citing works
Wu, S., Sun, C., Pei, S., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.03.056 · Cited by 85 · see citing works
Lü, H., Jiang, Y., & Chen, F. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.11.004 · Cited by 85 · see citing works
Wu, S., Sun, A., & Liu, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.01.054 · Cited by 85 · see citing works
Chen, J., Wang, F., Lee, F. S.-C., et al. (2005) · Talanta · doi:10.1016/j.talanta.2005.09.041 · Cited by 85 · see citing works
Li, A., Sun, A., & Liu, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.042 · Cited by 84 · see citing works
Ma, X., Tu, P., Chen, Y., et al. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(03)00315-7 · Cited by 83 · see citing works
Wei, Y., Zhang, T., & Ito, Y. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.01.058 · Cited by 82 · see citing works
Zhi, W., & Deng, Q. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.036 · Cited by 82 · see citing works
Ma, C., Li, G., Zhang, D., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.01.053 · Cited by 82 · see citing works
Preparative Separation of Polyphenols from Tea by High-Speed Countercurrent Chromatography
Degenhardt, A. G., Engelhardt, U. H., Lakenbrink, C., et al. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0000833 · Cited by 81 · see citing works
Li, H., Lai, J., Jiang, Y., et al. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01441-8 · Cited by 80 · see citing works
Wang, X. D., Cheng, C., Sun, Q., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.017 · Cited by 79 · see citing works
Multidimensional counter-current chromatographic system and its application
Yang, F., Quan, J., Zhang, T. Y., et al. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(97)01273-9 · Cited by 76 · see citing works
Li, H., & Chen, F. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01026-3 · Cited by 76 · see citing works
Liu, R., Li, A., Sun, A., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.12.026 · Cited by 74 · see citing works
Ma, X., Tian, W., Wu, L., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.02.052 · Cited by 73 · see citing works
Yang, F., Zhang, T., & Ito, Y. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00846-9 · Cited by 72 · see citing works
Zhou, T., Fan, G., Hong, Z., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.09.026 · Cited by 71 · see citing works
Wu, S., Sun, C., Cao, X., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.05.003 · Cited by 70 · see citing works
Huang, T., Shen, P., & Shen, Y. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.01.025 · Cited by 70 · see citing works
Shi, S., Huang, K., Zhang, Y., et al. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.09.016 · Cited by 70 · see citing works
Yan, J., Gang, C., Tong, S., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.02.064 · Cited by 69 · see citing works
Peng, J., Fan, G., Chai, Y., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.10.045 · Cited by 69 · see citing works
Counter-current chromatography
Sutherland, I., Heywood-Waddington, D., & Ito, Y. (1987) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)94671-0 · Cited by 68 · see citing works
Self-citationSimple Approach to the Development of a CCC Solvent Selection Protocol Suitable for Automation
Garrard, I. J. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200063571 · Cited by 68 · see citing works
Tian, G., Zhang, T., Yang, F., et al. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00480-5 · Cited by 68 · see citing works
Counter-current chromatography separation scaled up from an analytical column to a production column
Wood, P. L., Ignatova, S. N., Janaway, L., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.02.014 · Cited by 68 · see citing works
TIAN, G., Zhang, U., Zhang, T., et al. (2004) · Journal of Chromatography A · doi:10.1016/s0021-9673(04)01276-2 · Cited by 67 · see citing works
Kumar, N. S., & Rajapaksha, M. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.06.013 · Cited by 67 · see citing works
Tian, G., Zhang, Y., Zhang, T., et al. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00916-x · Cited by 66 · see citing works
