Cited by 274Alcohol Consumption and Health EffectsDrug-Induced Hepatotoxicity and ProtectionPharmacogenetics and Drug Metabolism

Metabolism of Alcohol

Lieber, Charles S.·2005·Clinics in Liver Disease

Abstract

Most tissues of the body contain enzymes capable of ethanol oxidation or nonoxidative metabolism, but significant activity occurs only in the liver and, to a lesser extent, in the stomach. Hence, medical consequences are predominant in these organs. In the liver, ethanol oxidation generates an excess of reducing equivalents, primarily as NADH, causing hepatotoxicity. An additional system, containing cytochromes P-450 inducible by chronic alcohol feeding, was demonstrated in liver microsomes and found to be a major cause of hepatotoxicity.

Integrity signals

Registry

Crossref · 10.1016/j.cld.2004.10.005

Cites

288 of 288 references verified0 citation errors · 0 not checkable

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  • The oxidative pathway is the major pathway for alcohol metabolism.

    “The oxidative pathway is the major pathway for alcohol metabolism and is composed of two steps.”
  • In the liver, alcohol is metabolized by oxidative and non-oxidative pathways.

    “In the liver, alcohol is metabolized by oxidative and non-oxidative pathways (Figure 1) [26,27].”

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Authors
Lieber, C. S.
Affiliations
James J. Peters VA Medical Center (US)
Corresponding author
Lieber, Charles S.
Venue
Clinics in Liver Disease
Publisher
Elsevier BV
Published
2005-02
Volume
9
Issue
1
Pages
1-35
ISSN
1089-3261 (ISSN-L)
OpenAlex
W2045003374
Cited by
274
References
293
Citations by year
2026: 4 · 2025: 16 · 2024: 9 · 2023: 13 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 7 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 17 · 2014: 18 · 2013: 11 · 2012: 15
FWCI
2.06
Type
journal article
Language
en
Open access
closed
Locations
  • Clinics in Liver Disease (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
alcohol metabolism, ethanol oxidation, liver, hepatotoxicity, NADH, cytochrome P450, chronic alcohol feeding, liver microsomes, stomach
MeSH terms
Alcohol Oxidoreductases, Ethanol, Alcoholism, Animals, Chronic Disease, Disease Models, Animal, Female, Humans, Liver Diseases, Alcoholic, Male, Microsomes, Liver, Mitochondria, Liver, Prognosis, Severity of Illness Index, Oxidative Stress, Disease Progression, Risk Assessment

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