Impaired wound healing

Menke, Nathan B.; Ward, Kevin R.; Witten, Tarynn M.; Bonchev, Danail G.; Diegelmann, Robert F.

doi:10.1016/j.clindermatol.2006.12.005

Cited by 792Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementDermatologic Treatments and Research

Impaired wound healing

Menke, Nathan B., Ward, Kevin R., Witten, Tarynn M., Bonchev, Danail G., Diegelmann, Robert F.·2007·Clinics in Dermatology

DOI 10.1016/j.clindermatol.2006.12.005

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Abstract

Nonhealing wounds represent a significant cause of morbidity and mortality for a large portion of the population. One of the underlying mechanisms responsible for the failure of chronic wounds to heal is an out-of-control inflammatory response that is self-sustaining. Underappreciation of the inherent complexity of the healing wound has led to the failure of monotherapies, with no significant reduction in wound healing times. A model of the inflammatory profile of a nonhealing wound is one in which the equilibrium between synthesis and degradation has been shifted toward degradation. This review summarizes the current information regarding acute wound healing responses as contrasted to the delayed response characteristic of chronic wounds. In addition, some initial complexity theoretical models are proposed to define and explain the underlying pathophysiology.

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Prolonged inflammation leads to increased levels of proteases that degrade extracellular matrix and growth factors.
“Prolonged inflammation leads to increased levels of proteases that degrade extracellular matrix (ECM) and growth factors.21,22”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [22]

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Authors: Menke, N. B., Ward, K. R., Witten, T. M., Bonchev, D. G., & Diegelmann, R. F.
Affiliations: Virginia Commonwealth University (US)
Corresponding author: Diegelmann, Robert F.
ORCID: Menke, Nathan B.
Witten, Tarynn M.
Diegelmann, Robert F.
Venue: Clinics in Dermatology
Publisher: Elsevier BV
Published: 2007-01
Volume: 25
Issue: 1
Pages: 19-25
ISSN: 0738-081X (ISSN-L)
DOI: 10.1016/j.clindermatol.2006.12.005
OpenAlex: W2043960873
Cited by: 792
References: 45
Citations by year: 2026: 16 · 2025: 38 · 2024: 47 · 2023: 64 · 2022: 49 · 2021: 76 · 2020: 60 · 2019: 38 · 2018: 56 · 2017: 37 · 2016: 51 · 2015: 44 · 2014: 45 · 2013: 36 · 2012: 47
FWCI: 2.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinics in Dermatology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
Keywords: delayed wound healing, chronic wounds, chronic inflammation, acute wound healing, extracellular matrix degradation, complexity theory, wound healing model
MeSH terms: Acute Disease, Chronic Disease, Humans, Inflammation, Models, Theoretical, Skin, Skin Ulcer, Wound Healing, Wounds, Penetrating, Treatment Failure

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