The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals
Open accessAbstract
Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-associated insulin resistance. Here, we used a conditional cell ablation system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c+ cells in obese mouse models. Our results show that CD11c+ cell depletion results in rapid normalization of insulin sensitivity. Furthermore, CD11c+ cell ablation leads to a marked decrease in inflammatory markers, both locally and systemically, as reflected by gene expression and protein levels. Together, these results indicate that these CD11c+ cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type II diabetes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Such conditional ablation resulted in a profound reduction of proinflammatory ATM accumulation, accompanied by rapid whole-body normalization of insulin sensitivity (43).”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [43]
In the citing paper
“M1-like macrophages secrete inflammatory cytokines such as TNF-α and IL-6, and studies in M1-like macrophage knockout mice suggest they also promote insulin resistance.”
From The Vasculature in Prediabetes (2018) · cites this paper as [84]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · cited 3×
“…shown that obesity is associated with increased macrophage content in skeletal muscle, including CD11c+ cells, and this muscle macrophage accumulation is accompanied by increased expression of inflammatory factors in muscle (Hevener et al., 2007; Nguyen et al., 2007; Weisberg et al., 2003).”
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · cited 1×
“Resident tissue macrophages display tremendous heterogeneity in their activities and functions, primarily reflecting the local metabolic and immune microenvironment (Gordon and Taylor, 2005; Mantovani et al., 2004).”
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · cited 1×
“Resident tissue macrophages display tremendous heterogeneity in their activities and functions, primarily reflecting the local metabolic and immune microenvironment (Gordon and Taylor, 2005; Mantovani et al., 2004).”
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · cited 10×
“These results suggest that the source of the IL-10 in the DT treated CD11c-DTR BMT mice are the remaining CD11c ATMs (Cancello et al., 2005; Lumeng et al., 2007).”
InfluentialKim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · cited 4×
“…in ATMs is associated with a decrease in adipose tissue inflammation and a reduction in obesityinduced insulin resistance (Ellacott et al., 2007; Kanda et al., 2006; Lesniewski et al., 2007; Nara et al., 2007; Neels and Olefsky, 2006; Nomiyama et al., 2007; Weisberg et al., 2006), while an…”
InfluentialCinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · cited 2×
“Previously, ATMs were shown to cluster around dead adipocytes in so-called crown-like structures (CLS; (Cinti et al., 2005; Strissel et al., 2007), and CD11c+ cells are localized to these ATM clusters (Lumeng et al., 2007).”
Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953 · cited 3×
“While transient DC depletion was not associated with signs of illness or long-term defects, repeated DT induction is lethal to the mouse (Jung et al., 2002).”
InfluentialObesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · cited 4×
“In both humans and rodents, adipose tissue macrophages (ATMs) accumulate in adipose tissue (AT) with increasing body weight, and evidence is mounting that implicates ATMs as a significant contributor to inflammation in obesity and a mediator of IR (Shoelson et al., 2007).”
InfluentialIKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Items 401–500 of 801
Geurts, L., Muccioli, G. G., Delzenne, N. M., & Cani, P. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055963 · Cited by 41
“Although there is evidence that macrophage accumulation occurs in the skeletal muscle during HF diet-induced obesity, the mechanisms remain elusive [1,48].”
BackgroundAndrogens, body fat Distribution and Adipogenesis
Zerradi, M., Dereumetz, J., Boulet, M., & Tchernof, A. (2014) · Current Obesity Reports · doi:10.1007/s13679-014-0119-6 · Cited by 45
Chatzigeorgiou, A., & Chavakis, T. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_8 · Cited by 44
Zeng, J., Zhang, Y., Hao, J., Sun, Y., Liu, S., Bernlohr, D., Sauter, E. R., Cleary, M. P., Suttles, J., & Li, B. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701416 · Cited by 41
“The pathogenic role of CD11c macrophages in obesity is well established (2, 5).”
BackgroundMethodInfluentialWensveen, F. M., Šestan, M., Wensveen, T. T., & Polić, B. (2019) · European Journal of Immunology · doi:10.1002/eji.201847895 · Cited by 42
DeVallance, E., Branyan, K., Lemaster, K. C., Anderson, R., Marshall, K. L., Olfert, I., Smith, D. M., Kelley, E. E., Bryner, R., Frisbee, J., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101285 · Cited by 35
“CD8 T cells produce monocyte chemoattractant proteins (MCPs) and macrophage inflammatory proteins, which modulate the infiltration of macrophages in adipose tissue [44].”
