New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress

Crosstalk of reactive oxygen species and NF-κB signaling

Morgan, M. J., & Liu, Z.-G. (2011) · Cell Research · doi:10.1038/cr.2010.178 · Cited by 3,505 · see citing works

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage

Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075 · see citing works

Mitochondrial free radical generation, oxidative stress, and aging

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693 · see citing works

ATM and related protein kinases: safeguarding genome integrity

Shiloh, Y. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1011 · Cited by 2,577 · see citing works

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798 · see citing works

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

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ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Brugarolas, J., Lei, K., Hurley, R. L., Manning, B. D., Reiling, J. H., Hafen, E., Witters, L. A., Ellisen, L. W., & Kaelin, W. G. (2004) · Genes & Development · doi:10.1101/gad.1256804 · Cited by 1,384 · see citing works

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

Ito, K., Hirao, A., Arai, F., Matsuoka, S., Takubo, K., Hamaguchi, I., Nomiyama, K., Hosokawa, K., Sakurada, K., Nakagata, N., et al. (2004) · Nature · doi:10.1038/nature02989 · Cited by 1,175 · cited 1× · see citing works

ATM Activation by Oxidative Stress

Guo, Z., Kozlov, S., Lavin, M. F., Person, M. D., & Paull, T. T. (2010) · Science · doi:10.1126/science.1192912 · Cited by 1,079 · see citing works

Role of oxidative stress and DNA damage in human carcinogenesis

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Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901 · see citing works

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

Riballo, E., Kühne, M., Rief, N., Doherty, A., Smith, G. C. M., Recio, M.-J., Reis, C., Dahm, K., Fricke, A., Krempler, A., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.10.029 · Cited by 837 · see citing works

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma.Preprint

Xu, Y., Ashley, T., Brainerd, E. E., Bronson, R. T., Meyn, M. S., & Baltimore, D. (1996) · Genes & Development · doi:10.1101/gad.10.19.2411 · Cited by 830 · see citing works

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762 · see citing works

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758 · see citing works

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717 · see citing works

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

Nussenzweig, A., Chen, C., Soares, V. D. C., Sanchez, M., Sokol, K. A., Nussenzweig, M. C., & Li, G. C. (1996) · Nature · doi:10.1038/382551a0 · Cited by 662 · see citing works

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644 · see citing works

Redox Regulation of NF-κB Activation: Distinct Redox Regulation Between the Cytoplasm and the Nucleus

Kabe, Y., Ando, K., Hirao, S., Yoshida, M., & Handa, H. (2005) · Antioxidants & Redox Signaling · doi:10.1089/ars.2005.7.395 · Cited by 585 · see citing works

Mechanisms that regulate production of reactive oxygen species by cytochrome P450

Zangar, R. C. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.01.018 · Cited by 555 · see citing works

Molecular Linkage Between the Kinase ATM and NF-κB Signaling in Response to Genotoxic Stimuli

Wu, Z., Shi, Y., Tibbetts, R. S., & Miyamoto, S. (2006) · Science · doi:10.1126/science.1121513 · Cited by 515 · see citing works

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

Elson, A., Wang, Y., Daugherty, C., Morton, C. C., Zhou, F., Campos-Torres, J., & Leder, P. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13084 · Cited by 498 · see citing works

RACK1 Competes with HSP90 for Binding to HIF-1α and Is Required for O2-Independent and HSP90 Inhibitor-Induced Degradation of HIF-1α

Liu, Y. V., Baek, J. H., Zhang, H., Diez, R., Cole, R. N., & Semenza, G. L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.001 · Cited by 477 · see citing works

AP Endonuclease-Independent DNA Base Excision Repair in Human Cells

Wiederhold, L. R., Leppard, J. B., Kedar, P. S., Karimi‐Busheri, F., Rasouli‐Nia, A., Weinfeld, M., Tomkinson, A. E., Izumi, T., Prasad, R., Wilson, S. H., et al. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.06.003 · Cited by 472 · see citing works

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

Gu, Y., Seidl, K. J., Rathbun, G. A., Zhu, C., Manis, J. P., van der Stoep, N., Davidson, L., Cheng, H.-L., Sekiguchi, J., Frank, K. M., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80386-6 · Cited by 451 · see citing works

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

Zhu, C., Bogue, M. A., Lim, D., Hasty, P., & Roth, D. B. (1996) · Cell · doi:10.1016/s0092-8674(00)80111-7 · Cited by 433 · see citing works

