Mismatch negativity in schizophrenia: a meta-analysis

Umbricht, Daniel; Krljes, Sanya

doi:10.1016/j.schres.2004.12.002

Cited by 742Schizophrenia research and treatmentHallucinations in medical conditionsMental Health and Psychiatry

Mismatch negativity in schizophrenia: a meta-analysis

Umbricht, Daniel, Krljes, Sanya·2005·Schizophrenia Research

DOI 10.1016/j.schres.2004.12.002

Open this paper in CoChat — free account

Abstract

Background Mismatch negativity (MMN) is an auditory event-related potential that provides an index of automatic context-dependent information processing and auditory sensory memory. Many studies have reported abnormalities in the generation of MMN in schizophrenia. The objective of this study was to assess the magnitude of this deficit and associated factors.Method Studies of MMN in schizophrenia were identified and included in a meta-analysis to estimate the mean effect size. Effects of duration of illness, gender ratio, age of patients, type of MMN (duration versus frequency MMN) and characteristics of the test paradigms (deviant probability, magnitude of standard-deviant difference) on effect size were assessed.Results Of 62 identified studies 32 met our inclusion criteria. The mean effect size was 0.99 (95% confidence intervals: 0.79, 1.29). Overall, no specific factor was significantly associated with MMN deficits, although MMN to stimuli differing in duration appeared more impaired in schizophrenia than MMN to frequency deviants. In addition, effect sizes of frequency MMN were significantly correlated with duration of illness.Conclusions MMN deficits are a robust feature in chronic schizophrenia and indicate abnormalities in automatic context-dependent auditory information processing and auditory sensory memory in these patients. Reports of normal MMN in first-episode schizophrenia and the association of deficits in frequency MMN with illness duration suggest that MMN may index ongoing neuropathological changes in the auditory cortex in schizophrenia.

Integrity signals

Registry

Crossref · 10.1016/j.schres.2004.12.002

Cites

122 of 122 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Individuals with schizophrenia often show reduced mismatch negativity responses, consistent with improper error signalling.
“Individuals with schizophrenia often show reduced mismatch negativity responses, consistent with improper error signalling (37).”
From Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders (2026) · cites this paper as [37]
Deficits in MMN generation were first reported in the early 1990s and have since been a widely replicated neurophysiological finding in schizophrenia.
“Deficits in MMN generation were first reported in the early 1990’s, and this finding has since been a widely replicated neurophysiological finding in schizophrenia (rev. in 3, 61, 62, 63)”
From Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia (2015) · cites this paper as [61]

Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,588 · see citing works
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,406 · see citing works
Trim and Fill: A Simple Funnel‐Plot–Based Method of Testing and Adjusting for Publication Bias in Meta‐Analysis
Duval, S., & Tweedie, R. (2000) · Biometrics · doi:10.1111/j.0006-341x.2000.00455.x · Cited by 14,099 · see citing works
Attention and Brain Function
Risto, N. (2018) · Routledge eBooks · doi:10.4324/9780429487354 · Cited by 2,047 · see citing works
Attention and brain function
Wijers, B. (1995) · Acta Psychologica · doi:10.1016/0001-6918(95)90043-8 · Cited by 1,318 · see citing works
Sensorimotor Gating and Schizophrenia
Braff, D. L. (1990) · Archives of General Psychiatry · doi:10.1001/archpsyc.1990.01810140081011 · Cited by 1,312 · see citing works
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208 · see citing works
‘Primitive intelligence’ in the auditory cortex
Näätänen, R., Tervaniemi, M. H., Sussman, E. S., Paavilainen, P., & Winkler, I. (2001) · Trends in Neurosciences · doi:10.1016/s0166-2236(00)01790-2 · Cited by 832 · see citing works
The perception of speech sounds by the human brain as reflected by the mismatch negativity (MMN) and its magnetic equivalent (MMNm)
Näätänen, R. (2001) · Psychophysiology · doi:10.1111/1469-8986.3810001 · Cited by 723 · see citing works
The mismatch negativity (MMN): towards the optimal paradigm
Näätänen, R., Pakarinen, S., Rinne, T., & Takegata, R. (2003) · Clinical Neurophysiology · doi:10.1016/j.clinph.2003.04.001 · Cited by 721 · see citing works
Cerebral Generators of Mismatch Negativity (MMN) and Its Magnetic Counterpart (MMNm) Elicited by Sound Changes
Alho, K. (1995) · Ear and Hearing · doi:10.1097/00003446-199502000-00004 · Cited by 705 · see citing works
Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.
Javitt, D. C., Steinschneider, M., Schroeder, C. E., & Arezzo, J. C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11962 · Cited by 662 · see citing works
Current trends in event-related potential research
Johnson, R., Rohrbaugh, J., & Parasuraman, R. (1987) · Elsevier eBooks · Cited by 639 · see citing works
Ketamine-Induced Deficits in Auditory and Visual Context-Dependent Processing in Healthy Volunteers
Umbricht, D., Schmid, L., Koller, R., Vollenweider, F. X., Hell, D., & Javitt, D. C. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1139 · Cited by 583 · see citing works
Self-citation
The Mismatch Negativity
Näätänen, R. (1995) · Ear and Hearing · doi:10.1097/00003446-199502000-00002 · Cited by 572 · see citing works
Responses of the primary auditory cortex to pitch changes in a sequence of tone pips: Neuromagnetic recordings in man
Hari, R., Hämäläinen, M., Ilmoniemi, R. J., Kaukoranta, E., Reinikainen, K., Salminen, J. S., Alho, K., Näätänen, R., & Sams, M. E. (1984) · Neuroscience Letters · doi:10.1016/0304-3940(84)90474-9 · Cited by 451 · see citing works
Mismatch negativity: An index of a preattentive processing deficit in schizophrenia
Shelley, A. M., Ward, P. B., Catts, S. V., Michie, P. T., Andrews, S., & McConaghy, N. (1991) · Biological Psychiatry · doi:10.1016/0006-3223(91)90126-7 · Cited by 411 · see citing works
Brain potential evidence for an auditory sensory memory deficit in schizophrenia
Catts, S. V., Shelley, A. M., Ward, P. B., Liebert, B. J., McConaghy, N., Andrews, S., & Michie, P. T. (1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.2.213 · Cited by 360 · see citing works
On the detection of auditory deviations: A pre‐attentive activation model
Schröger, E. (1997) · Psychophysiology · doi:10.1111/j.1469-8986.1997.tb02395.x · Cited by 354 · see citing works
Development of a memory trace for a complex sound in the human brain
Näätänen, R., Schröger, E., Karakaş, S., Tervaniemi, M. H., & Paavilainen, P. (1993) · Neuroreport · doi:10.1097/00001756-199305000-00010 · Cited by 354 · see citing works
Mismatch negativity potentials and cognitive impairment in schizophrenia
Baldeweg, T., Klugman, A., Gruzelier, J., & Hirsch, S. R. (2004) · Schizophrenia Research · doi:10.1016/j.schres.2003.09.009 · Cited by 321 · cited 1× · see citing works
“Paradigms investigating short-term plasticity at the level of the auditory cortex providing insights into mechanisms of learning and memory (Baldeweg et al., 2004; Sussman and Winkler, 2001).”
Background
Impaired Mismatch Negativity Generation Reflects Widespread Dysfunction of Working Memory in Schizophrenia
Javitt, D. C. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950190032005 · Cited by 306 · see citing works
Mismatch Negativity in Chronic Schizophrenia and First-Episode Schizophrenia
Salisbury, D. F., Shenton, M. E., Griggs, C. B., Bonner‐Jackson, A., & McCarley, R. W. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.8.686 · Cited by 285 · see citing works
Associated deficits in mismatch negativity generation and tone matching in schizophrenia
Javitt, D. C., Shelley, A. M., & Ritter, W. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00377-1 · Cited by 253 · see citing works
Elementary neuronal dysfunctions in schizophrenia
Freedman, R., Waldo, M. C., Bickford, P. C., & Nagamoto, H. T. (1991) · Schizophrenia Research · doi:10.1016/0920-9964(91)90035-p · Cited by 251 · see citing works
How specific are deficits in mismatch negativity generation to schizophrenia?
Umbricht, D., Koller, R., Schmid, L., Skrabo, A., Grübel, C., Huber, T., & Stassen, H. H. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01642-6 · Cited by 247 · see citing works
Self-citation
Neural representations of abstract stimulus features in the human brain as reflected by the mismatch negativity
Tervaniemi, M. H., Maury, S., & Näätänen, R. (1994) · Neuroreport · doi:10.1097/00001756-199403000-00027 · Cited by 244 · see citing works
Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval
Javitt, D. C., Grochowski, S., Shelley, A.-M., & Ritter, W. (1998) · Electroencephalography and Clinical Neurophysiology/Evoked Potentials Section · doi:10.1016/s0168-5597(97)00073-7 · Cited by 241 · see citing works
Pre-attentive detection of vowel contrasts utilizes both phonetic and auditory memory representations
Winkler, I., Lehtokoski, A., Alku, P., Vainio, M., Czigler, I., Csépe, V., Aaltonen, O., Raimo, I., Alho, K., Lang, H. A., et al. (1999) · Cognitive Brain Research · doi:10.1016/s0926-6410(98)00039-1 · Cited by 240 · see citing works
Effects of clozapine on auditory event-related potentials in schizophrenia
Umbricht, D., Javitt, D. C., Novak, G., Bates, J., Pollack, S. Z., Lieberman, J. A., & Kane, J. M. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00524-6 · Cited by 236 · see citing works
Self-citation
Impairment of early cortical processing in schizophrenia: An event-related potential confirmation study
Javitt, D. C., Doneshka, P., Zylberman, I., Ritter, W., & Vaughan, H. G. (1993) · Biological Psychiatry · doi:10.1016/0006-3223(93)90005-x · Cited by 236 · see citing works
What has MMN revealed about the auditory system in schizophrenia?
Michie, P. T. (2001) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00166-0 · Cited by 230 · see citing works
Visual Perceptual and Working Memory Impairments in Schizophrenia
Tek, C., Gold, J. M., Blaxton, T. A., Wilk, C. M., McMahon, R. P., & Buchanan, R. W. (2002) · Archives of General Psychiatry · doi:10.1001/archpsyc.59.2.146 · Cited by 213 · see citing works
Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex
