Cited by 288Muscle metabolism and nutritionNutrition and Health in AgingSpaceflight effects on biology

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Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

Deutz, Nicolaas E.P., Pereira, Suzette L., Hays, Nicholas P., Oliver, Jeffery S., Edens, Neile K., Evans, Chris M., Wolfe, Robert R.·2013·Clinical Nutrition

DOI 10.1016/j.clnu.2013.02.011

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Abstract

Background Loss of muscle mass due to prolonged bed rest decreases functional capacity and increases hospital morbidity and mortality in older adults. Objective To determine if HMB, a leucine metabolite, is capable of attenuating muscle decline in healthy older adults during complete bed rest. Design A randomized, controlled, double-blinded, parallel-group design study was carried out in 24 healthy (SPPB ≥ 9) older adult subjects (20 women, 4 men), confined to complete bed rest for ten days, followed by resistance training rehabilitation for eight weeks. Subjects in the experimental group were treated with HMB (calcium salt, 1.5 g twice daily - total 3 g/day). Control subjects were treated with an inactive placebo powder. Treatments were provided starting 5 days prior to bed rest till the end rehabilitation phase. DXA was used to measure body composition. Results Nineteen eligible older adults (BMI: 21-33; age: 60-76 year) were evaluable at the end of the bed rest period (Control n = 8; Ca-HMB n = 11). Bed rest caused a significant decrease in total lean body mass (LBM) (2.05 ± 0.66 kg; p = 0.02, paired t-test) in the Control group. With the exclusion of one subject, treatment with HMB prevented the decline in LBM over bed rest -0.17 ± 0.19 kg; p = 0.23, paired t-test). There was a statistically significant difference between treatment groups for change in LBM over bed rest (p = 0.02, ANOVA). Sub-analysis on female subjects (Control = 7, HMB = 8) also revealed a significant difference in change in LBM over bed rest between treatment groups (p = 0.04, ANOVA). However, differences in function parameters could not be observed, probably due to the sample size of the study. Conclusions In healthy older adults, HMB supplementation preserves muscle mass during 10 days of bed rest. These results need to be confirmed in a larger trial.

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Self-citation
Additional file 1 of Beta-hydroxy beta-methylbutyrate/arginine/glutamine (HMB/Arg/Gln) supplementation to improve the management of cachexia in patients with advanced lung cancer: an open-label, multicentre, randomised, controlled phase II trial (NOURISH)
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An Analysis of the Effect of ß-Hydroxy-ß-Methylbutyrate on the Flight Ability and Lifespan of Drosophila melanogaster
Beattie, A. E. (2014) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Evaluation of calcium β-hydroxy-β-methylbutyrate on performance of Bos indicus -influenced cattle in a subtropical environment
Pacheco, R. D. L., Gusmão, J., Maia, A. S. C., Terêncio, P. H., Bastos, J. P. S. T., Ávila, R., Johnson, B. J., Campanelli, V. P. C., Fonsêca, V. F. C., Moura, G. A. B., et al. (2026) · Journal of Animal Science · doi:10.1093/jas/skaf459
Integrated Untargeted and Targeted Metabolomics Reveals Distinct Bioactive Metabolite Profiles Between Probiotic Supplements and Yogurt
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The effects of bed rest on cardiometabolic health: A systematic review and meta‐analysis
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Déconditionnement et régénération du muscle strié squelettique : rôle du niveau d’activité contractile sur le développement d’infiltrations graisseuses
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Sources of Dietary Protein: A Focus on Eggs
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ПРОФИЛАКТИКА ВОЗРАСТНОГО СНИЖЕНИЯ МЫШЕЧНОЙ МАССЫ И ФУНКЦИЙ СКЕЛЕТНЫХ МЫШЦ: ФИЗИЧЕСКИЕ НАГРУЗКИ, ПИТАНИЕ И ЛЕКАРСТВЕННЫЕ ПРЕПАРАТЫ
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“Similarly, Deutz et al. (2013) observed no significant changes in total BMD following 10 days of bed rest in older adults, further reinforcing the limited ability of DXA to detect early or short-term bone loss associated with disuse.”
HMB supplementation combined with high-intensity functional exercise supports aerobic capacity but not strength in trained and untrained males: a randomized controlled trial
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Effects of a Multi-Ingredient MCT–Leucine–Creatine-Based Supplement (TLN-01) on Muscle Mass, Strength, and Plasma Amino Acid Profiles in Older Adults with Sarcopenia: A Randomized Controlled Trial
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“For example, supplementing approximately 2.5–3 g of leucine can acutely stimulate muscle protein synthesis [18], and even approximately 3 g of β -hydroxy β -methylbutyrate (HMB, a leucine metabolite) helps preserve muscle during bedrest [19].”
Influential
Béta-hidroxi-béta-metilbutirát tartalmú táplálékkiegészítő hatása az izomtömeg-paraméterekre elhízott, anyagcserezavarral társult steatoticus májbetegségben szenvedő cukorbetegekben
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Musculoskeletal decay and bone–muscle crosstalk during physical disuse: Mechanisms and integrated countermeasures
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Microbial‐derived Exerkines preserve muscle size and function during disuse in aged mice in a sex‐dependent manner
Daredia, J., Valentino, T. R., Ismaeel, A., Wen, Y., McCarthy, J. J., & Burke, B. I. (2026) · Physiological Reports · doi:10.14814/phy2.71137
Calf Injuries: Anatomy, Pathology, and Treatment
Hauer, T. M., Arner, J. W., Mauro, C. S., & Bradley, J. P. (2026) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-25-01090
Zinc lozenges and vitamin C for high-performance athletes
Hemilä, H. (2018) · doi:10.5281/zenodo.20305699

Authors: Deutz, N. E. P., Pereira, S. L., Hays, N. P., Oliver, J. S., Edens, N. K., Evans, C. M., & Wolfe, R. R.
Affiliations: University of Arkansas for Medical Sciences (US)
Abbott Nutrition (United States) (US)
Corresponding author: Deutz, Nicolaas E.P.
ORCID: Deutz, Nicolaas E.P.
Pereira, Suzette L.
Hays, Nicholas P.
Wolfe, Robert R.
Venue: Clinical Nutrition
Publisher: Elsevier BV
Published: 2013-10
Volume: 32
Issue: 5
Pages: 704-712
ISSN: 0261-5614 (ISSN-L)
DOI: 10.1016/j.clnu.2013.02.011
OpenAlex: W2129894754
Cited by: 287
References: 43
Citations by year: 2026: 18 · 2025: 19 · 2024: 21 · 2023: 17 · 2022: 19 · 2021: 26 · 2020: 36 · 2019: 19 · 2018: 30 · 2017: 21 · 2016: 21 · 2015: 18 · 2014: 14 · 2013: 7
FWCI: 11.61
Type: journal article
Language: en
Open access: closed
Locations: Clinical Nutrition (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Spaceflight effects on biology
Keywords: beta-hydroxy-beta-methylbutyrate, HMB supplementation, lean body mass, muscle mass loss, bed rest, disuse atrophy, older adults, leucine metabolites, body composition, sarcopenia prevention
MeSH terms: Aged, Aging, Bed Rest, Body Composition, Double-Blind Method, Female, Humans, Male, Middle Aged, Muscle Proteins, Musculoskeletal Physiological Phenomena, Valerates, Absorptiometry, Photon, Muscle, Skeletal, Dietary Supplements, Muscle Development, Whole Body Imaging, Muscle Strength, Resistance Training, Sarcopenia

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Effect of β-hydroxy-β-methylbutyrate (HMB) on lean body mass during 10 days of bed rest in older adults

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