Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis

Cellular mechanisms and physiological consequences of redox-dependent signalling

Holmström, K. M., & Finkel, T. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3801 · Cited by 2,093 · see citing works

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692 · see citing works

Fueling Immunity: Insights into Metabolism and Lymphocyte Function

Pearce, E. L., Poffenberger, M. C., Chang, C.-H., & Jones, R. G. (2013) · Science · doi:10.1126/science.1242454 · Cited by 1,363 · see citing works

Metabolic Regulation of T Lymphocytes

MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

Mitochondria in the Regulation of Innate and Adaptive Immunity

Weinberg, S. E., Sena, L. A., & Chandel, N. S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.002 · Cited by 960 · see citing works

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

Gerriets, V. A., Kishton, R. J., Nichols, A., Macintyre, A. N., Inoue, M., Ilkayeva, O., Winter, P. S., Liu, X., Priyadharshini, B., Slawinska, M. E., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci76012 · Cited by 729 · see citing works

The Energy Sensor AMPK Regulates T Cell Metabolic Adaptation and Effector Responses In Vivo

Blagih, J., Coulombe, F., Vincent, E. E., Dupuy, F., Galicia-Vázquez, G., Yurchenko, E., Raissi, T. C., van der Windt, G. J. W., Viollet, B., Pearce, E. L., et al. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.030 · Cited by 659 · see citing works

T Cell Activation in Rheumatoid Synovium Is B Cell Dependent

Takemura, S., Klimiuk, P. A., Braun, A. B., Goronzy, J. J., & Weyand, C. M. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.8.4710 · Cited by 536 · see citing works

Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain

Dröse, S., & Brandt, U. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-3573-0_6 · Cited by 519 · see citing works

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

Elson, A., Wang, Y., Daugherty, C., Morton, C. C., Zhou, F., Campos-Torres, J., & Leder, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13084 · Cited by 498 · see citing works

Effects of tempol and redox-cycling nitroxides in models of oxidative stress

Wilcox, C. S. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.01.003 · Cited by 466 · see citing works

Mechanisms of ATM Activation

Paull, T. T. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034335 · Cited by 458 · see citing works

Discrete Generation of Superoxide and Hydrogen Peroxide by T Cell Receptor Stimulation

Devadas, S., Zaritskaya, L., Rhee, S. G., Oberley, L., & Williams, M. S. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20010659 · Cited by 458 · see citing works

<i>N</i> ‐acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double‐blind, placebo‐controlled trial

Lai, Z., Hanczko, R., Bonilla, E., Caza, T. N., Clair, B., Bartos, A., Miklossy, G., Jimah, J., Doherty, E., Tily, H., et al. (2012) · Arthritis &amp; Rheumatism · doi:10.1002/art.34502 · Cited by 428 · see citing works

Cadherin-11 in Synovial Lining Formation and Pathology in Arthritis

Lee, D. M., Kiener, H. P., Agarwal, S. K., Noss, E. H., Watts, G. F. M., Chisaka, O., Takeichi, M., & Brenner, M. B. (2007) · Science · doi:10.1126/science.1137306 · Cited by 415 · see citing works

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection

Badovinac, V. P., Haring, J. S., & Harty, J. T. (2007) · Immunity · doi:10.1016/j.immuni.2007.04.013 · Cited by 406 · see citing works

Integrating canonical and metabolic signalling programmes in the regulation of T cell responses

Pollizzi, K. N., & Powell, J. D. (2014) · Nature reviews. Immunology · doi:10.1038/nri3701 · Cited by 379 · see citing works

Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity

Li, G., Yu, M., Lee, W.-W., Tsang, M., Krishnan, E., Weyand, C. M., & Goronzy, J. J. (2012) · Nature Medicine · doi:10.1038/nm.2963 · Cited by 349 · see citing works

Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene

Hultqvist, M. H., Olofsson, P., Holmberg, J., Bäckström, B. T., Tordsson, J. M., & Holmdahl, R. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403831101 · Cited by 343 · see citing works

Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells

Yang, Z., Fujii, H., Mohan, S. V., Goronzy, J. J., & Weyand, C. M. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130252 · Cited by 334 · see citing works

