The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
The Lipid Messenger OEA Links Dietary Fat Intake to Satiety
Open accessAbstract
Summary The association between fat consumption and obesity underscores the need to identify physiological signals that control fat intake. Previous studies have shown that feeding stimulates small-intestinal mucosal cells to produce the lipid messenger oleoylethanolamide (OEA) which, when administered as a drug, decreases meal frequency by engaging peroxisome proliferator-activated receptors-α (PPAR-α). Here we report that duodenal infusion of fat stimulates OEA mobilization in the proximal small intestine, whereas infusion of protein or carbohydrate does not. OEA production utilizes dietary oleic acid as a substrate and is disrupted in mutant mice lacking the membrane fatty-acid transporter CD36. Targeted disruption of CD36 or PPAR-α abrogates the satiety response induced by fat. The results suggest that activation of small-intestinal OEA mobilization, enabled by CD36-mediated uptake of dietary oleic acid, serves as a molecular sensor linking fat ingestion to satiety.
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Cites
Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α
LoVerme, J., Russo, R., La Rana, G., Fu, J., Farthing, J., Mattace-Raso, G., Meli, R., Hohmann, A., Calignano, A., & Piomelli, D. (2006) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111385 · Cited by 316
Self-citationNeuroanatomy of extrinsic afferents supplying the gastrointestinal tract
Berthoud, H. R., Blackshaw, L. A., Brookes, S. J. H., & Grundy, D. (2004) · Neurogastroenterology & Motility · doi:10.1111/j.1743-3150.2004.00471.x · Cited by 274 · cited 1×
“Alternatively, OEA may diffuse away from enterocytes to recruit neighboring vagal afferents in the mucosal and submucosal layers of the gut (Berthoud et al., 2004).”
Cited by
CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Silverstein, R. L., & Febbraio, M. (2009) · Science Signaling · doi:10.1126/scisignal.272re3 · Cited by 1,141
López-Miranda, J., Pérez-Jiménez, F., Ros, E., De Caterina, R., Badimón, L., Covas, M. I., Escrich, E., Ordovás, J. M., Soriguer, F., Abiá, R., et al. (2010) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.12.007 · Cited by 520
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
Goldberg, I. J., Eckel, R. H., & Abumrad, N. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800085-jlr200 · Cited by 362
Role of the Gut in Lipid Homeostasis
Abumrad, N. A., & Davidson, N. O. (2012) · Physiological Reviews · doi:10.1152/physrev.00019.2011 · Cited by 355
Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity
Chen, Z., Guo, L., Zhang, Y., L. Walzem, R., Pendergast, J. S., Printz, R. L., Morris, L. C., Matafonova, E., Stien, X., Kang, L., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72517 · Cited by 277
Metadata
- Authors
- Schwartz, G. J., Fu, J., Astarita, G., Li, X., Gaetani, S., Campolongo, P., Cuomo, V., & Piomelli, D.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 8
- Issue
- 4
- Pages
- 281-288
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W1968086274
- Cited by
- 371
- References
- 2
- FWCI
- 9.45
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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