Kropotov, J. D., NÄÄÄNEN, R., Sevostianov, A. V., Alho, K., Reinikainen, K., & Kropotova, O. V. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01226.x · Cited by 196 · see citing works
On the Origin and Development of the Mismatch Negativity
Csépe, V. (1995) · Ear and Hearing · doi:10.1097/00003446-199502000-00007 · Cited by 189 · see citing works
Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders
Michie, P. T., Innes-Brown, H., Todd, J., & Jablensky, A. V. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01379-3 · Cited by 187 · see citing works
Effects of the 5-HT2A Agonist Psilocybin on Mismatch Negativity Generation and AX-Continuous Performance Task: Implications for the Neuropharmacology of Cognitive Deficits in Schizophrenia
Umbricht, D., Vollenweider, F. X., Schmid, L., Grübel, C., Skrabo, A., Huber, T., & Koller, R. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300005 · Cited by 187 · see citing works
Self-citation
Schizophrenia : a neuropsychological perspective
Pantelis, C., Nelson, H. E., & Barnes, T. R. E. (1996) · Medical Entomology and Zoology · Cited by 183 · see citing works
Basic auditory dysfunction in dyslexia as demonstrated by brain activity measurements
Kujala, T., Myllyviita, K., Tervaniemi, M. H., Alho, K., Kallio, J., & Näätänen, R. (2000) · Psychophysiology · doi:10.1111/1469-8986.3720262 · Cited by 179 · see citing works
Duration and frequency mismatch negativity in schizophrenia
Michie, P. T., Budd, T. W., Todd, J., Rock, D. J., Wichmann, H., Box, J. E., & Jablensky, A. V. (2000) · Clinical Neurophysiology · doi:10.1016/s1388-2457(00)00275-3 · Cited by 178 · see citing works
Visuospatial working memory in patients with schizophrenia
Fleming, K., Goldberg, T. E., Binks, S. W., RANDOLPH, C. C., Gold, J. M., & Weinberger, D. R. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00263-6 · Cited by 176 · see citing works
Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction
Shelley, A. M. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00138-8 · Cited by 175 · see citing works
Word and Tone Working Memory Deficits in Schizophrenia
Wexler, B. E., Stevens, A. A., Bowers, A. A., Sernyak, M. J., & Goldman‐Rakic, P. S. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.12.1093 · Cited by 173 · see citing works
Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia.
Javitt, D. C., Strous, R. D., Grochowski, S., Ritter, W., & al, E. (1997) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.106.2.315 · Cited by 168 · see citing works
Intracortical Mechanisms of Mismatch Negativity Dysfunction in Schizophrenia
Javitt, D. C. (2000) · Audiology and Neurotology · doi:10.1159/000013882 · Cited by 161 · see citing works
Attention affects the organization of auditory input associated with the mismatch negativity system
Sussman, E. S., Ritter, W., & Vaughan, H. G. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01443-1 · Cited by 153 · see citing works
Discrimination of speech-like contrasts in the auditory thalamus and cortex
Kraus, N., McGee, T., Carrell, T. D., King, C. D., Littman, T. A., & Nicol, T. G. (1994) · The Journal of the Acoustical Society of America · doi:10.1121/1.411282 · Cited by 151 · see citing works
The Effects of a Sub-Anaesthetic Dose of Ketamine on Human Selective Attention
Oranje, B. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00118-9 · Cited by 147 · see citing works
Dynamic sensory updating in the auditory system
Sussman, E. S., & Winkler, I. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00067-2 · Cited by 145 · see citing works
Effect of ketamine on the neuromagnetic mismatch field in healthy humans
Kreitschmann‐Andermahr, I., Rosburg, T., Demme, U., Gaser, E., Nowak, H., & Sauer, H. (2001) · Cognitive Brain Research · doi:10.1016/s0926-6410(01)00043-x · Cited by 144 · see citing works
Effects of risperidone on auditory event-related potentials in schizophrenia
Umbricht, D., Javitt, D. C., Novak, G., Bates, J., Pollack, S. Z., Lieberman, J. A., & Kane, J. M. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001595 · Cited by 138 · see citing works
Self-citation
Impaired precision, but normal retention, of auditory sensory ("echoic") memory information in schizophrenia.
Javitt, D. C., Strous, R. D., Grochowski, S., et al. (1997) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.106.2.315 · Cited by 136 · see citing works
Impairment in frontal but not temporal components of mismatch negativity in schizophrenia
Baldeweg, T., Klugman, A., Gruzelier, J. H., & Hirsch, S. R. (2002) · International Journal of Psychophysiology · doi:10.1016/s0167-8760(01)00183-0 · Cited by 127 · see citing works
Dopamine modulates involuntary attention shifting and reorienting: an electromagnetic study
Kähkönen, S., Ahveninen, J., Pekkonen, E., Kaakkola, S., Huttunen, J., Ilmoniemi, R. J., & Jääskeläinen, I. P. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(02)00305-x · Cited by 123 · see citing works
Impaired Cortical Network for Preattentive Detection of Change in Speech Sounds in Schizophrenia: A High-Resolution Event-Related Potential Study
Kasai, K., Nakagome, K., Itoh, K., Koshida, I., Hata, A., Iwanami, A., Fukuda, M., & Kato, N. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.546 · Cited by 122 · see citing works
Amplitude reduction of the mismatch negativity in first-degree relatives of patients with schizophrenia
Jessen, F., Fries, T., Kucharski, C., Nishimura, T., Hoenig, K., Maier, W., Falkai, P., & Heun, R. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02072-9 · Cited by 121 · see citing works
Mismatch negativity in schizophrenia: a family study
Bramon, E. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)00132-4 · Cited by 116 · see citing works
Mismatch Negativity Responses in Schizophrenia: A Combined fMRI and Whole-Head MEG Study
Kircher, T. T. J., Rapp, A. M., Grodd, W., Buchkremer, G., Weiskopf, N., Lutzenberger, W., Ackermann, H., & Mathiak, K. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.294 · Cited by 108 · see citing works
Event-related potential correlates of impaired selective attention in children at high risk for schizophrenia
Schreiber, H., Stolz-Born, G., Kornhuber, H. H., & Jan Born, A. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90294-a · Cited by 104 · see citing works
Altered hemispheric asymmetry and positive symptoms in schizophrenia: equivalent current dipole of auditory mismatch negativity
Youn, T., Park, H., Kim, J., Kim, M. S., & Kwon, J. S. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(02)00154-8 · Cited by 103 · see citing works
Statistical parametric mapping of LORETA using high density EEG and individual MRI: Application to mismatch negativities in Schizophrenia
Park, H., Kwon, J. S., Youn, T., Pae, J. S., Kim, J., Kim, M., & Ha, K. (2002) · Human Brain Mapping · doi:10.1002/hbm.10059 · Cited by 103 · see citing works
Auditory Sensory Memory and the Cholinergic System: Implications for Alzheimer's Disease
Pekkonen, E., Hirvonen, J., Jääskeläinen, I. P., Kaakkola, S., & Huttunen, J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0805 · Cited by 102 · see citing works
Association between reduced duration mismatch negativity (MMN) and raised temporal discrimination thresholds in schizophrenia
Todd, J., Michie, P. T., & Jablensky, A. V. (2003) · Clinical Neurophysiology · doi:10.1016/s1388-2457(03)00246-3 · Cited by 101 · see citing works
A Functional Magnetic Resonance Imaging Study of Auditory Mismatch in Schizophrenia
