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Cited by 127Hip and Femur FracturesNutrition and Health in AgingBone health and osteoporosis research

The DOI matches its Crossref record; 45 of the 49 references it cites were found in a registry or an index.

Effects of protein-rich supplementation and nandrolone in lean elderly women with femoral neck fractures

Tidermark, Jan, Ponzer, Sari, Carlsson, Pronoti, Söderqvist, Anita, Brismar, Kerstin, Tengstrand, Birgitta, Cederholm, Tommy·2004·Clinical Nutrition
DOI 10.1016/j.clnu.2003.10.006
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Abstract

Aim To evaluate the effects of a protein-rich liquid supplementation, alone or in combination with the anabolic steroid nandrolone decanoate, on body composition, activities of daily living (ADL) status and the health-related quality of life (HRQoL) after a femoral neck fracture. Methods Sixty women, aged 83 +/- 5 years (mean +/- SD), BMI < 24 kg/m2 (20.4 +/- 2 kg/m2 ) and capable of co-operating, with a femoral neck fracture treated with internal fixation, were randomised to open treatment during 6 months with a protein-rich liquid formula alone (PR, Fortimel, 200 ml/day, 20 g protein/day) or in combination with nandrolone decanoate (PR/N, Deca-Durabol 25 mg i.m./3 weeks) or to a control group (C). The patients were re-examined after 6 and 12 months regarding body weight (BW), lean body mass (LBM, DXA), ADL status according to Katz, HRQoL according to EQ 5-D and fracture healing. Results LBM decreased in the C (-1.2 +/- 2 kg) and PR groups (-1.2 +/- 1 kg) but remained the same in the PR/N group (0.3 +/- 1 kg) (P < 0.05 between groups). ADL remained at a high level in the two intervention groups but declined significantly in the C group (P < 0.005 between groups). The decline in HRQoL was least pronounced in the PR/N group at 6 months (P < 0.05 between groups). Patients with fracture healing complications lost more BW (P < 0.05) and LBM (P < 0.01) than patients with uneventful fracture healing. Conclusion Protein-rich liquid supplementation in combination with nandrolone given for 6 months to lean elderly women after a femoral neck fracture may positively affect LBM, ADL and HRQoL.

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Research works printed but not linked: 2

  1. Bang, 1991, Comparison of acid ethanol extraction and acid gel filtration prior to IGF-I and IGF-II radioimmunoassays, Acta Endocrinol, 124, 620
  2. Bachrach-Lindström, 2000, Nutritional status and functional capacity after femoral neck fractures, Aging, 12, 366

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Metadata

Authors
Tidermark, J., Ponzer, S., Carlsson, P., Söderqvist, A., Brismar, K., Tengstrand, B., & Cederholm, T.
Affiliations
  • Karolinska Institutet (SE)
  • Karolinska University Hospital (SE)
Corresponding author
Tidermark, Jan
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2004-08
Volume
23
Issue
4
Pages
587-596
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2003.10.006
OpenAlex
W2057430676
Cited by
127
References
49
Citations by year
2026: 3 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 6 · 2018: 9 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 7 · 2012: 6
FWCI
6.09
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Hip and Femur Fractures
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Keywords
femoral neck fracture, nandrolone decanoate, lean body mass, body composition, activities of daily living, health-related quality of life, fracture healing complications, internal fixation, anabolic steroids
MeSH terms
Activities of Daily Living, Aged, Aged, 80 and over, Body Composition, Dietary Proteins, Female, Femoral Neck Fractures, Food, Formulated, Humans, Nandrolone, Nutritional Status, Quality of Life, Nutrition Assessment, Treatment Outcome, Fracture Healing, Anabolic Agents

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