The DOI matches its Crossref record; 235 of the 235 references it cites were found in a registry or an index.
Intestinal Barrier in Human Health and Disease
Open accessAbstract
The intestinal mucosa provides a selective permeable barrier for nutrient absorption and protection from external factors. It consists of epithelial cells, immune cells and their secretions. The gut microbiota participates in regulating the integrity and function of the intestinal barrier in a homeostatic balance. Pathogens, xenobiotics and food can disrupt the intestinal barrier, promoting systemic inflammation and tissue damage. Genetic and immune factors predispose individuals to gut barrier dysfunction, and changes in the composition and function of the gut microbiota are central to this process. The progressive identification of these changes has led to the development of the concept of ‘leaky gut syndrome’ and ‘gut dysbiosis’, which underlie the relationship between intestinal barrier impairment, metabolic diseases and autoimmunity. Understanding the mechanisms underlying this process is an intriguing subject of research for the diagnosis and treatment of various intestinal and extraintestinal diseases.
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Cites
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Richness of human gut microbiome correlates with metabolic markers
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Nitric oxide synthases: regulation and function
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Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
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Gut microbiota, metabolites and host immunity
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Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
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Cited by
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331
Self-citationIn Vitro Models of Biological Barriers for Nanomedical Research
Carton, F., & Malatesta, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168910 · Cited by 34
Unveiling The Therapeutic Potential of Probiotics: A Review
Tukaram, K. S., Sopanrao, S. R., & Kacharu, L. O. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.09.011 · Cited by 19
Metadata
- Authors
- Di Tommaso, N., Gasbarrini, A., & Ponziani, F. R.
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2021-12-06
- Volume
- 18
- Issue
- 23
- Pages
- 12836
- ISSN
- 1660-4601 (ISSN-L)
- OpenAlex
- W4200350756
- Cited by
- 533
- References
- 235
- FWCI
- 18.11
- Type
- journal article
- Language
- en
- Open access
- gold
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- Di Tommaso, N., Gasbarrini, A., & Ponziani, F. R. (2021). Intestinal Barrier in Human Health and Disease. International Journal of Environmental Research and Public Health. https://doi.org/10.3390/ijerph182312836
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
