Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets

Kohler, Siegfried; Thiel, Andreas

doi:10.1182/blood-2008-02-139154

Cited by 307T-cell and B-cell ImmunologyHematopoietic Stem Cell TransplantationImmunodeficiency and Autoimmune Disorders

Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets

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Kohler, Siegfried, Thiel, Andreas·2009·Blood

DOI 10.1182/blood-2008-02-139154

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Abstract

Early in life, thymic export establishes the size and the diversity of the human naive T-cell pool. Yet, on puberty thymic activity drastically decreases. Because the overall size of the naive T-cell pool decreases only marginally during ageing, peripheral postthymic expansion of naive T cells has been postulated to account partly for the maintenance of T-cell immunity in adults. So far, the analysis of these processes had been hampered by the inability to distinguish recent thymic emigrants from proliferated, peripheral, naive T cells. However, recently, CD31 has been introduced as a marker to distinguish 2 subsets of naive CD4+ T cells with distinct T-cell receptor excision circle (TREC) content in the peripheral blood of healthy humans. Here, we review studies that have characterized TREChi CD31+ thymicnaive CD4+ T cells and have accordingly used the assessment of this distinct subset of naive CD4+ T cells as a correlate of thymic activity. We will discuss further potential clinical applications and how more research on CD31+ thymicnaive and CD31− centralnaive CD4+ T cells may foster our knowledge of the impact of thymic involution on immune competence.

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Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant.
“Lymphopenia leads to an increase in the homeostatic proliferation of naive T cells, which is usually not sufficient to keep their number constant [332, 333].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [332]
In “The consequences of human homeostatic naive CD4+ T-cell proliferation for immunity” (page unavailable), the paper reports increased peripheral homeostatic T-cell proliferation in lymphopenic mice. It does not say that this proliferation is usually insufficient to maintain naive T-cell numbers; in “Homeostatic proliferation of human naive Th cells” (page unavailable), it instead describes naive T-cell numbers in young and elderly humans as relatively stable. (LLM, conf=0.85)
Experimental — accuracy not yet measured
Partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells.
“This setting of partial lymphopenia results in increasing naive T-cell homeostatic proliferation, although this is not sufficient to maintain a constant number of these cells [77, 78].”
From Aging of the immune system: Focus on inflammation and vaccination (2016) · cites this paper as [77]

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Review article Life after the thymus: CD31 and CD31 human naive CD4 T-cell subsets
Köhler, S., & Thiel, A. (2016)
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Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral blood
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Brief Definitive Report Two Subsets of Naive T Helper Cells with Distinct T Cell Receptor Excision Circle Content in Human Adult Peripheral Blood
Kimmig, S., Przybylski, G. K., Schmidt, C. A., Laurisch, K., Moewes, B., Radbruch, A., & Thiel, A. (2013)
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IL-7-Induced Proliferation of Human Naive CD4 T-Cells Relies on Continued Thymic Activity
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Homeostasis of the naive CD4+ T cell compartment during aging
Kilpatrick, R. D., Rickabaugh, T., Hultin, L. E., Hultin, P., Hausner, M. A., Detels, R., Phair, J., & Jamieson, B. D. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.3.1499 · Cited by 213 · see citing works

Authors: Kohler, S., & Thiel, A.
Affiliations: Clinical Immunology Group, Deutsches Rheuma-Forschungszentrum Berlin, Berlin; and
German Rheumatism Research Centre (DE)
ORCID: Thiel, Andreas
Venue: Blood
Publisher: American Society of Hematology
Published: 2009-01-22
Volume: 113
Issue: 4
Pages: 769-774
ISSN: 0006-4971 (ISSN-L)
1528-0020
DOI: 10.1182/blood-2008-02-139154
OpenAlex: W1999924197
Cited by: 307
References: 75
Citations by year: 2026: 4 · 2025: 10 · 2024: 12 · 2023: 6 · 2022: 11 · 2021: 25 · 2020: 18 · 2019: 23 · 2018: 21 · 2017: 18 · 2016: 24 · 2015: 21 · 2014: 25 · 2013: 23 · 2012: 18
FWCI: 1.10
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Blood (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords: CD31, naive CD4+ T cells, thymic emigrants, thymic involution, TREC, T cell receptor diversity, immunosenescence, T cell subsets
MeSH terms: Animals, Homeostasis, Humans, Immunity, Innate, Thymus Gland, CD4-Positive T-Lymphocytes, Platelet Endothelial Cell Adhesion Molecule-1, Cell Proliferation

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Life after the thymus: CD31+ and CD31− human naive CD4+ T-cell subsets

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