BackgroundLiu, C., Yuan, Y., Zhou, J., Hu, R., Ji, L., & Jiang, G. (2020) · BMC Endocrine Disorders · doi:10.1186/s12902-020-00617-1 · Cited by 46
Receptor for the Advanced Glycation End Products (RAGE) Pathway in Adipose Tissue Metabolism
Gutowska, K., Czajkowski, K., & Kuryłowicz, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241310982 · Cited by 40
Inflammatory and Oxidative Stress Markers in Skeletal Muscle of Obese Subjects
Catalán, V., Frühbeck, G., & Gómez‐Ambrosi, J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812504-5.00008-8 · Cited by 44
STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity
Admin, A., Cox, A. R., Chernis, N., Bader, D., Saha, P. K., Masschelin, P. M., Felix, J. B., Sharp, R., 连泽勤, Putluri, V., et al. (2020) · Diabetes · doi:10.2337/db20-0384 · Cited by 42
Duan, H., Jing, L., Xiang, J., Ju, C., Wu, Z., Liu, J., Ma, X., Chen, X., Liu, Z., Feng, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202103719 · Cited by 38
Liébana-García, R., López‐Almela, I., Olivares, M., Romaní‐Pérez, M., Manghi, P., Torres-Mayo, A., Tolosa-Enguís, V., Flor‐Duro, A., Bullich‐Vilarrubias, C., Rubio, T., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-01989-7 · Cited by 44
“Also, conditional ablation of CD11c + cells lowers the levels of inflammatory cytokines in WAT and rapidly improves glucose intolerance in DIO mice 45 .”
Adipose tissue macrophages: the inflammatory link between obesity and cancer?
Wagner, M., Steinskog, E. S. S., & Wiig, H. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.991311 · Cited by 39
“rapid normalization of insulin sensitivity in obese mice [33].”
BackgroundLutz, S. Z., Hennige, A. M., Feil, S. C., Peter, A., Gerling, A., Machann, J., Kröber, S. M., Rath, M., Schürmann, A., Weigert, C., et al. (2011) · Diabetes · doi:10.2337/db10-0760 · Cited by 41
“To characterize the cGKI-positive cells in the liver, sections were stained with antibodies against CRBP-I, a marker for hepatic stellate cells (18), and Mac-2, which is expressed in liver macrophages (19).”
Serum Amyloid A3 Gene Expression in Adipocytes is an Indicator of the Interaction with Macrophages
Sanada, Y., Yamamoto, T., Satake, R., Yamashita, A., Kanai, S., Katô, N., van de Loo, F. A. J., Nishimura, F., Scherer, P. E., & Yanaka, N. (2016) · Scientific Reports · doi:10.1038/srep38697 · Cited by 40
Onogi, Y., Wada, T., Okekawa, A., Matsuzawa, T., Watanabe, E., Ikeda, K., Nakano, M., Kitada, M., Koya, D., Tsuneki, H., et al. (2020) · Scientific Reports · doi:10.1038/s41598-019-57368-w · Cited by 39
Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue
Ahmad, F., Chung, Y. W., Tang, Y., Hockman, S. C., Liu, S., Khan, Y., Huo, K., Billings, E. M., Amar, M. J., Remaley, A. T., et al. (2016) · Scientific Reports · doi:10.1038/srep28056 · Cited by 41
Lammoglia, G. M., Zandt, C. E. V., Galvan, D. X., Orozco, J. L., Dellinger, M. T., & Rutkowski, J. M. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00208.2016 · Cited by 39
“The role of lymphatics in regulating tissue inflammation is highly relevant to the global obesity epidemic, wherein adipose tissue inflammation, notably infiltrating immune cells, are thought to drive the metabolic syndrome (1, 33, 52).”
BackgroundMetabolic Syndrome: Is Nlrp3 Inflammasome a Trigger or a Target of Insulin Resistance?
Mori, M. A., Bézy, O., & Kahn, C. R. (2011) · Circulation Research · doi:10.1161/res.0b013e318220b57b · Cited by 39
“This promotes classical M1 activation of macrophages that has been linked to the development of inflammation in adipose tissue and metabolic diseases.(14,15) These investigators further demonstrated that mice with ablation of the Nlrp3 receptor are resistant to diet-induced insulin resistance and hepatosteatosis and t…”
BackgroundLi, D., Cheng, Y., Zeng, X., Li, Y., Xia, Z., Yang, X., & Ren, D. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c04193 · Cited by 38
García-Hernández, M. H., Rodríguez-Varela, E., García-Jacobo, R. E., la Torre, M. H.-D., Uresti‐Rivera, E. E., González‐Amaro, R., & Portales‐Pérez, D. P. (2018) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2018.07.001 · Cited by 40
Wolff, G., Taranko, A. E., Meln, I., Weinmann, J., Sijmonsma, T., Lerch, S., Heide, D., Billeter, A. T., Tews, D., Krunic, D., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.10.007 · Cited by 41
“As reported previously [19,36], mRNA of the proinflammatory Cd11c marker was induced by HFD but showed a marked upregulation in Lum-Ko gWAT under HFD.”