Wible, C. G., Kubicki, M. R., Yoo, S., Kacher, D. F., Salisbury, D. F., Anderson, M. C., Shenton, M. E., Hirayasu, Y., Kikinis, R., Jolesz, F. A., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.6.938 · Cited by 101 · see citing works
Temporal discrimination in schizophrenic and affective disorders: Evidence for a dopamine-dependent internal clock
Rammsayer, T. H. (1990) · International Journal of Neuroscience · doi:10.3109/00207459008986593 · Cited by 100 · see citing works
Auditory Mismatch Negativity in Schizophrenia: Topographic Evaluation With a High-Density Recording Montage
Hirayasu, Y., Potts, G. F., O'Donnell, B. F., et al. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.9.1281 · Cited by 100 · see citing works
Attentional modulation of the mismatch negativity elicited by frequency differences between binaurally presented tone bursts
Trejo, L. J., Ryan-Jones, D. L., & Kramer, A. F. (1995) · Psychophysiology · doi:10.1111/j.1469-8986.1995.tb01214.x · Cited by 98 · see citing works
Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics
Kathmann, N., Wagner, M., Rendtorff, N., & Engel, R. R. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00309-q · Cited by 98 · see citing works
Panmodal Processing Imprecision as a Basis for Dysfunction of Transient Memory Storage Systems in Schizophrenia
Javitt, D. C., Liederman, E., Cienfuegos, A., & Shelley, A. M. (1999) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a033417 · Cited by 98 · see citing works
Tryptophan Depletion Effects on EEG and MEG Responses Suggest Serotonergic Modulation of Auditory Involuntary Attention in Humans
Ahveninen, J. (2002) · NeuroImage · doi:10.1006/nimg.2002.1142 · Cited by 97 · see citing works
Performance of patients with schizophrenia on a pen and paper visuospatial working memory task with short delay
Keefe, R. S. E., Roitman, S. E. L., & Dupre, R. L. (1997) · Schizophrenia Research · doi:10.1016/s0920-9964(97)00037-6 · Cited by 95 · see citing works
Impairment in activation of a frontal attention-switch mechanism in schizophrenic patients
Sato, Y., Yabe, H., Todd, J., Michie, P. T., Shinozaki, N., Sutoh, T., Hiruma, T., Nashida, T., Matsuoka, T., & Kaneko, S. (2002) · Biological Psychology · doi:10.1016/s0301-0511(02)00113-8 · Cited by 89 · see citing works
Does phenylethylamine act as an endogenous amphetamine in some patients?
Janssen, P., Leysen, J., Megens, A., & Awouters, F. (1999) · International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001522 · Cited by 88 · see citing works
Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection
Kreitschmann-Andermahr, I., Rosburg, T., Meier, T., Volz, H.-P., Nowak, H., & Sauer, H. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00115-7 · Cited by 87 · see citing works
Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs
O’Donnell, B. F., Hokama, H., McCarley, R. W., et al. (1994) · International Journal of Psychophysiology · doi:10.1016/0167-8760(94)90065-5 · Cited by 85 · see citing works
Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: valid outcome prediction of clozapine therapy in a three-year follow-up
Schall, U., Catts, S. V., Karayanidis, F., & Ward, P. B. (1999) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145799001418 · Cited by 82 · see citing works
Processing of auditory stimuli during visual attention in patients with schizophrenia
Alain, C., Hargrave, R., & Woods, D. L. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00478-2 · Cited by 81 · see citing works
Mismatch negativity and N2b attenuation as an indicator for dysfunction of the preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study
Kasai, K., Okazawa, K., Nakagome, K., et al. (1999) · Schizophrenia Research · doi:10.1016/s0920-9964(98)00116-9 · Cited by 80 · see citing works
Low Dose of Ethanol Suppresses Mismatch Negativity of Auditory Event‐Related Potentials
Jääskeläinen, I. P., Lehtokoski, A., Alho, K., Kujala, T., Pekkonen, E., Sinclair, J. D., Näätänen, R., & Sillanaukee, P. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01555.x · Cited by 79 · see citing works
The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures
Schall, U., Catts, S. V., Chaturvedi, S., Liebert, B. J., Redenbach, J., Karayanidis, F., & Ward, P. B. (1998) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114579800100x · Cited by 77 · see citing works
Do high or low doses of anxiolytics and hypnotics affect mismatch negativity in schizophrenic subjects? An EEG and MEG study
Kasai, K., Yamada, H., Kamio, S., Nakagome, K., Iwanami, A., Fukuda, M., Yumoto, M., Itoh, K., Koshida, I., Abe, O., et al. (2002) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00710-6 · Cited by 76 · see citing works
Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: A comparison with obsessive-compulsive disorder and healthy subjects
Oades, R. D., Dittmann-Balçar, A., Zerbin, D., & Grzella, I. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00214-4 · Cited by 75 · see citing works
Auditory sensory memory in schizophrenia: inadequate trace formation?
Todd, J., Michie, P. T., Budd, T. W., Rock, D. J., & Jablensky, A. V. (2000) · Psychiatry Research · doi:10.1016/s0165-1781(00)00205-5 · Cited by 75 · see citing works
The difference in Mismatch negativity between the acute and post-acute phase of schizophrenia
Shinozaki, N., Yabe, H., Sato, Y., Hiruma, T., Sutoh, T., Nashida, T., Matsuoka, T., & Kaneko, S. (2002) · Biological Psychology · doi:10.1016/s0301-0511(01)00129-6 · Cited by 72 · see citing works
Auditory event-related potential (ERP) and difference-wave topography in schizophrenic patients with/without active hallucinations and delusions: a comparison with young obsessive-compulsive disorder (OCD) and healthy subjects
Oades, R. D. (1996) · International Journal of Psychophysiology · doi:10.1016/0167-8760(96)00026-8 · Cited by 72 · see citing works
Separate memory‐related processing for auditory frequency and patterns
Alain, C., Achim, A., & Woods, D. L. (1999) · Psychophysiology · doi:10.1111/1469-8986.3660737 · Cited by 69 · see citing works
Altered auditory processing in acutely psychotic never-medicated first-episode patients
Valkonen‐Korhonen, M., Purhonen, M., Tarkka, I. M., Sipilä, P., Partanen, J. V., Karhu, J., & Lehtonen, J. (2003) · Cognitive Brain Research · doi:10.1016/s0926-6410(03)00199-x · Cited by 67 · see citing works
Continuous Performance Test and Schizophrenia: A Test of Stimulus-Response Compatibility, Working Memory, Response Readiness, or None of the Above?
Elvevåg, B., Weinberger, D. R., Suter, J. C., & Goldberg, T. E. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.5.772 · Cited by 63 · see citing works
Effects of Lorazepam on the Neuromagnetic Mismatch Negativity (MMNm) and Auditory Evoked Field Component N100m
Rosburg, T., Marinou, V., Haueisen, J., Smesny, S., & Sauer, H. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300477 · Cited by 58 · see citing works
Binaural information can converge in abstract memory traces
Paavilainen, P., Jaramillo, M., & Näätänen, R. (1998) · Psychophysiology · doi:10.1017/s0048577298970895 · Cited by 58 · see citing works
Neuromagnetic correlates of impaired automatic categorical perception of speech sounds in schizophrenia
Kasai, K., Yamada, H., Kamio, S., Nakagome, K., Iwanami, A., Fukuda, M., Yumoto, M., Itoh, K., Koshida, I., Abe, O., et al. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00382-6 · Cited by 57 · see citing works
Mismatch negativity in socially withdrawn children
