Cited by 77Circadian rhythm and melatoninMenopause: Health Impacts and TreatmentsLipoproteins and Cardiovascular Health

Melatonin treatment in peri‐ and postmenopausal women elevates serum high‐density lipoprotein cholesterol levels without influencing total cholesterol levels

Tamura, Hiroshi, Nakamura, Yasuhiko, Narimatsu, Akio, Yamagata, Yoshiaki, Takasaki, Akihisa, Reiter, Russel J., Sugino, Norihiro·2008·Journal of Pineal Research

Abstract

Abstract: The purpose of this study was to investigate the effects of melatonin on lipid metabolism in peri‐ and postmenopausal women. Forty‐six women were enrolled in these studies. The relationship between night‐time serum melatonin levels and serum total cholesterol, triglycerides, high‐density lipoprotein (HDL) cholesterol, low‐density lipoprotein (LDL) cholesterol was investigated in 36 women. Night‐time serum melatonin levels had a negative correlation with serum total cholesterol and LDL‐cholesterol, and a loose positive correlation with HDL‐cholesterol. To examine the effects of exogenous melatonin on lipid metabolism, serum levels of total cholesterol, HDL‐cholesterol, LDL‐cholesterol and triglycerides were determined in 10 women before the onset of therapy and after 1 month of oral melatonin administration (1 mg melatonin daily). Melatonin administration significantly increased the serum levels of HDL‐cholesterol. These results show that melatonin may influence cholesterol metabolism and suggest that the melatonin administration may become a new medical application for improvement of lipid metabolism and prevention of cardiovascular disease in peri‐ and postmenopausal women.

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Crossref · 10.1111/j.1600-079x.2008.00561.x

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Authors
Tamura, H., Nakamura, Y., Narimatsu, A., Yamagata, Y., Takasaki, A., Reiter, R. J., & Sugino, N.
Affiliations
  • The University of Texas at San Antonio Health Science Center (US)
  • Yamaguchi Prefecture Central Hospital (JP)
  • Ogori Daiichi General Hospital (JP)
  • Yamaguchi University (JP)
  • Saiseikai Shimonoseki General Hospital (JP)
Corresponding author
Tamura, Hiroshi
Venue
Journal of Pineal Research
Publisher
Wiley
Published
2008-07-14
Volume
45
Issue
1
Pages
101-105
ISSN
  • 0742-3098 (ISSN-L)
  • 1600-079X
OpenAlex
W2121214240
Cited by
77
References
48
Citations by year
2026: 1 · 2024: 5 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 4 · 2019: 7 · 2018: 7 · 2017: 7 · 2016: 8 · 2014: 6 · 2013: 7 · 2012: 7
FWCI
1.19
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Pineal Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Institute for Molecular and Cellular Regulation, Gunma University
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Keywords
melatonin, HDL cholesterol, lipid metabolism, postmenopausal women, perimenopausal women, total cholesterol, LDL cholesterol, triglycerides, cardiovascular disease prevention
MeSH terms
Adult, Aged, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Melatonin, Middle Aged, Triglycerides, Postmenopause, Perimenopause

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