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Cited by 43Parkinson's Disease Mechanisms and TreatmentsHelicobacter pylori-related gastroenterology studiesNeurological disorders and treatments

Eradication of Helicobacter pylori infection might improve clinical status of patients with Parkinson’s disease, especially on bradykinesia

Liu, Huijing, Su, Wen, Li, Shuhua, Du, Wei, Ma, Xinxin, Jin, Ying, Li, Kai, Chen, Haibo·2017·Clinical Neurology and Neurosurgery
DOI 10.1016/j.clineuro.2017.07.003
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Abstract

Objectives Previous studies have shown that Helicobacter pylori infection might make clinical status worse in patients with Parkinson's disease and Helicobacter pylori eradication might improve clinical status by modifying the pharmacokinetics of L-dopa. Here, we investigate whether Helicobacter pylori eradication could benefit idiopathic parkinsonism and Helicobacter pylori infection will effect which aspect of motor symptom significantly.Patients and methods A cohort study involving idiopathic Parkinson's disease patients, screened for Helicobacter status by 13 C urea breath test. Clinical status was evaluated by using the Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr stage. If patients had motor complications, they were quantified at the "on" time. The Helicobacter pylori positive patients could choose to receive Helicobacter pylori eradication or not by themselves. Group 1 was Helicobacter pylori negative patients. Group 2 was Helicobacter pylori positive patients who didn't receive eradication treatment. Group 3 was Helicobacter pylori positive patients who received successful eradication treatment. Repeat clinical assessments and 13 C urea breath test was performed at 1year later. Numerical data were expressed as mean±standard deviation (SD) RESULTS: Ninety-four consecutive patients with Parkinson's disease were recruited and underwent the initial 13 C urea breath test, but only forty-eight patients successfully completed the total study. In Group 3, the UPDRS-III scores (=Motor Examination Section Scores) were significantly lower 1year later compared to baseline (18.3±8.38 vs. 25.9±8.37, P=0.007). The differences were main in UPDRS-23 (=Finger Taps) (1.7±1.16 vs. 2.4±1.51, P=0.045), UPDRS-25 (Rapid Alternation Movements of Hands) (1.6±1.35 vs. 2.4±1.71, P=0.031) and UPDRS-26 (=Leg Agility) (1.3±1.25 vs.2.1±0.99, P=0.011). There was difference among three groups in the UPDRS-26 (P=0.040) of clinical status change of one year.Conclusion The eradication of Helicobacter might improve the clinical status of idiopathic parkinsonism, especially on bradykinesia.

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  • Changing the endotoxin-producing bacterial species can affect Parkinson's disease in patients and mouse models.

    “changing the endotoxin-producing bacterial species can affect the disease in patients and mouse models.”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [98]

  • Gut colonisation with endotoxin-producing Helicobacter pylori is associated with Parkinson's disease, and eradication of H. pylori improved PD symptoms.

    “Gut colonisation with endotoxin-producing Helicobacter pylori is associated with PD [96], and eradication of H. pylori improved PD symptoms [97, 98].”

    From The endotoxin hypothesis of neurodegeneration (2019) · cites this paper as [98]

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Authors
Liu, H., Su, W., Li, S., Du, W., Ma, X., Jin, Y., Li, K., & Chen, H.
Affiliations
Beijing Hospital (CN)
Corresponding author
  • Su, Wen
  • Chen, Haibo
ORCID
Venue
Clinical Neurology and Neurosurgery
Publisher
Elsevier BV
Published
2017-09
Volume
160
Pages
101-104
ISSN
0303-8467 (ISSN-L)
DOI
10.1016/j.clineuro.2017.07.003
OpenAlex
W2725782578
Cited by
43
References
25
Citations by year
2026: 3 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 8 · 2021: 5 · 2020: 4 · 2019: 5 · 2018: 5
FWCI
2.67
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Neurology and Neurosurgery (publishedVersion)
  • PubMed (publishedVersion)
Funders
Capital Characteristic Clinic Project of China (BJ-2012-147)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Surgery › Helicobacter pylori-related gastroenterology studies
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords
Helicobacter pylori infection, Helicobacter pylori eradication, Parkinson's disease, bradykinesia, motor symptoms, 13C-urea breath test, motor complications, Hoehn and Yahr stage, UPDRS-III, idiopathic parkinsonism, motor function improvement, 12-month follow-up
MeSH terms
Aged, Anti-Bacterial Agents, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Parkinson Disease, Dopamine Agents, Comorbidity, Helicobacter Infections, Outcome Assessment, Health Care, Hypokinesia, Proton Pump Inhibitors

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