The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
CD36, a Scavenger Receptor Involved in Immunity, Metabolism, Angiogenesis, and Behavior
Abstract
Signaling by CD36 is ligand and cell specific and is implicated in multiple human diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The scavenger receptor family recognizes danger-associated molecular patterns and expression of CD36 mediates cell-specific responses such as inflammatory responses, phagocytosis of apoptotic cells, fatty acid transport across the BBB, and lipid uptake, leading to activation of PPARγ transcriptional pathways.
“The scavenger receptor family recognizes danger‐associated molecular patterns and expression of CD36 mediates cell‐specific responses such as inflammatory responses, phagocytosis of apoptotic cells, fatty acid transport across the BBB, and lipid uptake, leading to activation of PPARγ transcriptional pathways (Canton et al. 2013; Silverstein and Febbraio 2009; Ioghen et al. 2021).”
From LDL Cholesterol Modulates Astrocyte Metabolism, Lipid Handling, and Morphology: Evidence From In Vitro and In Vivo Models (2026) · cites this paper as Silverstein and Febbraio 2009
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
CD36 is a sensor of diacylglycerides
Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zähringer, U., et al. (2005) · Nature · doi:10.1038/nature03253 · Cited by 873
Scavenger Receptors in Atherosclerosis: Beyond Lipid Uptake
Moore, K. J., & Freeman, M. W. (2006) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000229218.97976.43 · Cited by 562
Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype
Podrez, E. A., Byzova, T. V., Febbraio, M., Salomon, R. G., Ma, Y., Valiyaveettil, M., Poliakov, E., Sun, M., Finton, P. J., Curtis, B. R., et al. (2007) · Nature Medicine · doi:10.1038/nm1626 · Cited by 513
Self-citationCoraci, I. S., Husemann, J., Berman, J. W., Hulette, C., Dufour, J. H., Campanella, G. K., Luster, A. D., Silverstein, S. C., & El Khoury, J. B. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64354-4 · Cited by 398
A CD36-initiated Signaling Cascade Mediates Inflammatory Effects of β-Amyloid
Moore, K. J., El Khoury, J., Medeiros, L. A., Terada, K., Geula, C., Luster, A. D., & Freeman, M. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208788200 · Cited by 327
Class B Scavenger Receptor-Mediated Intestinal Absorption of Dietary β-Carotene and Cholesterol
van Bennekum, A., Werder, M., Thuahnai, S. T., Han, C.-H., Duong, P., Williams, D. L., Wettstein, P., Schulthess, G., Phillips, M. C., & Hauser, H. (2005) · Biochemistry · doi:10.1021/bi0484320 · Cited by 290
CD36 Deficiency Rescues Lipotoxic Cardiomyopathy
Yang, J., Sambandam, N., Han, X., Gross, R. W., Courtois, M., Kovacs, A., Febbraio, M., Finck, B. N., & Kelly, D. P. (2007) · Circulation Research · doi:10.1161/01.res.0000264104.25265.b6 · Cited by 246
Self-citationChen, K., Febbraio, M., Li, W., & Silverstein, R. L. (2008) · Circulation Research · doi:10.1161/circresaha.108.172064 · Cited by 202
Self-citation
Flagged first, then by citations
Research works printed but not linked: 114
- 10.1016/0005-2736(77)90025-6 · DOI
- Knowles D. M., Tolidijian B., Marboe C., Agati V. D., Grimes M., Chess L., Monoclonal anti-human monocyte antibodies OKM1 and OKM5 possess distinctive tissue distributions including differential reactivity with vascular endothelium. J. Immunol. 132, 2170–2173 (1984).6585420 · DOI
