Cited by 804Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

Open access

Patsouris, David, Li, Ping-Ping, Thapar, Divya, Chapman, Justin, Olefsky, Jerrold M., Neels, Jaap G.·2008·Cell Metabolism

DOI 10.1016/j.cmet.2008.08.015PMC PMC2630775

Open this paper in CoChat — free account Open PDF

Abstract

Obese adipose tissue is characterized by infiltration of macrophages. We and others recently showed that a specific subset of macrophages is recruited to obese adipose and muscle tissue. This subset expresses CD11c and produces high levels of proinflammatory cytokines that are linked to the development of obesity-associated insulin resistance. Here, we used a conditional cell ablation system, based on transgenic expression of the diphtheria toxin receptor under the control of the CD11c promoter, to study the effects of depletion of CD11c+ cells in obese mouse models. Our results show that CD11c+ cell depletion results in rapid normalization of insulin sensitivity. Furthermore, CD11c+ cell ablation leads to a marked decrease in inflammatory markers, both locally and systemically, as reflected by gene expression and protein levels. Together, these results indicate that these CD11c+ cells are a potential therapeutic target for treatment of obesity-related insulin resistance and type II diabetes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.cmet.2008.08.015

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · cited 3×
“…shown that obesity is associated with increased macrophage content in skeletal muscle, including CD11c+ cells, and this muscle macrophage accumulation is accompanied by increased expression of inflammatory factors in muscle (Hevener et al., 2007; Nguyen et al., 2007; Weisberg et al., 2003).”
The chemokine system in diverse forms of macrophage activation and polarization
MANTOVANI, A., SICA, A., SOZZANI, S., ALLAVENA, P., VECCHI, A., & LOCATI, M. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.09.015 · Cited by 6,534 · cited 1×
“Resident tissue macrophages display tremendous heterogeneity in their activities and functions, primarily reflecting the local metabolic and immune microenvironment (Gordon and Taylor, 2005; Mantovani et al., 2004).”
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190 · cited 1×
“Resident tissue macrophages display tremendous heterogeneity in their activities and functions, primarily reflecting the local metabolic and immune microenvironment (Gordon and Taylor, 2005; Mantovani et al., 2004).”
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · cited 10×
“These results suggest that the source of the IL-10 in the DT treated CD11c-DTR BMT mice are the remaining CD11c ATMs (Cancello et al., 2005; Lumeng et al., 2007).”
Influential
Differential Significance of Plasma Visfatin Concentrations according to Adiposity in Children and Adolescents
Kim, H. J., Park, S. Y., Choi, Y. J., Han, S. J., Lee, K. W., & Kim, D. J. (2013) · Hormone Research in Paediatrics · doi:10.1159/000348848 · Cited by 3,061
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
Kanda, H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26498 · Cited by 2,682 · cited 4×
“…in ATMs is associated with a decrease in adipose tissue inflammation and a reduction in obesityinduced insulin resistance (Ellacott et al., 2007; Kanda et al., 2006; Lesniewski et al., 2007; Nara et al., 2007; Neels and Olefsky, 2006; Nomiyama et al., 2007; Weisberg et al., 2006), while an…”
Influential
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
Cinti, S., Mitchell, G., Barbatelli, G., Murano, I., Ceresi, E., Faloia, E., Wang, S., Fortier, M., Greenberg, A. S., & Obin, M. S. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500294-jlr200 · Cited by 2,529 · cited 2×
“Previously, ATMs were shown to cluster around dead adipocytes in so-called crown-like structures (CLS; (Cinti et al., 2005; Strissel et al., 2007), and CD11c+ cells are localized to these ATM clusters (Lumeng et al., 2007).”
In vivo depletion of CD11c+ dendritic cells abrogates priming of CD8+ T cells by exogenous cell-associated antigens.
Jung, S., Unutmaz, D., Wong, P., Sano, G., Santos, K. D. L., Sparwasser, T., Wu, S., Vuthoori, S., Ko, K., Zavala, F., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00365-5 · Cited by 1,953 · cited 3×
“While transient DC depletion was not associated with signs of illness or long-term defects, repeated DT induction is lethal to the mouse (Jung et al., 2002).”
Influential
Obesity, Inflammation, and Insulin Resistance
Shoelson, S. E., Herrero, L., & Naaz, A. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.059 · Cited by 1,806 · cited 4×
“In both humans and rodents, adipose tissue macrophages (ATMs) accumulate in adipose tissue (AT) with increasing body weight, and evidence is mounting that implicates ATMs as a significant contributor to inflammation in obesity and a mediator of IR (Shoelson et al., 2007).”
Influential
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Self-citation

