Functional Impact of 10 Days of Bed Rest in Healthy Older Adults
Abstract
BACKGROUND: Many older individuals decline functionally during hospitalization, and the deleterious consequences of bed rest may be one cause. This study reports on the effect of 10 days of bed rest on multiple functional parameters in healthy older adults. METHODS: Healthy older men and women (n = 11, 67 +/- 5 years old) remained on bed rest for 10 days continuously, and consumed a eucaloric diet providing the Recommended Dietary Allowance for protein. Measures of lower extremity strength and power, aerobic capacity and physical performance, as well as physical activity were performed before and after bed rest. RESULTS: All measures of lower extremity strength were significantly lower after bed rest including isotonic knee extensor strength (-13.2 +/- 4.1%, p =.004) and stair-climbing power (-14 +/- 4.1%, p =.01). Maximal aerobic capacity was 12% lower after bed rest (p =.04), whereas measures of physical performance (Short Physical Performance Battery, and a five-item physical performance test) were not significantly different. Voluntary physical activity decreased after bed rest, and the percentage of time spent inactive increased (7.6 +/- 1.8%, p =.004). There were no medical complications. CONCLUSIONS: In healthy older adults, 10 days of bed rest results in a substantial loss of lower extremity strength, power, and aerobic capacity, and a reduction in physical activity, but has no effect on physical performance. Identification of interventions to maintain muscle function during hospitalization or periods of bed rest in older adults should be a high priority.
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Kortebein et al. observed a 0.95-kg loss of lean leg mass (0.66 kg week−1) after 10 days of bed rest in healthy older adults.
“Indeed, Kortebein et al. 36 observed a 0.95‐kg loss of lean leg mass (0.66 kg week−1) after 10 days of bed rest in healthy older adults, as inactivity‐induced loss of muscle mass predominantly affects the lower body musculature and is most rapid during the first days/weeks. 37”
From A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults (2023) · cites this paper as [36]
The passage labeled Abstract (page unavailable) says healthy older adults lost almost 1 kg of lower-extremity lean tissue after 10 days of bed rest, and the Discussion (page unavailable) also notes significant lean-tissue loss. The copy does not give the precise 0.95-kg figure or the stated 0.66-kg-per-week rate. (LLM, conf=0.84)
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- Authors
- Kortebein, P., Symons, T. B., Ferrando, A., Paddon-Jones, D., Ronsen, O., Protas, E., Conger, S., Lombeida, J., Wolfe, R., & Evans, W. J.
- Affiliations
- University of Arkansas for Medical Sciences (US)
- University of Kentucky (US)
- The University of Texas Medical Branch at Galveston (US)
- Georgia Institute of Technology (US)
- United States Department of Veterans Affairs (US)
- Corresponding author
- Kortebein, P.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2008-10-01
- Volume
- 63
- Issue
- 10
- Pages
- 1076-1081
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2118762638
- Cited by
- 550
- References
- 48
- Citations by year
- 2026: 23 · 2025: 39 · 2024: 47 · 2023: 33 · 2022: 42 · 2021: 50 · 2020: 51 · 2019: 40 · 2018: 33 · 2017: 39 · 2016: 38 · 2015: 26 · 2014: 20 · 2013: 24 · 2012: 12
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Arkansas
- University of Texas Medical Branch
- University of Arkansas for Medical Sciences
- Deutsches Krebsforschungszentrum
- National Institute on Aging (P01AG023591, P30AG024832)
- National Center for Research Resources (MO 1 RR 00073, M01RR014288, M01RR000073)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
- Keywords
- bed rest, older adults, functional decline, lower limb strength, quadriceps strength, cardiorespiratory fitness, physical performance, physical activity, muscle function, hospitalization, muscle atrophy
- MeSH terms
- Adult, Aged, 80 and over, Bed Rest, Female, Humans, Leg, Male, Middle Aged, Motor Activity, Movement, Physical Fitness, Muscle, Skeletal, Statistics, Nonparametric, Muscle Strength
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