- 10.1172/JCI14006 · DOI
- 10.1016/0092-8674(89)90406-6 · DOI
- 10.1016/0888-7543(95)80114-2 · DOI
- 10.1006/jmbi.1993.1580 · DOI
- 10.1242/jcs.01083 · DOI
- 10.1172/JCI112918 · DOI
- 10.1016/S0021-9258(18)42046-7 · DOI
- 10.1158/0008-5472.CAN-08-1166 · DOI
- 10.1083/jcb.138.3.707 · DOI
- 10.1038/71517 · DOI
- 10.1038/nm0402-349 · DOI
- 10.1002/jcp.21570 · DOI
- 10.1016/S0021-9258(19)50272-1 · DOI
- 10.1097/01.mol.0000183943.20277.26 · DOI
- 10.1126/science.1116006 · DOI
- 10.1084/jem.20082109 · DOI
- 10.1128/IAI.71.1.393-400.2003 · DOI
- 10.1172/JCI116019 · DOI
- 10.1084/jem.181.5.1857 · DOI
- 10.1084/jem.188.7.1359 · DOI · Paper page
- 10.1242/jcs.109.2.387 · DOI · Paper page
- 10.1074/jbc.M509769200 · DOI · Paper page
- 10.1172/JCI8574 · DOI
- 10.1523/JNEUROSCI.23-07-02665.2003 · DOI · Paper page
- 10.1084/jem.20021546 · DOI · Paper page
- 10.1016/S1074-7613(00)80410-0 · DOI
- 10.1126/science.284.5422.1991 · DOI
- 10.1172/JCI9259 · DOI
- 10.1074/jbc.M209649200 · DOI
- 10.1074/jbc.M205924200 · DOI
- 10.1161/01.ATV.20.8.1953 · DOI
- 10.4049/jimmunol.179.5.3242 · DOI
- 10.1523/JNEUROSCI.0035-05.2005 · DOI
- Park Y. M., Febbraio M., Silverstein R. L., CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and contributes to macrophage trapping in the arterial intima. J. Clin. Invest. 119, 136–145 (2009).19065049
- 10.1093/cvr/cvp081 · DOI
- 10.1056/NEJMcibr0810383 · DOI
- Ghosh A., Li W., Febbraio M., Espinola R. G., McCrae K., Silverstein R. L., Platelet CD36 mediates interactions with endothelial cell-derived microparticles and contributes to thrombosis in vivo. J. Clin. Invest. 118, 1934–1943 (2008).18431509
- 10.1242/jcs.037200 · DOI
- 10.1172/JCI24061 · DOI
- 10.1161/ATVBAHA.108.176644 · DOI
- 10.1161/01.ATV.0000148007.06370.68 · DOI
- 10.1016/j.atherosclerosis.2006.07.015 · DOI
- 10.1093/cvr/cvm093 · DOI
- 10.1016/j.cmet.2006.06.007 · DOI
- 10.1083/jcb.200501113 · DOI
- 10.1523/JNEUROSCI.17-07-02284.1997 · DOI
- 10.1074/jbc.M702887200 · DOI
- 10.1074/jbc.M600627200 · DOI
- 10.1074/jbc.272.34.21654 · DOI
- 10.1016/S0092-8674(00)81575-5 · DOI
- 10.1016/S0021-9258(17)46753-6 · DOI
- 10.1053/j.gastro.2007.11.037 · DOI
- 10.1074/jbc.M003826200 · DOI · Paper page
- 10.1074/jbc.M708086200 · DOI
- 10.1074/jbc.M703330200 · DOI
- 10.1007/s002329900111 · DOI
- Bonen A., Dyck D. J., Ibrahimi A., Abumrad N. A., Muscle contractile activity increases fatty acid metabolism and transport and FAT/CD36. Am. J. Physiol. 276, E642–E649 (1999).10198299
- 10.1016/j.tem.2008.11.001 · DOI
- 10.1139/H07-084 · DOI
- 10.1074/jbc.274.27.19055 · DOI · Paper page
- 10.1007/s00335-001-2132-9 · DOI
- 10.1016/S0140-6736(00)04138-6 · DOI
- 10.1111/j.1464-5491.2006.01888.x · DOI
- 10.1038/89969 · DOI
- 10.1172/JCI19528 · DOI
- 10.1152/ajpgi.00074.2008 · DOI · Paper page
- 10.1161/CIRCULATIONAHA.107.712901 · DOI
- 10.2337/db07-0907 · DOI
- 10.1038/5013 · DOI
- Pravenec M., Landa V., Zídek V., Musilová A., Kazdová L., Qi N., Wang J., St Lezin E., Kurtz T. W., Transgenic expression of CD36 in the spontaneously hypertensive rat is associated with amelioration of metabolic disturbances but has no effect on hypertension. Physiol. Res. 52, 681–688 (2003).14640889 · DOI
- 10.1194/jlr.M800237-JLR200 · DOI