Flagged first, then by citations

Show all 34 references

Sorted by citations

Items 501–600 of 801

Human Adipose Tissue Metabolism in Obesity
Lin, S., & Jensen, M. D. (2025) · Journal of Obesity & Metabolic Syndrome · doi:10.7570/jomes25025 · Cited by 25
“95,96 In humans, both systemic and adipose tissue inflammation have been associated with insulin resistance, 97 and anti-inflammatory medications have been shown to improve insulin resistance in some, 98 but not all studies.”
Interleukin-1β Downregulates RBP4 Secretion in Human Adipocytes
Kotnik, P., Keuper, M., Wabitsch, M., & Fischer‐Posovszky, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057796 · Cited by 24
“On the other hand, loss of adipose tissue is associated with a favorable adipokine profile, a decrease in adipose tissue inflammation, and an improved systemic insulin sensitivity [5].”
Background
Class III obesity rather than metabolic syndrome impacts clinical outcomes of acute pancreatitis: A propensity score weighted analysis
Blaszczak, A. M., Krishna, S. G., Hart, P. A., Bradley, D. P., Hsueh, W. A., Lara, L. F., Hussan, H., Hinton, A. M., Conwell, D. L., & Cruz‐Monserrate, Z. (2020) · Pancreatology · doi:10.1016/j.pan.2020.08.011 · Cited by 25
Time-restricted feeding reduces monocyte production by controlling hematopoietic stem and progenitor cells in the bone marrow during obesity
Kim, Y., Lee, Y., Lee, M. N., Nah, J., Yun, N., Wu, D., & Pae, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1054875 · Cited by 22
“While circulatingmonocytes (6) and adipose tissuemacrophage (ATM) (7, 8) are increasedwith obesity, the ablation of genes affecting activation (9, 10) or recruitment of myeloid cells (11) could normalize insulin sensitivity in obese insulin resistance animals.”
Background
Intermittent fasting favorably modulates adipokines and potentially attenuates atherosclerosis
Zein, M. A., Zein, O., Diab, R., Dimachkie, L., Sahebkar, A., Al‐Asmakh, M., Kobeissy, F. H., & Eid, A. H. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115876 · Cited by 28
Inflammation and insulin resistance: New targets encourage new thinking
Johnson, A. M. F., Hou, S., & Li, P. (2017) · BioEssays · doi:10.1002/bies.201700036 · Cited by 24
Self-citation
Obesity and dysregulated central and peripheral macrophage–neuron cross‐talk
Boura‐Halfon, S., Pecht, T., Jung, S., & Rudich, A. (2018) · European Journal of Immunology · doi:10.1002/eji.201747389 · Cited by 24
Low-dose naltrexone rescues inflammation and insulin resistance associated with hyperinsulinemia
Choubey, A., Girdhar, K., Kar, A. K., Kushwaha, S., Yadav, M. K., Ghosh, D., & Mondal, P. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra120.013484 · Cited by 25
“Moreover, the deletion ofM1-like macrophages ameliorates insulin resistance in obese mice, and the reduction of M2-like macrophages predisposes lean mice to the development of insulin resistance (29).”
Background
Effect of the Cannabinoid Receptor‐1 Antagonist Rimonabant on Inflammation in Mice With Diet‐Induced Obesity
Wang, Q., Perrard, X. D., Perrard, J. L., Mansoori, A., Smith, C. W., Ballantyne, C. M., & Wu, H. (2010) · Obesity · doi:10.1038/oby.2010.213 · Cited by 24
“Indeed, AT CD11c+ cells, which are increased and show proinflammatory characteristics in obesity (3,32), were reduced with rimonabant treatment.”
Background
14-Deoxygarcinol improves insulin sensitivity in high-fat diet-induced obese mice via mitigating NF-κB/Sirtuin 2-NLRP3-mediated adipose tissue remodeling
Chen, J.-L., Feng, Z.-L., Zhou, F., Lou, R., Peng, C., Ye, Y., & Lin, L.-G. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00958-8 · Cited by 21
“Accumulated evidence indicated that M1 macrophages are the major contributors of adipose tissue inflammation and insulin resistance in obese mice [7, 40, 46].”
Background
Anti‐inflammatory and anti‐chemotactic effects of dietary flaxseed oil on CD8+ T cell/adipocyte‐mediated cross‐talk
