Cited by 117Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

David, Renaud, Koulibaly, Malick, Benoit, Michel, Garcia, René, Caci, Hervé, Darcourt, Jacques, Robert, Philippe·2008·Clinical Neurology and Neurosurgery

DOI 10.1016/j.clineuro.2007.08.007

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Abstract

Objectives The aim of the present study was to stress the relationship between neuropsychiatric symptoms and most particularly apathy and striatal dopamine uptake in patients with Alzheimer's disease (AD) or dementia with Lewy body (DLB).Patients and methods Twenty-two patients (AD n=14; DLB n=8) were included. All patients had neuropsychological and behavioral examination including Mini Mental Test Examination (MMSE), Neuropsychiatric Inventory (NPI), and UPDRS for the motor activity assessment. Apathy dimensions, emotional blunting, lack of initiative and lack of interest were assessed using the Apathy Inventory (AI). Dopamine transporter (DAT) striatal uptake was assessed using (123)I-FP-CIT (DaTSCAN) SPECT. Quantitative measurements were obtained in 3D using a method which compensates for physical detection biases including partial volume effect.Results We observed a correlation between DAT uptake and NPI's domains only for apathy. More specifically using the AI, lack of initiative significantly correlated with bilateral putamen DAT uptake. Using partial correlation coefficients controlling for the UPDRS score, the correlation remained significant between lack of initiative and right and left putamen DAT uptake.Conclusion These results demonstrate a relationship between apathy and DAT levels independent from motor activity. They suggest that the patients with neurodegenerative diseases presenting with apathy are characterized by some degree of dopaminergic neuronal loss.