The endless tale of non-homologous end-joining

Weterings, E., & Chen, D. J. (2008) · Cell Research · doi:10.1038/cr.2008.3 · Cited by 418 · see citing works

PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

Bozulic, L., Sürücü, B., Hynx, D., & Hemmings, B. A. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.024 · Cited by 386 · see citing works

Tumor Hypoxia in Cancer Therapy

Brown, J. M. (2007) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(07)35015-5 · Cited by 359 · see citing works

Hypoxia Links ATR and p53 through Replication Arrest

Hammond, E. M., Denko, N. C., Dorie, M. J., Abraham, R. T., & Giaccia, A. J. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1834-1843.2002 · Cited by 321 · see citing works

ATR/ATM Targets Are Phosphorylated by ATR in Response to Hypoxia and ATM in Response to Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212360200 · Cited by 282 · see citing works

Common mechanisms of PIKK regulation

Lovejoy, C. A., & Cortez, D. (2009) · DNA Repair · doi:10.1016/j.dnarep.2009.04.006 · Cited by 277 · see citing works

Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo

Ouyang, H., Nussenzweig, A., Kurimasa, A., Soares, V. D. C., Li, X., Cordon‐Cardo, C., Li, W.-H., Cheong, N., Nussenzweig, M. C., Iliakis, G. E., et al. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.6.921 · Cited by 270 · see citing works

mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α

Cam, H., Easton, J. B., High, A., & Houghton, P. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.030 · Cited by 266 · see citing works

Nuclear initiated NF-κB signaling: nemo and ATM take center stage

Miyamoto, S. (2011) · Cell Research · doi:10.1038/cr.2010.179 · Cited by 253 · see citing works

A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

Wong, R. H.-F., Chang, I., Hudak, C. S. S., Hyun, S., Kwan, H. Y., & Sul, H. S. (2009) · Cell · doi:10.1016/j.cell.2008.12.040 · Cited by 253 · see citing works

Loss of the ataxia–telangiectasia gene product causes oxidative damage in target organs

Barlow, C., Dennery, P. A., Shigenaga, M. K., Smith, M. A., Morrow, J. D., Roberts, L. J., Wynshaw-Boris, A. J., & Levine, R. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.17.9915 · Cited by 246 · see citing works

Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice.

Kamsler, A., Daily, D., Hochman, A., Stern, N., Shiloh, Y., Rotman, G., & Barzilai, A. (2001) · PubMed · Cited by 235 · see citing works

PI3K/Akt Is Required for Heat Shock Proteins to Protect Hypoxia-inducible Factor 1α from pVHL-independent Degradation

Zhou, J., Schmid, T., Frank, R., & Brüne, B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m310164200 · Cited by 225 · see citing works

NF-κB-mediated adaptive resistance to ionizing radiation

Ahmed, K. M., & Li, J.-J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.09.022 · Cited by 222 · see citing works

ROS and innate immunity.

Kohchi, C., Inagawa, H., Nishizawa, T., & Soma, G. (2009) · PubMed · Cited by 214 · see citing works

ATM- and NEMO-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation in Response to Genotoxic Stress

Wu, Z.-H., Wong, E. T., Shi, Y., Niu, J., Chen, Z. J., Miyamoto, S., & Tergaonkar, V. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.010 · Cited by 207 · see citing works

ATM Activation and Signaling under Hypoxic Conditions

Bencokova, Z., Kaufmann, M. R., Pires, I. M., Lecane, P. S., Giaccia, A. J., & Hammond, E. M. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01301-08 · Cited by 205 · see citing works

microRNA-451: A conditional switch controlling glioma cell proliferation and migration

Godlewski, J. A., Bronisz, A., Nowicki, M. O., Chiocca, E. A., & Lawler, S. E. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12248 · Cited by 203 · see citing works

Essential Role for DNA-PKcs in DNA Double-Strand Break Repair and Apoptosis in ATM-Deficient Lymphocytes

Callén, E., Janković, M., Wong, N., Zha, S., Chen, H.-T., Difilippantonio, S., Virgilio, M. D., Heidkamp, G. F., Alt, F. W., Nussenzweig, A., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.025 · Cited by 198 · see citing works

