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Cited by 128Nutritional Studies and DietFood composition and propertiesCardiovascular Health and Risk Factors

The DOI matches its Crossref record; 53 of the 55 references it cites were found in a registry or an index.

Association between dietary fiber intake and risk of coronary heart disease: A meta-analysis

Wu, Yihua, Qian, Yufeng, Pan, Yiwen, Li, Peiwei, Yang, Jun, Ye, Xianhua, Xu, Geng·2015·Clinical Nutrition
DOI 10.1016/j.clnu.2014.05.009
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Abstract

Background & aims The association between coronary heart disease (CHD) and dietary fiber intake is not consistent, especially for the subtypes of dietary fiber. The aim of our study was to conduct a meta-analysis of existing cohort published studies assessing the association between dietary fiber intake and risk of CHD, and quantitatively estimating their dose-response relationships.Methods We searched PubMed and EMBASE before May 2013. Random-effect model was used to calculate the pool relative risk (RRs) for the incidence and mortality of CHD. Dose-response, subgroup analyses based on fiber subtypes, heterogeneity and publication bias were also carried out.Results Eighteen studies involving 672,408 individuals were finally included in the present study. The pooled-adjusted RRs of coronary heart disease for the highest versus lowest category of fiber intake were 0.93 (95% confidence interval (CI), 0.91-0.96, P < 0.001) for incidence of all coronary events and 0.83 (95% CI, 0.76-0.91, P < 0.001) for mortality. Further subgroup analyses based on fiber subtypes (cereal, fruit, and vegetable fiber), indicated that RRs were 0.92 (95% CI, 0.85-0.99, P = 0.032), 0.92 (95% CI, 0.86-0.98, P = 0.01), 0.95 (95% CI, 0.89-1.01, P = 0.098) respectively for all coronary event and 0.81 (95% CI, 0.72-0.92, P = 0.001), 0.68 (95% CI, 0.43-1.07, P = 0.094), 0.91 (95% CI, 0.74-1.12, P = 0.383) for mortality. In addition, a significant dose-response relationship was observed between fiber intake and the incidence and mortality of CHD (P < 0.001).Conclusions Our results indicate that consumption of dietary fiber is inversely associated with risk of coronary heart disease, especially for fiber from cereals and fruits. Besides, soluble and insoluble fibers have the similar effect. A significant dose-response relationship is also observed between fiber intake and CHD risk.

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Metadata

Authors
Wu, Y., Qian, Y., Pan, Y., Li, P., Yang, J., Ye, X., & Xu, G.
Affiliations
  • Zhejiang University (CN)
  • Second Affiliated Hospital of Zhejiang University (CN)
  • Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
Corresponding author
  • Ye, Xianhua
  • Xu, Geng
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2015-08
Volume
34
Issue
4
Pages
603-611
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2014.05.009
OpenAlex
W2143938233
Cited by
128
References
55
Citations by year
2026: 4 · 2025: 4 · 2024: 10 · 2023: 6 · 2022: 12 · 2021: 9 · 2020: 15 · 2019: 13 · 2018: 14 · 2017: 18 · 2016: 16 · 2015: 4
FWCI
2.10
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Natural Science Foundation of China (81302455)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Nursing › Nutrition and Dietetics › Food composition and properties
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
dietary fiber, coronary artery disease, cardiovascular risk, cereal fiber, fruit fiber, plant fibers, soluble dietary fiber, insoluble dietary fiber, dose-response relationship, coronary heart disease mortality, coronary heart disease incidence, cohort studies, publication bias, study heterogeneity, cardiovascular disease prevention, nutrition and disease prevention
MeSH terms
Edible Grain, Coronary Artery Disease, Dietary Fiber, Fruit, Humans, Risk Factors, Vegetables, Incidence, Databases, Factual

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