Chemometrics: A new scenario in herbal drug standardization
Open accessAbstract
Chromatography and spectroscopy techniques are the most commonly used methods in standardization of herbal medicines but the herbal system is not easy to analyze because of their complexity of chemical composition. Many cutting-edge analytical technologies have been introduced to evaluate the quality of medicinal plants and significant amount of measurement data has been produced. Chemometric techniques provide a good opportunity for mining more useful chemical information from the original data. Then, the application of chemometrics in the field of medicinal plants is spontaneous and necessary. Comprehensive methods and hyphenated techniques associated with chemometrics used for extracting useful information and supplying various methods of data processing are now more and more widely used in medicinal plants, among which chemometrics resolution methods and principal component analysis (PCA) are most commonly used techniques. This review focuses on the recent various important analytical techniques, important chemometrics tools and interpretation of results by PCA, and applications of chemometrics in quality evaluation of medicinal plants in the authenticity, efficacy and consistency.
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There is still a lack of proper standardizing techniques for the assessment of the quality, quantity and efficiency of medicinal plants used as therapeutics.
“The use of medicinal plants as therapeutics is the oldest prevalent system to deal with illness, but still there is a lack of proper standardizing techniques for the assessment of their quality, quantity and efficiency [19].”
From Validation and quantification of major biomarkers in ‘Mahasudarshan Churna’- an ayurvedic polyherbal formulation through high-performance thin-layer chromatography (2020) · cites this paper as [19]
The Future prospects section says that an effective standard for scientific quality estimation is still lacking. But the Introduction describes existing techniques for quantitative analysis, while its concern about efficacy is a shortage of safety and efficacy data—not a lack of techniques to assess efficacy. The source therefore supports the quality-standardization concern, but not the claim across all three assessments. (LLM, conf=0.84)
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“1042 with chemometrics is that once a reliable database and suitable analytical protocol are established, samples can be screened within a few minutes [3,14].”
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Simion, I. M., Casoni, D., & Sârbu, C. (2019) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2018.09.047 · Cited by 24 · see citing works
Hawrył, A., & Hawrył, M. (2020) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2020.1801460 · Cited by 7 · see citing works
- Authors
- Bansal, A., Chhabra, V., Rawal, R. K., & Sharma, S.
- Affiliations
- Indo Soviet Friendship College of Pharmacy (IN)
- Corresponding author
- Sharma, Simant
- ORCID
- Rawal, Ravindra K.
- Venue
- Journal of Pharmaceutical Analysis
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 4
- Issue
- 4
- Pages
- 223-233
- ISSN
- 2095-1779 (ISSN-L)
- PMC
- PMC5761221
- OpenAlex
- W2021686175
- Cited by
- 168
- References
- 112
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 15 · 2023: 17 · 2022: 23 · 2021: 22 · 2020: 23 · 2019: 18 · 2018: 13 · 2017: 8 · 2016: 7 · 2015: 5 · 2014: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Pharmaceutical Analysis (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- AICTE, New Delhi and PSCST, Punjab (PSO/POS/80/9334)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Spectroscopy and Chemometric Analyses
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- chemometrics, herbal medicine standardization, medicinal plants, quality assessment, principal component analysis, hyphenated analytical techniques, authenticity, efficacy, consistency
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