BLyS and APRIL in rheumatoid arthritis

Seyler, T. M. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25265 · Cited by 266 · see citing works

Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species

Gelderman, K. A., Hultqvist, M. H., Pizzolla, A., Zhao, M. F., Nandakumar, K. S., Mattsson, R., & Holmdahl, R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31935 · Cited by 239 · see citing works

The CD46-Jagged1 interaction is critical for human TH1 immunity

Friec, G. L., Sheppard, D., Whiteman, P., Karsten, C. M., Shamoun, S. A.-T., Laing, A. G., Bugeon, L., Dallman, M. J., Melchionna, T., Chillakuri, C., et al. (2012) · Nature Immunology · doi:10.1038/ni.2454 · Cited by 204 · see citing works

Chronic granulomatous disease: Overview and hematopoietic stem cell transplantation

Kang, E. M., Marciano, B., Ravin, S. S. D., Zarember, K. A., Holland, S. M., & Malech, H. L. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.03.028 · Cited by 181 · see citing works

Telomerase insufficiency in rheumatoid arthritis

Fujii, H., Shao, L., Colmegna, I., Goronzy, J. J., & Weyand, C. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811332106 · Cited by 172 · see citing works

T-cell aging in rheumatoid arthritis

Weyand, C. M., Yang, Z., & Goronzy, J. J. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000011 · Cited by 164 · see citing works

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis.

Shao, L., Fujii, H., Colmegna, I., Oishi, H., Goronzy, J. J., & Weyand, C. M. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20082251 · Cited by 159 · see citing works

T-cell metabolism in autoimmune disease

Yang, Z., Matteson, E. L., Goronzy, J. J., & Weyand, C. M. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0542-4 · Cited by 156 · see citing works

Back to the future: oral targeted therapy for RA and other autoimmune diseases

O’Shea, J. J., Laurence, A. D. J., & McInnes, I. B. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.7 · Cited by 136 · see citing works

Developments in the scientific understanding of rheumatoid arthritis

Goronzy, J. J., & Weyand, C. M. (2009) · Arthritis Research & Therapy · doi:10.1186/ar2758 · Cited by 130 · see citing works

Rapid and Specific Measurements of Superoxide Using Fluorescence Spectroscopy

Nazarewicz, R. R., Bikineyeva, A. T., & Dikalov, S. (2012) · SLAS DISCOVERY · doi:10.1177/1087057112468765 · Cited by 128 · see citing works

Spontaneous and aging-dependent development of arthritis in NADPH oxidase 2 deficiency through altered differentiation of CD11b+ and Th/Treg cells

Lee, K., Won, H. Y., Bae, M. A., Hong, J., & Hwang, E. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012645108 · Cited by 125 · see citing works

Evaluation of the In Vitro and In Vivo Antitumor Activities of Vitamin C and K-3 Combinations against Human Prostate Cancer

Jamison, J. M., Summers, J. L., Gilloteaux, J., & Taper, H. S. (2001) · Journal of Nutrition · doi:10.1093/jn/131.1.158s · Cited by 80 · see citing works

Reducing Mitochondrial ROS Improves Disease-related Pathology in a Mouse Model of Ataxia-telangiectasia

D’Souza, A. D., Parish, I. A., Krause, D. S., Kaech, S. M., & Shadel, G. S. (2012) · Molecular Therapy · doi:10.1038/mt.2012.203 · Cited by 72 · see citing works

DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis.

Shao, L., Goronzy, J. J., & Weyand, C. M. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000096 · Cited by 69 · see citing works

Atm-Deficient Mice Exhibit Increased Sensitivity to Dextran Sulfate Sodium–Induced Colitis Characterized by Elevated DNA Damage and Persistent Immune Activation

Westbrook, A. M., & Schiestl, R. H. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-2584 · Cited by 59 · see citing works

Hydrogen Peroxide As an Immunological Transmitter Regulating Autoreactive T Cells

Holmdahl, R., Sareila, O., Pizzolla, A., Winter, S., Hagert, C., Jaakkola, N., Kelkka, T., Olsson, L. M., Wing, K., & Bäckdahl, L. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2012.4734 · Cited by 50 · see citing works

Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia

Exley, A. R., Buckenham, S., Hodges, E., Hallam, R., Byrd, P., Last, J., Trinder, C., Harris, S., Screaton, N., Williams, A. P., et al. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.03.007 · Cited by 30 · see citing works

Process for immune defect and chromosomal translocation during early thymocyte development lacking ATM

Isoda, T., Takagi, M., Piao, J., Nakagama, S., Sato, M., Masuda, K., Ikawa, T., Azuma, M., Morio, T., Kawamoto, H., et al. (2012) · Blood · doi:10.1182/blood-2012-02-413195 · Cited by 27 · see citing works

A Modified Model of T-Cell Differentiation Based on mTOR Activity and MetabolismPreprint

Powell, J. D., Heikamp, E., Pollizzi, K. N., & Waickman, A. T. (2013) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2013.78.020214 · Cited by 21 · see citing works

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis &amp; Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5 · see citing works

Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies

Guo, Q., Wang, Y., Xu, D., Nossent, J. C., Pavlos, N. J., & Xu, J. (2018) · Bone Research · doi:10.1038/s41413-018-0016-9 · Cited by 1,829 · see citing works

Immunopathogenesis of Rheumatoid Arthritis

Firestein, G. S., & McInnes, I. B. (2017) · Immunity · doi:10.1016/j.immuni.2017.02.006 · Cited by 1,301 · see citing works

Lactate modulation of immune responses in inflammatory versus tumour microenvironments

Certo, M., Tsai, C.-H., Pucino, V., Ho, P.-C., & Mauro, C. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-0406-2 · Cited by 924 · see citing works

Metabolism of immune cells in cancer

Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877 · see citing works

The immunology of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Nature Immunology · doi:10.1038/s41590-020-00816-x · Cited by 822 · see citing works

The pentose phosphate pathway in health and disease

TeSlaa, T. A., Ralser, M., Fan, J., & Rabinowitz, J. D. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00863-2 · Cited by 690 · see citing works

The pathogenicity of Th17 cells in autoimmune diseases

Yasuda, K., Takeuchi, Y., & Hirota, K. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00733-8 · Cited by 560 · see citing works

Aging of the Immune System. Mechanisms and Therapeutic Targets

Weyand, C. M., & Goronzy, J. J. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-095aw · Cited by 554 · see citing works

Mechanisms underlying T cell ageing

Goronzy, J. J., & Weyand, C. M. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0180-1 · Cited by 506 · see citing works

Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring

Pucino, V., Certo, M., Bulusu, V., Cucchi, D., Goldmann, K., Pontarini, E., Haas, R., Smith, J., Headland, S. E., Blighe, K., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.10.004 · Cited by 538 · see citing works

Redox regulation of immunometabolism

Muri, J., & Köpf, M. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-00478-8 · Cited by 502 · see citing works

The immunopathogenesis of seropositive rheumatoid arthritis: from triggering to targeting

Malmström, V., Catrina, A. I., & Klareskog, L. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.124 · Cited by 452 · see citing works

Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction

Holers, V. M., Demoruelle, M. K., Kuhn, K. A., Buckner, J. H., Robinson, W. H., Okamoto, Y., Norris, J. M., & Deane, K. D. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0070-0 · Cited by 425 · see citing works

The spectrum of T cell metabolism in health and disease

Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 421 · see citing works

Energy metabolism in health and diseases

Liu, H., Wang, S., Wang, J., Guo, X., Song, Y., Fu, K., Gao, Z., Liu, D., He, W., & Yang, L. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02141-x · Cited by 438 · see citing works

Fibroblast-like synoviocyte metabolism in the pathogenesis of rheumatoid arthritis

Bustamante, M. F., Garcia‐Carbonell, R., Whisenant, K. D., & Gumá, M. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1303-3 · Cited by 410 · see citing works

Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases

Fugger, L. H., Jensen, L. T., & Rossjohn, J. (2020) · Cell · doi:10.1016/j.cell.2020.03.007 · Cited by 403 · see citing works