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“Mini-mental state”
Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia
Cummings, J. L., Mega, M., Gray, K., Rosenberg-Thompson, S., Carusi, D. A., & Gornbein, J. (1994) · Neurology · doi:10.1212/wnl.44.12.2308 · Cited by 7,568 · cited 1×
“Neuropsychiatric symptoms were assessed with the Neuropsychiatric Inventory (NPI) which is based on a structured interview with a caregiver who is familiar with the patient [ 24 ].”
Method
Handbook of Affective Sciences
(2002) · doi:10.1093/oso/9780195126013.001.0001 · Cited by 5,113
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop
McKeith, I. G., Galasko, D., Kosaka, K., Perry, E. K., Dickson, D. W., Hansen, L. A., Salmon, D. P., Lowe, J., Mirra, S. S., Byrne, E. J., et al. (1996) · Neurology · doi:10.1212/wnl.47.5.1113 · Cited by 3,960
J Neuropsychiatry Clin Neurosci
Yudofsky, S. C., & Hales, R. E. (1992) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.4.4.359 · Cited by 3,818
The human orbitofrontal cortex: linking reward to hedonic experience
Kringelbach, M. L. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1747 · Cited by 2,180
Parsing reward
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869
Apathy and the Functional Anatomy of the Prefrontal Cortex–Basal Ganglia Circuits
Levy, R., & Dubois, B. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhj043 · Cited by 1,285
The behavioural and motor consequences of focal lesions of the basal ganglia in man.
Bhatia, K., & Marsden, C. (1994) · Brain : a journal of neurology · doi:10.1093/brain/117.4.859 · Cited by 1,137
The spectrum of behavioral changes in Alzheimer's disease
Mega, M., Cummings, J., Fiorello, T., & Gornbein, J. (1996) · Neurology · doi:10.1212/wnl.46.1.130 · Cited by 1,124
Correction for partial volume effects in PET: principle and validation.
ROUSSET, O. G., Ma, Y., & Evans, A. C. (1998) · PubMed · Cited by 919
Frontal-subcortical circuits and neuropsychiatric disorders
Mega, M. S., & Cummings, J. L. (1994) · Journal of Neuropsychiatry · doi:10.1176/jnp.6.4.358 · Cited by 726
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre study
McKeith, I., O'Brien, J., Walker, Z., Tatsch, K., Booij, J., Darcourt, J., Padovani, A., Giubbini, R., Bonuccelli, U., Volterrani, D., et al. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70057-1 · Cited by 716
Differential diagnosis and classification of apathy
Marin, R. S. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.1.22 · Cited by 625
Erratum to: “Parsing reward” [Trends Neurosci. 26 (2003) 507–513]
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.09.001 · Cited by 562
Cholinergic interneuron characteristics and nicotinic properties in the striatum
Zhou, F., Wilson, C. J., & Dani, J. A. (2002) · Journal of Neurobiology · doi:10.1002/neu.10150 · Cited by 465
The Apathy Inventory: assessment of apathy and awareness in Alzheimer's disease, Parkinson's disease and mild cognitive impairment
Robert, P. H., Clairet, S., Benoît, M., Koutaich, J., Bertogliati, C., Tible, O., Caci, H. M., Borg, M., Brocker, P., & Bedoucha, P. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.755 · Cited by 403
Syndromic Validity of Apathy in Alzheimer's Disease
STARKSTEIN, S. E., Petracca, G., Chemerinski, E., & Kremer, J. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.872 · Cited by 394
Dopamine Transporter Loss Visualized With FP-CIT SPECT in the Differential Diagnosis of Dementia With Lewy Bodies
O'Brien, J. T., Colloby, S. J., Fenwick, J., Williams, E. D., Firbank, M., Burn, D. J., Aarsland, D., & McKeith, I. G. (2004) · Archives of Neurology · doi:10.1001/archneur.61.6.919 · Cited by 333
Association Between Age-Related Decline in Brain Dopamine Activity and Impairment in Frontal and Cingulate Metabolism
Volkow, N. D., Logan, J., Fowler, J. S., Wang, G., Gur, R. C., Wong, C., Felder, C. A., Gatley, S. J., Ding, Y., HITZEMANN, R. J., et al. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.75 · Cited by 286
A magnetic resonance imaging study of putamen nuclei in major depression
Husain, M. M., McDonald, W. M., Doraiswamy, P. M., Figiel, G. S., Na, C., Escalona, P. R., Boyko, O. B., Nemeroff, C. B., & Krishnan, K. R. R. (1991) · Psychiatry Research: Neuroimaging · doi:10.1016/0925-4927(91)90001-7 · Cited by 256
The role of the striatal dopamine transporter in cognitive aging
Erixon-Lindroth, N., Farde, L., Wahlin, T. R., Sóvágó, J., Halldin, C., & Bäckman, L. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2004.09.005 · Cited by 252
Striatal dopamine transporter imaging correlates with anxiety and depression symptoms in Parkinson's disease.
Weintraub, D. A., Newberg, A. B., Cary, M. S., Siderowf, A. D., Moberg, P. J., Kleiner‐Fisman, G., Duda, J. E., Stern, M. B., Mozley, D. P., & Katz, I. R. (2005) · PubMed · Cited by 245
Apathy: Concept, Syndrome, Neural Mechanisms, and Treatment.
Marin, R. (1996) · PubMed · doi:10.1053/scnp00100304 · Cited by 230
Cerebral Blood Flow Correlates of Apathy in Alzheimer Disease
Craig, A., Cummings, J. L., Fairbanks, L. A., Itti, L., Miller, B. L., Li, J. J., & Mena, I. G. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550110056012 · Cited by 223
Perfusion Brain SPECT and Statistical Parametric Mapping Analysis Indicate That Apathy Is a Cingulate Syndrome: A Study in Alzheimer's Disease and Nondemented Patients
Migneco, O., Benoît, M., Koulibaly, P. M., Dygai, I., Bertogliati, C., Desvignes, P., Robert, P. H., Malandain, G., Bussiere, F., & Darcourt, J. (2001) · NeuroImage · doi:10.1006/nimg.2000.0741 · Cited by 191
Regional cerebral metabolism in early Alzheimer's disease with clinically significant apathy or depression
Holthoff, V. A., Beuthien-Baumann, B., Kalbe, E., Lüdecke, S., Lenz, O., Zündorf, G., Spirling, S., Schierz, K., Winiecki, P., Sorbi, S., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.035 · Cited by 190
Imaging of dopamine transporters with iodine-123-FP-CIT SPECT in healthy controls and patients with Parkinson's disease.
Booij, J., Habraken, J. B. A., Bergmans, P., Tissingh, G., Winogrodzka, A., Wolters, E. C., Janssen, A. G. M., Stoof, J. C., & van Royen, E. A. (1998) · PubMed · Cited by 178
Iodine-123-beta-CIT and iodine-123-FPCIT SPECT measurement of dopamine transporters in healthy subjects and Parkinson's patients.
Seibyl, J. P., MAREK, K. L., Sheff, K., Zoghbi, S. S., Baldwin, R. M., Charney, D. S., van Dyck, C. H., & Innis, R. B. (1998) · PubMed · Cited by 164
Elevated Putamen D 2 Receptor Binding Potential in Major Depression With Motor Retardation: An [ 11 C]Raclopride Positron Emission Tomography Study
Meyer, J. H., McNeely, H. E., Sagrati, S., Boovariwala, A., Martin, K., Verhoeff, N. P. L. G., Wilson, A. A., & Houle, S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1594 · Cited by 160
Brain perfusion correlates of the apathy inventory dimensions of Alzheimer's disease
Benoit, M., Clairet, S., Koulibaly, P. M., Darcourt, J., & Robert, P. H. (2004) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1163 · Cited by 147
Behavioral and Psychological Symptoms in Alzheimer’s Disease
Benoît, M., Dygai, I., Migneco, O., Robert, P. H., Bertogliati, C., Darcourt, J., Bénoliel, J., Aubin-Brunet, V., & Pringuey, D. (1999) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000017198 · Cited by 133
Cholinergic Drugs for Alzheimer's Disease Enhance in Vitro Dopamine Release
Zhang, L., Zhou, F.-M., & Dani, J. A. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.000299 · Cited by 122
Brain perfusion in Alzheimer's disease with and without apathy: a SPECT study with statistical parametric mapping analysis
Benoît, M., Koulibaly, P. M., Migneco, O., Darcourt, J., Pringuey, D., & Robert, P. H. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00003-3 · Cited by 118
Quantitative accuracy of dopaminergic neurotransmission imaging with (123)I SPECT.
Soret, M., Koulibaly, P. M., Darcourt, J., Hapdey, S., & Buvat, I. (2003) · PubMed · Cited by 110
Ultrastructural features of the choline acetyltransferase-containing neurons and relationships with nigral dopaminergic and cortical afferent pathways in the rat striatum
Dimova, R. N., Vuillet, J., Nieoullon, A., & Goff, L. K. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90489-3 · Cited by 98
Lack of initiative and interest in Alzheimer's disease: a single photon emission computed tomography study
Robert, P. H., Darcourt, G., Koulibaly, M. P., Clairet, S., Benoit, M., Garcia, R., Dechaux, O., & Darcourt, J. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01088.x · Cited by 98
123I-FP-CIT SPECT imaging of dopamine transporters in patients with cerebrovascular disease and clinical diagnosis of vascular parkinsonism.
Lorberboym, M., Djaldetti, R., Melamed, E., Sadeh, M., & Lampl, Y. (2004) · PubMed · Cited by 94
Progression of dopaminergic degeneration in dementia with Lewy bodies and Parkinson’s disease with and without dementia assessed using 123I-FP-CIT SPECT
Colloby, S. J., Williams, E. D., Burn, D. J., Lloyd, J. J., McKeith, I. G., & O'Brien, J. T. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1830-z · Cited by 92
Dual-tracer dopamine transporter and perfusion SPECT in differential diagnosis of parkinsonism using template-based discriminant analysis.
Laere, K. V., Casteels, C., Ceuninck, L. D., Vanbilloen, B., Maes, A. F., Mortelmans, L. A., Vandenberghe, W., Verbruggen, A., & Dom, R. (2006) · PubMed · Cited by 79
Utilizing compensatory task conditions for episodic memory in Alzheimer's disease
Bäckman, L. (1996) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.1996.tb05880.x · Cited by 59
Dopamine D2 receptor plays a role in memory function: implications of dopamine–acetylcholine interaction in the ventral hippocampus
Fujishiro, H., Umegaki, H., Suzuki, Y., Kurotani, S., Yamaguchi, Y., & Iguchi, A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-0072-x · Cited by 47
The Neural Substrates of Motivation
Duffy, J. D. (1997) · Psychiatric Annals · doi:10.3928/0048-5713-19970101-07 · Cited by 43
Partial volume effect correction in SPECT for striatal uptake measurements in patients with neurodegenerative diseases: impact upon patient classification
Soret, M., Koulibaly, P. M., Darcourt, J., & Buvat, I. (2006) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-0003-4 · Cited by 41
Cholinesterase inhibitor use does not significantly influence the ability of 123I-FP-CIT imaging to distinguish Alzheimer's disease from dementia with Lewy bodies
Taylor, J., Colloby, S. J., McKeith, I. G., Burn, D. J., Williams, D. M., Patterson, J., & O'Brien, J. T. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.111666 · Cited by 15

