Melatonin treatment improves blood pressure, lipid profile, and parameters of oxidative stress in patients with metabolic syndrome: Melatonin in metabolic syndrome
Abstract
Experimental studies have proven that melatonin has many beneficial pleiotropic actions. The aim of this study was to assess melatonin efficacy in patients with metabolic syndrome (MS). The study included 33 healthy volunteers (who were not treated with melatonin) and 30 patients with MS, who did not respond to 3-month lifestyle modification. Patients with MS were treated with melatonin (5 mg/day, 2 hr before bedtime) for 2 months. The following parameters were studied: systolic and diastolic blood pressure (SBP, DBP), levels of glucose, serum lipids, C-reactive protein, fibrinogen, activities of antioxidative enzymes: catalase (CAT), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), thiobarbituric acid reactive substrates (TBARS). After 2-month therapy in comparison with baseline, the following significant changes were measured: systolic blood pressure (132.8±9.8 versus 120.5±11.0 mmHg, P<0.001), DBP (81.7±8.8 versus 75±7.4 mmHg, P<0.01), low-density lipoprotein cholesterol (LDL-C) (149.7±26.4 versus 139.9±30.2 mg/dL, P<0.05), TBARS (0.5±0.2 versus 0.4±0.1 μm/gHb, P<0.01), and CAT (245.9±46.9 versus 276.8±39.4 U/gHb). Melatonin administered for 2 months significantly improved antioxidative defense (increase in CAT activity, decrease in TBARS level) and lipid profile (decrease in LDL-C), and lowered blood pressure. We conclude that melatonin therapy may be of benefit for patients with MS, particularly with arterial hypertension. Further studies with higher doses of melatonin or prolonged supplementation are awaited.
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Sample size was calculated as 21 subjects per group using 95% CI and 90% power based on mean±SD HDL-c from a cited study; assuming 10% dropout, 23 per group.
“The mean ± standard deviation (SD) of high-density lipoprotein cholesterol (HDL-c) 21 was applied for sample size computation. Considering the confidence interval (CI) of 95% and power of 90%, 21 subjects were calculated for each group. Supposing a 10% drop-out rate, the sample size for each group is considered 23.”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [21]
Melatonin (5 mg/day, two hours before bedtime) improved LDL cholesterol and blood pressure in thirty metabolic syndrome patients after two months.
“Improvements in LDL cholesterol and blood pressure have been shown in as few as two months of melatonin use (5 mg/day, two hours before bedtime) in thirty patients with documented metabolic syndrome who had not responded to a three-month intervention of therapeutic lifestyle modifications [119].”
From Is Melatonin the “Next Vitamin D”?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements (2022) · cites this paper as [119]
Melatonin administration may improve lipid profiles in lean subjects.
“Lean subjects may also profit from melatonin administration as well, as it improved lipid profiles.171,172”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [171]
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Misra, H. P., & Fridovich, I. (1972) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)45228-9 · Cited by 9,097 · see citing works
A SPECTROPHOTOMETRIC METHOD FOR MEASURING THE BREAKDOWN OF HYDROGEN PEROXIDE BY CATALASE
Beers, R. F., & Sizer, I. W. (1952) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)50881-x · Cited by 6,781 · see citing works
Regulation of antioxidant enzymes: a significant role for melatonin
Rodrı́guez, C., Mayo, J. C., Sainz, R. M., Antolı́n, I., Herrera, F., Martı́n, V., & Reiter, R. J. (2003) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00092.x · Cited by 1,990 · see citing works
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601 · see citing works
The Autoxidation of Human Red Cell Lipids Induced by Hydrogen Peroxide
Stocks, J., & Dormandy, T. L. (1971) · British Journal of Haematology · doi:10.1111/j.1365-2141.1971.tb00790.x · Cited by 973 · see citing works
Drabkin, D. L. (1946) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41272-5 · Cited by 923 · see citing works
Stern, M. P., Williams, K., González-Villalpando, C., Hunt, K. J., & Haffner, S. M. (2004) · Diabetes Care · doi:10.2337/diacare.27.11.2676 · Cited by 735 · see citing works