Aging, obesity, and inflammatory age-related diseases

Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371 · see citing works

Successful and Maladaptive T Cell Aging

Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362 · see citing works

Metabolism as a guiding force for immunity

Jung, J., Zeng, H., & Horng, T. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0217-x · Cited by 345 · see citing works

Metabolic regulation of inflammation

Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320 · see citing works

Mitochondria, Oxidative Stress and Innate Immunity

Chen, Y., Zhou, Z., & Min, W. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01487 · Cited by 315 · see citing works

Targeting metabolism to regulate immune responses in autoimmunity and cancer

Patel, C. H., Leone, R. D., Horton, M. R., & Powell, J. D. (2019) · Nature Reviews Drug Discovery · doi:10.1038/s41573-019-0032-5 · Cited by 307 · see citing works

Metabolic adaptation of lymphocytes in immunity and disease

Chapman, N. M., & Chi, H.-B. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.012 · Cited by 263 · see citing works

Immunometabolism in early and late stages of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.49 · Cited by 296 · see citing works

Neutrophils in the Pathogenesis of Rheumatoid Arthritis and Systemic Lupus Erythematosus: Same Foe Different M.O.

Alarcon, M. F., McLaren, Z., & Wright, H. L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.649693 · Cited by 279 · see citing works

Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents

Pérez-Torres, I., Guarner‐Lans, V., & Rubio-Ruiz, M. E. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18102098 · Cited by 252 · see citing works

Lactate at the crossroads of metabolism, inflammation, and autoimmunity

Pucino, V., Bombardieri, M., Pitzalis, C., & Mauro, C. (2016) · European Journal of Immunology · doi:10.1002/eji.201646477 · Cited by 243 · see citing works

Immunometabolism in systemic lupus erythematosus

Morel, L. M. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.43 · Cited by 216 · see citing works

Inhibition of JAK-STAT Signaling Suppresses Pathogenic Immune Responses in Medium and Large Vessel Vasculitis

Zhang, H., Watanabe, R., Berry, G. J., Tian, L., Goronzy, J. J., & Weyand, C. M. (2017) · Circulation · doi:10.1161/circulationaha.117.030423 · Cited by 218 · see citing works

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis

Fang, Q., Zhou, C., & Nandakumar, K. S. (2020) · Mediators of Inflammation · doi:10.1155/2020/3830212 · Cited by 218 · see citing works

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193 · see citing works

Redox Imbalance in Inflammation: The Interplay of Oxidative and Reductive Stress

Bellanti, F., Coda, A. R. D., Trecca, M. I., Buglio, A. L., Serviddio, G., & Vendemiale, G. (2025) · Antioxidants · doi:10.3390/antiox14060656 · Cited by 212 · see citing works

The DNA Repair Nuclease MRE11A Functions as a Mitochondrial Protector and Prevents T Cell Pyroptosis and Tissue Inflammation

Li, Y., Shen, Y., Jin, K., Wen, Z., Cao, W., Wu, B., Wen, R. M., Tian, L., Berry, G. J., Goronzy, J. J., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.016 · Cited by 188 · see citing works

Molecular mechanisms underpinning T helper 17 cell heterogeneity and functions in rheumatoid arthritis

van Hamburg, J. P., & Tas, S. W. (2017) · Journal of Autoimmunity · doi:10.1016/j.jaut.2017.12.006 · Cited by 186 · see citing works

T cells, aging and senescence

Pangrazzi, L., & Weinberger, B. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.110887 · Cited by 181 · see citing works

A single bacterium restores the microbiome dysbiosis to protect bones from destruction in a rat model of rheumatoid arthritis

Pan, H., Guo, R., Ju, Y., Wang, Q., Zhu, J., Xie, Y., Zheng, Y., Li, T., Liu, Z., Lu, L., et al. (2019) · Microbiome · doi:10.1186/s40168-019-0719-1 · Cited by 178 · see citing works

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

Yang, X., Chang, Y., & Wei, W. (2020) · Cell Proliferation · doi:10.1111/cpr.12854 · Cited by 176 · see citing works

Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma

Chen, D., Ning, W.-R., Jiang, Z.-Z., Peng, Z.-P., Zhu, L., Zhuang, S., Kuang, D., Zheng, L., & Wu, Y. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.04.007 · Cited by 170 · see citing works

