Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis
Abstract
Objective Although disconnection syndrome has been considered a core pathophysiologic mechanism of schizophrenia, little is known about the temporal behavior of mismatch negativity (MMN) generators in individuals with schizophrenia or clinical high risk (CHR) for psychosis.Methods MMN was assessed in 29 schizophrenia patients, 40 CHR subjects, and 47 healthy controls (HCs). Individual realistic head models and the minimum L2 norm algorithm were used to generate a current source density (CSD) model of MMN. The strength and time course of MMN CSD activity were calculated separately for the frontal and temporal cortices and were compared across brain regions and groups.Results Schizophrenia patients and CHR subjects displayed lower MMN CSD strength than HCs in both the temporal and frontal cortices. We found a significant time delay in MMN generator activity in the frontal cortex relative to that in the temporal cortex in HCs. However, the sequential temporo-frontal activities of MMN generators were disrupted in both the schizophrenia and CHR groups.Conclusions Impairments and altered temporal behavior of MMN multiple generators were observed even in individuals at risk for psychosis.Significance These findings suggest that aberrant MMN generator activity might be helpful in revealing the pathophysiology of schizophrenia.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MMN latency is altered in schizophrenia and ultra-high risk.
“MMN latency is also altered in schizophrenia and ultra-high risk (4).”
From A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia (2020) · cites this paper as [4]
Cites
(2005) · Cited by 5,977 · see citing works
A Solution for Reliable and Valid Reduction of Ocular Artifacts, Applied to the P300 ERP
Semlitsch, H. V., Anderer, P., Schuster, P., & Presslich, O. (1986) · Psychophysiology · doi:10.1111/j.1469-8986.1986.tb00696.x · Cited by 2,021 · see citing works
(1995) · PubMed · Cited by 1,320 · see citing works
Miller, T. J., McGlashan, T. H., Rosen, J. L., Somjee, L., Markovich, P. J., Stein, K., & Woods, S. W. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.5.863 · Cited by 872 · see citing works
Giard, M., Perrin, F., Pernier, J., & Bouchet, P. (1990) · Psychophysiology · doi:10.1111/j.1469-8986.1990.tb03184.x · Cited by 871 · see citing works
‘Primitive intelligence’ in the auditory cortex
Näätänen, R., Tervaniemi, M. H., Sussman, E. S., Paavilainen, P., & Winkler, I. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01790-2 · Cited by 827 · see citing works
Mismatch negativity in schizophrenia: a meta-analysis
Umbricht, D., & Krljes, S. (2005) · Schizophrenia Research · doi:10.1016/j.schres.2004.12.002 · Cited by 742 · see citing works
Early selective-attention effects on the evoked potential: A critical review and reinterpretation
Näätänen, R., & Michie, P. T. (1979) · Biological Psychology · doi:10.1016/0301-0511(79)90053-x · Cited by 659 · see citing works
Gamma frequency-range abnormalities to auditory stimulation in schizophrenia
Kwon, J. S., O'Donnell, B. F., Wallenstein, G. V., Greene, R. W., Hirayasu, Y., Nestor, P. G., Hasselmo, M. E., Potts, G. F., Shenton, M. E., & McCarley, R. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.11.1001 · Cited by 654 · see citing works
Self-citationThe Contribution of the Anterior Cingulate Cortex to Executive Processes in Cognition
Carter, C. S., Botvinick, M., & Cohen, J. D. (1999) · Reviews in the Neurosciences · doi:10.1515/revneuro.1999.10.1.49 · Cited by 624 · see citing works
Separate Time Behaviors of the Temporal and Frontal Mismatch Negativity Sources
Rinne, T., Alho, K., Ilmoniemi, R. J., Virtanen, J. P., & Näätänen, R. (2000) · NeuroImage · doi:10.1006/nimg.2000.0591 · Cited by 514 · see citing works
Opitz, B., Rinne, T., Mecklinger, A., von Cramon, D. Y., & Schröger, E. (2002) · NeuroImage · doi:10.1006/nimg.2001.0970 · Cited by 513 · see citing works
Linear and Nonlinear Current Density Reconstructions