Li, H., & Chen, F. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01232-8 · Cited by 64 · see citing works
Peng, J., Fan, G., Qu, L., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.091 · Cited by 64 · see citing works
Liu, R., Chu, X., Sun, A., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.099 · Cited by 64 · see citing works
Han, Q., Song, J., Qiao, C., et al. (2006) · Journal of Separation Science · doi:10.1002/jssc.200600089 · Cited by 63 · see citing works
Lu, J., WEI, Y., & Yuan, Q. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.06.038 · Cited by 63 · see citing works
Liu, R., Feng, L., Sun, A., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.09.047 · Cited by 63 · see citing works
Wang, X. D., Wang, Y., Yuan, J.-P., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.09.011 · Cited by 61 · see citing works
Tian, G., Zhang, T., Zhang, Y., et al. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01495-9 · Cited by 60 · see citing works
Chen, L. J., Song, H., Lan, X., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.11.072 · Cited by 59 · see citing works
Peng, J., Dong, F., Xu, Q., et al. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.099 · Cited by 59 · see citing works
Wang, X., Li, F., Zhang, H., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.023 · Cited by 58 · see citing works
Yao, S., Liu, R., Huang, X., et al. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.11.056 · Cited by 58 · see citing works
Zhou, T., Bin, C., Fan, G., et al. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.041 · Cited by 57 · see citing works
Li, H., & Chen, F. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.06.025 · Cited by 56 · see citing works
Liu, Z., Wang, J., Shen, P., et al. (2006) · Separation and Purification Technology · doi:10.1016/j.seppur.2006.03.009 · Cited by 56 · see citing works
Liu, R., Sun, Q., Shi, Y.-R., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.041 · Cited by 56 · see citing works
Wang, Q., Lee, F. S.-C., & Wang, X. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.06.135 · Cited by 56 · see citing works
Liu, R., Li, A., & Sun, A. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.08.127 · Cited by 55 · see citing works
LU, H., JIANG, Y., & Chen, F. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.09.022 · Cited by 55 · see citing works
Ma, X., Wu, L., Ito, Y., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.077 · Cited by 55 · see citing works
Gu, M., Wang, X., Su, Z. G., & Ouyang, F. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.11.057 · Cited by 54 · see citing works
Jiang, Y., Lü, H., & Chen, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.01.033 · Cited by 54 · see citing works
Peng, J., Fan, G., & Wu, Y. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.079 · Cited by 54 · see citing works
Lu, Y., Sun, C., Liu, R., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.01.141 · Cited by 52 · see citing works
Yang, F., Zhang, T., Liu, Q., et al. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00359-9 · Cited by 52 · see citing works
Tong, S., Yan, J., & Lou, J. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500274638 · Cited by 52 · see citing works
Wu, H., Su, Z. C., Yang, Y., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.11.013 · Cited by 52 · see citing works
Du, Q., Li, L., & Jerz, G. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.072 · Cited by 52 · see citing works
Sun, A., Sun, Q., & Liu, R. (2007) · Journal of Separation Science · doi:10.1002/jssc.200600334 · Cited by 52 · see citing works
Lee, Y.-W., Voyksner, R. D., Pack, T. W., Cook, C. E., Fang, Q., & Ito, Y. (1990) · Analytical Chemistry · doi:10.1021/ac00202a004 · Cited by 50 · see citing works
A NEW HYPOTHESIS ON PHASE DISTRIBUTION IN COUNTERCURRENT CHROMATOGRAPHY
Sutherland, I., Muytjens, J., Prins, M., et al. (2000) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-100100486 · Cited by 50 · see citing works
Self-citationLi, H., & Chen, F. (2005) · Journal of Separation Science · doi:10.1002/jssc.200400002 · Cited by 49 · see citing works
Wang, X., Geng, Y., Li, F., et al. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.03.103 · Cited by 48 · see citing works