Metabolic Control of Autoimmunity and Tissue Inflammation in Rheumatoid Arthritis

Qiu, J., Wu, B., Goodman, S. B., Berry, G. J., Goronzy, J. J., & Weyand, C. M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.652771 · Cited by 166 · see citing works

The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment

Wang, X., Fan, D., Cao, X., Ye, Q., Wang, Q., Zhang, M., & Xiao, C. (2022) · Antioxidants · doi:10.3390/antiox11061153 · Cited by 165 · see citing works

N-myristoyltransferase deficiency impairs activation of kinase AMPK and promotes synovial tissue inflammation

Wen, Z., Jin, K., Shen, Y., Yang, Z., Li, Y., Wu, B., Tian, L., Shoor, S., Roche, N. E., Goronzy, J. J., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0296-7 · Cited by 160 · see citing works

Mitochondrial Metabolism Regulation of T Cell–Mediated Immunity

Steinert, E. M., Vasan, K., & Chandel, N. S. (2021) · Annual Review of Immunology · doi:10.1146/annurev-immunol-101819-082015 · Cited by 154 · see citing works

Glycolysis Rate-Limiting Enzymes: Novel Potential Regulators of Rheumatoid Arthritis Pathogenesis

Zuo, J., Tang, J., Lü, M., Zhou, Z., Li, Y., Tian, H., Liu, E., Gao, B., Liu, T., & Shao, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.779787 · Cited by 153 · see citing works

Metabolic signatures of T-cells and macrophages in rheumatoid arthritis

Weyand, C. M., Zeisbrich, M., & Goronzy, J. J. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.04.010 · Cited by 149 · see citing works

Inhibition of Glycolysis Reduces Disease Severity in an Autoimmune Model of Rheumatoid Arthritis

Abboud, G., Choi, S., Kanda, N., Zeumer-Spataro, L., Roopenian, D. C., & Morel, L. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01973 · Cited by 141 · see citing works

Mitochondrial aspartate regulates TNF biogenesis and autoimmune tissue inflammation

Wu, B., Zhao, T. V., Jin, K., Hu, Z., Abdel, M. P., Warrington, K. J., Goronzy, J. J., & Weyand, C. M. (2021) · Nature Immunology · doi:10.1038/s41590-021-01065-2 · Cited by 141 · see citing works

Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

Li, Y., Shen, Y., Hohensinner, P. J., Ju, J., Wen, Z., Goodman, S. B., Zhang, H., Goronzy, J. J., & Weyand, C. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.013 · Cited by 138 · see citing works

The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway

Wen, Z., Shen, Y., Berry, G. J., Shahram, F., Li, Y., Watanabe, R., Liao, Y. J., Goronzy, J. J., & Weyand, C. M. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal3322 · Cited by 133 · see citing works

Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells

Shen, Y., Wen, Z., Li, Y., Matteson, E. L., Hong, J., Goronzy, J. J., & Weyand, C. M. (2017) · Nature Immunology · doi:10.1038/ni.3808 · Cited by 130 · see citing works

B-cell-specific diversion of glucose carbon utilization reveals a unique vulnerability in B cell malignancies

Xiao, G., Chan, L. N., Klemm, L., Braas, D., Chen, Z., Geng, H., Zhang, Q. C., Aghajanirefah, A., Cosgun, K. N., Sadras, T., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.048 · Cited by 129 · see citing works

Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response

Luque‐Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J., & Luz‐Crawford, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00798 · Cited by 128 · see citing works

Review: Metabolic Control of Immune System Activation in Rheumatic Diseases

Perl, A. (2017) · Arthritis & Rheumatology · doi:10.1002/art.40223 · Cited by 112 · see citing works

Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells

Wu, B., Qiu, J., Zhao, T. V., Wang, Y., Maeda, T., Goronzy, I. N., Akiyama, M., Ohtsuki, S., Jin, K., Tian, L., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.10.025 · Cited by 112 · see citing works

Metabolomics in rheumatoid arthritis: Advances and review

Xu, L., Chang, C., Jiang, P., Wei, K., Zhang, R., Jin, Y., Zhao, J., Xu, L., Shi, Y., Guo, S., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.961708 · Cited by 110 · see citing works