Bar‐Haim, Y., Marshall, P. J., Fox, N. A., Schorr, E. A., & Gordon-Salant, S. M. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00175-6 · Cited by 52 · see citing works
An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia
Shutara, Y., Koga, Y., Fujita, K., Takeuchi, H., Mochida, M., & Takemasa, K. (1996) · Brain Topography · doi:10.1007/bf01184786 · Cited by 50 · see citing works
Impaired Temporal Lobe Processing of Preattentive Auditory Discrimination in Schizophrenia
Pekkonen, E., Katila, H., Ahveninen, J., et al. (2002) · Schizophrenia Bulletin · doi:10.1093/oxfordjournals.schbul.a006954 · Cited by 50 · see citing works
Dissociation of the mismatch negativity and processing negativity attentional waveforms with nitrous oxide
Pang, E. W., & Fowler, B. (1999) · Psychophysiology · doi:10.1111/1469-8986.3650552 · Cited by 46 · see citing works
Effects of naltrexone and ethanol on auditory event-related brain potentials
Jääskeläinen, I. P., Hirvonen, J., Kujala, T., Alho, K., Eriksson, C. J. P., Lehtokoski, A., Pekkonen, E., Sinclair, J. D., Yabe, H., Näätänen, R., et al. (1998) · Alcohol · doi:10.1016/s0741-8329(97)00104-3 · Cited by 45 · see citing works
Effects of clonidine on event-related potential measures of information processing.
Cc, D., & Wh, K. (1987) · PubMed · Cited by 42 · see citing works
Normal time course of auditory recognition in schizophrenia, despite impaired precision of the auditory sensory ("echoic") memory code.
March, L., Cienfuegos, A., Goldbloom, L. M., Ritter, W., Cowan, N., & Javitt, D. C. (1999) · Journal of Abnormal Psychology · doi:10.1037//0021-843x.108.1.69 · Cited by 41 · see citing works
Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge.
Grzella, I., Müller, B. W., Oades, R. D., Bender, S., Schall, U., Zerbin, D., Wolstein, J., & Sartory, G. (2001) · PubMed Central · Cited by 41 · see citing works
Mismatch negativity in detection of interval duration deviation in schizophrenia
Davalos, D. B., Kisley, M. A., Polk, S. D., et al. (2003) · Neuroreport · doi:10.1097/00001756-200307010-00019 · Cited by 36 · see citing works
Deficits in automatically detecting changes in conjunction of auditory features in patients with schizophrenia
Alain, C., Bernstein, L. J., Cortese, F., He, Y., & Zipursky, R. B. (2002) · Psychophysiology · doi:10.1111/1469-8986.3950599 · Cited by 36 · see citing works
Possible roles for mismatch negativity in neuropsychiatry.
Gene‐Cos, N., RING, H. A., Pottinger, R. C., & Barrett, G. (1999) · PubMed · Cited by 35 · see citing works
Normal time course of auditory recognition in schizophrenia, despite impaired precision of the auditory sensory ("echoic") memory code.
March, L., Cienfuegos, A., Goldbloom, L. M., et al. (1999) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.108.1.69 · Cited by 34 · see citing works
Mismatch negativity is not correlated with neuroendocrine indicators of catecholaminergic activity in healthy subjects
Hansenne, M., Pinto, E., Scantamburlo, G., Couvreur, A., Reggers, J., Fuchs, S., Pitchot, W., & Ansseau, M. (2002) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.468 · Cited by 32 · see citing works
Preattentive periodicity detection in auditory patterns as governed by time and intensity information
Schröger, E., Tervaniemi, M. H., Wolff, C., & Näätänen, R. (1996) · Cognitive Brain Research · doi:10.1016/0926-6410(96)00023-7 · Cited by 31 · see citing works
Enhanced Selective Attention After Low-Dose Administration of the Benzodiazepine Antagonist Flumazenil
Smolnik, R., Pietrowsky, R., Fehm, H. L., & Jan Born, A. (1998) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199806000-00010 · Cited by 31 · see citing works
Overnight Effects of Triazolam on Cognitive Function: An Event-Related Potentials Study
Nakagome, K., Ichikawa, I., Kanno, O., Akaho, R., Suzuki, M., Takazawa, S., Watanabe, H., & Kazamatsuri, H. (1998) · Neuropsychobiology · doi:10.1159/000026547 · Cited by 30 · see citing works
Towards the Possible Clinical Application of the Mismatch Negativity Component of Event-Related Potentials
Csépe, V., & Molnár, M. (1997) · Audiology and Neurotology · doi:10.1159/000259256 · Cited by 29 · see citing works
The relationship of mismatch negativity to quantitative EEG and morphological findings in schizophrenia
Kirino, E., & Inoue, R. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(99)00012-6 · Cited by 29 · see citing works
Electrophysiological and neuropsychological effects of a central alpha2-antagonist atipamezole in healthy volunteers
Mervaala, E., Alhainen, K., Helkala, E.-L., Partanen, J. V., Jousmäki, V., Väyrynen, M., Heinonen, E., & Riekkinen, P. J. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90010-n · Cited by 28 · see citing works
The effects of benzodiazepines on event-related potential indices of automatic and controlled processing in schizophrenia
Murakami, T., Nakagome, K., Kamio, S., Kasai, K., Iwanami, A., HIRAMATSU, K., Fukuda, M., Hata, A., Honda, M., Watanabe, A., et al. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(01)00302-5 · Cited by 17 · see citing works
Do loudness cues contribute to duration mismatch negativity reduction in schizophrenia?
Todd, J., Michie, P. T., & Jablensky, A. V. (2001) · Neuroreport · doi:10.1097/00001756-200112210-00042 · Cited by 17 · see citing works
Die Mismatch-Negativität (MMN) in der Schizophrenieforschung
Rosburg, T., Kreitschmann‐Andermahr, I., & Sauer, H. (2004) · Der Nervenarzt · doi:10.1007/s00115-003-1674-3 · Cited by 13 · see citing works
Relationship of Mismatch Negativity to Background EEG and Morphological Findings in Schizophrenia
Kirino, E., & Inoue, R. (1999) · Neuropsychobiology · doi:10.1159/000026592 · Cited by 13 · see citing works
Mismatch negativity in schizophrenia research. An indicator of early processing disorders of acoustic information
Rosburg, T., Kreitschmann‐Andermahr, I., & Sauer, H. (2004) · Der Nervenarzt · Cited by 12 · see citing works
[The value of cognitive psychophysiological studies in a comprehensive approach to schizophrenia (treatment of information and attention capacities in acute-stage schizophrenia)].
Lembreghts, M., & Timsit-Berthier, M. (1993) · PubMed · Cited by 10 · see citing works
[Electrophysiologic correlates of selective attention in children and adolescents at increased risk of schizophrenia].
Schreiber, H., Stolz-Born, G., Kornhuber, H. H., et al. (1996) · PubMed · Cited by 5 · see citing works
Deficits in Auditory and Visual Context-Dependent Processing in Schizophrenia
Javitt, D. C., Shelley, A.-M., Silipo, G., & Lieberman, J. A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.12.1131 · Cited by 4 · see citing works
Mismatch field to minor pitch changes in single and paired tones: neuromagnetic source localization from derived fields.
Csépe, V., Pantev, C., Hampson, S. R., et al. (1995) · PubMed · Cited by 3 · see citing works
Deficits in mismatch negativity in schizophrenia: Predictor of outcome or result of illness progression?
Umbricht, D., Javitt, D. C., Bates, J. C., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)80401-2 · Cited by 2 · see citing works
Self-citation
Mismatch negativity amplitude and heschl's gyrus volume in first-episode schizophrenia
Salisbury, D. F., Kasai, K., Shenton, M. E., et al. (2003) · Schizophrenia Research · doi:10.1016/s0920-9964(03)80393-6 · Cited by 1 · see citing works
[ERP study of information processing disturbance on schizophrenia--from aspects of automatic processing and controlled processing].
Kirino, E., & Shinomiya, M. (1996) · PubMed · Cited by 1 · see citing works