Fuchs, M., Wagner, M., Köhler, T., & Wischmann, H.-A. (1999) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199905000-00006 · Cited by 436 · see citing works
Bora, E., Fornito, A., Raduà, J., Walterfang, M., Seal, M. L., Wood, S. J., Yücel, M., Velakoulis, D., & Pantelis, C. (2011) · Schizophrenia Research · doi:10.1016/j.schres.2010.12.020 · Cited by 425 · see citing works
Prefrontal cortex involvement in preattentive auditory deviance detection:
Doeller, C. F., Opitz, B., Mecklinger, A., Krick, C. M., Reith, W., & Schröger, E. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00389-6 · Cited by 337 · see citing works
Lesions of frontal cortex diminish the auditory mismatch negativity
Alho, K., Woods, D. L., Algazi, A. P., Knight, R. T., & Näätänen, R. (1994) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)00173-1 · Cited by 326 · see citing works
Javitt, D. C., Zukin, S. R., Heresco-Levy, U., & Umbricht, D. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs069 · Cited by 322 · see citing works
Schizophrenia and the disconnection hypothesis
Friston, K. J. (1999) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.1999.tb05985.x · Cited by 321 · see citing works
An improved boundary element method for realistic volume-conductor modeling
Fuchs, M., Drenckhahn, R., Wischmann, H.-A., & Wagner, M. (1998) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.704867 · Cited by 299 · see citing works
Bora, E., Lin, A. P., Wood, S. J., Yung, A. R., McGorry, P. D., & Pantelis, C. (2014) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12261 · Cited by 293 · see citing works
Prediction of Psychosis by Mismatch Negativity
Bodatsch, M., Ruhrmann, S., Wagner, M., Müller, R., Schultze‐Lutter, F., Frommann, I., Brinkmeyer, J., Gäebel, W., Maier, W., Klosterkötter, J., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.057 · Cited by 284 · see citing works
A review of structural neuroimaging in schizophrenia: from connectivity to connectomics
Wheeler, A. L., & Voineskos, A. N. (2014) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2014.00653 · Cited by 250 · see citing works
Perez, V. B., Woods, S. W., Roach, B. J., Ford, J. M., McGlashan, T. H., Srihari, V. H., & Mathalon, D. H. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.038 · Cited by 246 · see citing works
Effects of clozapine on auditory event-related potentials in schizophrenia
Umbricht, D., Javitt, D. C., Novak, G., Bates, J., Pollack, S. Z., Lieberman, J. A., & Kane, J. M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00524-6 · Cited by 236 · see citing works
Alterations in White Matter Evident Before the Onset of Psychosis
Carletti, F., Woolley, J. B., Bhattacharyya, S., Pérez‐Iglesias, R., Fusar‐Poli, P., Valmaggia, L., Broome, M. R., Bramon, E., Johns, L., Giampietro, V., et al. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbs053 · Cited by 211 · see citing works
Mismatch Negativity, Social Cognition, and Functioning in Schizophrenia Patients
Wynn, J. K., Sugar, C. A., Horan, W. P., Kern, R. S., & Green, M. F. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.024 · Cited by 194 · see citing works
Schizophrenics have fewer and smaller P300s: A single-trial analysis
Ford, J. M., White, P. M., Lim, K. O., & Pfefferbaum, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91198-3 · Cited by 193 · see citing works
Crossley, N., Mechelli, A., Fusar-Poli, P., Broome, M., Matthíasson, P., Johns, L., Bramon, E., Valmaggia, L., Williams, S. C. R., & McGuire, P. (2009) · Human Brain Mapping · doi:10.1002/hbm.20834 · Cited by 182 · see citing works
Benetti, S., Mechelli, A., Picchioni, M., Broome, M. R., Williams, S., & McGuire, P. K. (2009) · Brain · doi:10.1093/brain/awp098 · Cited by 181 · see citing works
Lee, S.-H., Kubicki, M., Asami, T., Seidman, L. J., Goldstein, J. M., Mesholam-Gately, R. I., McCarley, R. W., & Shenton, M. E. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2012.11.029 · Cited by 176 · see citing works
