The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Resulting free fatty acids can be taken up via scavenger receptors such as CD36 and CD68 by microglia.
“The resulting FFAs can in turn be taken up via scavenger receptors, such as CD36 and CD68 by microglia (22).”
From Reduced Angiopoietin-Like 4 Expression in Multiple Sclerosis Lesions Facilitates Lipid Uptake by Phagocytes via Modulation of Lipoprotein-Lipase Activity (2019) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
MacArthur, J. M., Bishop, J. R., Stanford, K. I., Wang, L., Bensadoun, A., Witztum, J. L., & Esko, J. D. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29154 · Cited by 216
Nahlé, Z., Hsieh, M., Pietka, T., Coburn, C. T., Grimaldi, P. A., Zhang, M. Q., Das, D., & Abumrad, N. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706478200 · Cited by 122 · cited 1×
“In muscle during fasting, activation of PPARy upregulates CD36 to increase FA utilization (46).”
BackgroundSelf-citation
Flagged first, then by citations
Research works printed but not linked: 50
- Merkel, 1998, Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia, J. Clin. Invest., 102, 893, 10.1172/JCI2912 · DOI
- Kim, 2001, Tissue-specific overexpression of lipoprotein lipase causes tissue- specific insulin resistance, Proc. Natl. Acad. Sci. USA., 98, 7522, 10.1073/pnas.121164498 · DOI · Paper page
- Weinstock, 1997, Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase, Proc. Natl. Acad. Sci. USA., 94, 10261, 10.1073/pnas.94.19.10261 · DOI
- Kratky, 2005, Endothelial lipase provides an alternative pathway for FFA uptake in lipoprotein lipase-deficient mouse adipose tissue, J. Clin. Invest., 115, 161, 10.1172/JCI200515972 · DOI
- Pappan, 2005, Pancreatic beta-cell lipoprotein lipase independently regulates islet glucose metabolism and normal insulin secretion, J. Biol. Chem., 280, 9023, 10.1074/jbc.M409706200 · DOI
- Greenwood, 1985, The relationship of enzyme activity to feeding behavior in rats: lipoprotein lipase as the metabolic gatekeeper, Int. J. Obes., 9, 67
- Merkel, 2002, Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake, J. Biol. Chem., 277, 7405, 10.1074/jbc.M107914200 · DOI
- Augustus, 2004, Cardiac-specific knock-out of lipoprotein lipase alters plasma lipoprotein triglyceride metabolism and cardiac gene expression, J. Biol. Chem., 279, 25050, 10.1074/jbc.M401028200 · DOI
- Augustus, 2006, Loss of lipoprotein lipase-derived fatty acids leads to increased cardiac glucose metabolism and heart dysfunction, J. Biol. Chem., 281, 8716, 10.1074/jbc.M509890200 · DOI
- Ziouzenkova, 2003, Lipolysis of triglyceride-rich lipoproteins generates PPAR ligands: evidence for an antiinflammatory role for lipoprotein lipase, Proc. Natl. Acad. Sci. USA., 100, 2730, 10.1073/pnas.0538015100 · DOI
- Chawla, 2003, PPARdelta is a very low-density lipoprotein sensor in macrophages, Proc. Natl. Acad. Sci. USA., 100, 1268, 10.1073/pnas.0337331100 · DOI · Paper page
- Sattler, 1996, Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle, Biochem. J., 318, 15, 10.1042/bj3180015 · DOI
- Vogel, 2002, Retinol-binding protein-deficient mice: biochemical basis for impaired vision, Biochemistry., 41, 15360, 10.1021/bi0268551 · DOI
- van Bennekum, 1999, Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester, J. Lipid Res., 40, 565, 10.1016/S0022-2275(20)32461-5 · DOI
- Zilversmit, 1973, A proposal linking atherogenesis to the interaction of endothelial lipoprotein lipase with triglyceride-rich lipoproteins, Circ. Res., 33, 633, 10.1161/01.RES.33.6.633 · DOI
- Babaev, 1999, Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo, J. Clin. Invest., 103, 1697, 10.1172/JCI6117 · DOI · Paper page
- Wang, 2008, Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized free fatty acids that induce endothelial cell inflammation, J. Lipid Res.
