A review of peripheral biomarkers in major depression: The potential of inflammatory and oxidative stress biomarkers

Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771 · see citing works

A Meta-Analysis of Cytokines in Major Depression

Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., & Lanctôt, K. L. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.033 · Cited by 4,729 · see citing works

Overweight, Obesity, and Depression: A Systematic Review and Meta-analysis of Longitudinal Studies

Luppino, F. S., de Wit, L. M., Bouvy, P. F., Stijnen, T., Cuijpers, P., Penninx, B. W. J. H., & Zitman, F. G. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.2 · Cited by 4,322 · see citing works

Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.

Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works

Beneficial Effects of Green Tea—A Review

Cabrera, C., Artacho, R., & Giménez, R. (2006) · Journal of the American College of Nutrition · doi:10.1080/07315724.2006.10719518 · Cited by 1,904 · see citing works

A Randomized Controlled Trial of the Tumor Necrosis Factor Antagonist Infliximab for Treatment-Resistant Depression: The Role of Baseline Inflammatory Biomarkers

Raison, C. L., Rutherford, R. E., Woolwine, B. J., Shuo, C., Schettler, P., Drake, D. F., Haroon, E., & Miller, A. H. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.4 · Cited by 1,617 · see citing works

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

Ng, F., Berk, M., Dean, O., & Bush, A. I. (2008) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145707008401 · Cited by 1,069 · see citing works

Chronic fatigue syndrome

Prins, J. B., van der Meer, J. W., & Bleijenberg, G. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68073-2 · Cited by 974 · see citing works

CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies.

Valkanova, V., Ebmeier, K. P., & Allan, C. L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.06.004 · Cited by 972 · see citing works

Interleukin (IL)-6, Tumour Necrosis Factor Alpha (TNF-α) and Soluble Interleukin-2 Receptors (SIL-2R) Are Elevated in Patients with Major Depressive Disorder: A Meta-Analysis and Meta-Regression

Liu, Y., Ho, R. C.-M., & Mak, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.08.003 · Cited by 948 · see citing works

The Effect of Antidepressant Medication Treatment on Serum Levels of Inflammatory Cytokines: A Meta-Analysis

Hannestad, J., DellaGioia, N., & Bloch, M. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.132 · Cited by 914 · see citing works

Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression

Leonard, B., & Maes, M. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.12.005 · Cited by 805 · see citing works

Race and Gender Differences in C-Reactive Protein Levels

Khera, A., McGuire, D. K., Murphy, S. A., Stanek, H. G., Das, S. R., Vongpatanasin, W., Wians, F. H., Grundy, S. M., & de Lemos, J. A. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.04.051 · Cited by 773 · see citing works

The STAR*D project results: A comprehensive review of findings

Warden, D., Rush, A. J., Trivedi, M. H., Fava, M., & Wisniewski, S. R. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0061-3 · Cited by 727 · see citing works

Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments

Bilici, M., Efe, H., Köroğlu, M. A., Uydu, H. A., Bekaroğlu, M., & Değer, O. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00199-3 · Cited by 718 · see citing works

Obesity and C ‐reactive protein in various populations: a systematic review and meta‐analysis

Choi, J., Joseph, L., & Pilote, L. (2012) · Obesity Reviews · doi:10.1111/obr.12003 · Cited by 657 · see citing works

Depression and C-Reactive Protein in US Adults: Data From the Third National Health and Nutrition Examination Survey

Ford, D. E., & Erlinger, T. P. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.9.1010 · Cited by 544 · see citing works

Kynurenine pathway in major depression: Evidence of impaired neuroprotection

Myint, A.-M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.013 · Cited by 527 · see citing works

Is depression an inflammatory disorder?

Raison, C. L., & Miller, A. H. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0232-0 · Cited by 524 · see citing works

Antioxidant Effects of Tea: Evidence from Human Clinical Trials

Rietveld, A. G., & Wiseman, S. A. (2003) · Journal of Nutrition · doi:10.1093/jn/133.10.3285s · Cited by 501 · see citing works

Elevated C-Reactive Protein Levels, Psychological Distress, and Depression in 73 131 Individuals

Wium-Andersen, M. K., Ørsted, D. D., Nielsen, S. F., & Nordestgaard, B. G. (2013) · JAMA Psychiatry · doi:10.1001/2013.jamapsychiatry.102 · Cited by 489 · see citing works

Major depressive disorder is accompanied with oxidative stress: short-term antidepressant treatment does not alter oxidative-antioxidative systems

Sarandol, A., Sarandol, E., Eker, S. S., Erdinc, S., Vatansever, E., & Kirli, S. (2007) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.829 · Cited by 486 · see citing works