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

Fearon, U., Hanlon, M. M., Floudas, A., & Veale, D. J. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00771-x · Cited by 107 · see citing works

Mitochondrial Dysfunction and Oxidative Stress in Rheumatoid Arthritis

López-Armada, M. J., Fernández-Rodríguez, J. A., & Blanco, F. J. (2022) · Antioxidants · doi:10.3390/antiox11061151 · Cited by 108 · see citing works

Immune Aging- A Mechanism in Autoimmune Disease

Zheng, Y., Liu, Q., Goronzy, J., & Weyand, C. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101814 · Cited by 95 · see citing works

Effect of Increased Lactate Dehydrogenase A Activity and Aerobic Glycolysis on the Proinflammatory Profile of Autoimmune CD8+ T Cells in Rheumatoid Arthritis

Souto‐Carneiro, M., Klika, K. D., Abreu, M., Meyer, A. P., Saffrich, R., Sandhoff, R., Jennemann, R., Kraus, F. V., Tykocinski, L., Eckstein, V., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41420 · Cited by 101 · see citing works

Mitochondrial Reactive Oxygen Species and Type 1 Diabetes

Chen, J., Stimpson, S. E., Fernandez‐Bueno, G. A., & Mathews, C. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7346 · Cited by 100 · see citing works

Reactive Oxygen Species in Autoimmune Cells: Function, Differentiation, and Metabolism

Lin, W., Shen, P., Song, Y., Huang, Y., & Tu, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.635021 · Cited by 97 · see citing works

Mitochondria as Key Players in the Pathogenesis and Treatment of Rheumatoid Arthritis

Clayton, S. A., MacDonald, L., Kurowska‐Stolarska, M., & Clark, A. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.673916 · Cited by 95 · see citing works

Why remission is not enough: underlying disease mechanisms in RA that prevent cure

Schett, G. A., Tanaka, Y., & Isaacs, J. D. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-00543-5 · Cited by 93 · see citing works

Aging-associated HELIOS deficiency in naive CD4+ T cells alters chromatin remodeling and promotes effector cell responses

Zhang, H., Jadhav, R. R., Cao, W., Goronzy, I. N., Zhao, T. V., Jin, J., Ohtsuki, S., Hu, Z., Morales, J., Greenleaf, W. J., et al. (2022) · Nature Immunology · doi:10.1038/s41590-022-01369-x · Cited by 85 · see citing works

Immunometabolism: An Overview and Therapeutic Prospects in Autoimmune Diseases

Stathopoulou, C., Nikoleri, D., & Bertsias, G. K. (2019) · Immunotherapy · doi:10.2217/imt-2019-0002 · Cited by 87 · see citing works

DNA damage and transcription stress cause ATP-mediated redesign of metabolism and potentiation of anti-oxidant buffering

Milanese, C., Bombardieri, C. R., Sepe, S., Barnhoorn, S., Payán‐Gómez, C., Caruso, D., Audano, M., Pedretti, S., Vermeij, W. P., Brandt, R. M. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12640-5 · Cited by 79 · see citing works

Rheumatoid arthritis CD14+ monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease

McGarry, T., Hanlon, M. M., Marzaioli, V., Cunningham, C. C., Krishna, V., Murray, K., Hurson, C. J., Gallagher, P., Nagpal, S., Veale, D. J., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1237 · Cited by 81 · see citing works

Metabolic Checkpoints in Rheumatoid Arthritis

Pucino, V., Certo, M., Varricchi, G., Marone, G., Ursini, F., Rossi, F. W., de Paulis, A., Mauro, C., Raza, K., & Buckley, C. D. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00347 · Cited by 79 · see citing works

Fine tuning of immunometabolism for the treatment of rheumatic diseases

Rhoads, J. P., Major, A. S., & Rathmell, J. C. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.54 · Cited by 80 · see citing works

Arachidonic acid-regulated calcium signaling in T cells from patients with rheumatoid arthritis promotes synovial inflammation

