Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

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A DNA damage checkpoint response in telomere-initiated senescence

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.Preprint

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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

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Functionally significant insulin-like growth factor I receptor mutations in centenarians

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CD28− T cells: their role in the age-associated decline of immune function

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Effectiveness of Pneumococcal Polysaccharide Vaccine in Older Adults

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Practice parameter for the diagnosis and management of primary immunodeficiency

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CD56brightCD16− Killer Ig-Like Receptor− NK Cells Display Longer Telomeres and Acquire Features of CD56dim NK Cells upon Activation

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Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

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Human CD4+ CD25hi Foxp3+ regulatory T cells are derived by rapid turnover of memory populations in vivo

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Delayed ageing through damage protection by the Arf/p53 pathway

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The immune system in extreme longevity

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A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

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ATAXIA-TELANGIECTASIA

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Immunodeficiency and infections in ataxia-telangiectasia

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Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets

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Pneumococcal Type 22F Polysaccharide Absorption Improves the Specificity of a Pneumococcal-Polysaccharide Enzyme-Linked Immunosorbent Assay

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Evidence of premature immune aging in patients thymectomized during early childhood

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Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals

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ATM Is Required for Efficient Recombination between Immunoglobulin Switch Regions

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Mutations associated with variant phenotypes in ataxia-telangiectasia.

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Ataxia Telangiectasia in the British Isles: The Clinical and Laboratory Features of 70 Affected Individuals

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Survival probability in ataxia telangiectasia

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CD45‐assisted PanLeucogating for accurate, cost‐effective dual‐platform CD4+ T‐cell enumeration

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Reconstitution of T-cell receptor repertoire diversity following T-cell depleted allogeneic bone marrow transplantation is related to hematopoietic chimerism

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Quantifying the development of the peripheral naive CD4+ T-cell pool in humans

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Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia

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Development and validation of a nonaplex assay for the simultaneous quantitation of antibodies to nine Streptococcus pneumoniae serotypes

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Lessons from the study of T-cell differentiation in persistent human virus infection

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CD127 and CD25 Expression Defines CD4+ T Cell Subsets That Are Differentially Depleted during HIV Infection

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Regulation of Reactive Oxygen Species by Atm Is Essential for Proper Response to DNA Double-Strand Breaks in Lymphocytes

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Immunodeficiency in ataxia telangiectasia is correlated strongly with the presence of two null mutations in the ataxia telangiectasia mutated gene

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Phase 1 trial of a 13-valent pneumococcal conjugate vaccine in healthy adults

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Mutations at the ataxia‐telangiectasia locus and clinical phenotypes of A–T patients

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ATM Is Not Required in Somatic Hypermutation of VH, but Is Involved in the Introduction of Mutations in the Switch μ Region

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Immunosenescence and Cytomegalovirus: where do we stand after a decade?

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Skewed T-cell receptor repertoire, decreased thymic output, and predominance of terminally differentiated T cells in ataxia telangiectasia

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ATM deficiency impairs thymocyte maturation because of defective resolution of T cell receptor α locus coding end breaks

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Measurement of peripheral B cell subpopulations in common variable immunodeficiency (CVID) using a whole blood method

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Human Memory B Lymphocyte Subsets Fulfill Distinct Roles in the Anti-Polysaccharide and Anti-Protein Immune Response

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Modeling ATM mutant proteins from missense changes confirms retained kinase activity

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Immunization of Aged Mice with a Pneumococcal Conjugate Vaccine Combined with an Unmethylated CpG-Containing Oligodeoxynucleotide Restores Defective Immunoglobulin G Antipolysaccharide Responses and Specific CD4+-T-Cell Priming to Young Adult Levels

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Molecular, Cellular, and Antigen Requirements for Development of Age-Associated T Cell Clonal Expansions In Vivo

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Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes

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ATM deficiency disrupts Tcra locus integrity and the maturation of CD4+CD8+ thymocytes

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Expression of CD27 and CD23 on peripheral blood B lymphocytes in humans of different ages.

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Aberrant V(D)J Recombination in Ataxia Telangiectasia Mutated-Deficient Lymphocytes Is Dependent on Nonhomologous DNA End Joining

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Pneumococcal conjugate vaccine followed by pneumococcal polysaccharide vaccine; immunogenicity in patients with ataxia-telangiectasia

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Aberrantly resolved RAG-mediated DNA breaks in Atm-deficient lymphocytes target chromosomal breakpoints in cis

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Phenotypic variations between affected siblings with ataxia-telangiectasia: ataxia-telangiectasia in Japan

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ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo

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A Novel ICOS-Independent, but CD28- and SAP-Dependent, Pathway of T Cell-Dependent, Polysaccharide-Specific Humoral Immunity in Response to Intact Streptococcus pneumoniae versus Pneumococcal Conjugate Vaccine

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Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

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T-cell aging in rheumatoid arthritis

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Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity

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Impaired Natural Killer Cell Phenotype and Function in Idiopathic and Heritable Pulmonary Arterial Hypertension

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Ataxia-telangiectasia (A-T): An emerging dimension of premature ageing

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The natural history of ataxia-telangiectasia (A-T): A systematic review

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Inflammation, a significant player of Ataxia–Telangiectasia pathogenesis?