Cao, X., Tian, Y., Zhang, T., et al. (2003) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120021268 · Cited by 47 · see citing works
Emerging issues in traditional Chinese medicine
Siow, Y. L., Gong, Y., Au-Yeung, K. K. W., et al. (2005) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y05-029 · Cited by 47 · see citing works
Ouyang, X., JIN, M., & He, C. (2007) · Separation and Purification Technology · doi:10.1016/j.seppur.2007.02.005 · Cited by 47 · see citing works
Sun, Q., Sun, A., & Liu, R. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.11.046 · Cited by 47 · see citing works
Li, H., & Chen, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.07.006 · Cited by 46 · see citing works
Geng, Y., Liu, J., Lv, R., et al. (2007) · Separation and Purification Technology · doi:10.1016/j.seppur.2007.04.015 · Cited by 46 · see citing works
Gao, M., Gu, M., & Liu, C. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.04.030 · Cited by 46 · see citing works
Yang, F., & Ito, Y. (2002) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01464-9 · Cited by 46 · see citing works
Li, H., & Chen, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.10.091 · Cited by 46 · see citing works
Ma, X., Tu, P., Chen, Y., et al. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.10.014 · Cited by 46 · see citing works
Zhao, C., & He, C. (2006) · Journal of Separation Science · doi:10.1002/jssc.200500464 · Cited by 46 · see citing works
Wang, Q., LEE, F., & Wang, X. (2004) · Journal of Chromatography A · doi:10.1016/s0021-9673(04)01086-6 · Cited by 46 · see citing works
pH-Zone-refining counter-current chromatography of lappaconitine from Aconitum sinomontanum Nakai
Yang, F., & Ito, Y. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01032-9 · Cited by 45 · see citing works
H., C., Wang, K., Sun, Z., et al. (2006) · Chromatographia · doi:10.1365/s10337-006-0789-7 · Cited by 45 · see citing works
Li, H., & Chen, F. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.09.005 · Cited by 45 · see citing works
Wei, Y., Zhang, T., & Ito, Y. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.08.015 · Cited by 45 · see citing works
Recent Progress in Countercurrent Chromatography
Pan, Y., & Lu, Y. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701190948 · Cited by 45 · see citing works
Lü, J.-H., Wei, Y., & Yuan, Q. (2006) · Separation and Purification Technology · doi:10.1016/j.seppur.2006.10.022 · Cited by 44 · see citing works
Peng, J., Fan, G., & Wu, Y. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.072 · Cited by 43 · see citing works
Du, Q., Jerz, G., He, Y., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.064 · Cited by 43 · see citing works
Wang, X., Li, F., Sun, Q., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.11.077 · Cited by 43 · see citing works
Tang, Q., Yang, C., Ye, W., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.01.058 · Cited by 42 · see citing works
Zhou, T., Zhu, Z., Wang, C., Fan, G., Peng, J., Chai, Y., & Wu, Y. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.01.050 · Cited by 42 · see citing works
Lü, H., Jiang, Y., & Chen, F. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.08.012 · Cited by 42 · see citing works
Wu, S., Sun, C., Wang, K., & Pan, Y. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.11.072 · Cited by 42 · see citing works
Modelling CCC Using an Eluting Countercurrent Distribution Model
Sutherland, I., de Folter, J., & Wood, P. L. (2003) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120021260 · Cited by 42 · see citing works
Self-citationKim, C. Y., & Kim, J. (2007) · Phytochemical Analysis · doi:10.1002/pca.958 · Cited by 40 · see citing works
Jin, W., & Tu, P. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.08.009 · Cited by 39 · see citing works
Yang, F., Quan, J., Zhang, T., et al. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00624-4 · Cited by 38 · see citing works
Peng, J., Yang, G., Fan, G., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.073 · Cited by 38 · see citing works
Hostettmann, K., Marston, A., & Hostettmann, M. (1998) · Springer eBooks · doi:10.1007/978-3-662-03631-0_7 · Cited by 38 · see citing works
Zhang, Q., Chen, L., Ye, H., et al. (2007) · Journal of Separation Science · doi:10.1002/jssc.200600544 · Cited by 37 · see citing works
