Cited by 170Psoriasis: Treatment and PathogenesisDermatology and Skin DiseasesSpondyloarthritis Studies and Treatments

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Innate immunity and antimicrobial defense systems in psoriasis

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Büchau, Amanda S., Gallo, Richard L.·2007·Clinics in Dermatology

DOI 10.1016/j.clindermatol.2007.08.016PMC PMC2699547

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Abstract

Psoriasis is a chronic inflammatory disorder that is mediated by elements of the innate and adaptive immune systems. Its characteristic features in the skin consist of inflammatory changes in both dermis and epidermis, with abnormal keratinocyte differentiation and proliferation. Despite the elucidation of many aspects of psoriasis pathogenesis, some puzzling questions remain to be answered. A major question currently debated is whether psoriasis is a primary abnormality of the epidermal keratinocyte or a reflection of dysregulated bone marrow-derived immunocytes. In this review we will focus on understanding the role of the innate immune system in psoriasis and how this provides a rational solution to address the origin of this multifactorial disease. Innate immunity is nonspecific and genetically based. It protects the body against the constant risk of pathogens through the use of rapidly mobilized defenses that are able to recognize and kill a variety of threats (bacteria, fungi, viruses, etc). The key mechanisms of innate immune responses are the existence of receptors to recognize pathogens and the production of factors that kill pathogens, such as antimicrobial peptides and proteins. Any combination of excessive sensitivity of the innate detection system, or dysregulation of the response system, can manifest both an epidermal phenotype and an abnormal T-cell function. Thus, the multidimensional action of the innate immune system, its triggers, and its recently understood role in T-cell function argue for an important role for innate mechanisms of recognition and response in the pathogenesis of psoriasis.

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See all 170

Authors: Büchau, A. S., & Gallo, R. L.
Affiliations: University of California San Diego (US)
Corresponding author: Gallo, Richard L.
ORCID: Gallo, Richard L.
Venue: Clinics in Dermatology
Publisher: Elsevier BV
Published: 2007-11
Volume: 25
Issue: 6
Pages: 616-624
ISSN: 0738-081X (ISSN-L)
DOI: 10.1016/j.clindermatol.2007.08.016
PMC: PMC2699547
OpenAlex: W2164880184
Cited by: 169
References: 95
Citations by year: 2026: 1 · 2025: 7 · 2024: 14 · 2023: 11 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 7 · 2018: 11 · 2017: 9 · 2016: 11 · 2015: 9 · 2014: 11 · 2013: 8 · 2012: 11
FWCI: 0.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Clinics in Dermatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R21AI048176, R01AI052453, R37AI052453)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR052728, R29AR044379, R01AR045676, R01AR044379)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Health Sciences › Medicine › Rheumatology › Spondyloarthritis Studies and Treatments
Keywords: psoriasis, innate immunity, antimicrobial peptides, antimicrobial defense, pathogen recognition receptors, keratinocyte differentiation, T cell dysfunction, skin inflammation, psoriasis pathogenesis
MeSH terms: Bacterial Infections, Humans, Immunity, Active, Immunity, Cellular, Immunity, Innate, S100 Proteins, Psoriasis, Skin, Cytokines, Antimicrobial Cationic Peptides, Toll-Like Receptors

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Innate immunity and antimicrobial defense systems in psoriasis

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