BackgroundNutrient Sensing in CD11c Cells Alters the Gut Microbiota to Regulate Food Intake and Body Mass
Chagwedera, D. N., Ang, Q. Y., Bisanz, J. E., Leong, Y. A., Ganeshan, K., Cai, J., Patterson, A. D., Turnbaugh, P. J., & Chawla, A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.002 · Cited by 40
Conen, D., Vollenweider, P., Rousson, V., Marques-Vidal, P. M., Paccaud, F. M., Waeber, G., & Bochud, M. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwq308 · Cited by 38
Dai, M., Wu, L., Wang, P., Zheng, W., Xu, X., & Wang, D. W. (2017) · Scientific Reports · doi:10.1038/srep46743 · Cited by 38
Identity Crisis: CD301b + Mononuclear Phagocytes Blur the M1-M2 Macrophage Line
Knudsen, N. H., & Lee, C. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.004 · Cited by 37
“Although depletion of the prototypic CD11c+ M1macrophages has been shown to protect against high-fat diet-induced insulin resistance in mice (Patsouris et al., 2008), the function of the mixed M1-M2 phenotype in meta-inflammation remains unclear.”
BackgroundGambaro, S. E., Zubiría, M. G., Portales, A. E., Rey, M. A., Rumbo, M., & Giovambattista, A. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.08.004 · Cited by 37
Chronic NOS inhibition accelerates NAFLD progression in an obese rat model
Sheldon, R. D., Padilla, J., Jenkins, N. T., Laughlin, M. H., & Rector, R. S. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00247.2014 · Cited by 37
McGillicuddy, F. C., Reynolds, C. M., Finucane, O., Coleman, E., Harford, K. A., Grant, C., Sergi, D., Williams, L. M., Mills, K. H. G., & Roche, H. M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00297.2013 · Cited by 36
Fat Stress and Liver Resistance
Ogawa, W., & Kasuga, M. (2008) · Science · doi:10.1126/science.1167571 · Cited by 36
Non-alcoholic steatohepatitis in morbidly obese patients
Tran, A., & Gual, P. (2013) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2012.07.005 · Cited by 42
Fujisaka, S., Usui, I., Nawaz, A., Takikawa, A., Kado, T., Igarashi, Y., & Tobe, K. (2016) · Diabetology International · doi:10.1007/s13340-016-0290-y · Cited by 39
Role of MicroRNAs in Obesity-Induced Metabolic Disorder and Immune Response
Zhong, H., Ma, M., Liang, T., & Guo, L. (2018) · Journal of Immunology Research · doi:10.1155/2018/2835761 · Cited by 36
“Infiltrating macrophages accumulated in muscle induce M1 activation [51].”
BackgroundTff3, as a Novel Peptide, Regulates Hepatic Glucose Metabolism
Xue, Y., Shen, L., Cui, Y., Zhang, H., Chen, Q., Cui, A., Fang, F., & Chang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075240 · Cited by 37
“Genetic deletion of macrophage inflammatory pathway components protects against obesity-induced insulin resistance and glucose intolerance [38,39].”
The modern interleukin-1 superfamily: Divergent roles in obesity
Lee, M. K. S., Yvan‐Charvet, L., Masters, S. L., & Murphy, A. J. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.001 · Cited by 39
An Easy, Convenient Cell and Tissue Extraction Protocol for Nuclear Magnetic Resonance Metabolomics
Mathéus, N., Hansen, S., Rozet, E., Peixoto, P., Maquoi, E., Lambert, V., Noël, A., Frédérich, M., Mottet, D., & Tullio, P. D. (2014) · Phytochemical Analysis · doi:10.1002/pca.2498 · Cited by 36
Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases
Festuccia, W. T. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900768 · Cited by 35
Guo, C., Liu, J., & Li, H. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110912 · Cited by 34
Jeong, J. H., Lee, Y. R., Park, H. G., & Lee, W. L. (2015) · Physical Activity and Nutrition · doi:10.5717/jenb.2015.15060203 · Cited by 35
“M1 macrophages powerfully express TLR4, which produces pro-inflammatory cytokines such as TNF-a.”