- 10.1016/S0009-8981(01)00658-1 · DOI
- 10.2337/diacare.26.2.471 · DOI
- 10.1055/s-0037-1613910 · DOI
- 10.1093/hmg/ddn060 · DOI
- 10.2119/2006-00088.Rac · DOI
- 10.1194/jlr.M300143-JLR200 · DOI
- 10.1021/bi060701u · DOI · Paper page
- 10.1126/science.271.5248.518 · DOI · Paper page
- 10.1016/j.ibmb.2007.11.003 · DOI
- 10.1093/chemse/bjm087 · DOI
- 10.1073/pnas.0803309105 · DOI
- 10.1038/nature06328 · DOI
- 10.1016/j.cell.2008.04.046 · DOI
- 10.1016/j.cell.2008.06.010 · DOI
- 10.1083/jcb.200610081 · DOI
- 10.1172/JCI25299 · DOI
- 10.1074/jbc.M707478200 · DOI
- 10.1152/ajpregu.00211.2007 · DOI
- 10.1096/fj.07-8415com · DOI
- 10.1016/j.cmet.2008.08.005 · DOI
- 10.1074/jbc.M109.007849 · DOI
- 10.1074/jbc.271.37.22315 · DOI
- 10.1074/jbc.M800008200 · DOI
- 10.1074/jbc.270.7.2981 · DOI
- 10.1016/S0021-9258(19)37179-0 · DOI
- 10.1074/jbc.273.52.34875 · DOI
- 10.1074/jbc.M709195200 · DOI
- 10.1073/pnas.88.17.7844 · DOI
- 10.1083/jcb.126.1.111 · DOI
- 10.1091/mbc.e04-07-0616 · DOI
- 10.1074/jbc.M307722200 · DOI
- 10.1074/jbc.M202465200 · DOI
- 10.1126/science.7504322 · DOI
- 10.1128/IAI.73.12.8179-8187.2005 · DOI
- 10.1182/blood.V97.6.1689 · DOI
- 10.4049/jimmunol.177.5.3162 · DOI
- 10.1074/jbc.M602794200 · DOI
- 10.1189/jlb.0907656 · DOI
- 10.4049/jimmunol.181.10.7147 · DOI
- 10.1084/jem.194.9.1289 · DOI
- 10.1006/excr.1999.4458 · DOI
Cited by
Sorted by citations
The metabolic signature of macrophage responses
Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021
Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease
Ipsen, D. H., Lykkesfeldt, J., & Tveden-Nyborg, P. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2860-6 · Cited by 1,471
Genetic determinants of the gut microbiome in UK twins
Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048
Sheedy, F. J., Grebe, A., Rayner, K. J., Kalantari, P., Ramkhelawon, B., Carpenter, S. B., Becker, C. E., Ediriweera, H. N., Mullick, A. E., Golenbock, D. T., et al. (2013) · Nature Immunology · doi:10.1038/ni.2639 · Cited by 935
Scavenger receptors in homeostasis and immunity
Canton, J., Neculai, D., & Grinstein, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3515 · Cited by 838
O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.005 · Cited by 790
Kawano, Y., Edwards, M., Huang, Y., Bilate, A. M., Araujo, L. P., Tanoue, T., Atarashi, K., Ladinsky, M. S., Reiner, S. L., Wang, H. H., et al. (2022) · Cell · doi:10.1016/j.cell.2022.08.005 · Cited by 349
The Evolution of Extracellular Matrix
Özbek, S., Balasubramanian, P. G., Chiquet-Ehrismann, R., Tucker, R. P., & Adams, J. C. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-03-0251 · Cited by 347
Brain Perivascular Macrophages Initiate the Neurovascular Dysfunction of Alzheimer Aβ Peptides
Park, L., Uekawa, K., Garcia-Bonilla, L., Koizumi, K., Murphy, M., Pistik, R., Younkin, L., Younkin, S., Zhou, P., Carlson, G., et al. (2017) · Circulation Research · doi:10.1161/circresaha.117.311054 · Cited by 259
A subset of Kupffer cells regulates metabolism through the expression of CD36
Blériot, C., Barreby, E., Dunsmore, G., Ballaire, R., Chakarov, S., Ficht, X., De Simone, G., Andreata, F., Fumagalli, V., Guo, W., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.08.006 · Cited by 236
Disclosure of the culprits: macrophages-versatile regulators of wound healing.
