Cited by 117Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

David, Renaud, Koulibaly, Malick, Benoit, Michel, Garcia, René, Caci, Hervé, Darcourt, Jacques, Robert, Philippe·2008·Clinical Neurology and Neurosurgery

DOI 10.1016/j.clineuro.2007.08.007

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Abstract

Objectives The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB).Patients and methods Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect.Results We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake.Conclusion These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.

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Authors: David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., & Robert, P.
Affiliations: Centre Hospitalier Universitaire de Nice (FR)
Centre Antoine Lacassagne (FR)
Corresponding author: David, Renaud
ORCID: David, Renaud
Caci, Hervé
Darcourt, Jacques
Robert, Philippe
Venue: Clinical Neurology and Neurosurgery
Publisher: Elsevier BV
Published: 2008-01
Volume: 110
Issue: 1
Pages: 19-24
ISSN: 0303-8467 (ISSN-L)
DOI: 10.1016/j.clineuro.2007.08.007
OpenAlex: W2149316815
Cited by: 117
References: 52
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 4
FWCI: 3.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Neurology and Neurosurgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: apathy, dopamine transporter, striatum, putamen, Alzheimer's disease, dementia with Lewy bodies, neuropsychiatric symptoms, lack of initiative, emotional blunting, dopaminergic neuron loss, DaTSCAN, partial volume correction
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon, Lewy Body Disease, Dopamine Plasma Membrane Transport Proteins

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

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