Peng, J., Fan, G., & Wu, Y. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.05.097 · Cited by 37 · see citing works
Liu, J., Yue, H., Henkel, T., et al. (2002) · Phytochemical Analysis · doi:10.1002/pca.608 · Cited by 33 · see citing works
Wang, Y., & Liu, B. (2007) · Phytochemical Analysis · doi:10.1002/pca.999 · Cited by 32 · see citing works
Chen, F., Lü, H., & Jiang, Y. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.04.023 · Cited by 31 · see citing works
Yan, J., Tong, S., Li, J., et al. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600598985 · Cited by 31 · see citing works
LI, H., & Chen, F. (2004) · Journal of Chromatography A · doi:10.1016/s0021-9673(04)01103-3 · Cited by 31 · see citing works
Peng, J., Jiang, Y., Fan, G., et al. (2006) · Separation and Purification Technology · doi:10.1016/j.seppur.2006.03.010 · Cited by 30 · see citing works
Young Kim, C., Ahn, M., & Kim, J. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500531391 · Cited by 30 · see citing works
Gu, M., Su, Z. G., & Ouyang, F. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600674968 · Cited by 30 · see citing works
A New Small Coil‐Volume CCC Instrument for Direct Interfacing with MS
Janaway, L., Hawes, D. J., Ignatova, S. N., et al. (2003) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120021254 · Cited by 29 · see citing works
Shi, S., Jiang, D. L., Zhao, M., et al. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.056 · Cited by 29 · see citing works
He, S., Lu, Y., Wu, B., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.02.102 · Cited by 28 · see citing works
Liu, R., Kong, L., Li, A., et al. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070601093846 · Cited by 28 · see citing works
Kim, C. Y., Lee, H. J., Lee, M. K., et al. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700168 · Cited by 27 · see citing works
Ma, Y., Aisha, H. A., Liao, L., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.04.040 · Cited by 27 · see citing works
Zhao, M., Ito, Y., & Tu, P. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.07.010 · Cited by 27 · see citing works
Chen, L. J., Song, H., Du, Q., et al. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200058350 · Cited by 26 · see citing works
Separation and Identification of Flavonoids in an Extract from the Seeds of Oroxylum indicum by CCC
Chen, L., Games, D. E., Jones, J. J., et al. (2003) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120021271 · Cited by 26 · see citing works
Jerz, G., Arrey, T. N., Wray, V., et al. (2007) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2007.03.024 · Cited by 26 · see citing works
Zhang, T., Cai, D.-G., & Ito, Y. (1988) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)82171-3 · Cited by 25 · see citing works
Isolation and Identification of Phenolic Compounds in the Fruit of Benincasa hispida by HSCCC
Du, Q., Zhang, Q., & Ito, Y. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200038620 · Cited by 25 · see citing works
Han, C. C., Chen, J., Liu, J., et al. (2006) · Talanta · doi:10.1016/j.talanta.2006.05.016 · Cited by 25 · see citing works
Tong, S., Yan, J., & Lou, J. (2006) · Phytochemical Analysis · doi:10.1002/pca.938 · Cited by 25 · see citing works
How to achieve rapid separations in counter-current chromatography
Chen, L., & Sutherland, I. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.02.019 · Cited by 23 · see citing works
Self-citationLiu, Z., JIN, Y., SHEN, P., et al. (2006) · Talanta · doi:10.1016/j.talanta.2006.08.023 · Cited by 23 · see citing works
Kim, C. Y., Ahn, M., & Kim, J. (2006) · Journal of Separation Science · doi:10.1002/jssc.200500316 · Cited by 23 · see citing works
Chapter 7 Special uses of a support-free liquid stationary phase
Billardello, B., & Berthod, A. (2002) · Comprehensive analytical chemistry · doi:10.1016/s0166-526x(02)80010-1 · Cited by 22 · see citing works
Yang, F. Q., Zhang, T., Mo, B., et al. (1998) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826079808001950 · Cited by 22 · see citing works
Isolation of esculetin from Cichorium glandulosum by high-speed countercurrent chromatography