What is a mental/psychiatric disorder? From DSM-IV to DSM-V

Stein, D. J., Phillips, K. A., Bolton, D., Fulford, K. W. M., Sadler, J. Z., & Kendler, K. S. (2010) · Psychological Medicine · doi:10.1017/s0033291709992261 · Cited by 481 · see citing works

Functional Biomarkers of Depression: Diagnosis, Treatment, and Pathophysiology

Schmidt, H. D., Shelton, R. C., & Duman, R. S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.151 · Cited by 477 · see citing works

Oxidative damage and major depression: the potential antioxidant action of selective serotonin re-uptake inhibitors

Khanzode, S. D., Dakhale, G. N., Khanzode, S. S., Saoji, A., & Palasodkar, R. (2003) · Redox Report · doi:10.1179/135100003225003393 · Cited by 458 · see citing works

IDO and interferon-α-induced depressive symptoms: a shift in hypothesis from tryptophan depletion to neurotoxicity

Wichers, M. C., Koek, G. H., Robaeys, G., Verkerk, R., Scharpé, S., & Maes, M. (2005) · Molecular Psychiatry · doi:10.1038/sj.mp.4001600 · Cited by 445 · see citing works

Antioxidant enzyme activities and oxidative stress in affective disorders

Erkan Ozcan, M., Gulec, M., Ozerol, E., Polat, R., & Akyol, O. (2004) · International Clinical Psychopharmacology · doi:10.1097/00004850-200403000-00006 · Cited by 368 · see citing works

Clustering of depression and inflammation in adolescents previously exposed to childhood adversity

Miller, G. E., & Cole, S. W. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.02.034 · Cited by 331 · see citing works

Association of depressive disorders, depression characteristics and antidepressant medication with inflammation

Vogelzangs, N., Duivis, H. E., Beekman, A. T. F., Kluft, C., Neuteboom, J., Hoogendijk, W., Smit, J. H., de Jonge, P., & Penninx, B. W. J. H. (2012) · Translational Psychiatry · doi:10.1038/tp.2012.8 · Cited by 323 · cited 1× · see citing works

Adenosine Deaminase, Nitric Oxide, Superoxide Dismutase, and Xanthine Oxidase in Patients with Major Depression: Impact of Antidepressant Treatment

Herken, H., Gurel, A., Selek, S., Armutcu, F., Ozen, M. E., Bulut, M., Kap, O., Yumru, M., Savas, H. A., & Akyol, O. (2007) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.10.005 · Cited by 322 · see citing works

Association of high-sensitivity C-reactive protein with <i>de novo</i> major depression

Pasco, J. A., Nicholson, G. C., Williams, L. J., Jacka, F. N., Henry, M. J., Kotowicz, M. A., Schneider, H. G., Leonard, B. E., & Berk, M. (2010) · British Journal of Psychiatry · doi:10.1192/bjp.bp.109.076430 · Cited by 321 · see citing works

Gender and C-reactive protein: Data from the Multiethnic Study of Atherosclerosis (MESA) cohort

Gilchrist, S. C., Cushman, M., Criqui, M. H., Rundek, T., Blumenthal, R. S., D'Agostino, R. B., & Herrington, D. M. (2006) · American Heart Journal · doi:10.1016/j.ahj.2006.02.015 · Cited by 314 · see citing works

Increased Serum Levels of 8-Hydroxy-2′-Deoxyguanosine in Clinical Depression

Forlenza, M. J., & Miller, G. E. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000195780.37277.2a · Cited by 307 · see citing works

Increased neopterin and interferon-gamma secretion and lower availability of L-tryptophan in major depression: Further evidence for an immune response

Maes, M., Scharpé, S., Meltzer, H. Y., Okayli, G., Bosmans, E., D'Hondt, P., Vanden Bossche, B., & Cosyns, P. (1994) · Psychiatry Research · doi:10.1016/0165-1781(94)90003-5 · Cited by 302 · see citing works

Differential association of somatic and cognitive symptoms of depression and anxiety with inflammation: findings from the Netherlands Study of Depression and Anxiety (NESDA)

Duivis, H. E., Vogelzangs, N., Kupper, N., de Jonge, P., & Penninx, B. W. J. H. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.01.002 · Cited by 282 · see citing works

A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: Exploring the causes of heterogeneity

Hiles, S. A., Baker, A. L., de Malmanche, T., & Attia, J. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.06.001 · Cited by 274 · see citing works

Distribution of C-Reactive Protein Values in the United States

Woloshin, S., & Schwartz, L. M. (2005) · New England Journal of Medicine · doi:10.1056/nejm200504143521525 · Cited by 271 · see citing works

Cumulative Depression Episodes Predict Later C-Reactive Protein Levels: A Prospective Analysis

Copeland, W. E., Shanahan, L., Worthman, C., Angold, A., & Costello, E. J. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.023 · Cited by 265 · see citing works