Monk, J. M., Liddle, D. M., Brown, M. J., Zarepoor, L., Boer, A. A. D., David, W. L., Power, K. A., & Robinson, L. E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500541 · Cited by 23
CD11c.DTR mice develop a fatal fulminant myocarditis after local or systemic treatment with diphtheria toxin
Männ, L., Kochupurakkal, N. M., Martin, C., Verjans, E., Grüneboom, A., Sody, S., Kraus, A., Dalimot, J. J., Bergmüller, E., Jung, S., et al. (2016) · European Journal of Immunology · doi:10.1002/eji.201546245 · Cited by 24
A Role for Timp3 in Microbiota-Driven Hepatic Steatosis and Metabolic Dysfunction
Mavilio, M., Marchetti, V., Fabrizi, M., Stöhr, R., Marino, A., Casagrande, V., Fiorentino, L., Cardellini, M., Kappel, B. A., Monteleone, I., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.027 · Cited by 24
“The role of CD11c + accumulation as part of the ATM burden in obesity and the consequent effect on glucose intolerance has been recently discussed (Patsouris et al., 2008; Wentworth et al., 2010; Wu et al., 2010).”
Background
Adipose Tissue Macrophages in Rheumatoid Arthritis: Prevalence, Disease‐Related Indicators, and Associations With Cardiometabolic Risk Factors
Giles, J. T., Ferrante, A. W., Broderick, R., Zartoshti, A., Rose, J., Downer, K., Zhang, H., & WINCHESTER, R. J. (2017) · Arthritis Care & Research · doi:10.1002/acr.23253 · Cited by 23
“In mice, ablation of adipose CD11c macrophages, a subset with high-level expression of proinflammatory cytokines, resulted in a reduction in adipose ATM content, lower adipose cytokine and chemokine expression, reduced circulating cytokine levels, and improved whole-body insulin sensitivity (21), suggesting a central…”
Background
Treatment of obesity-related inflammation with a novel synthetic pentacyclic oleanane triterpenoids via modulation of macrophage polarization
Yang, N., Tang, Q., Qin, W., Li, Z., Wang, D., Zhang, W., Cao, X., Lu, Y. Z., Ge, X., Sun, H., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.053 · Cited by 23
“Other studies have indicated that M2 activation ameliorates obesity-related inflammation and related insulin resistance [37,38].”
Background
Expression of dendritic cell markers CD11c/BDCA-1 and CD123/BDCA-2 in coronary artery disease upon activation in whole blood
Brussel, I. V., Vré, E. A. V., Meyer, G. R. Y. D., Vrints, C. J., Bosmans, J. M., & Bult, H. (2010) · Journal of Immunological Methods · doi:10.1016/j.jim.2010.09.031 · Cited by 22
Ubiquitin ligase Cbl-b and obesity-induced insulin resistance [Review]
Abe, T., Hirasaka, K., Kohno, S., Ochi, A., Yamagishi, N., Ohno, A., Teshima-Kondo, S., & Nikawa, T. (2014) · Endocrine Journal · doi:10.1507/endocrj.ej14-0048 · Cited by 22
The Exercise Training Modulatory Effects on the Obesity-Induced Immunometabolic Dysfunctions
Soltani, N., Marandi, S. M., Kazemi, M., & Esmaeil, N. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s234992 · Cited by 27
“Several studies have shown that this axis is a critical regulatory mechanism in AT homeostasis.(20,21,24) Additionally, VAT endothelial cells and fibroblasts predominately produce IL-33 belonging to the IL-1 superfamily.”
Background
Type 2 diabetes is associated with increased circulating levels of 3-hydroxydecanoate activating GPR84 and neutrophil migration
Mikkelsen, R. B., Arora, T., Trôst, K., Dmytriyeva, O., Yang-Jensen, S. K., Meijnikman, A. S., Olofsson, L. E., Lappa, D., Aydin, Ö., Nielsen, J., et al. (2022) · iScience · doi:10.1016/j.isci.2022.105683 · Cited by 24
Exploring the Interplay between Fatty Acids, Inflammation, and Type 2 Diabetes
Nicholas, D., Mbongue, J. C., Garcia-Pérez, D., Sorensen, D. W., Bennit, H. R. F., León, M. A. D., & Langridge, W. H. R. (2024) · Immuno · doi:10.3390/immuno4010006 · Cited by 22
“An investigation focused on depleting CD11c+ adipose tissue macrophages in obese diabetic mice has suggested that dendritic cells (DCs) could potentially have a significant role in the development of insulin resistance induced by obesity [61].”