Flagged first, then by citations

Sorted by citations

The mismatch negativity: a review of underlying mechanisms
Garrido, M. I., Kilner, J. M., Stephan, K. E., & Friston, K. J. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2008.11.029 · Cited by 1,441 · see citing works
“More than 30 studies have found significant reductions of MMN amplitude in patients with schizophrenia, both for frequency and duration deviants (Umbricht and Krljes, 2005).”
Background
Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400
Duncan, C. C., Barry, R. J., Connolly, J. F., Fischer, C., Michie, P. T., Näätänen, R., Polich, J., Reinvang, I., & Van Petten, C. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.07.045 · Cited by 1,191 · see citing works
Dysconnection in schizophrenia: from abnormal synaptic plasticity to failures of self-monitoring
Stephan, K. E., Friston, K. J., & Frith, C. D. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn176 · Cited by 1,134 · see citing works
Synaptic plasticity and dysconnection in schizophrenia
Stephan, K. E., Baldeweg, T., & Friston, K. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.005 · Cited by 841 · see citing works
Mismatch negativity (MMN), the deviance-elicited auditory deflection, explained
May, P. J. C., & Tiitinen, H. (2010) · Psychophysiology · doi:10.1111/j.1469-8986.2009.00856.x · Cited by 549 · see citing works
When Doors of Perception Close: Bottom-up Models of Disrupted Cognition in Schizophrenia
Javitt, D. C. (2009) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.032408.153502 · Cited by 503 · see citing works
A Meta-Analysis of Mismatch Negativity in Schizophrenia: From Clinical Risk to Disease Specificity and Progression
Erickson, M. A., Ruffle, A., & Gold, J. M. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.08.025 · Cited by 426 · see citing works
Sensory Processing Dysfunction in the Personal Experience and Neuronal Machinery of Schizophrenia
Javitt, D. C., & Freedman, R. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2014.13121691 · Cited by 403 · see citing works
A systematic review of the antipsychotic properties of cannabidiol in humans
Iseger, T. A., & Bossong, M. G. (2015) · Schizophrenia Research · doi:10.1016/j.schres.2015.01.033 · Cited by 261 · see citing works
Deviant matters: duration, frequency, and intensity deviants reveal different patterns of mismatch negativity reduction in early and late schizophrenia
Todd, J., Michie, P. T., Schall, U., Karayanidis, F., Yabe, H., & Näätänen, R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.02.016 · Cited by 257 · see citing works
Modeling Deficits From Early Auditory Information Processing to Psychosocial Functioning in Schizophrenia
Thomas, M. L., Green, M. F., Hellemann, G., Sugar, C. A., Tarasenko, M., Calkins, M. E., Greenwood, T. A., Gur, R. E., Gur, R. C., Lazzeroni, L. C., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.2980 · Cited by 206 · see citing works
Did I do that? Abnormal predictive processes in schizophrenia when button pressing to deliver a tone
Ford, J. M., Palzes, V. A., Roach, B. J., & Mathalon, D. H. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt072 · Cited by 210 · see citing works
A perceptual inference mechanism for hallucinations linked to striatal dopamine
Cassidy, C. M., Balsam, P. D., Weinstein, J. J., Rosengard, R. J., Slifstein, M., Daw, N. D., Abi-Dargham, A., & Horga, G. (2018) · Current Biology · doi:10.1016/j.cub.2017.12.059 · Cited by 176 · see citing works
Deficits in predictive coding underlie hallucinations in schizophrenia
Horga, G., Schatz, K. C., Abi-Dargham, A., & Peterson, B. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0200-14.2014 · Cited by 176 · see citing works
Stratified medicine for mental disorders
Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.010 · Cited by 186 · see citing works
Frontal Responses During Learning Predict Vulnerability to the Psychotogenic Effects of Ketamine: Linking Cognition, Brain Activity, and Psychosis
Corlett, P. R., Honey, G. D., Aitken, M. R. F., Dickinson, A., Shanks, D. R., Absalom, A. R., Lee, M., Pomarol-Clotet, E., Murray, G. K., McKenna, P. J., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.6.611 · Cited by 182 · see citing works
Translational perspectives for computational neuroimaging
Stephan, K. E., Iglesias, S., Heinzle, J., & Diaconescu, A. O. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.008 · Cited by 169 · see citing works
Stimulus-Specific Adaptation in Auditory Cortex Is an NMDA-Independent Process Distinct from the Sensory Novelty Encoded by the Mismatch Negativity
Farley, B. J., Quirk, M. C., Doherty, J. J., & Christian, E. P. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2793-10.2010 · Cited by 183 · see citing works
Modelling trial-by-trial changes in the mismatch negativity
Lieder, F., Daunizeau, J., Garrido, M. I., Friston, K. J., & Stephan, K. E. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002911 · Cited by 168 · see citing works
Impaired MMN/P3a complex in first-episode psychosis: cognitive and psychosocial associations
Hermens, D. F., Ward, P. B., Hodge, M. A. R., Kaur, M., Naismith, S. L., & Hickie, I. B. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.019 · Cited by 170 · see citing works
Translating Glutamate: From Pathophysiology to Treatment
Javitt, D. C., Schoepp, D., Kalivas, P. W., Volkow, N. D., Zarate, C., Merchant, K., Bear, M. F., Umbricht, D., Hajos, M., Potter, W. Z., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002804 · Cited by 168 · see citing works
Self-citation
Meta-analysis and systematic review of the literature characterizing auditory mismatch negativity in individuals with autism
Schwartz, S., Shinn-Cunningham, B., & Tager-Flusberg, H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.01.008 · Cited by 137 · see citing works
Deficits in high- (>60 Hz) gamma-band oscillations during visual processing in schizophrenia
Grützner, C., Wibral, M., Sun, L., Rivolta, D., Singer, W., Maurer, K., & Uhlhaas, P. J. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00088 · Cited by 140 · see citing works
Forecasting psychosis by event-related potentials-systematic review and specific meta-analysis
Bodatsch, M., Brockhaus-Dumke, A., Klosterkötter, J., & Ruhrmann, S. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.025 · Cited by 135 · see citing works
Deep temporal models and active inference
Friston, K. J., Rosch, R., Parr, T., Price, C., & Bowman, H. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.04.004 · Cited by 119 · see citing works
Improvement in mismatch negativity generation during d-serine treatment in schizophrenia: Correlation with symptoms
Kantrowitz, J. T., Epstein, M. L., Lee, M., Lehrfeld, N., Nolan, K. A., Shope, C., Petkova, E., Silipo, G., & Javitt, D. C. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.02.027 · Cited by 123 · see citing works
Mismatch negativity encoding of prediction errors predicts S-ketamine-induced cognitive impairments
Schmidt, A., Bachmann, R., Kometer, M., Csomor, P. A., Stephan, K. E., Seifritz, E., & Vollenweider, F. X. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.261 · Cited by 121 · see citing works
Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS
Green, M. F., Butler, P. D., Chen, Y., Geyer, M. A., Silverstein, S., Wynn, J. K., Yoon, J. H., & Zemon, V. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbn156 · Cited by 113 · see citing works
Anticipating the future: Automatic prediction failures in schizophrenia
Ford, J. M., & Mathalon, D. H. (2012) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.09.004 · Cited by 113 · see citing works
Modeling ketamine effects on synaptic plasticity during the mismatch negativity
Schmidt, A., Diaconescu, A. O., Kometer, M., Friston, K. J., Stephan, K. E., & Vollenweider, F. X. (2013) · Cerebral Cortex · doi:10.1093/cercor/bhs238 · Cited by 109 · see citing works
Mismatch negativity indexes illness-specific impairments of cortical plasticity in schizophrenia: a comparison with bipolar disorder and Alzheimer’s disease
Baldeweg, T., & Hirsch, S. R. (2015) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2014.03.008 · Cited by 108 · see citing works
How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control
Kenemans, J. L., & Kähkönen, S. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.157 · Cited by 104 · see citing works
Differential Relationships of Mismatch Negativity and Visual P1 Deficits to Premorbid Characteristics and Functional Outcome in Schizophrenia
Friedman, T., Sehatpour, P., Dias, E., Perrin, M., & Javitt, D. C. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.10.037 · Cited by 102 · see citing works
The psychoses: Cluster 3 of the proposed meta-structure for DSM-V and ICD-11: Paper 4 of 7 of the thematic section: ‘A proposal for a meta-structure for DSM-V and ICD-11’
Carpenter, W. T., Bustillo, J. R., Thaker, G. K., van Os, J., Krueger, R. F., & Green, M. J. (2009) · Psychological Medicine · doi:10.1017/s0033291709990286 · Cited by 99 · see citing works
Computational Modeling of Electroencephalography and Functional Magnetic Resonance Imaging Paradigms Indicates a Consistent Loss of Pyramidal Cell Synaptic Gain in Schizophrenia
Adams, R. A., Pinotsis, D., Tsirlis, K., Unruh, L., Mahajan, A., Horas, A. M., Convertino, L., Summerfelt, A., Sampath, H., Du, X. M., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.07.024 · Cited by 98 · see citing works
Mismatch Negativity is a Sensitive and Predictive Biomarker of Perceptual Learning During Auditory Cognitive Training in Schizophrenia
Perez, V. B., Tarasenko, M., Miyakoshi, M., Pianka, S. T., Makeig, S. D., Braff, D. L., Swerdlow, N. R., & Light, G. A. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.25 · Cited by 94 · see citing works
