Metabolism of Alcohol
Abstract
Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.
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The oxidative pathway is the major pathway for alcohol metabolism.
“The oxidative pathway is the major pathway for alcohol metabolism and is composed of two steps.”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [26]
In the liver, alcohol is metabolized by oxidative and non-oxidative pathways.
“In the liver, alcohol is metabolized by oxidative and non-oxidative pathways (Figure 1) [26,27].”
From Pathophysiological Aspects of Alcohol Metabolism in the Liver (2021) · cites this paper as [26]
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- Authors
- Lieber, C. S.
- Affiliations
- James J. Peters VA Medical Center (US)
- Corresponding author
- Lieber, Charles S.
- Venue
- Clinics in Liver Disease
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 9
- Issue
- 1
- Pages
- 1-35
- ISSN
- 1089-3261 (ISSN-L)
- OpenAlex
- W2045003374
- Cited by
- 274
- References
- 293
- Citations by year
- 2026: 4 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 15
- FWCI
- 2.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Liver Disease (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- alcohol metabolism, ethanol oxidation, liver, hepatotoxicity, NADH, cytochrome P450, chronic alcohol feeding, liver microsomes, stomach
- MeSH terms
- Alcohol Oxidoreductases, Ethanol, Alcoholism, Animals, Chronic Disease, Disease Models, Animal, Female, Humans, Liver Diseases, Alcoholic, Male, Microsomes, Liver, Mitochondria, Liver, Prognosis, Severity of Illness Index, Oxidative Stress, Disease Progression, Risk Assessment
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