Sindrilaru, A., & Scharffetter-Kochanek, K. (2013) · Advances in Wound Care · doi:10.1089/wound.2012.0407 · Cited by 223
DeFilippis, R. A., Chang, H., Dumont, N., Rabban, J. T., Chen, Y.-Y., Fontenay, G. V., Berman, H. K., Gauthier, M. L., Zhao, J., Hu, D., et al. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0107 · Cited by 212
Self-citationPark, L., Wang, G., Zhou, P., Zhou, J., Pitstick, R., Previti, M. L., Younkin, L., Younkin, S. G., Van Nostrand, W. E., Cho, S., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015413108 · Cited by 156
Immunomodulatory Role of the Extracellular Matrix Within the Liver Disease Microenvironment
McQuitty, C. E., Williams, R., Chokshi, S., & Urbani, L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574276 · Cited by 146
The impact of nanoparticle ligand density on dendritic-cell targeted vaccines
Bandyopadhyay, A., Fine, R. L., Demento, S., Bockenstedt, L. K., & Fahmy, T. M. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2010.12.054 · Cited by 141
Role of Cellular Senescence in Type II Diabetes
Narasimhan, A., Flores, R. R., Robbins, P. D., & Niedernhofer, L. J. (2021) · Endocrinology · doi:10.1210/endocr/bqab136 · Cited by 133
Rosa, B. A., Ahmed, M., Singh, D. K., Choreño-Parra, J. A., Cole, J., Jiménez-Álvarez, L. A., Rodríguez-Reyna, T. S., Singh, B., Gonzalez, O., Carrion, R., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01829-4 · Cited by 106
CD36 and Na/K-ATPase-α1 Form a Proinflammatory Signaling Loop in Kidney
Kennedy, D. J., Chen, Y., Huang, W., Viterna, J., Liu, J., Westfall, K., Tian, J., Bartlett, D. J., Tang, W. H. W., Xie, Z., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.112.198770 · Cited by 101
Self-citationCD36 mediates endothelial dysfunction downstream of circulating factors induced by O3 exposure
Robertson, S., Colombo, E. S., Lucas, S. N., Hall, P. R., Febbraio, M., Paffett, M. L., & Campen, M. J. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft107 · Cited by 82
Self-citationModification of lipoprotein metabolism and function driving atherogenesis in diabetes
Luciani, L., Pedrelli, M., & Parini, P. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117545 · Cited by 72
Advancements in therapeutic drugs targeting of senescence
Zhu, M., Meng, P., Ling, X., & Zhou, L. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320964125 · Cited by 68
CD36 gene polymorphism is associated with Alzheimer's disease
Šerý, O., Janoutová, J., Ewerlingová, L., Hálová, A., Lochman, J., Janout, V., Khan, N. A., & Balcar, V. J. (2017) · Biochimie · doi:10.1016/j.biochi.2017.01.009 · Cited by 44
Broos, J. Y., van der Burgt, R. T. M., Konings, J., Rijnsburger, M., Werz, O., de Vries, H. E., Giera, M., & Kooij, G. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02981-w · Cited by 41
Wang, X., Shang, Y., Wei, Q., Wu, X., Dou, H., Zhang, H., Zhou, S., Sha, W., Sun, G., Ma, S., et al. (2022) · Microbial Ecology · doi:10.1007/s00248-021-01806-8 · Cited by 36
CD36 Participates in PrP106–126-Induced Activation of Microglia
Kouadir, M., Yang, L., Tan, R., Shi, F., Lu, Y., Zhang, S., Yin, X., Zhou, X., & Zhao, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030756 · Cited by 34
Cabrera-Reyes, F., Parra-Ruiz, C., Yuseff, M. I., & Zanlungo, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.790568 · Cited by 24
Wei, P., Sun, F.-D., Zuo, L.-M., Qu, J., Chen, P., Xu, L.-D., & Luo, S.-Z. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.779595 · Cited by 11
Baumart, G. J., Rodrigues, M. S., Sholl, J. N., de Sousa, A. C., Weber, A. F., Costa‐Beber, L. C., Farias, H. R., Costa, M. V., Peres, A. M., de Camargo, P. R., et al. (2026) · Journal of Neurochemistry · doi:10.1111/jnc.70403 · Cited by 2
Metadata
- Authors
- Silverstein, R. L., & Febbraio, M.
- Affiliations
- Department of Cell Biology, Lerner Research Institute, Cleveland Clinic Foundation and Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH 44195, USA.
- Venue
- Science Signaling
- Published
- 2009-05-26
- Volume
- 2
- Issue
- 72
- ISSN
- 1945-0877
- 1937-9145
- PMC
- PMC2811062
- Cited by
- 1,141
- References
- 9
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