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

Roberts, S. A., Strande, N. T., Burkhalter, M. D., Strom, C. N., Havener, J. M., Hasty, P., & Ramsden, D. A. (2010) · Nature · doi:10.1038/nature08926 · Cited by 196 · see citing works

A Proteomic Analysis of Ataxia Telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) Substrates Identifies the Ubiquitin-Proteasome System as a Regulator for DNA Damage Checkpoints

Mu, J., Wáng, Y., Luo, H., Leng, M., Zhang, J., Yang, T., Besusso, D., Jung, S. Y., & Qin, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700079200 · Cited by 172 · see citing works

Correction of Radiation Sensitivity in Ataxia Telangiectasia Cells by a Truncated IκB-α

Jung, M., Zhang, Y., Lee, S., & Dritschilo, A. (1995) · Science · doi:10.1126/science.7777860 · Cited by 171 · see citing works

Hypothesis: Ataxia‐telangiectasia: Is ATM a sensor of oxidative damage and stress?

Rotman, G., & Shiloh, Y. (1997) · BioEssays · doi:10.1002/bies.950191011 · Cited by 160 · see citing works

Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia

Lavin, M. F., Gueven, N., Bottle, S. E., & Gatti, R. A. (2007) · British Medical Bulletin · doi:10.1093/bmb/ldm012 · Cited by 159 · see citing works

Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK

Das, B. B., Antony, S., Gupta, S., Dexheimer, T. S., Redon, C. E., Garfield, S., Shiloh, Y., & Pommier, Y. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.302 · Cited by 151 · see citing works

The role of LKB1 and AMPK in cellular responses to stress and damage

Alexander, A., & Walker, C. L. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.010 · Cited by 144 · see citing works

ATM and the Catalytic Subunit of DNA-Dependent Protein Kinase Activate NF-κB through a Common MEK/Extracellular Signal-Regulated Kinase/p90rsk Signaling Pathway in Response to Distinct Forms of DNA Damage

Panta, G. R., Kaur, S., Cavin, L. G., Cortés, M. L., Mercurio, F., Lothstein, L., Sweatman, T. W., Israel, M., & Arsura, M. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.5.1823-1835.2004 · Cited by 127 · see citing works

Distinct roles of ATR and DNA‐PKcs in triggering DNA damage responses in ATM‐deficient cells

Tomimatsu, N., Mukherjee, B., & Burma, S. (2009) · EMBO Reports · doi:10.1038/embor.2009.60 · Cited by 127 · see citing works

Requirement of the ATM/p53 Tumor Suppressor Pathway for Glucose Homeostasis

Armata, H. L., Golebiowski, D., Jung, D. Y., Ko, H. J., Kim, J. K., & Sluss, H. K. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00347-10 · Cited by 120 · see citing works

HIF-1 Inhibitors for Cancer Therapy: From Gene Expression to Drug Discovery

Semenza, G. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789649402 · Cited by 116 · cited 2× · see citing works

Chk2-dependent phosphorylation of XRCC1 in the DNA damage response promotes base excision repair

Chou, W., Wang, H., Wong, F., Ding, S., Wu, P., Shieh, S., & Shen, C. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.229 · Cited by 104 · see citing works

Accumulation of DNA Damage and Reduced Levels of Nicotine Adenine Dinucleotide in the Brains of Atm-deficient Mice

Stern, N., Hochman, A., Zemach, N., Weizman, N., Hammel, I., Shiloh, Y., Rotman, G., & Barzilai, A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106798200 · Cited by 104 · see citing works

Human base excision repair complex is physically associated to DNA replication and cell cycle regulatory proteins

Parlanti, E., Locatelli, G. A., Maga, G., & Eugenia Dogliotti, Y. (2007) · Nucleic Acids Research · doi:10.1093/nar/gkl1159 · Cited by 101 · see citing works

Inhibition of ATR Leads to Increased Sensitivity to Hypoxia/Reoxygenation

Hammond, E. M., Dorie, M. J., & Giaccia, A. J. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1520 · Cited by 101 · see citing works

AP-site cleavage activity of tyrosyl-DNA phosphodiesterase 1

Lebedeva, N. A., Rechkunova, N. I., & Lavrik, O. I. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.01.032 · Cited by 98 · see citing works

Antioxidant N-acetyl cysteine reduces incidence and multiplicity of lymphoma in Atm deficient mice

