Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

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Postprandial increase of oleoylethanolamide mobilization in small intestine of the Burmese python (Python molurus)

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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

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The Endocannabinoid System and Pain

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A neuroscientist's guide to lipidomics

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The Lipid Messenger OEA Links Dietary Fat Intake to Satiety

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Minocycline Treatment Inhibits Microglial Activation and Alters Spinal Levels of Endocannabinoids in a Rat Model of Neuropathic Pain

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Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy: Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism

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Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models

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The contribution of cyclooxygenase‐2 to endocannabinoid metabolism and action

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Endocannabinoids: A unique opportunity to develop multitarget analgesics

Maione, S., Costa, B., & Marzo, V. D. (2013) · Pain · doi:10.1016/j.pain.2013.03.023 · Cited by 102 · see citing works

Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy

Citraro, R., Russo, E., Scicchitano, F., van Rijn, C. M., Cosco, D., Avagliano, C., Russo, R., D’Agostino, G., Petrosino, S., Guida, F., et al. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2012.11.017 · Cited by 101 · see citing works

Palmitoylethanolamide counteracts reactive astrogliosis induced by β-amyloid peptide

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Palmitoylethanolamide controls reactive gliosis and exerts neuroprotective functions in a rat model of Alzheimer’s disease

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Systemic Administration of Oleoylethanolamide Protects from Neuroinflammation and Anhedonia Induced by LPS in Rats

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Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia

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Palmitoylethanolamide counteracts autistic-like behaviours in BTBR T+tf/J mice: Contribution of central and peripheral mechanisms

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Intrathecal Rosiglitazone Acts at Peroxisome Proliferator–Activated Receptor-γ to Rapidly Inhibit Neuropathic Pain in Rats

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Antineuropathic Profile of N-Palmitoylethanolamine in a Rat Model of Oxaliplatin-Induced Neurotoxicity

Mannelli, L. D. C., Pacini, A., Corti, F., Boccella, S., Luongo, L., Esposito, E., Cuzzocrea, S., Maione, S., Calignano, A., & Ghelardini, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128080 · Cited by 91 · see citing works

Inhibition of fatty acid amide hydrolase produces PPAR‐α‐mediated analgesia in a rat model of inflammatory pain

Sagar, D. R., Kendall, D. A., & Chapman, V. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.335 · Cited by 88 · see citing works

The role of the endocannabinoid system in lipogenesis and fatty acid metabolism

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Oleoylethanolamide, Neuroinflammation, and Alcohol Abuse

Orío, L., Alén, F., Pavón, F. J., Serrano, A., & García‐Bueno, B. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00490 · Cited by 90 · see citing works

Fatty acid amide hydrolase blockade attenuates the development of collagen-induced arthritis and related thermal hyperalgesia in mice

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Chapter 5 The Endocannabinoid System as A Target for Novel Anxiolytic and Antidepressant Drugs

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Proinflammatory Stimuli Control N-Acylphosphatidylethanolamine-Specific Phospholipase D Expression in Macrophages

Zhu, C., Solorzano, C., Sahar, S., Realini, N., Fung, E. S., Sassone‐Corsi, P., & Piomelli, D. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.070201 · Cited by 84 · see citing works

N -Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition

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N -Acylethanolamine Metabolism Interacts with Abscisic Acid Signaling in Arabidopsis thaliana Seedlings

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Microglia produce and hydrolyze palmitoylethanolamide

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Generation of N-Acylphosphatidylethanolamine by Members of the Phospholipase A/Acyltransferase (PLA/AT) Family

Uyama, T., Ikematsu, N., Inoue, M., Shinohara, N., Jin, X., Tsuboi, K., Tonai, T., Tokumura, A., & Ueda, N. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.368712 · Cited by 82 · see citing works

Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series

Hesselink, J. M. K., & Hekker (2012) · Journal of Pain Research · doi:10.2147/jpr.s32143 · Cited by 80 · see citing works

Palmitoylethanolamide and stearoylethanolamide levels in the interstitium of the trapezius muscle of women with chronic widespread pain and chronic neck-shoulder pain correlate with pain intensity and sensitivity

Ghafouri, N., Ghafouri, B., Larsson, B. K., Stensson, N., Fowler, C. J., & Gerdle, B. U. C. (2013) · Pain · doi:10.1016/j.pain.2013.05.002 · Cited by 79 · see citing works

Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments

Ford, A. C., Vanner, S. J., Kashyap, P., & Nasser, Y. (2024) · Gastroenterology · doi:10.1053/j.gastro.2024.01.045 · Cited by 79 · see citing works

Antinociceptive and antiedematogenic activities of fenofibrate, an agonist of PPAR alpha, and pioglitazone, an agonist of PPAR gamma

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Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands

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A novel composite formulation of palmitoylethanolamide and quercetin decreases inflammation and relieves pain in inflammatory and osteoarthritic pain models

Britti, D., Crupi, R., Impellizzeri, D., Gugliandolo, E., Fusco, R., Schievano, C., Morittu, V. M., Evangelista, M., Paola, R. D., & Cuzzocrea, S. (2017) · BMC Veterinary Research · doi:10.1186/s12917-017-1151-z · Cited by 76 · see citing works

Palmitoylethanolamide Reduces Granuloma-Induced Hyperalgesia by Modulation of Mast Cell Activation in Rats

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Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase

Karbarz, M. J., Luo, L., Chang, L., Tham, C.-S., Palmer, J. A., Wilson, S. J., Wennerholm, M. L., Brown, S. M., Scott, B. P., Apodaca, R. L., et al. (2009) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31818c7cbd · Cited by 74 · see citing works

A Second Generation of Carbamate‐Based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in vivo

