CoChat
Sign Up
Cited by 106Rheumatoid Arthritis Research and TherapiesNatural Compounds in Disease TreatmentAutoimmune and Inflammatory Disorders Research

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Anti-inflammatory effect of all-trans-retinoic acid in inflammatory arthritis

Nozaki, Yuji, Yamagata, Toshiaki, Sugiyama, Masafumi, Ikoma, Shinya, Kinoshita, Koji, Funauchi, Masanori·2006·Clinical Immunology
DOI 10.1016/j.clim.2005.11.012
Open this paper in CoChat — free account

Abstract

Objective To determine whether all-trans-retinoic acid (ATRA) improves the destruction of joints and the effect of cytokines on DBA/1J mice with collagen-induced arthritis (CIA).Methods Starting from the time of type II collagen injection, DBA/1J mice were injected intraperitoneally with PBS or 0.5 mg of ATRA 3 times per week for 35 days. The effects of treatment were monitored by determining arthritis and histological scores and measuring cellular proliferation, production of cytokines (IL-2, IL-10, IL-12, IL-6, IFN-gamma, and TNF-alpha) and IgG, and the expression of mRNAs for inducible nitric oxide synthase (iNOS), monocyte chemoattractant protein-1 (MCP-1), and CXCR3.Results The arthritis score and incidence of arthritis were lower in the mice treated with ATRA than in those treated with PBS. Histopathologic evidence of joint damage was 34% lower, and the infiltrations of macrophages were reduced in the mice treated with ATRA compared with those treated with PBS. Type II collagen- and ConA-stimulated proliferation of spleen cells, the production of cytokines (IL-6, IL-12, and TNF-alpha), the serum levels of total IgG and IgG1 anti-collagen antibodies, and the expression of mRNAs for MCP-1 were significantly reduced in the mice treated with ATRA than in those treated with PBS.Conclusion ATRA improved the clinical course and reduced the production of inflammatory cytokines, immunoglobulin, and chemokines in murine CIA. These data suggest that ATRA might be also effective for the treatment of inflammatory arthritis like human rheumatoid arthritis.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.clim.2005.11.012

Cites

37 of 37 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 37 references

Research works printed but not linked: 1

  1. Orfanos, 1983, Evidence for antiinflammatory activities for oral and synthetic retinoids, Br. J. Dermatol., 25, 55

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Nozaki, Y., Yamagata, T., Sugiyama, M., Ikoma, S., Kinoshita, K., & Funauchi, M.
Affiliations
Kindai University (JP)
Corresponding author
Kinoshita, Koji
ORCID
Venue
Clinical Immunology
Publisher
Elsevier BV
Published
2006-06
Volume
119
Issue
3
Pages
272-279
ISSN
1521-6616 (ISSN-L)
DOI
10.1016/j.clim.2005.11.012
OpenAlex
W1964207984
Cited by
106
References
37
Citations by year
2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 4 · 2017: 4 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 12
FWCI
3.94
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
  • Health Sciences › Medicine › Hematology › Autoimmune and Inflammatory Disorders Research
Keywords
all-trans retinoic acid, inflammatory arthritis, collagen-induced arthritis, rheumatoid arthritis, anti-inflammatory activity, cytokines, type II collagen, anti-collagen antibodies, MCP-1, CXCR3, inducible nitric oxide synthase, macrophage infiltration, immunosuppression
MeSH terms
Animals, Anti-Inflammatory Agents, Arthritis, Experimental, Collagen, Gene Expression Regulation, Immunoglobulin G, Joints, Male, Mice, Inbred DBA, RNA, Messenger, Spleen, Tretinoin, Cytokines, Chemokine CCL2, Receptors, Chemokine, Cell Proliferation, Mice, Nitric Oxide Synthase Type II, Receptors, CXCR3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review