Reliene, R., & Schiestl, R. H. (2006) · DNA repair · doi:10.1016/j.dnarep.2006.05.003 · Cited by 97 · see citing works

Xanthine Oxidase–Dependent Regulation of Hypoxia-Inducible Factor in Cancer Cells

Griguer, C. E., Oliva, C. R., Kelley, E. E., Giles, G. I., Lancaster, J. R., & Gillespie, G. Y. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3364 · Cited by 92 · see citing works

Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest

Hammond, E. M., Green, S., & Giaccia, A. J. (2003) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2003.08.017 · Cited by 90 · see citing works

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia

Bouquet, F., Ousset, M., Biard, D. S. F., Fallone, F., Dauvillier, S., Frit, P., Salles, B., & Muller, C. (2011) · Journal of Cell Science · doi:10.1242/jcs.078030 · Cited by 88 · see citing works

The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation

Hammond, E. M., & Giaccia, A. J. (2004) · DNA repair · doi:10.1016/j.dnarep.2004.03.035 · Cited by 84 · see citing works

Long-term VEGF-A expression promotes aberrant angiogenesis and fibrosis in skeletal muscle

Karvinen, H., Pasanen, E., Rissanen, T. T., Korpisalo, P., Vähäkangas, E., Jaźwa, A., Giacca, M., & Ylä‐Herttuala, S. (2011) · Gene Therapy · doi:10.1038/gt.2011.66 · Cited by 83 · see citing works

The Enzyme Ribonucleotide Reductase: Target for Antitumor and Anti-HIV Therapy

Szekeres, T., Fritzer‐Szekeres, M., Elford, H. L., & Jayaram, H. N. (1997) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408369709006424 · Cited by 81 · see citing works

Detection of Oxidative Clustered DNA Lesions in X-Irradiated Mouse Skin Tissues and Human MCF-7 Breast Cancer Cells

Gollapalle, E., Wang, R., Adetolu, R., Tsao, D., Francisco, D., Sigounas, G., & Georgakilas, A. G. (2007) · Radiation Research · doi:10.1667/rr0659.1 · Cited by 79 · see citing works

The ATM gene and protein: possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress.

Rotman, G., & Shiloh, Y. (1997) · PubMed · Cited by 78 · see citing works

ATM mediates constitutive NF-κB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia

Grosjean-Raillard, J., Tailler, M., Adès, L., Perfettini, J., Fabre, C., Braun, T., de Botton, S., Fenaux, P., & Kroemer, G. (2008) · Oncogene · doi:10.1038/onc.2008.457 · Cited by 74 · see citing works

DNA-Dependent Protein Kinase Phosphorylation of IκBα and IκBβ Regulates NF-κB DNA Binding Properties

Liu, L., Kwak, Y.-T., Bex, F., Garcı́a-Martı́nez, L. F., Li, X., Meek, K., Lane, W. S., & Gaynor, R. B. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.7.4221 · Cited by 71 · see citing works

DNA-PKcs Controls an Endosomal Signaling Pathway for a Proinflammatory Response by Natural Killer Cells

Rajagopalan, S., Moyle, M. W., Joosten, I., & Long, E. O. (2010) · Science Signaling · doi:10.1126/scisignal.2000467 · Cited by 71 · see citing works

Association of DNA-dependent protein kinase with hypoxia inducible factor-1 and its implication in resistance to anticancer drugs in hypoxic tumor cells

Um, J. H., Kang, C., Bae, J. H., Shin, G. G., Kim, D. W., Kim, D. W., Chung, B., & Kim, S. H. (2004) · Experimental & Molecular Medicine · doi:10.1038/emm.2004.32 · Cited by 71 · see citing works

DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells

Peddi, P., Loftin, C. W., Dickey, J. S., Hair, J. M., Burns, K. J., Aziz, K., Francisco, D., Panayiotidis, M. I., Sedelnikova, O. A., Bonner, W. M., et al. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.02.033 · Cited by 71 · see citing works

Dissociation of GLUT4 Translocation and Insulin-stimulated Glucose Transport in Transgenic Mice Overexpressing GLUT1 in Skeletal Muscle

Hansen, P. A., Wang, W., Marshall, B. A., Holloszy, J. O., & Mueckler, M. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18173 · Cited by 71 · see citing works

In Vivo Analysis of Protein Kinase B (PKB)/Akt Regulation in DNA-PKcs-null Mice Reveals a Role for PKB/Akt in DNA Damage Response and Tumorigenesis