Rinne, T., Degerman, A., & Alho, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.01.017 · Cited by 161 · see citing works
Progressive Structural Brain Changes During Development of Psychosis
Ziermans, T. B., Schothorst, P. F., Schnack, H. G., Koolschijn, P. C. M. P., Kahn, R. S., van Engeland, H., & Durston, S. (2010) · Schizophrenia Bulletin · doi:10.1093/schbul/sbq113 · Cited by 157 · see citing works
Jemel, B., Achenbach, C., Müller, B. W., Röpcke, B., & Oades, R. D. (2002) · Brain Topography · doi:10.1023/a:1019944805499 · Cited by 140 · see citing works
Effects of risperidone on auditory event-related potentials in schizophrenia
Umbricht, D., Javitt, D. C., Novak, G., Bates, J., Pollack, S. Z., Lieberman, J. A., & Kane, J. M. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001595 · Cited by 138 · see citing works
Forecasting psychosis by event-related potentials-systematic review and specific meta-analysis
Bodatsch, M., Brockhaus-Dumke, A., Klosterkötter, J., & Ruhrmann, S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.025 · Cited by 135 · see citing works
Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy
Rosburg, T. (2005) · Brain · doi:10.1093/brain/awh442 · Cited by 121 · see citing works
Takahashi, H., Rissling, A. J., Pascual-Marqui, R. D., Kirihara, K., Pela, M., Sprock, J., BRAFF, D. L., & Light, G. A. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.09.074 · Cited by 117 · see citing works
Cho, K. I. K., Shenton, M. E., Kubicki, M. R., Jung, W. H., Lee, T. Y., Yun, J., Kim, S. N., & Kwon, J. S. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbv169 · Cited by 112 · see citing works
Self-citationThe Role of Anterior Cingulate Cortex in Working Memory is Shaped by Functional Connectivity
Lenartowicz, A., & McIntosh, A. R. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054475127 · Cited by 107 · see citing works
von Hohenberg, C. C., Pasternak, O., Kubicki, M. R., Ballinger, T., Vu, M.-A. T., Swisher, T., Green, K., Giwerc, M., Dahlben, B., Goldstein, J. M., et al. (2013) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt079 · Cited by 104 · see citing works
Glutamate in schizophrenia: clinical and research implications
GOFF, D. C., & Wine, L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00079-0 · Cited by 93 · see citing works
Disentangling early sensory information processing deficits in schizophrenia
Rissling, A. J., BRAFF, D. L., Swerdlow, N. R., Hellemann, G., Rassovsky, Y., Sprock, J., Pela, M., & Light, G. A. (2012) · Clinical Neurophysiology · doi:10.1016/j.clinph.2012.02.079 · Cited by 88 · see citing works
Pre-Attentive Auditory Processing in Ultra-High-Risk for Schizophrenia with Magnetoencephalography
Shin, K. S., Kim, J. S., Kang, D.-H., Koh, Y., Choi, J., O’Donnell, B. F., Chung, C. K., & Kwon, J. S. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.12.024 · Cited by 87 · see citing works
Self-citationEffects of NMDA receptor antagonist memantine on mismatch negativity
Korostenskaja, M., Nikulin, V. V., Kičić, D., Nikulina, A. V., & Kähkönen, S. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2007.01.007 · Cited by 77 · see citing works
Piškulić, D., Liu, L., Cadenhead, K. S., Cannon, T. D., Cornblatt, B. A., McGlashan, T. H., Perkins, D. O., Seidman, L. J., Tsuang, M. T., Walker, E. F., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.017 · Cited by 72 · see citing works
Peters, B. D., Dingemans, P. M. A. J., Dekker, N., Blaas, J., Akkerman, E. M., van Amelsvoort, T., Majoie, C. B. L. M., den Heeten, G. J., LINSZEN, D. H., & de Haan, L. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2009.10.008 · Cited by 70 · see citing works
Liasis, A. C., Towell, A., Alho, K., & Boyd, S. G. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(00)00077-x · Cited by 66 · see citing works
Auditory mismatch impairments are characterized by core neural dysfunctions in schizophrenia
Gaebler, A. J., Mathiak, K., Koten, J. W., König, A. A., Koush, Y., Weyer, D., Depner, C., Matentzoglu, S., Edgar, J. C., Willmes, K., et al. (2015) · Brain · doi:10.1093/brain/awv049 · Cited by 65 · see citing works
