Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease

Zubair Wahid Baloch; P Carayon; Bernard Conte‐Devolx; Laurence M. Demers; Ulla Feldt‐Rasmussen; Jean-François Henry; Virginia A LiVosli; Patricia Niccoli; Rhys John; Jean Ruf; Peter P.A. Smyth; Carole Ann Spencer; Jan R. Stockigt

doi:10.1089/105072503321086962

Cited by 1,212Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentClinical Laboratory Practices and Quality Control

Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease

Zubair Wahid Baloch, P Carayon, Bernard Conte‐Devolx, Laurence M. Demers, Ulla Feldt‐Rasmussen, Jean-François Henry, Virginia A LiVosli, Patricia Niccoli +5 more·2003·Thyroid

DOI 10.1089/105072503321086962

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Central hypothyroidism represents a major false negative result of the reflex TSH strategy, a widely accepted method for screening thyroid function by a first-line TSH measurement.
“Therefore, CeH represents a major false negative result of the 'reflex TSH strategy,' which is a widely accepted method for screening thyroid function by a first-line TSH measurement [4-7].”
From 2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism (2018) · cites this paper as [5]
Over 95% of rigorously screened individuals without thyroid disease or autoantibodies have TSH concentrations below 2.5 mIU/L.
“over 95% of rigorously screened individuals without thyroid disease or autoantibodies have TSH concentrations below 2.5 mIU/L [11].”
From Age-related variation in thyroid function – a narrative review highlighting important implications for research and clinical practice (2023) · cites this paper as [11]
The diagnosis of hypothyroidism in routine clinical setting is based on a TSH screening strategy, but this strategy is useless in central hypothyroidism where an inappropriately low/normal serum TSH concentration is seen.
“The diagnosis of hypothyroidism is in the routine clinical setting based on a TSH screening strategy (Baloch et al., 2003;Feldt-Rasmussen and Klose, 2020), but this strategy is useless in case of central hypothyroidism where an inappropriately low/normal serum TSH concentration is seen (Feldt-Rasmussen et al., 2018;Persani et al., 2018).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Baloch et al., 2003
The biochemical hormonal changes of central hypothyroidism are not very different from those of critical illness and other situations of non-thyroidal illness.
“Furthermore, the biochemical hormonal changes of central hypothyroidism are not very different from those of critical illness and other situations of non-thyroidal illness (Baloch et al., 2003;Feldt-Rasmussen, 2020;Peeters and Boelen, 2021; Van den Berghe, 2014) (Fig. 3).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Baloch et al., 2003
Estimates of free T4 concentrations are widely measured on different platforms with huge interlaboratory variability.
“Finally, estimates of free T4 concentrations are widely measured on different platforms in Clinical Biochemical Laboratories, with the unfortunate result of a huge Recovery from transient thyroiditis Isolated hypothyroxinaemia interlaboratory variability (Baloch et al., 2003;Esfandiari and Papaleontiou, 2017;Feldt-Rasmussen, 2020;Welsh and Soldin, 2016).”
From The hypothalamus-pituitary-thyroid (HPT)-axis and its role in physiology and pathophysiology of other hypothalamus-pituitary functions (2021) · cites this paper as Baloch et al., 2003

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Authors: Baloch, Z. W., Carayon, P., Conte‐Devolx, B., Demers, L. M., Feldt‐Rasmussen, U., Henry, J.-F., LiVosli, V. A., Niccoli, P., John, R., Ruf, J., Smyth, P. P. A., Spencer, C. A., & Stockigt, J. R.
Affiliations: University of Pennsylvania (US)
ORCID: Zubair Wahid Baloch
Ulla Feldt‐Rasmussen
Jean Ruf
Peter P.A. Smyth
Carole Ann Spencer
Venue: Thyroid
Publisher: SAGE Publications
Published: 2003-01
Volume: 13
Issue: 1
Pages: 3-3
ISSN: 1050-7256 (ISSN-L)
1557-9077
DOI: 10.1089/105072503321086962
OpenAlex: W2336907646
Cited by: 1,212
References: 0
Citations by year: 2026: 15 · 2025: 36 · 2024: 15 · 2023: 39 · 2022: 41 · 2021: 47 · 2020: 54 · 2019: 52 · 2018: 66 · 2017: 78 · 2016: 74 · 2015: 67 · 2014: 66 · 2013: 78 · 2012: 60
FWCI: 23.88
Type: journal article
Language: en
Open access: closed
Licence: www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations: Thyroid (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords: thyroid dysfunction, thyroid function tests, laboratory diagnosis, disease surveillance, thyroid hormones
MeSH terms: Humans, Thyroid Diseases, Thyroid Function Tests, Clinical Laboratory Techniques

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