BackgroundInfluentialThe macrophage at the intersection of immunity and metabolism in obesity
Samaan, M. C. (2011) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-3-29 · Cited by 34
“Furthermore, dendritic cell were detected in muscle from high fat fed mice, and fatty acid treatment of bone marrow derived macrophages [BMDM] and dendritic cells [BMDC] induced inflammation in the BMDC and not BMDM [126].”
BackgroundInfluentialCharacterization of immune cells in psoriatic adipose tissue
Rose, S. M., Stansky, E., Dagur, P. K., Samsel, L., Weiner, E., Jahanshad, A., Doveikis, J., Naik, H. B., Playford, M. P., McCoy, J. P., et al. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0258-2 · Cited by 34
“have shown that adipose immune cells contribute to obesity and insulin resistance, including T cells [3-7], B cells [8,9], dendritic cells [10,11], neutrophils [12,13], mast cells [14], and adipose tissue macrophages [ATM] [15-17], while eosinophils [18] and T regulatory cells (Tregs) may protect against insulin resis…”
BackgroundANT2 drives proinflammatory macrophage activation in obesity
Moon, J.-S., da Cunha, F. F., Huh, J. Y., Andreyev, A. Y., Lee, J., Mahata, S. K., Reis, F. C. G., Nasamran, C. A., & Lee, Y. S. (2021) · JCI Insight · doi:10.1172/jci.insight.147033 · Cited by 36
Cox, A. R., Masschelin, P. M., Saha, P., Felix, J. B., Sharp, R., Lian, Z., Xia, Y., Chernis, N., Bader, D. A., Kim, K. H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2022.09.019 · Cited by 33
Hagman, D. K., Kuzma, J. N., Larson, I. A., Foster‐Schubert, K. E., Kuan, L.-Y., Cignarella, A., Geamanu, E. D., Makar, K. W., Gottlieb, J. R., & Kratz, M. (2012) · Journal of Immunological Methods · doi:10.1016/j.jim.2012.08.018 · Cited by 34
Macadamia Oil Supplementation Attenuates Inflammation and Adipocyte Hypertrophy in Obese Mice
de Lima, E. A., Silveira, L. S., Masi, L. N., Crisma, A. R., Davanso, M. R., de Souza, G. I. D. M. H., Santamarina, A. B., Moreira, R. G., Martins, A. R., de Sousa, L. G. O., et al. (2014) · Mediators of Inflammation · doi:10.1155/2014/870634 · Cited by 34
“The increase in local inflammation is potentiated by the recruitment of macrophages to adipose tissue and polarization ofM2macrophages (macrophages type 2) toM1macrophages (macrophages type 1) [16, 22, 23].”
BackgroundThomas, A. P., Dunn, T. N., Oort, P. J., Grino, M., & Adams, S. H. (2011) · Journal of Nutrition · doi:10.3945/jn.110.127068 · Cited by 34
“Ablation of immune cells expressing CD11c normalizes insulin sensitivity in obese mice (42).”
BackgroundA mouse model for a partially inactive obesity-associated human MC3R variant
Lee, B., Koo, J., Jun, J. Y., Gavrilova, O., Lee, Y., Seo, A. Y., Taylor-Douglas, D. C., Adler‐Wailes, D. C., Chen, F., Gardner, R., et al. (2016) · Nature Communications · doi:10.1038/ncomms10522 · Cited by 34
Nishina, S., & Hino, K. (2022) · Cancers · doi:10.3390/cancers14020454 · Cited by 34
“M1 macrophage deletion increases sensitivity to insulin in obese mice [84,85], and a reduction in M2 macrophages predisposes lean mice to insulin resistance [86].”
BackgroundHuang, J., Chiang, M., Yet, S., & Chau, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038626 · Cited by 33
“. Depletion of CD11c-positve cells has been shown to normalize the insulin sensitivity in obese mice”
BackgroundKim, J. H., Lee, E., Friedline, R. H., Suk, S., Jung, D. Y., Dağdeviren, S., Hu, X., Inashima, K., Noh, H. L., Kwon, J. Y., et al. (2017) · The FASEB Journal · doi:10.1096/fj.201701017r · Cited by 33
“Of importance, we and others have shown that obesitymediated inflammation and locally secreted cytokines in skeletal muscle may be directly and causally associated with insulin resistance (5, 6).”