Ye, Z., Shen, Y., Jin, K., Qiu, J., Hu, B., Jadhav, R. R., Sheth, K., Weyand, C. M., & Goronzy, J. J. (2021) · Nature Communications · doi:10.1038/s41467-021-21242-z · Cited by 80 · see citing works

Acod1-mediated inhibition of aerobic glycolysis suppresses osteoclast differentiation and attenuates bone erosion in arthritis

Kachler, K., Andreev, D., Thapa, S., Royzman, D., Gießl, A., Karuppusamy, S., Perez, M. L., Liu, M., Hofmann, J., Gessner, A., et al. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224774 · Cited by 77 · see citing works

DNA damage, metabolism and aging in pro-inflammatory T cells

Li, Y., Goronzy, J. J., & Weyand, C. M. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2017.10.027 · Cited by 79 · see citing works

Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione

Liang, J., Jahraus, B., Balta, E., Ziegler, J. D., Hübner, K., Blank, N., Niesler, B., Wabnitz, G. H., & Samstag, Y. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02584 · Cited by 74 · see citing works

Sulforaphane as anticancer agent: a double-edged sword? Tricky balance between effects on tumor cells and immune cells

Liang, J., Hänsch, G. M., Hübner, K., & Samstag, Y. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.11.006 · Cited by 72 · see citing works

Mitochondrial Dysfunction in Rheumatoid Arthritis

Ma, C., Wang, J., Hong, F., & Yang, S. (2022) · Biomolecules · doi:10.3390/biom12091216 · Cited by 71 · see citing works

Metabolic regulation of TH17 cells

Shen, H., & Shi, L. Z. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.03.005 · Cited by 68 · see citing works

The interplay between obesity, immunosenescence, and insulin resistance

Shimi, G., Sohouli, M. H., Ghorbani, A., Shakery, A., & Zand, H. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00414-7 · Cited by 73 · see citing works

Bacterial Genotoxin-Induced DNA Damage and Modulation of the Host Immune Microenvironment

Martin, O. C. B., & Frisan, T. (2020) · Toxins · doi:10.3390/toxins12020063 · Cited by 66 · see citing works

Redox-sensitive signaling in inflammatory T cells and in autoimmune disease

Weyand, C. M., Shen, Y., & Goronzy, J. J. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.004 · Cited by 66 · see citing works

How the redox state regulates immunity

Mullen, L., Mengozzi, M., Hanschmann, E.-M., Alberts, B. M., & Ghezzi, P. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.12.022 · Cited by 65 · see citing works

A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22

Chang, H., Liu, G., Dwivedi, N., Sun, B., Okamoto, Y., Kinslow, J. D., Deane, K. D., Demoruelle, M. K., Norris, J. M., Thompson, P. R., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90045 · Cited by 61 · see citing works

Immunometabolism and autoimmunity

Freitag, J., Berod, L., Kamradt, T., & Sparwasser, T. D. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.77 · Cited by 60 · see citing works

Metabolism Characteristics of Th17 and Regulatory T Cells in Autoimmune Diseases

Qin, Y., Gao, C., & Luo, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.828191 · Cited by 62 · see citing works

The metabolic signature of T cells in rheumatoid arthritis

Weyand, C. M., Wu, B., & Goronzy, J. J. (2019) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000683 · Cited by 59 · see citing works

Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis

Cai, W., Yu, Y., Zong, S.-Y., & Wei, F. (2020) · Inflammation Research · doi:10.1007/s00011-020-01391-5 · Cited by 62 · see citing works

Cancer and Autoimmune Diseases: A Tale of Two Immunological Opposites?

Elkoshi, Z. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.821598 · Cited by 61 · see citing works

ROS fine-tunes the function and fate of immune cells

Liu, S., Huang, B., Cao, J., Wang, Y., Xiao, H., Zhu, Y., & Zhang, H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110069 · Cited by 61 · see citing works

Immunometabolic Pathways and Its Therapeutic Implication in Autoimmune Diseases

Wang, T., Jiao, Y., & Zhang, X. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08821-6 · Cited by 59 · see citing works

The Lipid Paradox as a Metabolic Checkpoint and Its Therapeutic Significance in Ameliorating the Associated Cardiovascular Risks in Rheumatoid Arthritis Patients

