Banking on ATM as a new target in metabolic syndrome
Open accessAbstract
In this issue of Cell Metabolism, Semenkovich and his colleagues show that ATM, a protein well known for its roles in the cellular response to DNA breaks, may also be linked to metabolic and cardiovascular diseases (Schneider et al., 2006). ATM seemingly does this by inhibiting JNK, a stress kinase involved in inflammation with related effects in insulin resistance and atherosclerosis. In an interesting twist, the authors show that chloroquine, an antimalarial drug, also activates ATM, which inhibits JNK, and improves insulin sensitivity and cardiovascular effects. These findings provide potential new insights into the pathogenesis and treatment of metabolic syndrome.
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The M1 macrophage population demonstrates a positive correlation with insulin resistance and dominates in states of overnutrition by targeting FFA-mediated increases in proinflammatory responses.
“The M1 population demonstrates a positive correlation with insulin resistance and dominates in states of overnutrition by targeting FFA-mediated increases in proinflammatory responses (14,40).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [40]
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- Authors
- Shoelson, S. E.
- Affiliations
- Joslin Diabetes Center (US)
- Corresponding author
- Shoelson, Steven E.
- ORCID
- Shoelson, Steven E.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2006-11
- Volume
- 4
- Issue
- 5
- Pages
- 337-338
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2021872118
- Cited by
- 29
- References
- 7
- Citations by year
- 2022: 1 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2450 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- ATM kinase, metabolic syndrome, JNK, chloroquine, insulin resistance, atherosclerosis, inflammation, cardiovascular disease, antimalarial drugs, kinase activation
- MeSH terms
- Animals, Chloroquine, DNA-Binding Proteins, Macrophages, Mutation, Phosphoprotein Phosphatases, Signal Transduction, Protein Serine-Threonine Kinases, Mice, Knockout, Cell Cycle Proteins, Metabolic Syndrome, Tumor Suppressor Proteins, Atherosclerosis, Mice, Dual-Specificity Phosphatases, Ataxia Telangiectasia Mutated Proteins
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