The DOI matches its Crossref record; 58 of the 61 references it cites were found in a registry or an index.
Antioxidative enzymes and increased oxidative stress in depressive women
Abstract
Objectives To investigate the activities of the main antioxidative enzymes and oxidative stress in women with depressive disorder (DD).Methods In 35 drug-naive women with DD and 35 age matched healthy women enzymes superoxide dismutase (CuZnSOD), catalase (CAT), glutathione peroxidase (GPX1), glutathione reductase (GR) and paraoxonase (PON1), concentrations of conjugated dienes (CD), reduced glutathione (GSH) and anthropometric and clinical data were investigated.Results Women with DD were found to have decreased activities of GPX1 (p<0.05), decreased concentrations of GSH (p<0.05), and increased activities of GR (p<0.05), CuZnSOD (p<0.001), and concentrations of CD (p<0.05). Activity of GPX1 was positively correlated with concentration of GSH (p<0.05). Concentrations of CD were positively correlated with TG (p<0.01).Conclusion Our set of depressive women was characterized by changes indicating an increased oxidative stress, as well as by certain features of metabolic syndrome.
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“or a significant increase in most of the studies [123, 124, 128, 129].”
From Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches (2016) · cites this paper as [129]
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Metadata
- Authors
- Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A.
- Affiliations
- Charles University (CZ)
- Corresponding author
- Kodydková, Jana
- Venue
- Clinical Biochemistry
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 42
- Issue
- 13-14
- Pages
- 1368-1374
- ISSN
- 0009-9120 (ISSN-L)
- OpenAlex
- W2037761163
- Cited by
- 197
- References
- 61
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 8 · 2020: 19 · 2019: 6 · 2018: 13 · 2017: 16 · 2016: 11 · 2015: 14 · 2014: 22 · 2013: 14 · 2012: 19
- FWCI
- 7.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Biochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Health (MSM0021620820)
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- depressive disorders, oxidative stress, antioxidant enzymes, women, glutathione peroxidase 1, superoxide dismutase, catalase, glutathione reductase, paraoxonase 1, reduced glutathione, conjugated dienes, metabolic syndrome, triglycerides
- MeSH terms
- Aged, Alkadienes, Catalase, Depressive Disorder, Enzymes, Female, Glutathione, Glutathione Peroxidase, Glutathione Reductase, Humans, Middle Aged, Oxidation-Reduction, Spectrophotometry, Superoxide Dismutase, Triglycerides, Oxidative Stress, Aryldialkylphosphatase
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