Regional atrophy of the insular cortex is associated with neuropsychiatric symptoms in Alzheimer's disease patients
Abstract
BACKGROUND: Alzheimer's disease (AD) is a devastating illness that results in progressive cognitive decline and neuropsychiatric symptoms. The neuropsychiatric symptoms are associated with a rapid decline in cognition and activities of daily living and increased mortality, however the neuroanatomical localisation involved in the development of neuropsychiatric symptoms remains poorly understood. The aim of this study was to identify the association with the regional volume of the insular cortex and each neuropsychiatric symptom in patients with AD. METHODS: Subjects diagnosed with AD (n = 40) were evaluated. Magnetic resonance images were obtained and the insular cortex was subdivided into four subregions through the central sulcus of the insula and bilaterally: right anterior insular cortex, right posterior insular cortex, left anterior insular cortex and left posterior insular cortex. The neuropsychiatric symptoms were assessed using the Neuropsychiatric Inventory. A partial correlation analysis was performed. RESULTS: A significant negative correlation existed between apathy, the irritability subscale score and the volume ratio of the bilateral anterior insular cortex and right posterior insular cortex (r = -0.457, -0.433 and -0.572, respectively, p = 0.032, 0.044 and 0.005, respectively). CONCLUSION: The findings suggest that the regional atrophy of the insular cortex is associated with neuropsychiatric symptoms in AD patients.
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Apathy in Alzheimer's disease is associated with decreased insula volume.
“Two studies report an association of apathy with decreased insula volume (Moon et al., 2014; Stanton et al., 2013) although they disagree on whether this is bilateral or unilateral.”
From Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits? (2015) · cites this paper as Moon et al., 2014
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Neuropsychiatric symptoms in Alzheimer's disease: what might be associated brain circuits?
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- Authors
- Moon, Y., Moon, W.-J., Kim, H., & Han, S.-H.
- Affiliations
- Konkuk University (KR)
- Pediatrics and Genetics (US)
- Venue
- European Neurology
- Publisher
- S. Karger AG
- Published
- 2014
- Volume
- 71
- Issue
- 5-6
- Pages
- 223-229
- ISSN
- 0014-3022 (ISSN-L)
- 1421-9913
- OpenAlex
- W1989919992
- Cited by
- 56
- References
- 31
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 3 · 2023: 11 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 9 · 2015: 3
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- Alzheimer's disease, insula, regional brain atrophy, neuropsychiatric symptoms, apathy, irritability, anterior insula, posterior insular cortex, cortical volume, Neuropsychiatric Inventory
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Cerebral Cortex, Female, Humans, Irritable Mood, Functional Laterality, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Organ Size, Retrospective Studies, Severity of Illness Index, Apathy
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