The chemistry of melatonin's interaction with reactive species
Allegra, M., Reiter, R. J., Tan, D. ‐., Gentile, C., Tesoriere, L., & Livrea, M. A. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02112.x · Cited by 718 · see citing works
Tamura, H., Takasaki, A., Miwa, I., Taniguchi, K., Maekawa, R., Asada, H., Taketani, T., Matsuoka, A., Yamagata, Y., 嶋村, 勝., et al. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00524.x · Cited by 694 · see citing works
Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin
Reiter, R. J., Paredes, S. D., Manchester, L. C., & Tan, D.-X. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903044914 · Cited by 477 · see citing works
Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 474 · see citing works
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451 · see citing works
Techniques in Free Radical Research
(1991) · Laboratory techniques in biochemistry and molecular biology · doi:10.1016/s0075-7535(08)x7003-2 · Cited by 441 · see citing works
Melatonin: reducing the toxicity and increasing the efficacy of drugs
Reiter, R. J., Tan, D., Sainz, R. M., Mayo, J. C., & López‐Burillo, S. (2002) · Journal of Pharmacy and Pharmacology · doi:10.1211/002235702760345374 · Cited by 418 · see citing works
Cardiovascular diseases: protective effects of melatonin
Tengattini, S., Reiter, R. J., Tan, D., Terrón, M. P., Rodella, L. F., & Rezzani, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 337 · see citing works
Gitto, E., Pellegrino, S., Gitto, P., Barberi, I., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00649.x · Cited by 291 · see citing works
Melatonin ameliorates nonalcoholic fatty liver induced by high‐fat diet in rats
Pan, M., Song, Y., Xu, J., & Gan, H. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00346.x · Cited by 170 · see citing works
Melatonin reduces night blood pressure in patients with nocturnal hypertension
Grossman, E., Laudon, M., Yalcin, R., Zengil, H., Peleg, E., Sharabi, Y., Kamari, Y., Shen-Orr, Z., & Zisapel, N. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.02.002 · Cited by 168 · see citing works
Prolonged melatonin administration decreases nocturnal blood pressure in women
CAGNACCI, A., CANNOLETTA, M., RENZI, A., BALDASSARI, F., ARANGINO, S., & VOLPE, A. (2005) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2005.05.008 · Cited by 156 · see citing works
Jung, K. H., Hong, S., Zheng, H., Lee, H., Lee, D., Lee, D., Lee, S. Y., & Hong, S. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00748.x · Cited by 150 · see citing works
Impaired nocturnal melatonin secretion in non-dipper hypertensive patients.
Jonas, M., Garfinkel, D., Zisapel, N., Laudon, M., & Grossman, E. (2003) · PubMed · Cited by 149 · see citing works
Parallel Morning and Evening Surge in Stroke Onset, Blood Pressure, and Physical Activity
Stergiou, G. S., Vemmos, K. N., Pliarchopoulou, K. M., Synetos, A. G., Roussias, L. G., & Mountokalakis, T. D. (2002) · Stroke · doi:10.1161/01.str.0000016971.48972.14 · Cited by 147 · see citing works
Hoyos, M. G., Guerrero, J. M., Pérez‐Cano, R., Oliván, J., Romero, F. F., García‐Pergañeda, A., & Osuna, C. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.280304.x · Cited by 123 · see citing works
Samantaray, S., Sribnick, E. A., Das, A., et al. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00534.x · Cited by 118 · see citing works
Zeman, M., Dulková, K., Bada, V., & Herichová, I. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.08.034 · Cited by 94 · see citing works
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Kozakiewicz, M., Pawluk, H., Czuczejko, J., Kornatowski, T., Bartosz, G., & Kędziora, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00666.x · Cited by 87 · see citing works
Pecháňová, O., Zicha, J., Paulis, L., Zenebe, W. J., Dobešová, Z., Vranková, S., Jendeková, L., Sládková, M., Dovinová, I., Šimko, F., et al. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2007.01.035 · Cited by 86 · see citing works
Effect of melatonin on the maintenance of cholesterol homeostasis in the rat
Chan, T. Y., & Tang, P. L. (1995) · Endocrine Research · doi:10.1080/07435809509030483 · Cited by 80 · see citing works
Effect of melatonin on cholesterol absorption in rats
Hussain, S. A. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00415.x · Cited by 79 · see citing works
Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment
Šimko, F., & Pecháňová, O. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00697.x · Cited by 78 · see citing works
Tamura, H., Nakamura, Y., Narimatsu, A., Yamagata, Y., Takasaki, A., Reiter, R. J., & Sugino, N. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00561.x · Cited by 77 · see citing works
Melatonin–insulin interactions in patients with metabolic syndrome
Robeva, R. N., Кirilov, G., Tomova, A., & Kumanov, P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00527.x · Cited by 76 · see citing works
Blood pressure‐lowering effect of melatonin in type 1 diabetes
Cavallo, A., Daniels, S. R., Dolan, L. M., Bean, J. A., & Khoury, J. C. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00126.x · Cited by 69 · see citing works
Filippis, D. D., Iuvone, T., Esposito, G., Steardo, L., Arnold, G. H., Paul, A. P., Joris, G., & Benedicte, Y. D. W. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00526.x · Cited by 65 · see citing works
Mullerwieland, D., Behnke, B., Koopmann, K., & Krone, W. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2198 · Cited by 64 · cited 1× · see citing works
“The results of animal studies suggest several mechanisms that may be responsible for the hypolipidemic effects of melatonin: decrease in intestinal cholesterol absorption [33], inhibition of cholesterol biosynthesis and LDL-C accumulation [34], interactions with LDL-C receptors [35], or inhibition of fatty acid transp…”
BackgroundAntioxidative effects of melatonin administration in elderly primary essential hypertension patients
Kędziora–Kornatowska, K., Szewczyk‐Golec, K., Czuczejko, J., Pawluk, H., de Lumen, K. V. M., Kozakiewicz, M., Bartosz, G., & Kędziora, J. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00592.x · Cited by 60 · see citing works
Melatonin and estradiol effects on food intake, body weight, and leptin in ovariectomized rats
Sánchez, S., Alonso‐González, C., González, A., Martínez‐Campa, C., Mediavilla, M. D., Cos, S., & Sánchez‐Barceló, E. J. (2007) · Maturitas · doi:10.1016/j.maturitas.2007.06.006 · Cited by 59 · see citing works
Blood pressure response to melatonin in type 1 diabetes
Cavallo, A., Daniels, S. R., Dolan, L. M., Khoury, J. C., & Bean, J. A. (2004) · Pediatric Diabetes · doi:10.1111/j.1399-543x.2004.00031.x · Cited by 40 · see citing works
Carampin, P., Rosan, S., Dalzoppo, D., Zagotto, G., & Zatta, P. F. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00020.x · Cited by 40 · see citing works
Melatonin attenuates lipopolysaccharide‐induced acute lung inflammation in sleep‐deprived mice
Lee, Y., Kim, J., Lee, K., et al. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00621.x · Cited by 37 · see citing works
Dauchy, R. T., Blask, D. E., Sauer, L. A., et al. (2003) · PubMed · Cited by 32 · see citing works
Ding, C., Cao, Y., Zhou, L., et al. (2001) · PubMed · Cited by 25 · see citing works
Okatani, Y., Wakatsuki, A., Watanabe, K., et al. (2001) · European Journal of Pharmacology · doi:10.1016/s0014-2999(01)00802-0 · Cited by 14 · see citing works
Flagged first, then by citations
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Sorted by citations
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Karamitri, A., & Jockers, R. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0130-1 · Cited by 268 · see citing works
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Smolensky, M. H., Hermida, R. C., & Portaluppi, F. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.003 · Cited by 237 · see citing works
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
Lucassen, E. A., Rother, K. I., & Cizza, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06655.x · Cited by 191 · see citing works
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Ferlazzo, N., Andolina, G., Cannata, A., Costanzo, M. G., Rizzo, V., Currò, M., Ientile, R., & Caccamo, D. (2020) · Antioxidants · doi:10.3390/antiox9111088 · Cited by 189 · see citing works
Minich, D. M., Henning, M., Darley, C., Fahoum, M., Schuler, C. B., & Frame, J. (2022) · Nutrients · doi:10.3390/nu14193934 · Cited by 176 · see citing works
“Improvements in LDL cholesterol and blood pressure have been shown in as few as two months of melatonin use (5 mg/day, two hours before bedtime) in thirty patients with documented metabolic syndrome who had not responded to a three-month intervention of therapeutic lifestyle modifications [120].”