Glutamatergic Modulation of Auditory Information Processing in the Human Brain
Gunduz-Bruce, H., Reinhart, R. M. G., Roach, B. J., Gueorguieva, R., Oliver, S., D'Souza, D. C., Ford, J. M., Krystal, J. H., & Mathalon, D. H. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.09.031 · Cited by 93 · see citing works
The role of the primary auditory cortex in the neural mechanism of auditory verbal hallucinations
Kompus, K., Falkenberg, L. E., Bless, J. J., Johnsen, E., Kroken, R. A., Kråkvik, B., Larøi, F., Løberg, E.-M., Vedul-Kjelsås, E., Westerhausen, R., et al. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00144 · Cited by 91 · see citing works
Glycine transport inhibitors in the treatment of schizophrenia
Javitt, D. C. (2012) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25758-2_12 · Cited by 83 · see citing works
Sensory prediction errors in the continuum of psychosis
Randeniya, R., Oestreich, L. K. L., & Garrido, M. I. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.04.019 · Cited by 78 · see citing works
Impaired prefrontal synaptic gain in people with psychosis and their relatives during the mismatch negativity
Ranlund, S., Adams, R. A., Díez, Á., Constante, M., Dutt, A., Hall, M., Maestro Carbayo, A., McDonald, C., Petrella, S., Schulze, K., et al. (2016) · Human Brain Mapping · doi:10.1002/hbm.23035 · Cited by 77 · see citing works
Mismatch negativity (MMN) as a tool for translational investigations into early psychosis: A review
Tada, M., Kirihara, K., Mizutani, S., Uka, T., Kunii, N., Koshiyama, D., Fujioka, M., Usui, K., Nagai, T., Araki, T., et al. (2019) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2019.02.009 · Cited by 74 · see citing works
A single high dose of escitalopram increases mismatch negativity without affecting processing negativity or P300 amplitude in healthy volunteers
Wienberg, M., Glenthoj, B., Jensen, K., & Oranje, B. (2010) · Journal of Psychopharmacology · doi:10.1177/0269881109102606 · Cited by 68 · see citing works
A predictive coding account of MMN reduction in schizophrenia
Wacongne, C. (2016) · Biological Psychology · doi:10.1016/j.biopsycho.2015.10.011 · Cited by 68 · see citing works
Abnormal intrinsic and extrinsic connectivity within the magnetic mismatch negativity brain network in schizophrenia: a preliminary study
Dima, D., Frangou, S., Burge, L., Braeutigam, S., & James, A. C. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2011.12.024 · Cited by 65 · see citing works
Disruption of Conscious Access in Schizophrenia
Berkovitch, L., Dehaene, S., & Gaillard, R. (2017) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2017.08.006 · Cited by 60 · see citing works
Reduced Auditory Mismatch Negativity Reflects Impaired Deviance Detection in Schizophrenia
Koshiyama, D., Kirihara, K., Tada, M., Nagai, T., Fujioka, M., Usui, K., Araki, T., & Kasai, K. (2020) · Schizophrenia Bulletin · doi:10.1093/schbul/sbaa006 · Cited by 63 · see citing works
Emotion-related visual mismatch responses in Schizophrenia: impairments and correlations with emotion recognition
Csukly, G., Stefanics, G., Komlósi, S., Czigler, I., & Czobor, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075444 · Cited by 60 · see citing works
Neurophysiologic markers of abnormal brain activity in schizophrenia
Rissling, A. J., Makeig, S., Braff, D. L., & Light, G. A. (2010) · Current Psychiatry Reports · doi:10.1007/s11920-010-0149-z · Cited by 58 · see citing works
Selective Prefrontal Disinhibition in a Roving Auditory Oddball Paradigm Under N-Methyl-D-Aspartate Receptor Blockade
Rosch, R. E., Auksztulewicz, R., Leung, P. D., Friston, K. J., & Baldeweg, T. (2019) · Biological Psychiatry: Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.07.003 · Cited by 56 · see citing works
Aberrant auditory processing in schizophrenia and in subjects at ultra-high-risk for psychosis
Shin, K. S., Kim, J. S., Kim, S. N., Koh, Y., Jang, J. H., An, S. K., O'Donnell, B. F., Chung, C. K., & Kwon, J. S. (2012) · Schizophrenia Bulletin · doi:10.1093/schbul/sbr138 · Cited by 47 · see citing works
Impaired mismatch negativity is associated with current functional status rather than genetic vulnerability to schizophrenia
Kim, M., Kim, S. N., Lee, S., Byun, M. S., Shin, K. S., Park, H. Y., Jang, J. H., & Kwon, J. S. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.02.012 · Cited by 46 · see citing works
Predicting Remission in Subjects at Clinical High Risk for Psychosis Using Mismatch Negativity
Kim, M., Lee, T. H., Yoon, Y. B., Lee, T. Y., & Kwon, J. S. (2018) · Schizophrenia Bulletin · doi:10.1093/schbul/sbx102 · Cited by 45 · see citing works
When it’s time for a change: failures to track context in schizophrenia
Ford, J. M., Roach, B. J., Miller, R. M., Duncan, C. C., Hoffman, R. E., & Mathalon, D. H. (2010) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2010.05.005 · Cited by 43 · see citing works
Late deviance detection in rats is reduced, while early deviance detection is augmented by the NMDA receptor antagonist MK-801
Harms, L., Fulham, W. R., Todd, J., Meehan, C., Schall, U., Hodgson, D. M., & Michie, P. T. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2017.03.042 · Cited by 40 · see citing works
Clinical Staging for Youth Mental Disorders: Progress in Reforming Diagnosis and Clinical Care
McGorry, P. D., & Mei, C. (2021) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-050620-030405 · Cited by 38 · see citing works
Parsing components of auditory predictive coding in schizophrenia using a roving standard mismatch negativity paradigm
McCleery, A., Mathalon, D. H., Wynn, J. K., Roach, B. J., Hellemann, G. S., Marder, S. R., & Green, M. F. (2019) · Psychological Medicine · doi:10.1017/s0033291718004087 · Cited by 35 · see citing works
Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia
Ballesteros, A., Summerfelt, A., Du, X., Jiang, P., Chiappelli, J., Tagamets, M., O’Donnell, P., Kochunov, P., & Hong, L. E. (2013) · Clinical Neurophysiology · doi:10.1016/j.clinph.2013.05.021 · Cited by 34 · see citing works
In vivo assay of cortical microcircuitry in frontotemporal dementia: a platform for experimental medicine studies
Shaw, A. D., Hughes, L. E., Moran, R., Coyle-Gilchrist, I., Rittman, T., & Rowe, J. B. (2021) · Cerebral Cortex · doi:10.1093/cercor/bhz024 · Cited by 30 · see citing works
Impairment in predictive processes during auditory mismatch negativity in ScZ: evidence from event-related fields
Sauer, A., Zeev‐Wolf, M., Grent‐'t‐Jong, T., Recasens, M., Wacongne, C., Wibral, M., Helbling, S., Peled, A., Grinshpoon, A., Singer, W., et al. (2017) · Human Brain Mapping · doi:10.1002/hbm.23716 · Cited by 31 · see citing works
Aberrant temporal behavior of mismatch negativity generators in schizophrenia patients and subjects at clinical high risk for psychosis
Kim, M., Cho, K. I. K., Yoon, Y. B., Lee, T. Y., & Kwon, J. S. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.11.027 · Cited by 30 · see citing works
Model-based prediction of muscarinic receptor function from auditory mismatch negativity responses
Schöbi, D., Homberg, F., Frässle, S., Endepols, H., Moran, R. J., Friston, K. J., Tittgemeyer, M., Heinzle, J., & Stephan, K. E. (2021) · NeuroImage · doi:10.1016/j.neuroimage.2021.118096 · Cited by 25 · see citing works
Hallucinations, neuroplasticity, and prediction errors in schizophrenia
McCleery, A., Wynn, J. K., & Green, M. F. (2018) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12413 · Cited by 25 · see citing works
Neurophysiological and Psychological Predictors of Social Functioning in Patients with Schizophrenia and Bipolar Disorder
Kim, Y., Kwon, A., Min, D., Kim, S., Jin, M. J., & Lee, S.-H. (2019) · Psychiatry Investigation · doi:10.30773/pi.2019.07.28 · Cited by 24 · see citing works
Modulation of Attention and Stress with Arousal: The Mental and Physical Effects of Riding a Motorcycle
Vaughn, D. A., Maggiora, M. B., Vaughn, K. J., Maggiora, C. J., Tavakoli, A.-V., Liang, W., Zava, D., Cohen, M. S., & Lenartowicz, A. (2021) · Brain Research · doi:10.1016/j.brainres.2020.147203 · Cited by 13 · see citing works
“…may choose to assess the temporal nature of this hormonal shift in search of prophylactic potential, given that elevated glucocorticoid levels have been shown to contribute to neuronal death, among other undesirable outcomes (Dinkel et al., 2003; Kerr et al., 1991; Krystal, 1993; Uno et al., 1989).”
Background
Emotional context restores cortical prediction error responses in schizophrenia
Vogel, B. O., Stasch, J., Walter, H., & Neuhaus, A. H. (2018) · Schizophrenia Research · doi:10.1016/j.schres.2018.02.030 · Cited by 10 · see citing works
Predictive coding and neurocomputational psychiatry: a mechanistic framework for understanding mental disorders
Shaw, A. D., Sumner, R. L., & Berndt, L. C. S. (2026) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2025.1713833 · Cited by 9 · see citing works
“Individuals with schizophrenia often show reduced mismatch negativity responses, consistent with improper error signalling (37).”
The effect of deviance predictability on mismatch negativity in schizophrenia patients
Horacek, M., Kärgel, C., Scherbaum, N., & Müller, B. W. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.02.010 · Cited by 9 · see citing works
A neural mechanism underlying predictive visual motion processing in patients with schizophrenia
Scheliga, S., Schwank, R., Scholle, R., Habel, U., & Kellermann, T. (2022) · Psychiatry Research · doi:10.1016/j.psychres.2022.114934 · Cited by 8 · see citing works
Visual mismatch negativity in Parkinson's psychosis and potential for testing treatment mechanisms
Vignando, M., ffytche, D., Mazibuko, N., Palma, G., Montagnese, M., Dave, S., Nutt, D. J., Gabay, A. S., Tai, Y. F., Batzu, L., et al. (2024) · Brain Communications · doi:10.1093/braincomms/fcae291 · Cited by 6 · see citing works