BackgroundResultTargeting gp130 to prevent inflammation and promote insulin action
Kraakman, M. J., Allen, T. L., Whitham, M., Iliades, P., Kammoun, H. L., Estévez, E., Lancaster, G. I., & Febbraio, M. A. (2013) · Diabetes Obesity and Metabolism · doi:10.1111/dom.12170 · Cited by 35
“[38] used a conditional cell deletion system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c+ cells in obese mouse models.”
MethodGut microbiota, immunity, and bile acid metabolism: decoding metabolic disease interactions
Zhao, Q., Wu, J., Ding, Y., Pang, Y., & Jiang, C. (2023) · Life Metabolism · doi:10.1093/lifemeta/load032 · Cited by 31
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production
Hildreth, A. D., Padilla, E. T., Gupta, M., Wong, Y. Y., Sun, R., Legala, A. R., & O’Sullivan, T. E. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00934-4 · Cited by 35
“Furthermore, depletion of CD11c-expressing cells significantly impacts the accumulation and effects of inflammatory macrophages in the WAT 13,32 .”
Kayser, B. D., Goran, M. I., & Bouret, S. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121954 · Cited by 35
“Previous studies have shown that ablation of CD11c cells [25] or reduction of their cytokine production [28] mitigates insulin resistance in obesity, suggesting that at least part of the metabolic impairment we observed in SL-HFD mice is attributed to the large increase in M1 macrophage recruitment and subsequent cyto…”
BackgroundQiu, T., Li, M., Tanner, M. A., Yang, Y., Sowers, J. R., Korthuis, R. J., & Hill, M. A. (2018) · Metabolism · doi:10.1016/j.metabol.2018.03.002 · Cited by 31
“Depletion of CD11c+ cells has previously been shown to lead to a marked reduction of inflammatory responses in both obese VAT and the systemic circulation [47].”
BackgroundMethodInfluentialPassive Exercise Using Whole-Body Periodic Acceleration Enhances Blood Supply to Ischemic Hindlimb
Rokutanda, T., Izumiya, Y., Miura, M., Fukuda, S., Shimada, K., Izumi, Y., Nakamura, Y., Araki, S., Hanatani, S., Matsubara, J., et al. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.229773 · Cited by 32
Loss of CCR5 results in glucose intolerance in diet-induced obese mice
Kennedy, A. J., Webb, C. D., Hill, A. A., Gruen, M. L., Jackson, L. G., & Hasty, A. H. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00177.2013 · Cited by 30
“This immune cell infiltration occurs not only in AT but also in other metabolic tissues, including liver and muscle (17, 28, 30, 32), resulting in increased systemic IR and glucose intolerance.”
BackgroundRegulation of systemic metabolism by tissue-resident immune cell circuits
Li, J. H., Hepworth, M. R., & O’Sullivan, T. E. (2023) · Immunity · doi:10.1016/j.immuni.2023.05.001 · Cited by 36
Kim, W.-K., Choi, E., Sul, O., Park, Y.-K., Kim, E.-S., Yu, R., Suh, J., & Choi, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072108 · Cited by 31
“CD11c deficiency ameliorates IR and improves glucose metabolism in obese mice [22], supporting the role of CD11c in IR.”
BackgroundPae, M., Baek, Y., Lee, S., & Wu, D. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.011 · Cited by 31
Takei, A., Nagashima, S., Takei, S., Yamamuro, D., Murakami, A., Wakabayashi, T., Isoda, M., Yamazaki, H., Ebihara, C., Takahashi, M., et al. (2019) · Diabetes · doi:10.2337/db19-0076 · Cited by 31
“Adipose tissue inflammation and insulin resistance are ameliorated by inhibiting the accumulation of ATMs through genetic ablation of CD11c(1) cells (4) or knockdown of C-C motif chemokine receptor 2 (CCR2) in macrophages (5).”
BackgroundExploiting the obesity-associated immune microenvironment for cancer therapeutics
Desharnais, L., Walsh, L. A., & Quail, D. F. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107923 · Cited by 31
Vick, L. V., Canter, R. J., Monjazeb, A. M., & Murphy, W. J. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.07.004 · Cited by 35
BNIP3-mediated mitophagy in macrophages regulates obesity-induced adipose tissue metaflammation
Kim, S., Choi, C., Son, Y., Lee, J., Joo, S., & Lee, Y. (2025) · Autophagy · doi:10.1080/15548627.2025.2487035 · Cited by 34
Muniz, M. G. R., Palfreeman, M., Setzu, N. R., Guillen, M. A. S., Portillo, P. S., Garza, K. M., Gosselink, K. L., & Spencer, C. T. (2018) · BioMed Research International · doi:10.1155/2018/3412732 · Cited by 30
“This activation results in increased production of proinflammatory cytokines and adipokines by macrophages and T cells in an attempt to control and remove excess fat and fat-swollen cells [10, 11].”