Clapper, J. R., Vacondio, F., King, A. R., Duranti, A., Tontini, A., Silva, C., Sanchini, S., Tarzia, G., Mor, M., & Piomelli, D. (2009) · ChemMedChem · doi:10.1002/cmdc.200900210 · Cited by 74 · see citing works

Pioglitazone rapidly reduces neuropathic pain through astrocyte and nongenomic PPARγ mechanisms

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Macrophage-derived lipid agonists of PPAR-αas intrinsic controllers of inflammation

Pontis, S., Ribeiro, A., Sasso, O., & Piomelli, D. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1092944 · Cited by 74 · see citing works

Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice

Russo, R., Caro, C. D., Avagliano, C., Cristiano, C., Rana, G. L., Raso, G. M., Canani, R. B., Meli, R., & Calignano, A. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.11.026 · Cited by 74 · see citing works

PPARs and pain

Okine, B. N., Gaspar, J. C., & Finn, D. P. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14339 · Cited by 71 · see citing works

Strategies to increase the activity of microglia as efficient protectors of the brain against infections

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The Nervous System and Metabolic Dysregulation: Emerging Evidence Converges on Ketogenic Diet Therapy

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A systematic review of the effects of oleoylethanolamide, a high‐affinity endogenous ligand of PPAR‐α, on the management and prevention of obesity

Tutunchi, H., Saghafi‐Asl, M., & Ostadrahimi, A. (2019) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13238 · Cited by 67 · see citing works

Central administration of oxytocin reduces hyperalgesia in mice: Implication for cannabinoid and opioid systems

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The effect of the palmitoylethanolamide analogue, palmitoylallylamide (L-29) on pain behaviour in rodent models of neuropathy

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Activation of peroxisome proliferator-activated receptor γ in brain inhibits inflammatory pain, dorsal horn expression of Fos, and local edema

Morgenweck, J., Abdel‐Aleem, O. S., McNamara, K. C., Donahue, R. R., Badr, M. Z., & Taylor, B. K. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.10.008 · Cited by 66 · see citing works

A Lipid Gate for the Peripheral Control of Pain

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Non-Neuronal Cell Modulation Relieves Neuropathic Pain: Efficacy of the Endogenous Lipid Palmitoylethanolamide

Bettoni, I., Comelli, F., Colombo, A., Bonfanti, P., & Costa, B. (2013) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527311312010008 · Cited by 66 · see citing works

15d-Prostaglandin J2 Inhibits Inflammatory Hypernociception: Involvement of Peripheral Opioid Receptor

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Peroxisome Proliferator-Activated Receptor-γ Ligand, 15-Deoxy-Δ12,14-Prostaglandin J2, Reduces Neutrophil Migration via a Nitric Oxide Pathway

Napimoga, M. H., Vieira, S. M., Dal-Secco, D., de Freitas, A., Souto, F. O., Mestriner, F., Alves-Filho, J. C., Grespan, R., Kawai, T., Ferreira, S. H., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.1.609 · Cited by 65 · see citing works

Peroxisome Proliferator-Activated Receptor α Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons

Khasabova, I. A., Xiong, Y., Coicou, L. G., Piomelli, D., & Seybold, V. S. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0130-12.2012 · Cited by 64 · see citing works

Rapid pain modulation with nuclear receptor ligands

Fehrenbacher, J. C., LoVerme, J., Clarke, W. P., Hargreaves, K., Piomelli, D., & Taylor, B. K. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2008.12.019 · Cited by 63 · see citing works

Localization of the Endocannabinoid-Degrading Enzyme Fatty Acid Amide Hydrolase in Rat Dorsal Root Ganglion Cells and Its Regulation after Peripheral Nerve Injury

Lever, I. J., Robinson, M., Cibelli, M., Paule, C. C., Sántha, P., Yee, L., Hunt, S. P., Cravatt, B. F., Elphick, M. R., Nagy, I., et al. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4071-08.2009 · Cited by 63 · see citing works

Lack of Sterol Regulatory Element Binding Factor-1c Imposes Glial Fatty Acid Utilization Leading to Peripheral Neuropathy

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Implication of allopregnanolone in the antinociceptive effect of N -palmitoylethanolamide in acute or persistent pain

Sasso, O., Russo, R., Vitiello, S., Raso, G. M., D’Agostino, G., Iacono, A., Rana, G. L., Vallée, M., Cuzzocrea, S., Piazza, P. V., et al. (2011) · Pain · doi:10.1016/j.pain.2011.08.010 · Cited by 62 · see citing works

Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats

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Advances in the discovery of N-acylethanolamine acid amidase inhibitors

Bandiera, T., Ponzano, S., & Piomelli, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.04.011 · Cited by 60 · see citing works

Actions of 3-methyl-N-oleoyldopamine, 4-methyl-N-oleoyldopamine and N-oleoylethanolamide on the rat TRPV1 receptor in vitro and in vivo

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Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system

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Rapid broad-spectrum analgesia through activation of peroxisome proliferator-activated receptor-alpha.

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LoVerme, J., Russo, R., Rana, G. L., Fu, J., Farthing, J. N., Meli, R., Hohmann, A. G., Calignano, A., & Piomelli, D. (2006)

A role for PPAR-alpha in the Central Nervous System in pain and inflammation control

D’Agostino, G. (2010)

Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-κB nuclear signalling in dorsal root ganglia

D’Agostino, G., Rana, G. L., Russo, R., Sasso, O., Iacono, A., Esposito, E., Raso, G. M., Cuzzocrea, S., LoVerme, J., Piomelli, D., et al. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.04.022 · Cited by 134 · see citing works

A role for PPAR α in the medial prefrontal cortex in formalin‐evoked nociceptive responding in rats

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