Behl, T., Kaur, I., Sehgal, A., Zengin, G., Brisc, C., Brisc, M. C., Munteanu, M. A., Nistor-Cseppento, C. D., & BUNGAU, S. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249505 · Cited by 59 · see citing works

A20: a master regulator of arthritis

Wu, Y., He, X., Huang, N., Yu, J., & Shao, B. (2020) · Arthritis Research & Therapy · doi:10.1186/s13075-020-02281-1 · Cited by 53 · see citing works

Glycolysis, a driving force of rheumatoid arthritis

Gan, P., Wu, H., Zhu, Y., Shu, Y., & Wei, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111913 · Cited by 57 · see citing works

Mucosa–Environment Interactions in the Pathogenesis of Rheumatoid Arthritis

Lucchino, B., Spinelli, F. R., Iannuccelli, C., Guzzo, M. P., Conti, F., & Franco, M. D. (2019) · Cells · doi:10.3390/cells8070700 · Cited by 55 · see citing works

Endothelial cell and T‐cell crosstalk: Targeting metabolism as a therapeutic approach in chronic inflammation

Certo, M., Elkafrawy, H., Pucino, V., Cucchi, D., Cheung, K. C.-P., & Mauro, C. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15002 · Cited by 52 · see citing works

Glucose transporter 1 in rheumatoid arthritis and autoimmunity

Zezina, E. A., Sercan-Alp, Ö., Herrmann, M., & Biesemann, N. (2020) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1483 · Cited by 53 · see citing works

Immunosenescence of T cells: a key player in rheumatoid arthritis

Gao, Y. Q., Cai, W., Zhou, Y., Li, Y., Cheng, J., & Wei, F. (2022) · Inflammation Research · doi:10.1007/s00011-022-01649-0 · Cited by 53 · see citing works

Immune Aging in Rheumatoid Arthritis

Weyand, C. M., & Goronzy, J. J. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43105 · Cited by 56 · see citing works

Metabolic Targets for Treatment of Autoimmune Diseases

Piranavan, P., Bhamra, M. S., & Perl, A. (2020) · Immunometabolism · doi:10.20900/immunometab20200012 · Cited by 52 · see citing works

Interleukin‐34 Reprograms Glycolytic and Osteoclastic Rheumatoid Arthritis Macrophages via Syndecan 1 and Macrophage Colony‐Stimulating Factor Receptor

Raemdonck, K. V., Umar, S., Palasiewicz, K., Volin, M. V., Elshabrawy, H. A., Romay, B., Tetali, C., Ahmed, A., Amin, M. A., Zomorrodi, R. K., et al. (2021) · Arthritis & Rheumatology · doi:10.1002/art.41792 · Cited by 49 · see citing works

T-Cell Aging-Associated Phenotypes in Autoimmune Disease

Zhao, T. V., Sato, Y., Goronzy, J. J., & Weyand, C. M. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.867950 · Cited by 50 · see citing works

Immunometabolism: A new target for improving cancer immunotherapy

Guo, C., Chen, S., Liu, W., Ma, Y., Li, J., Fisher, P. B., Fang, X., & Wang, X. (2019) · Advances in cancer research · doi:10.1016/bs.acr.2019.03.004 · Cited by 52 · see citing works

Metabolic interventions repair CD4+ T cells in RA

Shipman, L. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.54

Evidence for the role of an altered redox state in hyporesponsiveness of synovial T cells in rheumatoid arthritis

Maurice, M. M., Nakamura, H., van der Voort, E. A., Vliet, A. I. V., Staal, F. J. T., Tak, P. P., Breedveld, F. C., & Verweij, C. L. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.3.1458 · Cited by 165 · see citing works

Metabolic control of arthritis: Switch pathways to treat

Tsokos, G. C. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf4953 · Cited by 20 · see citing works

Immunometabolism in the development of rheumatoid arthritis

Weyand, C. M., & Goronzy, J. J. (2020) · Immunological Reviews · doi:10.1111/imr.12838 · Cited by 193 · see citing works

Metabolic reprogramming of T cells in RA

Leah, E. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.158 · Cited by 5 · see citing works