Jung, M. H., Jang, J. H., Kang, D., Choi, J., Shin, N. Y., Kim, H. S., An, S. K., Shin, M., & Kwon, J. S. (2010) · Psychiatry Investigation · doi:10.4306/pi.2010.7.4.257 · Cited by 65 · see citing works
Self-citationMismatch Negativity in Recent-Onset and Chronic Schizophrenia: A Current Source Density Analysis
Fulham, W. R., Michie, P. T., Ward, P. B., Rasser, P. E., Todd, J., Johnston, P., Thompson, P. M., & Schall, U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100221 · Cited by 56 · see citing works
Early intervention in psychosis: Insights from Korea
Kwon, J. S., Byun, M. S., Lee, T. Y., & An, S. K. (2012) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2012.02.007 · Cited by 46 · see citing works
Self-citationKim, M., Kim, S. N., Lee, S., Byun, M. S., Shin, K. S., Park, H. Y., Jang, J. H., & Kwon, J. S. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.02.012 · Cited by 46 · see citing works
Self-citationCognition in at-risk mental states for psychosis
de Paula, A. L. D., Hallak, J. E. C., Maia-de-Oliveira, J. P., Bressan, R. A., & Machado-de-Sousa, J. P. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.09.006 · Cited by 43 · see citing works
Miyanishi, T., Sumiyoshi, T., Higuchi, Y., Seo, T., & Suzuki, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061152 · Cited by 37 · see citing works
Treen, D., Vila, S., Mollà, L., Forcadell, E., Chamorro, J., Bulbena, A., & Pérez, V. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.01.005 · Cited by 27 · see citing works
Li, J., Su, Y., Wang, H., Zhao, Y., Liao, X.-M., Wang, X., & Si, T. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00017 · Cited by 26 · see citing works
Coordinate system matching for neuromagnetic and morphological reconstruction overlay
Fuchs, M., Wischmann, H.-A., Wagner, M., et al. (1995) · IEEE Transactions on Biomedical Engineering · doi:10.1109/10.376136 · Cited by 25 · see citing works
Wu, H., Wang, X., Gao, Y., Lin, F., Song, T., Zou, Y., Xu, L., & Lei, H. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.02.043 · Cited by 23 · see citing works
Lim, K., Lee, T. Y., Kim, M., Chon, M., Yun, J., Kim, S. N., & Kwon, J. S. (2016) · Early Intervention in Psychiatry · doi:10.1111/eip.12363 · Cited by 8 · see citing works
Self-citationLurito (2000) · doi:10.1002/1097-0193(200007)10:3
Flagged first, then by citations
Cited by
Sorted by citations
A Predictive Coding Perspective on Mismatch Negativity Impairment in Schizophrenia
Kirihara, K., Tada, M., Koshiyama, D., Fujioka, M., Usui, K., Araki, T., & Kasai, K. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00660 · Cited by 51 · see citing works
“MMN latency is also altered in schizophrenia and ultra-high risk (4).”
BackgroundPredicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity
Kim, M., Lee, T. H., Yoon, Y. B., Lee, T. Y., & Kwon, J. S. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx102 · Cited by 45 · see citing works
Self-citation
- Authors
- Kim, M., Cho, K. I. K., Yoon, Y. B., Lee, T. Y., & Kwon, J. S.
- Affiliations
- Seoul National University (KR)
- Corresponding author
- Kwon, Jun Soo
- Venue
- Clinical Neurophysiology
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 128
- Issue
- 2
- Pages
- 331-339
- ISSN
- 1388-2457 (ISSN-L)
- OpenAlex
- W2565916550
- Cited by
- 30
- References
- 60
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 2 · 2017: 3
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation of Korea
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
- Keywords
- mismatch negativity, schizophrenia, clinical high risk for psychosis, current source density, disconnection syndrome, frontal cortex, temporal cortex, auditory event-related potentials, schizophrenia pathophysiology
- MeSH terms
- Adolescent, Adult, Evoked Potentials, Female, Frontal Lobe, Humans, Male, Psychotic Disorders, Schizophrenia, Temporal Lobe, Case-Control Studies, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