Plasma kynurenine levels are elevated in suicide attempters with major depressive disorder

Sublette, M. E., Galfalvy, H. C., Fuchs, D., Lapidus, M., Grunebaum, M. F., Oquendo, M. A., John Mann, J., & Postolache, T. T. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.05.002 · Cited by 250 · see citing works

Raised Plasma Levels of Tumor Necrosis Factor α in Patients With Depression: Normalization During Electroconvulsive Therapy

Hestad, K. A., Tønseth, S., Støen, C. D., Ueland, T., & Aukrust, P. (2003) · The Journal of ECT · doi:10.1097/00124509-200312000-00002 · Cited by 235 · see citing works

Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis

Hiles, S. A., Baker, A., de Malmanche, T., & Attia, J. (2012) · Psychological Medicine · doi:10.1017/s0033291712000128 · Cited by 218 · see citing works

Lipid peroxidation and antioxidant protection in patients during acute depressive episodes and in remission after fluoxetine treatment

Gałecki, P., Szemraj, J., Bieńkiewicz, M., Florkowski, A., & Gałecka, E. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70084-2 · Cited by 214 · see citing works

In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS‐damaged neoepitopes

Maes, M. H. J., Kubera, M., Leunis, J., Berk, M., Geffard, M., & Bosmans, E. (2012) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2012.01908.x · Cited by 209 · see citing works

Depressive and anxiety symptoms in the early puerperium are related to increased degradation of tryptophan into kynurenine, a phenomenon which is related to immune activation

Maes, M. H. J., Verkerk, R. M., Bonaccorso, S., Ombelet, W. U. A. M., Bosmans, E., & Scharpé, S. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01853-2 · Cited by 203 · see citing works

Antioxidative enzymes and increased oxidative stress in depressive women

Kodydková, J., Vávrová, L., Zeman, M., Jirák, R., Macášek, J., Staňková, B., Tvrzická, E., & Žák, A. (2009) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2009.06.006 · Cited by 197 · see citing works

Diurnal, Seasonal, and Blood-Processing Patterns in Levels of Circulating Fibrinogen, Fibrin D-Dimer, C-Reactive Protein, Tissue Plasminogen Activator, and von Willebrand Factor in a 45-Year-Old Population

Rudnicka, A. R., Rumley, A., Lowe, G. D. O., & Strachan, D. P. (2007) · Circulation · doi:10.1161/circulationaha.106.635169 · Cited by 187 · see citing works

Endogenous Reproductive Hormones and C-reactive Protein Across the Menstrual Cycle: The BioCycle Study

Gaskins, A. J., Wilchesky, M., Mumford, S. L., Whitcomb, B. W., Browne, R. W., Wactawski‐Wende, J., Perkins, N. J., & Schisterman, E. F. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kwr343 · Cited by 185 · see citing works

The relevance of oxidative stress status in first episode and recurrent depression

Stefanescu, C., & Ciobica, A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.022 · Cited by 179 · see citing works

Activation of cell-mediated immunity in depression: Association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression

Maes, M. H. J., Mihaylova, I., Kubera, M., & Ringel, K. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.09.006 · Cited by 170 · see citing works

The Association Between C-Reactive Protein Levels and Depression: Results from the Northern Finland 1966 Birth Cohort Study

Liukkonen, T., Silvennoinen-Kassinen, S., Jokelainen, J., Räsänen, P., Leinonen, M., Meyer-Rochow, V. B., & Timonen, M. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.016 · Cited by 163 · see citing works

Increased 8-hydroxy-deoxyguanosine, a marker of oxidative damage to DNA, in major depression and myalgic encephalomyelitis / chronic fatigue syndrome.

Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2009) · PubMed · Cited by 157 · see citing works

Depression and C-Reactive Protein: Population-Based Health 2000 Study

Elovainio, M., Aalto, A.-M., Kivimäki, M., Pirkola, S., Sundvall, J., Lönnqvist, J., & Reunanen, A. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31819e333a · Cited by 157 · see citing works

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

Lopresti, A. L., Hood, S. D., & Drummond, P. D. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881112458732 · Cited by 151 · see citing works

Effects of long-term antidepressant treatment on oxidative status in major depressive disorder: A 24-week follow-up study

Kotan, V. O., Sarandol, E., Kirhan, E., Ozkaya, G., & Kirli, S. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.03.021 · Cited by 149 · see citing works

Depression and depressive symptoms in rheumatoid arthritis patients: an analysis of their occurrence and determinants

Abdel-Nasser, A. M. (1998) · British journal of rheumatology · doi:10.1093/rheumatology/37.4.391 · Cited by 149 · see citing works

Interplay between the pro-oxidant and antioxidant systems and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression

Rybka, J., Kędziora-Kornatowska, K., Banaś-Leżańska, P., Majsterek, I., Carvalho, L. A., Cattaneo, A., Anacker, C., & Kędziora, J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.019 · Cited by 146 · see citing works

A community-based study on determinants of circulating markers of cellular immune activation and kynurenines: the Hordaland Health Study

Theofylaktopoulou, D., Midttun, Ø., Ulvik, A., Ueland, P. M., Tell, G. S., Vollset, S. E., Nygard, O. K., & Eussen, S. J. P. M. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12092 · Cited by 129 · see citing works

The association between anxiety and C-reactive protein (CRP) levels: results from the Northern Finland 1966 Birth Cohort Study

Liukkonen, T., Räsänen, P., Jokelainen, J., Leinonen, M., Järvelin, M.-R., Meyer-Rochow, V. B., & Timonen, M. (2011) · European Psychiatry · doi:10.1016/j.eurpsy.2011.02.001 · Cited by 127 · see citing works

Inflammatory Biomarkers and Depression

Müller, N., Myint, A.-M., & Schwarz, M. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9210-2 · Cited by 125 · see citing works

Oxidative stress parameters after combined fluoxetine and acetylsalicylic acid therapy in depressive patients

Gałecki, P., Szemraj, J., Bieńkiewicz, M., Zboralski, K., & Gałecka, E. (2009) · Human Psychopharmacology: Clinical and Experimental · doi:10.1002/hup.1014 · Cited by 124 · see citing works

Treatment response and cognitive impairment in major depression: Association with C-reactive protein

Chang, H. H., Lee, I. H., Gean, P. W., Lee, S.-Y., Chi, M. H., Yang, Y. K., Lu, R.-B., & Chen, P. S. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2011.07.239 · Cited by 120 · see citing works

Depression and oxidative damage to lipids

Yager, S., Forlenza, M. J., & Miller, G. E. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.010 · Cited by 120 · see citing works

Increased plasma levels of 8-iso-PGF2α and IL-6 in an elderly population with depression

Dimopoulos, N., Piperi, C., Psarra, V., Lea, R. W., & Kalofoutis, A. (2008) · Psychiatry Research · doi:10.1016/j.psychres.2007.07.019 · Cited by 118 · see citing works

The possible role of the kynurenine pathway in adolescent depression with melancholic features

Gabbay, V., KLEIN, R. G., Katz, Y., Mendoza, S., Guttman, L. E., Alonso, C. M., Babb, J. S., Hirsch, G. S., & Liebes, L. (2010) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02245.x · Cited by 115 · see citing works

C‐reactive protein across the menstrual cycle

Wander, K., Brindle, E., & O’Connor, K. A. (2008) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20785 · Cited by 115 · see citing works

Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation

Hughes, M. M., Carballedo, A., McLoughlin, D. M., Amico, F., Harkin, A., Frodl, T., & Connor, T. J. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.05.010 · Cited by 104 · see citing works

(Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors

Maes, M. H. J., Leonard, B. E., Fernandez, A., Kubera, M., Nowak, G., Veerhuis, R., Gardner, A., Ruckoanich, P., Geffard, M., Altamura, C. A., et al. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.02.019 · Cited by 102 · see citing works

Increased oxidative stress in patients with depression and its relationship to treatment

Chung, C. P., Schmidt, D. E., Stein, C. M., Morrow, J. D., & Salomon, R. M. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.10.018 · Cited by 99 · see citing works

A way forward for research on biomarkers for psychiatric disorders

Boksa, P. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130018 · Cited by 98 · see citing works

Oxidative stress and inflammatory markers are associated with depression and nicotine dependence

Vargas, H. O., Nunes, S. O. V., de Castro, M. R. P., Vargas, M. M., Barbosa, D. S., Bortolasci, C. C., Venugopal, K., Dodd, S., & Berk, M. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.03.059 · Cited by 98 · see citing works

Depression and Chronic Diseases: It Is Time for a Synergistic Mental Health and Primary Care Approach

Voinov, B., Richie, W. D., & Bailey, R. K. (2013) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.12r01468 · Cited by 98 · see citing works

Inflammatory and Cell-Mediated Immune Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Depression: Inflammatory Markers Are Higher in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome than in Depression

Maes, M. H. J., Twisk, F., & Ringel, K. (2012) · Psychotherapy and Psychosomatics · doi:10.1159/000336803 · Cited by 97 · see citing works

Sex-differentiated changes in C-reactive protein from ages 9 to 21: The contributions of BMI and physical/sexual maturation

Shanahan, L., Copeland, W., Worthman, C. M., Erkanli, A., Angold, A. C., & Costello, E. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.04.010 · Cited by 96 · see citing works

Increase in Plasma Proinflammatory Cytokines After Electroconvulsive Therapy in Patients With Depressive Disorder

Lehtimäki, K. A., Keränen, T., Huuhka, M., Palmio, J., Hurme, M., Leinonen, E. V. J., & Peltola, J. (2008) · Journal of Ect · doi:10.1097/yct.0b013e3181571abb · Cited by 92 · see citing works

The six most essential questions in psychiatric diagnosis: a pluralogue part 1: conceptual and definitional issues in psychiatric diagnosis

Phillips, J. E., FRANCES, A. J., Cerullo, M. A., Chardavoyne, J., Decker, H. S., First, M. B., Ghaemi, S. N., Greenberg, G., Hinderliter, A. C., Kinghorn, W. A., et al. (2012) · Philosophy Ethics and Humanities in Medicine · doi:10.1186/1747-5341-7-3 · Cited by 92 · see citing works

C-reactive protein is elevated in atypical but not nonatypical depression: Data from the National Health and Nutrition Examination Survey (NHANES) 1999–2004

Hickman, R. J., Khambaty, T., & Stewart, J. C. (2014) · Journal of Behavioral Medicine · doi:10.1007/s10865-013-9510-0 · Cited by 90 · see citing works

Somatization, but not depression, is characterized by disorders in the tryptophan catabolite (TRYCAT) pathway, indicating increased indoleamine 2,3-dioxygenase and lowered kynurenine aminotransferase activity.

Maes, M. H. J., Gałecki, P., Verkerk, R. M., & Rief, W. (2011) · PubMed · Cited by 89 · see citing works

Diagnostic classifications in depression and somatization should include biomarkers, such as disorders in the tryptophan catabolite (TRYCAT) pathway

Maes, M. H. J., & Rief, W. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2011.09.029 · Cited by 88 · see citing works

Oxidative stress and therapeutic implications in psychiatric disorders

Zhang, X. Y., & Yao, J. K. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.03.003 · Cited by 81 · see citing works

Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression

Hoekstra, R., van den Broek, W. W., Fekkes, D., Bruijn, J. A., Mulder, P. G. H., & Pepplinkhuizen, L. (2001) · Psychiatry Research · doi:10.1016/s0165-1781(01)00282-7 · Cited by 79 · see citing works

Lower whole blood glutathione peroxidase (GPX) activity in depression, but not in myalgic encephalomyelitis / chronic fatigue syndrome: another pathway that may be associated with coronary artery disease and neuroprogression in depression.

Maes, M. H. J., Mihaylova, I., Kubera, M., Uytterhoeven, M., Vrydags, N., & Bosmans, E. (2011) · PubMed · Cited by 76 · see citing works

The association between serum levels of neopterin and number of depressive episodes of major depression

Çelik, C., Erdem, M., Çaycı, T., Özdemir, B. H., Akgül, E. Ö., Kurt, Y. G., Yaman, H., Isıntas, M., Özgen, F., & Özşahin, A. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.01.002 · Cited by 76 · see citing works

Tryptophan Metabolism and Immunogenetics in Major Depression: A Role for Interferon-γ Gene

Myint, A. M., Bondy, B., Baghai, T. C., Eser, D., Nothdurfter, C., Schüle, C., Zill, P., Müller, N., Rupprecht, R., & Schwarz, M. J. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.04.003 · Cited by 74 · see citing works

Systemic oxidatively generated DNA/RNA damage in clinical depression: associations to symptom severity and response to electroconvulsive therapy

Jorgensen, A., Krogh, J., Miskowiak, K., Bolwig, T. G., Kessing, L. V., Fink-Jensen, A., Nordentoft, M., Henriksen, T., Weimann, A., Poulsen, H. E., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.02.011 · Cited by 74 · see citing works

KYNURENINE METABOLITES AND INFLAMMATION MARKERS IN DEPRESSED PATIENTS TREATED WITH FLUOXETINE OR COUNSELLING

Mackay, G., Forrest, C. M., Christofides, J. A., Bridel, M. A., Mitchell, S. L., Cowlard, R., Stone, T. W., & Darlington, L. G. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05077.x · Cited by 66 · see citing works

Oxidative stress in depressive patients with gastric adenocarcinoma

Wei, Y., Zhou, F., He, D., Bai, J.-R., Ding, H., Wang, X., & Nan, K. (2009) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145709000091 · Cited by 64 · see citing works

Cytokines in major depression

Maes, M. H. J. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90652-1 · Cited by 63 · see citing works

Association between Depression and C-Reactive Protein

Ma, Y., Chiriboga, D. E., Pagoto, S. L., Rosal, M. C., Li, W., Merriam, P. A., Hébert, J. R., Whited, M. C., & Ockene, I. S. (2011) · Cardiology Research and Practice · doi:10.4061/2011/286509 · Cited by 61 · see citing works

Indoleamine 2,3-dioxygenase activation and depressive symptoms in patients with coronary artery disease.

Swardfager, W., Herrmann, N., Dowlati, Y., Oh, P., Kiss, A., Walker, S., & Lanctôt, K. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.019 · Cited by 54 · see citing works

Effects of fluoxetine and escitalopram on C-reactive protein in patients of depression

Chavda, N., & Kantharia, N. D. (2011) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.77091 · Cited by 45 · see citing works

Prepartum Depressive Symptoms Correlate Positively with C-Reactive Protein Levels and Negatively with Tryptophan Levels: A Preliminary Report.

Scrandis, D. A., LANGENBERG, P. W., Tonelli, L. H., Sheikh, T. M., Manogura, A. C., Alberico, L. A., Hermanstyne, T. O., Fuchs, D., Mighty, H. E., Hasday, J. D., et al. (2008) · PubMed · Cited by 42 · see citing works

Inflammation and treatment response to sertraline in patients with coronary heart disease and comorbid major depression

Bot, M., Carney, R. M., Freedland, K. E., Rubin, E. H., Rich, M. W., Steinmeyer, B. C., & Mann, D. L. (2011) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.11.006 · Cited by 41 · see citing works

Pterin metabolism in depression: an extension of the amine hypothesis and possible marker of response to ECT

Anderson, D. N., Abou‐Saleh, M. T., Collins, J., Hughes, K. R., Cattell, R. J., Hamon, C. G. B., Blair, J. A., & Dewey, M. E. (1992) · Psychological Medicine · doi:10.1017/s0033291700038435 · Cited by 40 · see citing works

Variation in high-sensitivity C-reactive protein levels over 24 hours in patients with stable coronary artery disease.

Koc, M., Karaarslan, O., Abalı, G., & Batur, M. K. (2010) · Europe PMC (PubMed Central) · Cited by 39 · see citing works

Effects of Sertraline on Circulating Markers of Oxidative Stress in Depressed Patients With Chronic Heart Failure: A Pilot Study

Michalakeas, C. A., Parissis, J., Douzenis, A., Nikolaou, M., Varounis, C., Andreadou, I., Antonellos, N., Markantonis-Kiroudis, S., PARASKEVAIDIS, I. A., Ikonomidis, I., et al. (2011) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2011.05.004 · Cited by 36 · see citing works

Lipid Peroxidation and Depressed Mood in Community-Dwelling Older Men and Women

Milaneschi, Y., Cesari, M., Simonsick, E. M., Vogelzangs, N., Kanaya, A. M., Yaffe, K. S., Patrignani, P., Metti, A. L., Kritchevsky, S. B., Pahor, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0065406 · Cited by 35 · see citing works

Menstrual cycle effects on the metabolism of tryptophan loads

Hrboticky, N., Leiter, L. A., & Anderson, G. H. (1989) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/50.1.46 · Cited by 32 · see citing works

Impact of Cardiovascular Risk Factors and Inflammatory Status on Urinary 8-OHdG in Essential Hypertension

Roselló‐Lletí, E., de Burgos, F. G., Morillas, P., et al. (2011) · American Journal of Hypertension · doi:10.1038/ajh.2011.202 · Cited by 29 · see citing works

Plasma neopterin in major depression: relationship to basal and stimulated pituitary–adrenal cortical axis function

O’Toole, S. M., Chiappelli, F., & Rubín, R. T. (1998) · Psychiatry Research · doi:10.1016/s0165-1781(98)00019-5 · Cited by 29 · see citing works

A matter of fat: insulin resistance and oxidative stress

Codoñer-Franch, P., Navarro-Ruíz, A., Fernández-Ferri, M., Arilla-Codoñer, Á., Ballester‐Asensio, E., & Valls-Bellés, V. (2012) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2011.00847.x · Cited by 27 · see citing works

Depressive symptoms and oxidative DNA damage in Japanese municipal employees

Yi, S., Nanri, A., Matsushita, Y., Kasai, H., Kawai, K., & Mizoue, T. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.05.035 · Cited by 25 · see citing works

The relationships between high-sensitivity C-reactive protein and incident depressed mood among older adults

Luukinen, H., Jokelainen, J., & Hedberg, P. (2010) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365510903410548 · Cited by 25 · see citing works

DSM-IV Major Depressive Episode criteria: An evaluation of reliability and validity across three different rating methods

Hilsenroth, M. J., Baity, M. R., Mooney, M. A., & Meyer, G. J. (2004) · International Journal of Psychiatry in Clinical Practice · doi:10.1080/13651500310004795 · Cited by 18 · see citing works

Translating potential biomarker candidates for schizophrenia and depression to animal models of psychiatric disorders

Kluge, W., Alsaif, M., Guest, P., Schwarz, E., & Bahn, S. (2011) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.11.61 · Cited by 13 · see citing works

Association of STAI and SDS Scores With 8-Hydroxydeoxyguanosine and Serotonin Levels in Young Women With Depressive Symptoms

Iida, T., Chikamura, C., Inoue, K., et al. (2011) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.23.1.e10 · Cited by 10 · see citing works

Elevated C-reactive protein levels.

Verma, U. L., Hameed, C., & Tejani, N. (1984) · PubMed · Cited by 10 · see citing works

Corrigendum to “Interplay between the pro-oxidant and antioxidant system, and proinflammatory cytokine levels, in relation to iron metabolism and the erythron in depression” [Free Rad. Bio. Med. 63C (2013) 187–194]

Rybka, J., Kędziora–Kornatowska, K., Banaś-Leżańska, P., et al. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.035 · Cited by 3 · see citing works

Altered fecal microbiota composition in patients with major depressive disorder

Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.016 · Cited by 2,275 · see citing works

Immune mechanisms linked to depression via oxidative stress and neuroprogression

Bakunina, N., Pariante, C. M., & Zunszain, P. A. (2015) · Immunology · doi:10.1111/imm.12443 · Cited by 444 · see citing works

Biomarkers for depression: recent insights, current challenges and future prospects

Strawbridge, R., Young, A. H., & Cleare, A. J. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s114542 · Cited by 415 · see citing works

Neurobiological effects of exercise on major depressive disorder: A systematic review

Schuch, F. B., Deslandes, A. C., Stubbs, B., Gosmann, N. P., Silva, C. T. B. D., & Fleck, M. P. D. A. (2016) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.11.012 · Cited by 279 · see citing works

Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models

Pillinger, T., D’Ambrosio, E., McCutcheon, R., & Howes, O. D. (2019) · Molecular Psychiatry · doi:10.1038/s41380-018-0058-9 · Cited by 230 · see citing works

Kynurenine pathway dysfunction in the pathophysiology and treatment of depression: Evidences from animal and human studies

Réus, G. Z., Jansen, K., Titus, S., Carvalho, A. F., Gabbay, V., & Quevedo, J. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.05.007 · Cited by 221 · see citing works

Peripheral Markers of Depression

Nobis, A., Zalewski, D., & Waszkiewicz, N. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123793 · Cited by 197 · see citing works

A specific inflammatory profile underlying suicide risk? Systematic review of the main literature findings

Serafini, G., Parisi, V. M., Aguglia, A., Amerio, A., Sampogna, G., Fiorillo, A., Pompili, M., & Amore, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072393 · Cited by 172 · see citing works

DeepMood: Forecasting Depressed Mood Based on Self-Reported Histories via Recurrent Neural Networks

Suhara, Y., Xu, Y., & Pentland, A. '. (2017) · Proceedings of the 26th International Conference on World Wide Web · doi:10.1145/3038912.3052676 · Cited by 163 · see citing works

The Young and the Stressed: Stress, Impulse Control, and Health in College Students

Leppink, E. W., Odlaug, B. L., Lust, K., Christenson, G., & Grant, J. E. (2016) · Journal of Nervous &amp; Mental Disease · doi:10.1097/nmd.0000000000000586 · Cited by 142 · see citing works

Flavonoid-rich orange juice intake and altered gut microbiome in young adults with depressive symptom: a randomized controlled study

Park, M., Choi, J., & Lee, H.-J. (2020) · Nutrients · doi:10.3390/nu12061815 · Cited by 139 · see citing works

Effects of Mindfulness-Based Interventions on Biomarkers and Low-Grade Inflammation in Patients with Psychiatric Disorders: A Meta-Analytic Review

Sanada, K., Montero-Marin, J., Barceló-Soler, A., Ikuse, D., Ota, M., Hirata, A., Yoshizawa, A., Hatanaka, R., Valero, M. S., Demarzo, M., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072484 · Cited by 96 · see citing works

Curcumin and major depression: A randomised, double-blind, placebo-controlled trial investigating the potential of peripheral biomarkers to predict treatment response and antidepressant mechanisms of change

Lopresti, A. L., Maes, M., Meddens, M. J. M., Maker, G. L., Arnoldussen, E., & Drummond, P. D. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.11.015 · Cited by 99 · see citing works

Bifidobacterium pseudocatenulatum CECT 7765 ameliorates neuroendocrine alterations associated with an exaggerated stress response and anhedonia in obese mice

Agusti, A., Moya-Pérez, A., Campillo, I., Montserrat-de la Paz, S., Cerrudo, V., Perez-Villalba, A., & Sanz, Y. (2018) · Molecular Neurobiology · doi:10.1007/s12035-017-0768-z · Cited by 85 · see citing works