BackgroundBader, J. E., Enos, R. T., Velázquez, K. T., Carson, M. S., Sougiannis, A. T., McGuinness, O. P., Robinson, C. M., & Murphy, E. A. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00438.2018 · Cited by 31
“Therapies specifically targeting individual macrophage phenotypes or a specific tissue macrophage may be more effective than general systemic macrophage depletion (36).”
BackgroundA Role for Oncostatin M in the Impairment of Glucose Homeostasis in Obesity
Piquer‐Garcia, I., Campderrós, L., Taxerås, S. D., Gavaldà‐Navarro, A., Pardo, R., Vila, M., Pellitero, S., Martínez, E., Tarascó, J., Moreno, P., et al. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz090 · Cited by 33
Hul, M. V., Karnik, K., Canene‐Adams, K., de Souza, M., den Abbeele, P. V., Marzorati, M., Delzenne, N. M., Everard, A., & Cani, P. D. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00108.2020 · Cited by 33
“Since diabetes and insulin resistance were frequently associated with adipose tissue inflammation (7, 40, 57), we measured various macrophage infiltration markers in the subcutaneous (SAT) and visceral adipose tissue (VAT) using quantitative PCR analysis (Fig.”
MethodObesity, Inflammation, and Insulin Resistance
Ellies, L. G., Johnson, A., & Olefsky, J. M. (2013) · Springer eBooks · doi:10.1007/978-1-4614-6819-6_1 · Cited by 31
Self-citationWang, W., He, B., Shi, W., Liang, X., Ma, J., Shan, Z., Hu, Z., & Danesh, F. R. (2012) · Kidney International · doi:10.1038/ki.2011.457 · Cited by 30
“Recent data showed that a specific subset of CD11cþ cells are targets for free fatty acid–mediated increases in expression of proinflammatory cytokine.(19) We revealed that mice consuming high-fat diet showed significantly increased CD11cþ cells number in glomeruli and tubulointerstitium, which was substantially reduc…”
BackgroundTissue factor pathways linking obesity and inflammation
Samad, F., & Ruf, W. (2015) · Hämostaseologie · doi:10.5482/hamo-14-11-0068 · Cited by 30
“Weight loss or protection from diet-induced obesity, as seen in mice with abolished TF-PAR2 signaling (3), typically reduce the inflammatory macrophage population in the visceral adipose tissue and, importantly, genetic ablation of adipose tissue macrophages rapidly improves insulin sensitivity and ameliorates glucose…”
Krishna, K. B., Stefanović-Račić, M., Dedousis, N. L., SIPULA, I. J., & O'Doherty, R. M. (2016) · Physiological Reports · doi:10.14814/phy2.12708 · Cited by 33
“2011) and to some genetically obese mouse models that maintain metabolic health despite their obesity (Patsouris et al. 2008; de Roos et al. 2009; Spite et al. 2011; Wang et al. 2013).”
BackgroundDo flavanols-rich natural products relieve obesity-related insulin resistance?
Engin, A. B., Tsatsakis, A. M., Tsoukalas, D., & Engin, A. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.055 · Cited by 30
“Proinflammatory CD11c+ macrophages are responsible for the macrophage-linked fragment of inflammation and insulin resistance (Patsouris et al., 2008).”
BackgroundMacrophages as Key Players during Adipose Tissue–Liver Crosstalk in Nonalcoholic Fatty Liver Disease
Korf, H., Boesch, M., Meelberghs, L., & der Merwe, V. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1687851 · Cited by 29
The Sick Adipose Tissue: New Insights Into Defective Signaling and Crosstalk With the Myocardium
Bermúdez, V., Durán, P., Rojas, E., Diaz, M. P., Rivas, J., Nava, M., Chacín, M., de Bravo, M. C., Carrasquero, R., Ponce, C. C., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.735070 · Cited by 31
Komori, T., Tanaka, M., Furuta, H., Akamizu, T., Miyajima, A., & Morikawa, Y. (2015) · Diabetologia · doi:10.1007/s00125-015-3613-9 · Cited by 29
Association between systemic immune-inflammation index and insulin resistance and mortality
Deng, X., Liu, D., Li, M., He, J., & Fu, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-51878-y · Cited by 28
“…in the expression of pro-inflammatory genes (such as macrophage and pro-inflammatory cytokine IL-6) and an increase in the expression of anti-inflammatory genes (such as anti-inflammatory cytokine IL-10) in ATMs, leading to the restoration of insulin sensitivity in obese insulin resistant mice 39 .”