Sürücü, B., Bozulic, L., Hynx, D., Parcellier, A., & Hemmings, B. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803053200 · Cited by 69 · see citing works

PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro

Toulany, M., Dittmann, K., Fehrenbacher, B., Schaller, M., Baumann, M. A., & Rodemann, H. P. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.06.017 · Cited by 58 · see citing works

Tdp1 protects against oxidative DNA damage in non‐dividing fission yeast

Hassine, S. B., & Arcangioli, B. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.9 · Cited by 55 · see citing works

Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 -deficient mouse embryonic fibroblasts

Wirthner, R., Wrann, S., Balamurugan, K., Wenger, R. H., & Stiehl, D. P. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn231 · Cited by 51 · see citing works

Loss of ATM positively regulates the expression of hypoxia inducible factor 1 (HIF-1) through oxidative stress: Role in the physiopathology of the disease

Ousset, M., Bouquet, F., Fallone, F., Biard, D. S. F., Dray, C., Valet, P., Salles, B., & Muller, C. (2010) · Cell Cycle · doi:10.4161/cc.9.14.12253 · Cited by 51 · see citing works

Phosphorylation of p50 NF-κB at a Single Serine Residue by DNA-dependent Protein Kinase Is Critical for VCAM-1 Expression upon TNF Treatment

Ju, J., Naura, A. S., Errami, Y., Zerfaoui, M., Kim, H., Kim, J. G., Elmageed, Z. Y. A., Abdel‐Mageed, A. B., Giardina, C. A., Beg, A. A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.158352 · Cited by 50 · see citing works

Redox Control of Protein–DNA Interactions: From Molecular Mechanisms to Significance in Signal Transduction, Gene Expression, and DNA Replication

Shlomai, J. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.3029 · Cited by 47 · see citing works

DNA‐dependent protein kinase is involved in heat shock protein‐mediated accumulation of hypoxia‐inducible factor‐1α in hypoxic preconditioned HepG2 cells

Kang, M. J., Jung, S. M., Kim, M. J., Bae, J. H., Kim, H. B., Kim, J. Y., Park, S. J., Song, H. S., Kim, D. W., Kang, C., et al. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06725.x · Cited by 36 · see citing works

Oxidative Damage and Defective DNA Repair is Linked to Apoptosis of Migrating Neurons and Progenitors During Cerebral Cortex Development in Ku70-Deficient Mice

Narasimhaiah, R., Tuchman, A., Lin, S. L., & Naegele, J. R. (2004) · Cerebral Cortex · doi:10.1093/cercor/bhh171 · Cited by 34 · see citing works

Processing of clustered DNA damage in human breast cancer cells MCF-7 with partial DNA-PKcs deficiency

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Artemis is a negative regulator of p53 in response to oxidative stress

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The Nature of Brain Degenerative Diseases as Reflected by the Genome Instability Disease Ataxia-Telangiectasia

Mitiagin, Y., Trop-Steinberg, S., Zemach, N., Ronen, S. A., & Barzilai, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-21135-4_26

The catalytic subunit of DNA-dependent protein kinase is required for cellular resistance to oxidative stress independent of DNA double-strand break repair

Li, M., Lin, Y., Palchik, G. A., Matsunaga, S., Wang, D., & Chen, B. P. C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.019 · Cited by 27 · see citing works

All Stressed Out Without ATM Kinase

Perry, J. J. P., & Tainer, J. A. (2011) · Science Signaling · doi:10.1126/scisignal.2001961 · Cited by 22 · see citing works

DNA‐PKcs and ATM modulate mitochondrial ADP‐ATP exchange as an oxidative stress checkpoint mechanism

Chen, W., Chiang, J., Shang, Z., Palchik, G. A., Newman, C., Zhang, Y., Davis, A. J., Lee, H., & Chen, B. P. C. (2023) · The EMBO Journal · doi:10.15252/embj.2022112094 · Cited by 22 · see citing works

Abstract SY11-03: Mechanisms of ATM activation

Paull, T. T., Lee, J., Ditch, S., & Guo, Z. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-sy11-03 · Cited by 1 · see citing works

The ATM protein kinase and cellular redox signaling: beyond the DNA damage response

Ditch, S., & Paull, T. T. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2011.10.002 · Cited by 325 · see citing works