Wu, H., Su, Z., Yili, A., et al. (2007) · Chemistry of Natural Compounds · doi:10.1007/s10600-007-0045-x · Cited by 21 · see citing works
Han, X., Pathmasiri, W., Bohlin, L., et al. (2003) · Journal of Chromatography A · doi:10.1016/j.chroma.2003.09.046 · Cited by 21 · see citing works
Fan, J., & He, C. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500530278 · Cited by 21 · see citing works
Separation of Aloins A and B from Aloe Vera Exudates by High Speed Countercurrent Chromatography
Cao, X., Huang, D., Dong, Y., et al. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701224887 · Cited by 21 · see citing works
Zhang, D., Teng, H., Li, G., et al. (2006) · Separation Science and Technology · doi:10.1080/01496390600785467 · Cited by 20 · see citing works
Luo, Y., Xu, Y., Chen, L., et al. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.11.072 · Cited by 20 · see citing works
Preparative Separation of Tripdiolide from Chinese Traditional Herb by Multidimensional CCC
Wei, J., Zhang, T., & Ito, Y. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200063550 · Cited by 20 · see citing works
Yuan, L. M., Zi, M., Ai, P., et al. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)01057-3 · Cited by 20 · see citing works
Peng, J., Fan, G., & Wu, Y. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600678357 · Cited by 20 · see citing works
Zhang, T.-Y., Pannell, L. K., Cai, D.-G., et al. (1988) · Journal of Liquid Chromatography · doi:10.1080/01483918808076728 · Cited by 20 · see citing works
Du, Q., & Yuan, J. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200060454 · Cited by 19 · see citing works
Lu, Y., Sun, C., & Pan, Y. (2006) · Journal of Separation Science · doi:10.1002/jssc.200500326 · Cited by 19 · see citing works
Separation and purification of 10-deacetylbaccatin III by high-speed counter-current chromatography
Cao, X., Tian, Y., Zhang, T. Y., et al. (1998) · Journal of Chromatography A · doi:10.1016/s0021-9673(98)00360-4 · Cited by 18 · see citing works
Lu, Y., Sun, C., Wang, Y., et al. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.06.073 · Cited by 18 · see citing works
HSCCC‐MS Study of Flavonoids in the Extracts from the Seeds of Oroxylum indicum
Chen, L. J., Song, H., Games, D. E., et al. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200063651 · Cited by 18 · see citing works
Suomin, F., Shi-feng, N., & Sun, W. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070601036324 · Cited by 17 · see citing works
Tian, G., Zhang, U., Zhang, T., et al. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.07.072 · Cited by 17 · see citing works
Yang, F., Zhang, T., Xu, G., et al. (2001) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-100104367 · Cited by 16 · see citing works
Kim, C., Jae, J., Hwang, H., et al. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500452051 · Cited by 16 · see citing works
Liang, Y. L., Hu, J., Chen, H., et al. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070601093812 · Cited by 15 · see citing works
Rapid and Simple Method for Quality Control of Raw Materials of Herbs by HSCCC
Wang, X. D., Liu, J., Zhang, T., et al. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701540522 · Cited by 15 · see citing works
Han, Q., Song, J. Z., Qiao, C. F., et al. (2006) · Journal of Separation Science · doi:10.1002/jssc.200600264 · Cited by 14 · see citing works
Zhang, T., Cao, X., & Han, X. (2003) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-120021267 · Cited by 14 · see citing works
Cheong, J. H., Kim, C. Y., & Kim, J. (2007) · Journal of Separation Science · doi:10.1002/jssc.200700019 · Cited by 14 · see citing works
Peng, J., Xu, L., Han, X., et al. (2007) · Chinese Journal of Analytical Chemistry · doi:10.1016/s1872-2040(07)60087-5 · Cited by 13 · see citing works
Liang, Y. L., Zhao-feng, H., Chen, H., et al. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070601084886 · Cited by 13 · see citing works
Peng, J., Han, X., Xu, Y., et al. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701588984 · Cited by 13 · see citing works
Wei, Y., & Ito, Y. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600678340 · Cited by 13 · see citing works
Isolation of Two Sucrose Esters from Polygala tenuifolia by High Speed Countercurrent Chromatography