BackgroundUnravelling monocyte functions: from the guardians of health to the regulators of disease
Mildner, A., Kim, K.-W., & Yona, S. (2024) · Discovery Immunology · doi:10.1093/discim/kyae014 · Cited by 35
“Similar results were observed upon macrophage depletion by clodronate liposomes or in chimeric CD11c DTR mice, which results in decreased accumulation of monocyte-derived cells in adipose tissue [125–127].”
ResultGRP94 regulates M1 macrophage polarization and insulin resistance
Song, L., Kim, D., Gou, W., Wang, J., Wang, P., Wei, Z., Liu, B., Li, Z., Gou, K., & Wang, H. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00542.2019 · Cited by 27
A three-party alliance in solid tumors
Wagner, M., & Dudley, A. C. (2013) · Adipocyte · doi:10.4161/adip.23016 · Cited by 28
Immune Cell Modulation of Cardiac Remodeling
Mortensen, R. M. (2012) · Circulation · doi:10.1161/circulationaha.112.097832 · Cited by 28
“5 their elimination led to less inflammation and abrogation of obesity-induced insulin resistance.(13) This may point to markedly different subpopulations of CD11c cells or to differences in function in different tissues.”
BackgroundLee, S. J., Kim, J. Y., Nogueiras, R., Linares, J. F., Pérez–Tilve, D., Jung, D. Y., Ko, H. J., Hofmann, S. M., Drew, A. F., Leitges, M., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.003 · Cited by 29
“Also, the ablation of macrophages normalizes insulin sensitivity in obesity (Patsouris et al., 2008), whereas genetic inactivation of PPARg or PPARd in macrophages leads to the inhibition of the alternative activation (also known as type 2 inflammation) of resident macrophages in liver and adipose tissue, which result…”
Role of innate immune cells in metabolism: from physiology to type 2 diabetes
Dalmas, É. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00736-5 · Cited by 28
Chattopadhyay, D., Das, S., Guria, S., Basu, S., & Mukherjee, S. (2021) · Biochemical Journal · doi:10.1042/bcj20210442 · Cited by 27
“genetic or chemical ablation of ATM improving insulin sensitivity (5,6).”
BackgroundRegulation of Diet-Induced Adipose Tissue and Systemic Inflammation by Salicylates and Pioglitazone
Kim, M., Yamamoto, Y., Kim, K.-J., Kamei, N., Shimada, T., Liu, L., Moore, K., Woo, J. R., Shoelson, S. E., & Lee, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082847 · Cited by 27
“M1 macrophages in AT are often defined as being CD11c, and numerous studies have shown that obesity increases CD11c ATM numbers [7,8].”
BackgroundZhu, Z., Yu, M., Xu, M., Ji, X. Y., Zong, X., Zhang, Z., Shang, W., Zhang, L., & Fang, P. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118355 · Cited by 26
Macrophage Depletion Disrupts Immune Balance and Energy Homeostasis
Lee, B., Qiao, L., Kinney, B., Feng, G., & Shao, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099575 · Cited by 27
“However, a study using iDTR mouse model to delete CD-11C positive cells showed no sign of severe inflammation and have no effect on body weight [8].”
BackgroundTNFRSF14 deficiency protects against ovariectomy-induced adipose tissue inflammation
Choi, E., Kim, W.-K., Sul, O., Park, Y.-K., Kim, E., Suh, J., Yu, R., & Choi, H. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0341 · Cited by 26
“Loss of ovarian function significantly increased serum ROS in mice (Phan et al. 2013), and menopause causes oxidative stress in humans (Sanchez-Rodriguez et al. 2012).”
BackgroundTime-Restricted Feeding Restores Obesity-Induced Alteration in Adipose Tissue Immune Cell Phenotype
Lee, Y., Kim, Y., Lee, M., Wu, D., & Pae, M. (2021) · Nutrients · doi:10.3390/nu13113780 · Cited by 26
“Depletion of CD11c+ cells resulted in rapid normalization of insulin sensitivity [16].”
BackgroundSui, B., Liu, J., Zheng, C., Dang, L., Ji, C., Cao, Y., Zhang, K., Liu, L., Dang, M., Zhang, L., et al. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00193-1 · Cited by 28
“4a, b).(39,40) Intriguingly, clodronate application also suppressed the miR-21 expression in bone under the ISO challenge (Fig.”