BackgroundRaygan, F., Ostadmohammadi, V., Bahmani, F., Reiter, R. J., & Asemi, Z. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2017.12.004 · Cited by 147 · see citing works
RetractedFoley, H. M., & Steel, A. E. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2018.11.003 · Cited by 144 · see citing works
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Kitagawa, A., Ohta, Y., & Ohashi, K. (2012) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00955.x · Cited by 116 · see citing works
Szewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works
Farias, T. D. S. M. D., Cruz, M. M., Sa, R. C. D. C. D., Severi, I., Perugini, J., Senzacqua, M., Cerutti, S. M., Giordano, A., Cinti, S., & Alonso-Vale, M. I. C. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00750 · Cited by 74 · see citing works
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Bahrami, M., Cheraghpour, M., Jafarirad, S., Alavinejad, P., Asadi, F., Hekmatdoost, A., Mohammadi, M., & Yari, Z. (2020) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2020.102452 · Cited by 60 · see citing works
Doosti-Irani, A., Ostadmohammadi, V., Mirhosseini, N., Mansournia, M., Reiter, R., Kashanian, M., Rahimi, M., Razavi, M., & Asemi, Z. (2018) · Hormone and Metabolic Research · doi:10.1055/a-0752-8462 · Cited by 52 · see citing works
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Onaolapo, A. Y., Adebisi, E. O., Adeleye, A. E., Olofinnade, A. T., & Onaolapo, O. J. (2020) · Endocrine, Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530319666191009161228 · Cited by 20 · see citing works
Noordam, R., Ramkisoensing, A., Loh, N. Y., Neville, M. J., Rosendaal, F. R., Willems van Dijk, K., van Heemst, D., Karpe, F., Christodoulides, C., & Kooijman, S. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02532 · Cited by 20 · see citing works
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- Authors
- Koziróg, M., Poliwczak, A. R., Duchnowicz, P., Koter-Michalak, M., Sikora, J., & Broncel, M.
- Affiliations
- Medical University of Lodz (PL)
- University of Łódź (PL)
- Corresponding author
- Broncel, Marlena
- Venue
- Journal of Pineal Research
- Publisher
- Wiley
- Published
- 2010-12-08
- Volume
- 50
- Issue
- 3
- Pages
- 261-266
- ISSN
- 0742-3098 (ISSN-L)
- OpenAlex
- W2100741632
- Cited by
- 299
- References
- 44
- Citations by year
- 2026: 9 · 2025: 4 · 2024: 20 · 2023: 24 · 2022: 19 · 2021: 22 · 2020: 20 · 2019: 21 · 2018: 26 · 2017: 21 · 2016: 20 · 2015: 15 · 2014: 31 · 2013: 25 · 2012: 12
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Pineal Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Keywords
- melatonin, metabolic syndrome, blood pressure, hypertension, lipid profile, LDL cholesterol, oxidative stress, antioxidant enzymes, catalase, lipid peroxidation, C-reactive protein, fibrinogen
- MeSH terms
- Blood Pressure, Catalase, Glutathione Peroxidase, Humans, Lipids, Cholesterol, LDL, Melatonin, Superoxide Dismutase, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Metabolic Syndrome
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