Jiang, Y., Tu, P., Chen, X., et al. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200058371 · Cited by 13 · see citing works
Yang, F., Ou, Q., & Yu, W. (1995) · Journal of Liquid Chromatography · doi:10.1080/10826079508009247 · Cited by 12 · see citing works
Lee, Y. W., Cook, C. E., Fang, Q., et al. (1989) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)89653-9 · Cited by 11 · see citing works
Huang, T., Shen, Y., & Shen, P. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500187566 · Cited by 11 · see citing works
Yua, L. M., Chen, X. X., Ai, P., et al. (2001) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-100107349 · Cited by 11 · see citing works
Yuan, L. M., Fu, R. N., Tan, N., et al. (2002) · Analytical Letters · doi:10.1081/al-120002372 · Cited by 10 · see citing works
Wei, Y., Zhang, T., & Ito, Y. (2001) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)00665-3 · Cited by 10 · see citing works
Qu, L., & Peng, J. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500479351 · Cited by 10 · see citing works
Preparative Separation of a Minor Active Chromone from Aloe vera Leaves by CCC
Cao, X., Dong, Y., Hua, Z., et al. (2005) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-200063655 · Cited by 9 · see citing works
Du, Q., & Wang, K. (2007) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070701386504 · Cited by 9 · see citing works
Sun, A., Feng, L., & Liu, R. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070500509306 · Cited by 8 · see citing works
Lu, Y., Sun, C., & Pan, Y. (2006) · Journal of Separation Science · doi:10.1002/jssc.200500363 · Cited by 8 · see citing works
Du, Q., & Gao, S. (2006) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826070600864924 · Cited by 7 · see citing works
(1977) · Proceedings of the Analytical Division of the Chemical Society · doi:10.1039/ad97714bx034 · Cited by 7 · see citing works
HSCCC Separation of a Stilbene Glucoside from Polygonum Multiflorum
Cao, X., Tian, Y., Zhang, T., et al. (1998) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826079808003452 · Cited by 6 · see citing works
Purification of a synthetic myristylated peptide by counter-current chromatography
Knight, M., Gluch, S., Takahashi, K., et al. (1991) · Journal of Chromatography A · doi:10.1016/s0021-9673(01)91631-0 · Cited by 6 · see citing works
AFFINITY ADSORBENTS WITH D-ALANINE AND D,L-ALANINE AS LIGANDS FOR VANCOMYCIN GROUP ANTIBIOTICS
Yuan, J., Xu, J., Niu, W., et al. (2001) · Journal of Liquid Chromatography & Related Technologies · doi:10.1081/jlc-100106091 · Cited by 6 · see citing works
Zhang, S. M., & Ou, Q. Y. (1995) · Microchemical Journal · doi:10.1006/mchj.1995.1079 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chemometrics: A new scenario in herbal drug standardization
Bansal, A., Chhabra, V., Rawal, R. K., & Sharma, S. (2014) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2013.12.001 · Cited by 168 · see citing works
Fang, L., Li, J., Zhou, J., Wang, X., & Guo, L. (2017) · Molecules · doi:10.3390/molecules22081310 · Cited by 20 · see citing works
- Authors
- Sutherland, I. A., & Fisher, D.
- Affiliations
- Brunel University of London (GB)
- Corresponding author
- Sutherland, Ian A.
- ORCID
- Sutherland, Ian A.
- Venue
- Journal of Chromatography A
- Publisher
- Elsevier BV
- Published
- 2009-01
- Volume
- 1216
- Issue
- 4
- Pages
- 740-753
- ISSN
- 0021-9673 (ISSN-L)
- OpenAlex
- W2160635294
- Cited by
- 192
- References
- 202
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 14 · 2017: 14 · 2016: 9 · 2015: 13 · 2014: 21 · 2013: 13 · 2012: 15
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Chromatography A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- International Plant Nutrition Institute
- Imperial College London
- Royal Botanical Gardens, Kew
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Physical Sciences › Chemistry › Spectroscopy › Analytical Chemistry and Chromatography
- Keywords
- countercurrent chromatography, Chinese herbal medicine, liquid stationary phases, natural product separation
- MeSH terms
- Countercurrent Distribution, Drugs, Chinese Herbal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review