- Beigneux, 2007, Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons, Cell Metab., 5, 279, 10.1016/j.cmet.2007.02.002 · DOI · Paper page
- Sukonina, 2006, Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue, Proc. Natl. Acad. Sci. USA., 103, 17450, 10.1073/pnas.0604026103 · DOI · Paper page
- Peterfy, 2007, Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia, Nat. Genet., 39, 1483, 10.1038/ng.2007.24 · DOI · Paper page
- Ling, 2003, Identification of functional prolactin (PRL) receptor gene expression: PRL inhibits lipoprotein lipase activity in human white adipose tissue, J. Clin. Endocrinol. Metab., 88, 1804, 10.1210/jc.2002-021137 · DOI
- Ricart-Jane, 2005, Changes in lipoprotein lipase modulate tissue energy supply during stress, J. Appl. Physiol., 99, 1343, 10.1152/japplphysiol.00971.2004 · DOI
- Yost, 1998, Effect of dietary macronutrient composition on tissue-specific lipoprotein lipase activity and insulin action in normal-weight subjects, Am. J. Clin. Nutr., 68, 296, 10.1093/ajcn/68.2.296 · DOI
- Wu, 2007, A transcription-dependent mechanism, akin to that in adipose tissue, modulates lipoprotein lipase activity in rat heart, Am. J. Physiol. Endocrinol. Metab., 293, E908, 10.1152/ajpendo.00634.2006 · DOI
- Ruge, 2000, Nutritional regulation of binding sites for lipoprotein lipase in rat heart, Am. J. Physiol. Endocrinol. Metab., 278, E211, 10.1152/ajpendo.2000.278.2.E211 · DOI
- Abumrad, 1998, Membrane transport of long-chain fatty acids. Evidence for a facilitated process, J. Lipid Res., 39, 2309, 10.1016/S0022-2275(20)33310-1 · DOI
- Berk, 1999, Mechanisms of cellular uptake of long chain free fatty acids, Mol. Cell. Biochem., 192, 17, 10.1023/A:1006832001033 · DOI
- Febbraio, 2001, CD36: a class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism, J. Clin. Invest., 108, 785, 10.1172/JCI14006 · DOI
- Baillie, A., G. S., C. T. Coburn, and N. A. Abumrad. 1996. Reversible binding of long-chain fatty acids to purified FAT, the adipose CD36 homolog. J. Membr. Biol. 153, : 75–81. · DOI
- Coburn, 2000, Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice, J. Biol. Chem., 275, 32523, 10.1074/jbc.M003826200 · DOI · Paper page
- Hajri, 2002, Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice, J. Clin. Invest., 109, 1381, 10.1172/JCI0214596 · DOI
- Hajri, 2007, CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue, Diabetes., 56, 1872, 10.2337/db06-1699 · DOI · Paper page
- Ibrahimi, 1999, Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin, J. Biol. Chem., 274, 26761, 10.1074/jbc.274.38.26761 · DOI · Paper page
- Pravenec, 2001, Transgenic rescue of defective Cd36 ameliorates insulin resistance in spontaneously hypertensive rats, Nat. Genet., 27, 156, 10.1038/84777 · DOI
- Laugerette, 2005, CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions, J. Clin. Invest., 115, 3177, 10.1172/JCI25299 · DOI
- Chen, 2001, Gut expression and regulation of FAT/CD36: possible role in fatty acid transport in rat enterocytes, Am. J. Physiol. Endocrinol. Metab., 281, E916, 10.1152/ajpendo.2001.281.5.E916 · DOI
- Nassir, 2007, CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine, J. Biol. Chem., 282, 19493, 10.1074/jbc.M703330200 · DOI
- Drover, 2005, CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood, J. Clin. Invest., 115, 1290, 10.1172/JCI21514 · DOI
- Drover, 2008, CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice, J. Biol. Chem., 283, 13108, 10.1074/jbc.M708086200 · DOI
- Sclafani, 2007, CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice, Am. J. Physiol. Regul. Integr. Comp. Physiol., 293, R1823, 10.1152/ajpregu.00211.2007 · DOI
- Goudriaan, 2005, CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance, J. Lipid Res., 46, 2175, 10.1194/jlr.M500112-JLR200 · DOI
- El-Yassimi, 2008, Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells, J. Biol. Chem., 283, 12949, 10.1074/jbc.M707478200 · DOI
- Schwartz, 2008, The lipid messenger OEA links dietary fat intake to satiety, Cell Metab., 8, 281, 10.1016/j.cmet.2008.08.005 · DOI
- Schwenk, 2008, Regulation of sarcolemmal glucose and fatty acid transporters in cardiac disease, Cardiovasc. Res., 79, 249, 10.1093/cvr/cvn116 · DOI