BackgroundThe role of adiponectin for immune cell function in metabolic diseases
Gao, M., Cui, D., & Xie, J. (2023) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15151 · Cited by 26
“Natural killer (NK) cells are important for antiviral immunity, and recent studies have shown that they also play a crucial role in main- taining AT homeostasis and IR.”
BackgroundInfluentialAdiposity and metabolic dysfunction in polycystic ovary syndrome
Sam, S. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0008 · Cited by 26
Oliveira, M. C. G., Gregory, N. S., Kolker, S. J., Rasmussen, L., Allen, L. H., & Sluka, K. A. (2020) · Molecular Neurobiology · doi:10.1007/s12035-019-01852-x · Cited by 26
Балмасова, И. П., Lomakin, Y. A., Babaev, E. A., Tsarev, V. N., Gabibov, A. G., Smirnov, I. V., Knorre, V. D., Ovchinnikova, L. A., Gnuchev, N. V., Khurs, E. N., et al. (2019) · Acta Naturae · doi:10.32607/20758251-2019-11-4-79-87 · Cited by 26
Kim, D. M., Lee, J. H., Pan, Q., Han, H. W., Shen, Z., Eshghjoo, S., Wu, C., Yang, W., Noh, J. Y., Threadgill, D. W., et al. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101852 · Cited by 28
“It is known that M1-like pro-in fl ammatory macrophages is commonly associated with insulin resistance under DIO [93,94].”
BackgroundCcdc3: A New P63 Target Involved in Regulation Of Liver Lipid Metabolism
Liao, W., Liu, H., Zhang, Y.-W., Jung, J. H., Chen, J., Su, X., Kim, Y. C., Flores, E. R., Wang, S. M., Czarny‐Ratajczak, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09228-8 · Cited by 25
Arivazhagan, L., Ruiz, H. H., Wilson, R. A., Manigrasso, M. B., Gugger, P. F., Fisher, E. A. A., Moore, K. J., Ramasamy, R., & Schmidt, A. M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315900 · Cited by 25
Influence of Polyphenols on Adipose Tissue: Sirtuins as Pivotal Players in the Browning Process
Flori, L., Piragine, E., Spezzini, J., Citi, V., Calderone, V., & Martelli, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119276 · Cited by 30
“…macrophages surround the dead adipocytes forming a “crown-like” structure and causing the release of triglycerides, previously contained in adipocytes, which further activate the M1 macrophages and promote the secretion of TNF-α , contributing to the chronicization of the inflammatory state [20,21].”
BackgroundRomeo, G. R., Pae, M., Eberlé, D., Lee, J., & Shoelson, S. E. (2013) · Diabetes · doi:10.2337/db13-0050 · Cited by 25
“It has also been proposed that CD11c+ ATMs express high levels of pro-inflammatory mediators and promote IR (7; 8).”
BackgroundObesity-associated miR-148a is regulated by cytokines and adipokines via a transcriptional mechanism
Shi, C., Pang, L., Ji, C., Wang, J., Lin, N., Chen, J., Chen, L., Yang, L., Huang, F., Zhou, Y., et al. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5940 · Cited by 25
“Previous studies have demonstrated that insulin resistance and obesity are closely associated with adipose tissue inflammation (3,4), indicating that suppressing adipocyte inflammation may have a beneficial effect on insulin sensitivity in obese individuals (5,6).”
Background
Metadata
- Authors
- Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G.
- Affiliations
- University of California San Diego (US)
- Pfizer (United States) (US)
- Corresponding author
- Neels, Jaap G.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 8
- Issue
- 4
- Pages
- 301-309
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC2630775
- OpenAlex
- W2011255130
- Cited by
- 804
- References
- 34
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 24 · 2023: 31 · 2022: 29 · 2021: 65 · 2020: 45 · 2019: 47 · 2018: 52 · 2017: 60 · 2016: 62 · 2015: 60 · 2014: 70 · 2013: 70 · 2012: 50
- FWCI
- 25.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Moores Cancer Center, UC San Diego Health
- University of California, San Diego
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK 033651, R37DK033651, P01DK074868, R01DK033651)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012303, HD012303, U54HD012303)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- CD11c+ macrophages, obesity, insulin resistance, adipose tissue macrophages, macrophage depletion, diphtheria toxin receptor, inflammation, type 2 diabetes, therapeutic target
- MeSH terms
- Adipose Tissue, Animals, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Liver, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Obesity, Gene Expression, Cytokines, Chemokines, Chemokine CCL2, Intercellular Signaling Peptides and Proteins, CD11c Antigen, Mice, Heparin-binding EGF-like Growth Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
