Cited by 86Dementia and Cognitive Impairment ResearchParkinson's Disease Mechanisms and TreatmentsEEG and Brain-Computer Interfaces

Comparison of quantitative EEG between patients with Alzheimer’s disease and those with Parkinson’s disease dementia

Fonseca, Lineu C., Tedrus, Gloria M.A.S., Carvas, Priscila N., Machado, Elaine C.F.A.·2013·Clinical Neurophysiology

Abstract

Objective Dementia frequently occurs in Parkinson's disease (PD) but its pathophysiological basis is little known. Comparative EEG studies of Alzheimer's disease (AD) and Parkinson's disease dementia (PDD) are still rare, but could provide knowledge on the different pathophysiological mechanisms involved. The objective of the present study was to comparatively evaluate the absolute power and coherence on the EEG for patients with AD and PDD.Methods This study assessed 38 adults with AD, 12 with PDD, 31 with Parkinson's disease without dementia, and 37 controls (CG) by a neurological evaluation, CERAD neuropsychological battery, executive functions tests and qEEG, calculating global absolute powers for the delta, theta, alpha and beta bands and inter- and intra-hemispheric coherences.Results The delta and theta powers were highest in PDD and lowest in CG (p<0.05). The beta frontal-occipital inter-hemispheric coherence was highest in PDD (p<0.05). Whereas, alpha and beta frontal inter-hemispheric coherence was highest in PDD and lowest in AD (p<0.05).Conclusion These results suggest that qEEG power and coherence measures are different in AD and PDD.Significance These qEEG differences must be related to the distinct mechanisms of cortical neural connections in AD and PDD.

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Crossref · 10.1016/j.clinph.2013.05.001

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Authors
Fonseca, L. C., Tedrus, G. M. A. S., Carvas, P. N., & Machado, E. C. F. A.
Affiliations
Pontifícia Universidade Católica de Campinas (BR)
Corresponding author
Fonseca, Lineu C.
Venue
Clinical Neurophysiology
Publisher
Elsevier BV
Published
2013-10
Volume
124
Issue
10
Pages
1970-1974
ISSN
1388-2457 (ISSN-L)
OpenAlex
W2056787211
Cited by
85
References
39
Citations by year
2026: 6 · 2025: 4 · 2024: 8 · 2023: 9 · 2022: 11 · 2021: 6 · 2020: 4 · 2019: 9 · 2018: 4 · 2017: 10 · 2016: 8 · 2015: 2 · 2014: 3 · 2013: 1
FWCI
3.30
Type
journal article
Language
en
Open access
closed
Locations
  • Clinical Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › EEG and Brain-Computer Interfaces
Keywords
Alzheimer's disease, Parkinson's disease dementia, quantitative EEG, EEG coherence, EEG spectral power, delta band, theta band, alpha band, beta band, interhemispheric coherence, cortical connectivity, dementia pathophysiology
MeSH terms
Aged, Alzheimer Disease, Analysis of Variance, Diagnosis, Differential, Electroencephalography, Female, Humans, Male, Neurologic Examination, Neuropsychological Tests, Parkinson Disease

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