The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Adherence to the Mediterranean diet is associated with the severity of non-alcoholic fatty liver disease
Abstract
Background & aims Nutrition has been proposed as a potential environmental factor affecting the risk of non-alcoholic fatty liver disease (NAFLD). In the present study, the impact of adherence to the Mediterranean diet (MD) on the presence and severity of NAFLD was explored.Methods Seventy-three consecutive adult patients with recent NAFLD diagnosis were included. Adherence to the MD was estimated with MedDietScore. Demographic and anthropometric data, body composition analysis and several biochemical and inflammatory markers were estimated. Liver stiffness measurements by transient elastography were available in 58 patients and liver biopsies in 34 patients. Fifty-eight patients were matched with 58 healthy controls in terms of age, sex and body mass index.Results MedDietScore was negatively correlated to patients' serum alanine aminotransferase (p = 0.03) and insulin levels (p = 0.001), insulin resistance index (p = 0.005) and severity of steatosis (p = 0.006) and positively to serum adiponectin levels (p = 0.04). Patients with non-alcoholic steatohepatitis (NASH) exhibited lower adherence to MD (29.3 ± 3.2 vs. 34.1 ± 4.4, p = 0.004) compared to those with simple fatty liver. Logistic regression analysis revealed that one unit increase in the MedDietScore was associated with 36% lower likelihood of having NASH (odds ratio: 0.64, 95% confidence interval: 0.45-0.92), after adjusting for sex and abdominal fat level. No difference in the MedDietScore was observed between patients and controls.Conclusions Higher adherence to the Mediterranean diet is not associated with lower likelihood of having NAFLD, but it is associated with less degree of insulin resistance and less severe liver disease among patients with NAFLD.
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“Cross-sectional and longitudinal reports evidenced a lower likelihood of NASH in patients who were adherent to the MedDiet [75,76], whereas randomized controlled crossover trials defined the superiority of this diet in the improvement of insulin sensitivity, metabolic parameters and steatosis over low-fat ones [77,78].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [76]
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Cites
Friedewald, W. T., Levy, R. I., & Fredrickson, D. S. (1972) · Clinical Chemistry · doi:10.1093/clinchem/18.6.499 · Cited by 32,423
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C. (1985) · Diabetologia · doi:10.1007/bf00280883 · Cited by 31,502
Design and validation of a histological scoring system for nonalcoholic fatty liver disease†
Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791
Dietary pattern analysis: a new direction in nutritional epidemiology
Hu, F. B. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200202000-00002 · Cited by 4,029
Nonalcoholic Steatohepatitis: A Proposal for Grading and Staging The Histological Lesions
Brunt, E. M., Janney, C. G., Di Bisceglie, A. M., Neuschwander-Tetri, B. A., & Bacon, B. R. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01377.x · Cited by 3,907
Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications
Fabbrini, E., Sullivan, S., & Klein, S. (2010) · Hepatology · doi:10.1002/hep.23280 · Cited by 2,100
Sofi, F., Abbate, R., Gensini, G. F., & Casini, A. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29673 · Cited by 1,605
The Effect of Mediterranean Diet on Metabolic Syndrome and its Components
Kastorini, C.-M., Milionis, H. J., Esposito, K., Giugliano, D., Goudevenos, J. A., & Panagiotakos, D. B. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.073 · Cited by 1,087
The Role of Insulin Resistance in Nonalcoholic Fatty Liver Disease
Utzschneider, K. M., & Kahn, S. E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0587 · Cited by 874
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Pirabbasi, E., Behbahani, H. B., Salimi, Z., Mansoori, A., Dehghanseresht, N., & Asadi, M. (2023) · Zahedan Journal of Research in Medical Sciences · doi:10.5812/zjrms-138464 · Cited by 1
El-Kader, S. M. A. (2017) · Advanced Research in Gastroenterology & Hepatology · doi:10.19080/argh.2017.03.555608
Affect of late-onset prenatal care on antenatal diagnosis.
Bodurtha, J. N., Corey, L., & Nance, W. E. (1986) · PubMed
Schott, S. L., & Minich, D. M. (2018) · Alternative and Complementary Therapies · doi:10.1089/act.2018.29172.ssc
Bobeck, K. A., Ordway, S. M., Sadowski, B. W., Tritsch, A. M., & Singla, M. B. (2019) · OBM Hepatology and Gastroenterology · doi:10.21926/obm.hg.1902025
La Nash, véritable fléau des sociétés modernes
Francès, P., Vidal, D., & Cartier, P. (2020) · L Aide-Soignante · doi:10.1016/j.aidsoi.2019.12.010
SEVERCAN, S. M., Bi̇lgi̇han, A., Erkan, G., Erçin, U., & Severcan, Ç. (2019) · Medical Studies · doi:10.5114/ms.2019.91245
Wong, R. J., Tran, T. T., Kaufman, H. W., Niles, J. K., & Gish, R. G. (2020) · Clinical Nutrition Experimental · doi:10.1016/j.yclnex.2020.03.002
Management of Nonalcoholic Fatty Liver Disease and Metabolic Syndrome
Harrison, S. A., Pence, M. M., Stratton, A., & Torres, D. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-37591-7.00027-6
Sureda, A., Capó, X., & Tejada, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816488-4.00007-3
Bischoff, S. C., Bernal, W. E., Dasarathy, S., Merli, M., Plank, L. D., Schütz, T., Plauth, M., Скрипник, І. М., & Shvets, O. (2021) · Modern Gastroenterology · doi:10.30978/mg-2021-1-59
Pancreas and Hepatobiliary Tract
Shah, R., Satyavada, S., & Davitkov, P. (2022) · Springer eBooks · doi:10.1007/978-3-030-94953-2_7
NAFLD – Prävention und ernährungsmedizinische Behandlungsmöglichkeiten
Roeb, E. (2022) · Ernährung & Medizin · doi:10.1055/a-1917-8335
Approaches in the Nutritional Management of Non Alcoholic Fatty Liver Disease
Suryavanshi, A., Sumar, A. I., Rathod, S. B., Rathod, S. B., & Rajbhar, K. (2023) · International Journal of Advanced Research in Science Communication and Technology · doi:10.48175/ijarsct-8677
MASLD – Prävention und ernährungsmedizinische Behandlungsmöglichkeiten
Roeb, E. (2023) · Aktuelle Ernährungsmedizin · doi:10.1055/a-2145-0934
Akdeniz diyeti ve Non alkolik yağlı karaciğer hastalığı
Bektaş, A., & Ulusoy, M. (2023) · Troia Medical Journal · doi:10.55665/troiamedj.1363991
Liu, Z., Jin, P., Liu, Y., Zhang, Z., Wu, X., Weng, M., Cao, S., Wang, Y., Zeng, C., Yang, R., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26036468
Wang, C., Song, Y., Wu, J., & Mei, H. (2026) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/cjgh/5125598
El‐Sehrawy, A. A. M. A., kandil, I., Elmazny, G. M., Salah, A. M., Abohassan, M., Alanazi, M. A., Labib, S., Eid, E. A., Jafarzadeh, F., & Elmahdy, R. (2026) · Scientific Reports · doi:10.1038/s41598-026-53487-3
Yang, C., Yu, H., Qu, Y., Wang, S., Guo, P., Fan, Z., & Cui, B. (2026) · Dermatologic Therapy · doi:10.1155/dth/8887579
Onay, T., & Uçar, A. (2026) · Nutrire · doi:10.1186/s41110-026-00527-7
Metadata
- Authors
- Kontogianni, M. D., Tileli, N., Margariti, A., Georgoulis, M., Deutsch, M., Tiniakos, D., Fragopoulou, E., Zafiropoulou, R., Manios, Y., & Papatheodoridis, G.
- Affiliations
- Harokopio University of Athens (GR)
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Kontogianni, Meropi D.
- Tileli, Nafsika
- Margariti, Aikaterini
- Georgoulis, Michael
- Deutsch, Melanie
- Tiniakos, Dina
- Fragopoulou, Elisabeth
- Zafiropoulou, Rodessa
- Papatheodoridis, George
- Venue
- Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 33
- Issue
- 4
- Pages
- 678-683
- ISSN
- 0261-5614 (ISSN-L)
- OpenAlex
- W2026099877
- Cited by
- 221
- References
- 34
- Citations by year
- 2026: 6 · 2025: 13 · 2024: 15 · 2023: 19 · 2022: 24 · 2021: 22 · 2020: 25 · 2019: 24 · 2018: 20 · 2017: 21 · 2016: 13 · 2015: 5 · 2014: 11
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- Mediterranean diet, non-alcoholic fatty liver disease, nonalcoholic steatohepatitis, dietary adherence, MedDietScore, insulin resistance, steatosis severity, adiponectin, alanine aminotransferase, liver stiffness
- MeSH terms
- Adolescent, Adult, Aged, Alanine Transaminase, Body Composition, Body Height, Body Weight, Cross-Sectional Studies, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Motor Activity, Patient Compliance, Body Mass Index, Logistic Models, Case-Control Studies, Diet, Mediterranean, Adiponectin, Waist Circumference, Young Adult, Non-alcoholic Fatty Liver Disease
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