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Ataxia telangiectasia syndrome: moonlighting ATM

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Germline ATM variants predispose to melanoma: a joint analysis across the GenoMEL and MelaNostrum consortia

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Age-associated changes in innate and adaptive immunity: role of the gut microbiota

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Body composition, muscle strength and hormonal status in patients with ataxia telangiectasia: a cohort study

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Utility of DNA, RNA, Protein, and Functional Approaches to Solve Cryptic Immunodeficiencies

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Programmed ageing: decline of stem cell renewal, immunosenescence, and Alzheimer's disease

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Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.

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Variable Abnormalities in T and B Cell Subsets in Ataxia Telangiectasia

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Association between cytomegalovirus infection and neurological disorders: A systematic review

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Abnormal cell-clearance and accumulation of autophagic vesicles in lymphocytes from patients affected with Ataxia-Teleangiectasia

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Infections and immune dysregulation in ataxia-telangiectasia children with hyper-IgM and non-hyper-IgM phenotypes: A single-center experience

Szczawińska-Popłonyk, A., Tąpolska‐Jóźwiak, K., Schwartzmann, E., & Pietrucha, B. M. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.972952 · Cited by 18 · see citing works

Altered NK-cell compartment and dysfunctional NKG2D/NKG2D-ligand axis in patients with ataxia-telangiectasia

Desimio, M. G., Finocchi, A., Matteo, G. D., Cesare, S. D., Giancotta, C., Conti, F., Chessa, L., Piane, M., Montin, D., Dellepiane, M., et al. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108802 · Cited by 8 · see citing works

B-cell subsets imbalance and reduced expression of CD40 in ataxia-telangiectasia patients

Pereira, C. T. M., Bichuetti-Silva, D. C., da Mota, N. V. F., Salomão, R., Brunialti, M. K. C., & Costa‐Carvalho, B. T. (2018) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2017.09.031 · Cited by 7 · see citing works

History of the Discovery and Development of Biomodulina T (InmunyVital®), a Useful Immunomodulator with a Broad Range of Clinical Applications

Martin, R. R. R., Gonzalez, O. G., González, C. R., & Gonzalez, R. R. R. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110167 · Cited by 6 · see citing works

Biomodulina T (InmunyVital®) Restores T Cells and Helps Contain COVID-19

Martin, R. R. R., Gonzalez, O. G., González, C. R., & Gonzalez, R. R. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.606447 · Cited by 4 · see citing works

Ataxia Telangiectasia

Taylor, A. M. R. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch23 · Cited by 1 · see citing works

Clinical and Immunological Diversity of Recombination Defects

IJspeert, H. (2014) · EUR Research Repository (Erasmus University Rotterdam)

Models of Immune Aging

O’Connor, J., Herrera, G., Jávega, B., & Martínez‐Romero, A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811353-0.00058-0

Novel genetic variants identification and immune profiling in ataxia telangiectasia patients

Jenni, R., Klaa, H., Chikhaoui, A., Zayoud, K., Cochet, E., Kraoua, I., Bürglen, L., & Yacoub‐Youssef, H. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07871-2

Follow-up studies of immunological disorders in patients with ataxia-telangiectasia

Matsuoka, M., Matsuoka, H., Okada, J., Mizuno, T., Urisu, A., Sato, C., Tsuge, I., & Torii, S. (1983) · Japanese Journal of Clinical Immunology · doi:10.2177/jsci.6.259

Immunodeficiency and infections in ataxia-telangiectasia

Nowak-Wegrzyn, A. H., Crawford, T. O., Winkelstein, J. A., Carson, K. A., & Lederman, H. M. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2003.12.046 · Cited by 332 · see citing works

In vivo and in vitro studies of immunodeficiency in Ataxia-telangiectasia

Carney, E. F. (2011) · University of Birmingham Institutional Research Archive (University of Birmingham)

Aged-related shifts in T cell homeostasis lead to intrinsic T cell defects

Haynes, L., & Swain, S. L. (2012) · Seminars in Immunology · doi:10.1016/j.smim.2012.04.001 · Cited by 65 · see citing works

Classical ataxia telangiectasia patients have a congenitally aged immune system with high expression of CD95.

Carney, E. F., Srinivasan, V., Moss, P. A., & Taylor, A. M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1101909 · Cited by 26 · see citing works