Cited by 228Wound Healing and TreatmentsHormonal and reproductive studiesDermatologic Treatments and Research

The hormonal regulation of cutaneous wound healing

Gilliver, Stephen C., Ashworth, Jason J., Ashcroft, Gillian S.·2007·Clinics in Dermatology

Abstract

Conditions of impaired wound healing in the elderly are associated with substantial morbidity and mortality and impose a significant financial burden upon the world's health services. The findings of a series of recent studies have served to highlight the contrasting contributions made by sex steroid hormones to the regulation of cutaneous repair processes. Although estrogens accelerate healing, the actions of the "male" sex hormones 5alpha-dihydrotestosterone and testosterone are primarily deleterious. The shift that occurs in the balance between serum estrogen and androgen levels as a normal feature of human aging may therefore have important consequences for fundamental tissue repair processes.

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Crossref · 10.1016/j.clindermatol.2006.09.012

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54 of 54 references verified0 citation errors · 0 not checkable

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Authors
Gilliver, S. C., Ashworth, J. J., & Ashcroft, G. S.
Affiliations
University of Manchester (GB)
Corresponding author
Ashcroft, Gillian S.
Venue
Clinics in Dermatology
Publisher
Elsevier BV
Published
2007-01
Volume
25
Issue
1
Pages
56-62
ISSN
0738-081X (ISSN-L)
OpenAlex
W1964074275
Cited by
228
References
54
Citations by year
2026: 8 · 2025: 19 · 2024: 19 · 2023: 9 · 2022: 23 · 2021: 11 · 2020: 8 · 2019: 14 · 2018: 7 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 13 · 2013: 9 · 2012: 10
FWCI
11.18
Type
journal article
Language
en
Open access
closed
Locations
  • Clinics in Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Wellcome Trust
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords
wound healing, hormonal regulation, sex hormones, estrogen, androgens, dihydrotestosterone, testosterone, aging
MeSH terms
Androgens, Dehydroepiandrosterone, Estrogens, Humans, Skin Physiological Phenomena, Wound Healing

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