A Double-Blind, Placebo-Controlled Trial Related to the Effects of Melatonin on Oxidative Stress and Inflammatory Parameters of Obese Women
Open accessAbstract
Obesity, the global epidemic health problem, results in chronic disorders. Melatonin supplementation may prevent the adverse health consequences of obesity. The aim of this study was to assess the effects of melatonin supplementation on inflammatory and oxidative stress parameters in obese women. In randomized, double-blind, placebo-controlled trial, 44 obese women were randomly assigned to melatonin (n=22) and placebo (n=22) groups. Subjects were supplemented with a daily dose of 6 mg melatonin or placebo with low calorie diet for 40 days. Serum TNF-α, IL-6, hsCRP, TAC, and MDA levels were assessed before and after intervention. In the melatonin group, mean serum TNF-α, IL-6, hsCRP, and MDA levels decreased significantly (p<0.05) from 3.52±0.72 pg/ml, 27.12±6.32 pg/ml, 2.54±0.49 mg/l, and 3.81±0.29 nmol/l to 1.73±0.07, 16.34±6.32, 1.67±0.27, and 2.79±0.29, respectively. Whilst in the placebo group the decrease in values were not statistically significant. Mean TAC level increased slightly (from 1.11±0.30 to 1.14±0.45 mmol/l) in the melatonin group whereas it decreased slightly (from 1.13±0.15 to 1.08±0.21 nmol/l) in the placebo group. Significant differences were observed only for TNF-α (p=0.02) and IL-6 (p=0.03) between the 2 study groups. Considering the improvements in inflammatory and oxidative stress factors in obese women, it seems that melatonin supplementation may provide beneficial effects in obesity treatment by ameliorating some of its complications. However, further studies are needed to make concise conclusions.
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Investigations about melatonin's effect on obesity in humans are scarce.
“The investigations about melatonin's effect on obesity in humans are scarce. 18-20”
From Melatonin supplementation improves glycemic hemostasis, lipid profile, and adipokine concentrations of obese women: A double-blind randomized clinical trial (2024) · cites this paper as [18]
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RetractedSzewczyk-Golec, K., Rajewski, P., Gackowski, M., Mila-Kierzenkowska, C., Wesołowski, R., Sutkowy, P., Pawłowska, M., & Woźniak, A. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/8494107 · Cited by 92 · see citing works
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Exogenous melatonin decreases circadian misalignment and body weight among early types
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Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works
Self-citation
- Authors
- Mesri Alamdari, N., Mahdavi, R., Roshanravan, N., Lotfi Yaghin, N., Ostadrahimi, A., & Faramarzi, E.
- Affiliations
- Students Research Committee, School of Nutrition, Tabriz University of Medical Science, Tabriz, Iran
- Tabriz University of Medical Sciences (IR)
- Venue
- Hormone and Metabolic Research
- Publisher
- Georg Thieme Verlag KG
- Published
- 2014-08-15
- Volume
- 47
- Issue
- 07
- Pages
- 504-508
- ISSN
- 0018-5043 (ISSN-L)
- 1439-4286
- OpenAlex
- W2331503031
- Cited by
- 93
- References
- 2
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 10 · 2023: 6 · 2022: 6 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 11 · 2017: 8 · 2016: 4 · 2015: 3
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Hormone and Metabolic Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- melatonin supplementation, obesity, oxidative stress, inflammation, TNF-α, interleukin-6, C-reactive protein, lipid peroxidation, malondialdehyde, women, hypocaloric diet
- MeSH terms
- Adult, C-Reactive Protein, Double-Blind Method, Female, Humans, Inflammation, Insulin Resistance, Malondialdehyde, Melatonin, Obesity, Tumor Necrosis Factor-alpha, Interleukin-6, Treatment Outcome, Oxidative Stress
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