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The role of microRNA-485 in neurodegenerative diseases

Ryu, In Soo, Kim, Dae Hoon, Cho, Hyun-Jeong, Ryu, Jin-Hyeob·2023·Reviews in the Neurosciences
DOI 10.1515/revneuro-2022-0039
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Abstract

Neurodegenerative diseases (NDDs) are age-related disorders characterized by progressive neurodegeneration and neuronal cell loss in the central nervous system. Neuropathological conditions such as the accumulation of misfolded proteins can cause neuroinflammation, apoptosis, and synaptic dysfunction in the brain, leading to the development of NDDs including Alzheimer’s disease (AD) and Parkinson’s disease (PD). MicroRNAs (miRNAs) are small noncoding RNA molecules that regulate gene expression post-transcriptionally via RNA interference. Recently, some studies have reported that some miRNAs play an important role in the development of NDDs by regulating target gene expression. MiRNA-485 (miR-485) is a highly conserved brain-enriched miRNA. Accumulating clinical reports suggest that dysregulated miR-485 may be involved in the pathogenesis of AD and PD. Emerging studies have also shown that miR-485 plays a novel role in the regulation of neuroinflammation, apoptosis, and synaptic function in the pathogenesis of NDDs. In this review, we introduce the biological characteristics of miR-485, provide clinical evidence of the dysregulated miR-485 in NDDs, novel roles of miR-485 in neuropathological events, and discuss the potential of targeting miR-485 as a diagnostic and therapeutic marker for NDDs.

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Metadata

Authors
Ryu, I. S., Kim, D. H., Cho, H.-J., & Ryu, J.-H.
Affiliations
  • Biorchestra Co. Ltd. , 17, Techno 4-ro, Yuseong-gu , Daejeon 34013 , South Korea
  • Department of Biomedical Laboratory Science , College of Medical Science, Konyang University , 158, Gwanjeodong-ro, Seo-gu , Daejeon 35365 , South Korea
ORCID
Ryu, In Soo
Venue
Reviews in the Neurosciences
Publisher
Walter de Gruyter GmbH
Published
2022-07-07
Volume
34
Issue
1
Pages
49-62
ISSN
  • 0334-1763
  • 2191-0200
DOI
10.1515/revneuro-2022-0039
Cited by
25
References
13
Language
en
Licence
creativecommons.org/licenses/by/4.0 (unspecified)

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