Acne: hormonal concepts and therapy
Abstract
Acne vulgaris is the most common skin condition observed in the medical community. Although we know that hormones are important in the development of acne, many questions remain unanswered regarding the mechanisms by which hormones exert their effects. Androgens such as dihydrotestosterone (DHT) and testosterone, the adrenal precursor dehydroepiandrosterone sulfate (DHEAS), estrogens such as estradiol, and other hormones, including growth hormone and insulin-like growth factors (IGFs), may be important in acne. It is not known whether these hormones are taken up from the serum by the sebaceous gland, whether they are produced locally within the gland, or whether a combination of these processes is involved. Finally, the cellular and molecular mechanisms by which these hormones exert their influence on the sebaceous gland have not been fully elucidated. Hormonal therapy is an option in women with acne not responding to conventional treatment or with signs of endocrine abnormalities.
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Hormones influence both acne development and severity.
“Consistent with the association between acne and puberty, hormones influence both acne development and severity.3”
From Diet and acne: A systematic review (2022) · cites this paper as [3]
Cites
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Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.
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Cutaneous androgen metabolism: basic research and clinical perspectives
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Diet and acne: A systematic review
Meixiong, J., Ricco, C., Vasavda, C., & Ho, B. K. (2022) · JAAD International · doi:10.1016/j.jdin.2022.02.012 · Cited by 108 · see citing works
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Skin steroidogenesis in health and disease
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- Authors
- Thiboutot, D.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Thiboutot, Diane
- ORCID
- Thiboutot, Diane
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2004-09
- Volume
- 22
- Issue
- 5
- Pages
- 419-428
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W1993984692
- Cited by
- 155
- References
- 6
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 10 · 2020: 8 · 2019: 4 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 6 · 2014: 10 · 2013: 7 · 2012: 8
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Acne and Rosacea Treatments and Effects
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Keywords
- acne, hormonal mechanisms, androgens, dihydrotestosterone, testosterone, dehydroepiandrosterone sulfate, estrogen, estradiol, insulin-like growth factor, growth hormone, sebaceous glands, hormone therapy, endocrine disorders, women
- MeSH terms
- Acne Vulgaris, Androgen Antagonists, Androgens, Estrogens, Female, Hormones, Humans, Sebaceous Glands, Somatomedins, Human Growth Hormone
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