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Different thermic effects of leptin in adolescent females with varying body fat content

Haas, Verena K., Gaskin, Kevin J., Kohn, Michael R., Clarke, Simon D., Müller, Manfred J.·2010·Clinical Nutrition
DOI 10.1016/j.clnu.2010.03.013
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Abstract

Background & aims Investigating the effect of leptin on energy expenditure in undernutrition might lead to a better understanding of the role of leptin in regulating body weight in humans. Methods 73 underweight female adolescents with anorexia nervosa (AN) were compared with 23 healthy normal weight (nwC), and 9 overweight girls (OW); 37 AN were followed during 7 months of weight recovery. Resting energy expenditure (REE, by indirect calorimetry), body composition (fat mass, FM; lean tissue mass, LTM; by Dual-Energy X-Ray Absorptiometry) and plasma hormones of leptin and 3,5,3'-Triiodothyronine (T(3)) were measured. Results In underweight, leptin, T(3) and REE adjusted for lean tissue mass (REE(LTM)) were decreased; in OW, FM and leptin were increased at unchanged T(3) and REE(LTM). There was a significant positive relation between FM and leptin at low and normal (AN, r(2) = 0.26; nwC, r(2) = 0.51, p Conclusions At low adiposity the interrelated fall of leptin and REE reflect an adaptive mechanism to preserve body weight. High leptin production associated with excessive adiposity was without effect on metabolic adaptation.

Overview

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Crossref · 10.1016/j.clnu.2010.03.013

Cites

3 of 3 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • In population studies on subjects differing in body weight, normal or elevated plasma leptin levels did not correlate with energy expenditure.

    “In population studies on subjects differing in body weight, normal or elevated plasma leptin levels did not correlate with energy expenditure [71, 72].”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [71]

  • The association between very low leptin levels and REE in severely underweight patients with anorexia nervosa disappeared during treatment, with increases in fat mass and plasma leptin concentrations.

    “this association disappeared again during treatment, i.e. with increases in fat mass and plasma leptin concentrations [71].”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [71]

  • There was a close association between very low leptin levels and REE in severely underweight patients with anorexia nervosa.

    “By contrast, there was a close association between very low leptin levels and REE in severely underweight patients with anorexia nervosa”

    From Changes in energy expenditure with weight gain and weight loss in humans (2016) · cites this paper as [71]

Citations

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Metadata

Authors
Haas, V. K., Gaskin, K. J., Kohn, M. R., Clarke, S. D., & Müller, M. J.
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2010-10
Volume
29
Issue
5
Pages
639-645
ISSN
0261-5614
DOI
10.1016/j.clnu.2010.03.013
Cited by
14
References
3
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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