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Cited by 147Circadian rhythm and melatoninAntioxidant Activity and Oxidative StressDiabetes Treatment and Management

The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.

RETRACTED: Melatonin administration lowers biomarkers of oxidative stress and cardio-metabolic risk in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial

Raygan, Fariba, Ostadmohammadi, Vahidreza, Bahmani, Fereshteh, Reiter, Russel J., Asemi, Zatollah·2019·Clinical Nutrition
DOI 10.1016/j.clnu.2017.12.004
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Abstract

Background & aims Melatonin may benefit diabetic people with coronary heart disease (CHD) through its beneficial effects on biomarkers of oxidative stress and cardio-metabolic risk. This investigation evaluated the effects of melatonin administration on metabolic status in diabetic patients with CHD.Methods This randomized, double-blind, placebo-controlled trial was conducted and involved 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to receive either 10 mg melatonin (2 melatonin capsules, 5 mg each) (n = 30) or placebo (n = 30) once a day for 12 weeks.Results Compared with the placebo, melatonin supplementation resulted in significant increases in plasma glutathione (GSH) (+64.7 ± 105.7 vs. -11.1 ± 137.6 μmol/L, P = 0.02) and nitric oxide (NO) (+0.9 ± 4.7 vs. -3.3 ± 9.6 μmol/L, P = 0.03), and significant decreases in malondialdehyde (MDA) (-0.2 ± 0.3 vs. +0.1 ± 0.5 μmol/L, P = 0.007), protein carbonyl (PCO) (-0.12 ± 0.08 vs. +0.03 ± 0.07 mmol/mg protein, P < 0.001) and serum high sensitivity C-reactive protein (hs-CRP) levels (-1463.3 ± 2153.8 vs. +122.9 ± 1230.4 ng/mL, P = 0.001). In addition, taking melatonin, compared with the placebo, significantly reduced fasting plasma glucose (-29.4 ± 49.0 vs. -5.5 ± 32.4 mg/dL, P = 0.03), serum insulin concentrations (-2.2 ± 4.1 vs. +0.7 ± 4.2 μIU/mL, P = 0.008), homeostasis model of assessment-estimated insulin resistance (-1.0 ± 2.2 vs. +0.01 ± 1.6, P = 0.04), total-/HDL-cholesterol ratio (-0.18 ± 0.38 vs. +0.03 ± 0.35, P = 0.02) and systolic (-4.3 ± 9.6 vs. +1.0 ± 7.5 mmHg, P = 0.01) and diastolic blood pressure (-2.8 ± 7.3 vs. +0.1 ± 3.6 mmHg, P = 0.04). Melatonin treatment also significantly increased quantitative insulin sensitivity check index (+0.006 ± 0.01 vs. -0.004 ± 0.01, P = 0.01) and serum HDL-cholesterol (+2.6 ± 5.5 vs. -0.01 ± 4.4 mg/dL, P = 0.04). Supplementation with melatonin had no significant effect on other metabolic parameters.Conclusions Overall, melatonin intake for 12 weeks to diabetic patients with CHD had beneficial effects on plasma GSH, NO, MDA, PCO, serum hs-CRP levels, glycemic control, HDL-cholesterol, total-/HDL-cholesterol ratio, blood pressures and parameters of mental health. Registered under ClinicalTrials.gov Identifier no. http://www.irct.ir: IRCT2017051333941N1.

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Crossref · 10.1016/j.clnu.2017.12.004This paper is marked retracted.

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Metadata

Authors
Raygan, F., Ostadmohammadi, V., Bahmani, F., Reiter, R. J., & Asemi, Z.
Affiliations
  • Kashan University of Medical Sciences (IR)
  • The University of Texas at San Antonio Health Science Center (US)
ORCID
Venue
Clinical Nutrition
Publisher
Elsevier BV
Published
2019-02
Volume
38
Issue
1
Pages
191-196
ISSN
0261-5614 (ISSN-L)
DOI
10.1016/j.clnu.2017.12.004
OpenAlex
W2774713064
Cited by
147
References
30
Citations by year
2026: 5 · 2025: 15 · 2024: 28 · 2023: 14 · 2022: 23 · 2021: 17 · 2020: 18 · 2019: 16
FWCI
7.55
Type
journal article
Language
en
Status
Retracted
Update notices
Open access
closed
Licence
Locations
  • Clinical Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Vice-chancellor for Research, KUMS, Kashan, and Iran (96025)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
melatonin supplementation, type 2 diabetes, coronary artery disease, oxidative stress, cardiometabolic risk, insulin resistance, insulin sensitivity, lipid profile, C-reactive protein, inflammation, nitric oxide, glutathione, malondialdehyde, protein carbonyls, fasting blood glucose, serum insulin, HDL cholesterol, LDL cholesterol, HDL/HDL2 ratio, HDL2
MeSH terms
Aged, Aged, 80 and over, Antioxidants, Blood Glucose, Blood Pressure, C-Reactive Protein, Coronary Disease, Diabetes Mellitus, Type 2, Double-Blind Method, Female, Glutathione, Humans, Insulin, Cholesterol, HDL, Male, Malondialdehyde, Melatonin, Middle Aged, Nitric Oxide, Biomarkers, Oxidative Stress

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