Melatonin treatment in peri‐ and postmenopausal women elevates serum high‐density lipoprotein cholesterol levels without influencing total cholesterol levels
Abstract
Abstract: The purpose of this study was to investigate the effects of melatonin on lipid metabolism in peri‐ and postmenopausal women. Forty‐six women were enrolled in these studies. The relationship between night‐time serum melatonin levels and serum total cholesterol, triglycerides, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol was investigated in 36 women. Night‐time serum melatonin levels had a negative correlation with serum total cholesterol and LDL‐cholesterol, and a loose positive correlation with HDL‐cholesterol. To examine the effects of exogenous melatonin on lipid metabolism, serum levels of total cholesterol, HDL‐cholesterol, LDL‐cholesterol and triglycerides were determined in 10 women before the onset of therapy and after 1 month of oral melatonin administration (1 mg melatonin daily). Melatonin administration significantly increased the serum levels of HDL‐cholesterol. These results show that melatonin may influence cholesterol metabolism and suggest that the melatonin administration may become a new medical application for improvement of lipid metabolism and prevention of cardiovascular disease in peri‐ and postmenopausal women.
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Melatonin administration may improve lipid profiles in lean subjects.
“Lean subjects may also profit from melatonin administration as well, as it improved lipid profiles.171,172”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [172]
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Self-citation
- Authors
- Tamura, H., Nakamura, Y., Narimatsu, A., Yamagata, Y., Takasaki, A., Reiter, R. J., & Sugino, N.
- Affiliations
- The University of Texas at San Antonio Health Science Center (US)
- Yamaguchi Prefecture Central Hospital (JP)
- Ogori Daiichi General Hospital (JP)
- Yamaguchi University (JP)
- Saiseikai Shimonoseki General Hospital (JP)
- Corresponding author
- Tamura, Hiroshi
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2008-07-14
- Volume
- 45
- Issue
- 1
- Pages
- 101-105
- ISSN
- 0742-3098 (ISSN-L)
- 1600-079X
- OpenAlex
- W2121214240
- Cited by
- 77
- References
- 48
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 8 · 2014: 6 · 2013: 7 · 2012: 7
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Institute for Molecular and Cellular Regulation, Gunma University
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- melatonin, HDL cholesterol, lipid metabolism, postmenopausal women, perimenopausal women, total cholesterol, LDL cholesterol, triglycerides, cardiovascular disease prevention
- MeSH terms
- Adult, Aged, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Melatonin, Middle Aged, Triglycerides, Postmenopause, Perimenopause
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