Mismatch negativity and auditory sensory memory evaluation
Grau, C., Escera, C., Yago, E., & Polo, M. D. (1998) · Neuroreport · doi:10.1097/00001756-199808030-00005 · Cited by 54 · see citing works
Mismatch Negativity: Different Water in the Same River
Picton, T. W., Alain, C., Otten, L. J., Ritter, W., & Achim, A. (2000) · Audiology and Neurotology · doi:10.1159/000013875 · Cited by 575 · see citing works
Sensory memory during physiological aging indexed by mismatch negativity (MMN)
Ruzzoli, M., Pirulli, C., Brignani, D., Maioli, C., & Miniussi, C. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.03.021 · Cited by 87 · see citing works
Preattentive auditory change detection relies on unitary sensory memory representations
Czigler, I., & Winkler, I. (1996) · Neuroreport · doi:10.1097/00001756-199611040-00002 · Cited by 41 · see citing works
The Development of Memory Trace Depending on the Number of the Standard Stimuli
Matuoka, T., Yabe, H., Shinozaki, N., et al. (2006) · Clinical EEG and Neuroscience · doi:10.1177/155005940603700312 · Cited by 10 · see citing works

Authors: Umbricht, D., & Krljes, S.
Affiliations: University of Zurich (CH)
Birkbeck, University of London (GB)
Corresponding author: Umbricht, Daniel
ORCID: Umbricht, Daniel
Venue: Schizophrenia Research
Publisher: Elsevier BV
Published: 2005-07
Volume: 76
Issue: 1
Pages: 1-23
ISSN: 0920-9964 (ISSN-L)
DOI: 10.1016/j.schres.2004.12.002
OpenAlex: W2125206183
Cited by: 742
References: 122
Citations by year: 2026: 28 · 2025: 26 · 2024: 38 · 2023: 27 · 2022: 30 · 2021: 34 · 2020: 43 · 2019: 49 · 2018: 39 · 2017: 43 · 2016: 42 · 2015: 47 · 2014: 43 · 2013: 46 · 2012: 30
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Schizophrenia Research (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Hallucinations in medical conditions
Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords: mismatch negativity, schizophrenia
MeSH terms: Auditory Cortex, Chronic Disease, Contingent Negative Variation, Electroencephalography, Evoked Potentials, Auditory, Humans, Mental Recall, Reference Values, Schizophrenia, Schizophrenic Psychology, Sensitivity and Specificity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Mismatch negativity in schizophrenia: a meta-analysis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks