Cited by 35Thyroid Disorders and TreatmentsClinical Laboratory Practices and Quality ControlThyroid Cancer Diagnosis and Treatment

Reference range of thyroid function (FT3, FT4 and TSH) among Indian adults

Marwaha, Raman Kumar, Tandon, Nikhil, Ganie, Mohd Ashraf, Mehan, Neena, Sastry, Aparna, Garg, M.K., Bhadra, Kuntal, Singh, Satveer·2013·Clinical Biochemistry

Abstract

Objectives To generate thyroid hormone reference norms using electro-chemiluminescence technique.Design and methods Cross sectional study on apparently normal 4349 Delhi adults (18-86 years). Predetermined exclusion criteria (goiter, hypoechogenicity or nodularity on ultrasound, elevated anti-thyroid peroxidase antibody, hypo or hyperthyroidism and family history of thyroid dysfunction) excluded 2433 subjects leaving 1916 (916 males and 1000 females) as the reference population.Results Mean age and BMI of the reference population were 41.2 ± 18.1 years and 24.5 ± 4.4 kg/m(2) respectively. Median urinary iodine excretion was 233.6 μg/L (79-458;3rd-97th centile). The population was categorized into various age groups (18-30, 31-40, 41-50, 51-60, 61-70 and ≥ 70 years). Overall FT3 and FT4 values in the reference population irrespective of age, ranged from 2.4-8.8 (mean 4.6 ± 0.9) pmol/L and 10.1-24.8 (mean 15.40 ± 2.0) pmol/L, respectively. Mean TSH value in the reference population was 2.2 ± 0.9 mIU/L which was significantly lower than that of total population (3.8 ± 6.1; p<0.001).Conclusion FT3 values were observed to be significantly higher in men than women (p=0.001). The centiles (3rd, 5th, 10th, 25th, 50th, 75th, 90th, 95th and 97th) of FT3, FT4 and TSH were derived for reference purposes in Indian adults. This community based study in Indian adults has established mean reference intervals for FT3, FT4 and TSH for different age groups for both sexes separately using strict exclusion criteria. These can be used as reference norms for Indian adults.

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Crossref · 10.1016/j.clinbiochem.2012.09.021

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Authors
Marwaha, R. K., Tandon, N., Ganie, M. A., Mehan, N., Sastry, A., Garg, M. K., Bhadra, K., & Singh, S.
Affiliations
  • Institute of Nuclear Medicine & Allied Sciences (IN)
  • All India Institute of Medical Sciences (IN)
  • Sher-i-Kashmir Institute of Medical Sciences (IN)
  • Army Hospital Research and Referral (IN)
Corresponding author
Marwaha, Raman Kumar
Venue
Clinical Biochemistry
Publisher
Elsevier BV
Published
2013-03
Volume
46
Issue
4-5
Pages
341-345
ISSN
0009-9120 (ISSN-L)
OpenAlex
W2008805242
Cited by
35
References
33
Citations by year
2026: 5 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 4 · 2020: 6 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 1
FWCI
0.26
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Biochemistry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Keywords
thyroid function, reference values, free thyroxine, free triiodothyronine, thyroid-stimulating hormone, age-related reference values, sex differences, urinary iodine excretion, Indian adults, Delhi
MeSH terms
Adolescent, Adult, Aged, Cross-Sectional Studies, Female, Humans, India, Male, Middle Aged, Reference Values, Thyroid Gland, Thyrotropin, Thyroxine, Triiodothyronine, Young Adult

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