The relationships of current suicidal ideation with inflammatory markers and heart rate variability in unmedicated patients with major depressive disorder

Chang, C.-C., Tzeng, N.-S., Kao, Y.-C., Yeh, C.-B., & Chang, H.-A. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.08.076 · Cited by 65 · see citing works

In a randomized, double-blind clinical trial, adjuvant atorvastatin improved symptoms of depression and blood lipid values in patients suffering from severe major depressive disorder

Haghighi, M., Khodakarami, S., Jahangard, L., Ahmadpanah, M., Bajoghli, H., Holsboer-Trachsler, E., & Brand, S. (2014) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.07.018 · Cited by 65 · see citing works

Bias in Peripheral Depression Biomarkers

Carvalho, A. F., Köhler, C. A., Brunoni, A. R., Miskowiak, K. W., Herrmann, N., Lanctôt, K. L., Hyphantis, T. N., Quevedo, J., Fernandes, B. S., & Berk, M. (2016) · Psychotherapy and Psychosomatics · doi:10.1159/000441457 · Cited by 52 · see citing works

Longitudinal associations between glucocorticoid receptor methylation and late-life depression

Kang, H.-J., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Kim, H.-R., Shin, M.-G., Yoon, J.-S., & Kim, J.-M. (2018) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2018.02.004 · Cited by 30 · see citing works

Protein arginine methyltransferase-1 deficiency restrains depression-like behavior of mice by inhibiting inflammation and oxidative stress via Nrf-2

Liu, H., Jiang, J., & Zhao, L. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.08.032 · Cited by 23 · see citing works

Comparing clinical responses and the biomarkers of BDNF and cytokines between subthreshold bipolar disorder and bipolar II disorder

Wang, T.-Y., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Wang, L.-J., Chen, P. S., Chen, S.-H., Chu, C.-H., Huang, S.-Y., Tzeng, N.-S., et al. (2016) · Scientific Reports · doi:10.1038/srep27431 · Cited by 21 · see citing works

Assessment of a Multi-Assay Biological Diagnostic Test for Mood Disorders in a Japanese Population

Yamamori, H., Ishima, T., Yasuda, Y., Fujimoto, M., Kudo, N., Ohi, K., Hashimoto, K., Takeda, M., & Hashimoto, R. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.019 · Cited by 19 · see citing works

Advancing depression management through biomarker discovery with a focus on genetic and epigenetic aspects: a comprehensive study on neurobiological, neuroendocrine, metabolic, and inflammatory pathways

Milic, J., Jovic, S., & Sapic, R. (2025) · Genes · doi:10.3390/genes16050487 · Cited by 19 · see citing works

Novel Phospholipid Signature of Depressive Symptoms in Patients with Coronary Artery Disease

Chan, P., Suridjan, I., Mohammad, D., Herrmann, N., Mazereeuw, G., Hillyer, L. M., Ma, D. W. L., Oh, P. I., & Lanctôt, K. L. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.117.008278 · Cited by 15 · see citing works

Urine 3-Nitrotyrosine and serum HDL as potential biomarkers of depression

Nobis, A., Zalewski, D., Samaryn, E., Maciejczyk, M., Zalewska, A., & Waszkiewicz, N. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12010377 · Cited by 12 · see citing works

Comparative Effectiveness of a Mindfulness-Based Intervention (M-Body) on Depressive Symptoms: Study Protocol of a Randomized Controlled Trial in a Federally Qualified Health Center (FQHC)

Burnett-Zeigler, I., Zhou, E., Martinez, J. H., Zumpf, K., Lartey, L., Moskowitz, J. T., Wisner, K. L., McDade, T., Brown, C. H., Gollan, J., et al. (2023) · Trials · doi:10.1186/s13063-022-07012-2 · Cited by 9 · see citing works

The future of precision medicine: towards a more predictive personalized medicine

Elemento, O. (2020) · Emerging Topics in Life Sciences · doi:10.1042/etls20190197 · Cited by 67 · see citing works

Precíziós és perszonalizált medicina

Sipka, S. (2016) · Orvosi Hetilap · doi:10.1556/650.2016.30564 · Cited by 1 · see citing works

Protein arrays for biomarker discovery in lupus

Hinchliffe, T. E., Lin, Z., & Wu, T. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201500060 · Cited by 13 · see citing works

Genomic medicine on the frontier of precision medicine

Hasanzad, M., Sarhangi, N., Naghavi, A., Ghavimehr, E., Khatami, F., Chimeh, S. E., Larijani, B. A., & Meybodi, H. R. A. (2021) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-021-00880-6 · Cited by 21 · see citing works

Precision (personalized) medicine

Walton, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95274-3.00002-6 · Cited by 3 · see citing works