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The microRNA-485-3p concentration in salivary exosome-enriched extracellular vesicles is related to amyloid β deposition in the brain of patients with Alzheimer’s disease

Ryu, In Soo, Kim, Dae Hoon, Ro, Ju-Ye, Park, Byeong-Gyu, Kim, Seo Hyun, Im, Jong-Yeop, Lee, Jun-Young, Yoon, Soo Jin, Kang, Heeyoung, Iwatsubo, Takeshi, Teunissen, Charlotte E., Cho, Hyun-Jeong, Ryu, Jin-Hyeob·2023·Clinical Biochemistry
DOI 10.1016/j.clinbiochem.2023.110603
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Abstract

Objectives Alzheimer's disease (AD) is an irreversible neurodegenerative disease characterized by progressive long-term memory loss and cognitive dysfunction. Neuroimaging tests for abnormal amyloid-β (Aβ) deposition are considered the most reliable methods for the diagnosis of AD; however, the cost for such testing is very high and generally not covered by national insurance systems. Accordingly, it is only recommended for individuals exhibiting clinical symptoms of AD supported by clinical cognitive assessments. Recently, it was suggested that dysregulated microRNA-485-3p (miRNA-485-3p) in the brain and cerebrospinal fluid is closely related to pathogenesis of AD. However, a relationship between circulating miRNA-485-3p in salivary exosome-enriched extracellular vesicles (EE-EV) and Aβ deposition in the brain has not been observed. Design & methods Using quantitative real-time polymerase chain reaction, we analyzed miRNA-485-3p concentration in salivary EE-EV. We used receiver operating characteristic (ROC) curve analysis to evaluate its predictive value for Aβ positron emission tomography (Aβ-PET) positivity in patients with AD. Results Our results showed that the miRNA-485-3p concentration in salivary EE-EV isolated from patients with AD was significantly increased compared with that in the healthy controls (p Conclusion These findings suggested that the miRNA-485-3p concentration in salivary EE-EV was closely related to Aβ deposition in the brain and had high diagnostic…

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Metadata

Authors
Ryu, I. S., Kim, D. H., Ro, J.-Y., Park, B.-G., Kim, S. H., Im, J.-Y., Lee, J.-Y., Yoon, S. J., Kang, H., Iwatsubo, T., Teunissen, C. E., Cho, H.-J., & Ryu, J.-H.
Venue
Clinical Biochemistry
Publisher
Elsevier BV
Published
2023-08
Volume
118
Pages
110603
ISSN
0009-9120
DOI
10.1016/j.clinbiochem.2023.110603
Cited by
45
References
6
Language
en
Licence
Funders
  • Ministry of Health and Welfare (HI18C1671)
  • Korea Health Industry Development Institute
  • Konyang University

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