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See all 117

Authors: David, R., Koulibaly, M., Benoit, M., Garcia, R., Caci, H., Darcourt, J., & Robert, P.
Affiliations: Centre Hospitalier Universitaire de Nice (FR)
Centre Antoine Lacassagne (FR)
Corresponding author: David, Renaud
ORCID: David, Renaud
Caci, Hervé
Darcourt, Jacques
Robert, Philippe
Venue: Clinical Neurology and Neurosurgery
Publisher: Elsevier BV
Published: 2008-01
Volume: 110
Issue: 1
Pages: 19-24
ISSN: 0303-8467 (ISSN-L)
DOI: 10.1016/j.clineuro.2007.08.007
OpenAlex: W2149316815
Cited by: 117
References: 52
Citations by year: 2026: 3 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 3 · 2019: 3 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 12 · 2014: 9 · 2013: 10 · 2012: 4
FWCI: 3.62
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Clinical Neurology and Neurosurgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: apathy, dopamine transporter, striatum, putamen, Alzheimer's disease, dementia with Lewy bodies, neuropsychiatric symptoms, lack of initiative, emotional blunting, dopaminergic neuron loss, DaTSCAN, partial volume correction
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Cerebral Cortex, Female, Humans, Image Processing, Computer-Assisted, Male, Neuropsychological Tests, Tomography, Emission-Computed, Single-Photon, Lewy Body Disease, Dopamine Plasma Membrane Transport Proteins

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Striatal dopamine transporter levels correlate with apathy in neurodegenerative diseases

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