- Holloway, 2008, Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview, Acta Physiol (Oxf)., 194, 293, 10.1111/j.1748-1716.2008.01878.x · DOI
- Bastie, 2005, FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms, J. Biol. Chem., 280, 14222, 10.1074/jbc.M413625200 · DOI
- Miranda, 2007, Regulation of receptors and transporters by ubiquitination: new insights into surprisingly similar mechanisms, Mol. Interv., 7, 157, 10.1124/mi.7.3.7 · DOI
- Smith, 2008, Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake, J. Biol. Chem., 283, 13578, 10.1074/jbc.M800008200 · DOI
- Love-Gregory, 2008, Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol, Hum. Mol. Genet., 17, 1695, 10.1093/hmg/ddn060 · DOI
- Yamashita, 2007, Physiological and pathological roles of a multi-ligand receptor CD36 in atherogenesis; insights from CD36-deficient patients, Mol. Cell. Biochem., 299, 19, 10.1007/s11010-005-9031-4 · DOI
Cited by
Sorted by citations
Mechanisms of Insulin Action and Insulin Resistance
Petersen, M. C., & Shulman, G. I. (2018) · Physiological Reviews · doi:10.1152/physrev.00063.2017 · Cited by 3,028
Dyslipidemia in obesity: Mechanisms and potential targets
Klop, B., Elte, J., & Cabezas, M. (2013) · Nutrients · doi:10.3390/nu5041218 · Cited by 1,665
Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
Fabbrini, E., Magkos, F., Mohammed, B. S., Pietka, T., Abumrad, N. A., Patterson, B. W., Okunade, A., & Klein, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904944106 · Cited by 972
Self-citationLipoprotein lipase links dietary fat to solid tumor cell proliferation
Kuemmerle, N. B., Rysman, E., Lombardo, P. S., Flanagan, A. J., Lipe, B. C., Wells, W. A., Pettus, J. R., Froehlich, H. M., Memoli, V. A., Morganelli, P. M., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0802 · Cited by 286
The nuclear receptor REV-ERBα is required for the daily balance of carbohydrate and lipid metabolism
Delezie, J., Dumont, S., Dardente, H., Oudart, H., Gréchez‐Cassiau, A., Klosen, P., Teboul, M., Delaunay, F., Pévet, P., & Challet, E. (2012) · The FASEB Journal · doi:10.1096/fj.12-208751 · Cited by 252
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183
Dubé, E., Gravel, A., Martin, C., Desparois, G., Moussa, I., Ethier-Chiasson, M., Forest, J.-C., Giguère, Y., Masse, A., & Lafond, J. (2012) · Biology of Reproduction · doi:10.1095/biolreprod.111.098095 · Cited by 180
Yan, H., Diao, H., Xiao, Y., Li, W., Yu, B., He, J., Yu, J., Zheng, P., Mao, X., Luo, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep31786 · Cited by 138
Free Fatty Acid Uptake in Humans With CD36 Deficiency
Hames, K. C., Vella, A., Kemp, B. J., & Jensen, M. D. (2014) · Diabetes · doi:10.2337/db14-0369 · Cited by 132
Distinct metabolic patterns during microglial remodeling by oleate and palmitate
Chausse, B., Kakimoto, P. A., Caldeira-da-Silva, C. C., Chaves-Filho, A. B., Yoshinaga, M. Y., da Silva, R. P., Miyamoto, S., & Kowaltowski, A. J. (2019) · Bioscience Reports · doi:10.1042/bsr20190072 · Cited by 59
Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A., Koop, A., Kluwe, J., Schulze zur Wiesch, J., et al. (2023) · Cells · doi:10.3390/cells12030341 · Cited by 55
Lipoprotein lipase activity is required for cardiac lipid droplet production
Trent, C. M., Yu, S., Hu, Y., Skoller, N., Huggins, L. A., Homma, S., & Goldberg, I. J. (2014) · Journal of Lipid Research · doi:10.1194/jlr.m043471 · Cited by 55
Self-citationKamermans, A., Rijnsburger, M., Chakraborty, A., van der Pol, S., de Vries, H. E., & van Horssen, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00950 · Cited by 25
Iwata, A., Maruyama, J., Natsuki, S., Nishiyama, A., Tamura, T., Tanaka, M., Shichino, S., Seki, T., Komai, T., Okamura, T., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06357-5 · Cited by 25
Metadata
- Authors
- Goldberg, I. J., Eckel, R. H., & Abumrad, N. A.
- Venue
- Journal of Lipid Research
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 50
- Pages
- S86-S90
- ISSN
- 0022-2275
- Cited by
- 362
- References
- 2
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review