The hormonal regulation of cutaneous wound healing
Abstract
Conditions of impaired wound healing in the elderly are associated with substantial morbidity and mortality and impose a significant financial burden upon the world's health services. The findings of a series of recent studies have served to highlight the contrasting contributions made by sex steroid hormones to the regulation of cutaneous repair processes. Although estrogens accelerate healing, the actions of the "male" sex hormones 5alpha-dihydrotestosterone and testosterone are primarily deleterious. The shift that occurs in the balance between serum estrogen and androgen levels as a normal feature of human aging may therefore have important consequences for fundamental tissue repair processes.
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Estradiol is of utmost importance in the process of wound healing.
“Recent studies have increasingly shown that estradiol is of utmost importance in the process of wound healing [49–51].”
From The pathophysiology of endometriosis and adenomyosis, tissue injury and repair (2009) · cites this paper as [50]
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- Authors
- Gilliver, S. C., Ashworth, J. J., & Ashcroft, G. S.
- Affiliations
- University of Manchester (GB)
- Corresponding author
- Ashcroft, Gillian S.
- ORCID
- Gilliver, Stephen C.
- Venue
- Clinics in Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-01
- Volume
- 25
- Issue
- 1
- Pages
- 56-62
- ISSN
- 0738-081X (ISSN-L)
- OpenAlex
- W1964074275
- Cited by
- 228
- References
- 54
- Citations by year
- 2026: 8 · 2025: 19 · 2024: 19 · 2023: 9 · 2022: 23 · 2021: 11 · 2020: 8 · 2019: 14 · 2018: 7 · 2017: 13 · 2016: 11 · 2015: 12 · 2014: 13 · 2013: 9 · 2012: 10
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinics in Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Keywords
- wound healing, hormonal regulation, sex hormones, estrogen, androgens, dihydrotestosterone, testosterone, aging
- MeSH terms
- Androgens, Dehydroepiandrosterone, Estrogens, Humans, Skin Physiological Phenomena, Wound Healing
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