Message Transmission Between Adipocyte and Macrophage in Obesity
Engin, A. B. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-63657-8_9 · Cited by 22
Compound C inhibits macrophage chemotaxis through an AMPK-independent mechanism
Lee, Y., Park, B., & Bae, E. J. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.12.015 · Cited by 22
“Three hours of migration was chosen because this time frame was previously determined to be the optimal period for measuring cell migration [3].”
Myeloid-specific deletion of Zfp36 protects against insulin resistance and fatty liver in diet-induced obese mice
Caracciolo, V., Young, J., Gonzales, D. M., Ni, Y., Flowers, S. J., Summer, R. S., Waldman, S. A., Kim, J. K., Jung, D. Y., Noh, H. L., et al. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00224.2017 · Cited by 20
Inducible Nitric Oxide Synthase Deficiency in Myeloid Cells Does Not Prevent Diet-Induced Insulin Resistance
Lu, M. M., Li, P., Pferdekamper, J., Fan, W., Saberi, M., Schenk, S., & Olefsky, J. M. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0462 · Cited by 21
“Hyperinsulinemic euglycemic clamp studies were performed as previously described (22).”
MethodSelf-citation
Isolation and characterization of muscle stem cells, fibro-adipogenic progenitors, and macrophages from human skeletal muscle biopsies
Jensen, J., Møller, A. B., Just, J., Mose, M., de Paoli, F. V., Billeskov, T. B., Fred, R. G., Pers, T. H., Pedersen, S. B., Petersen, K. K., et al. (2021) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00127.2021 · Cited by 21
Expression of the CD11c gene in subcutaneous adipose tissue is associated with cytokine level and insulin resistance in women with polycystic ovary syndrome
Tao, T., Li, S., Zhao, A., Zhang, Y., & Liu, W. Y. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0340 · Cited by 20
The emerging roles of extracellular vesicles in diabetes and diabetic complications
Zhou, F., Huang, L., Qu, S.-L., Chao, R., Chen, Y., Jiang, Z., & Zhang, C. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.07.032 · Cited by 21
Specific macrophage subsets accumulate in human subcutaneous and omental fat depots during obesity
Girón‐Ulloa, A., González‐Domínguez, E., Klimek, R. S., Patiño‐Martínez, E., Vargas‐Ayala, G., Segovia-Gamboa, N. C., Campos‐Peña, V., Rodríguez-Arellano, M. E., Meraz‐Ríos, M. A., Campos-Campos, S. F., et al. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12380 · Cited by 21
“In vivo ablation of CD11c cells reduces CLS formation, ameliorates inflammation and improves insulin sensitivity in obese animals, which underscores the significance of the macrophage phenotypic switch from M2-like cells to proinflammatory M1-like cells in the pathogenesis of the metabolic syndrome.(9) In humans, earl…”
Background
Immunometabolism of dendritic cells in health and disease
Guo, C., & Chi, H. (2023) · Advances in immunology · doi:10.1016/bs.ai.2023.10.002 · Cited by 21
Hematopoietic Progenitors and the Bone Marrow Niche Shape the Inflammatory Response and Contribute to Chronic Disease
Xu, Y., Murphy, A. J., & Fleetwood, A. J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042234 · Cited by 23
Sex-specific regulation of IL-10 production in human adipose tissue in obesity
Subramanian, N., Tavira, B., Hofwimmer, K., Gutsmann, B., Massier, L., Abildgaard, J., Juul, A., Rydén, M., Arner, P., & Laurencikiene, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.996954 · Cited by 20
Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease
Zhang, C., Shi, Y., Liu, C., Sudesh, S. M., Zhao, H., Li, P., Liu, Q., Ma, Y., Shi, A., & Cai, H. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02273-4 · Cited by 24
“Reduction of ATMs or TNF-α by their depletion or ablation of MCP1 or its receptor in mice was associated with improved insulin sensitivity [59–61].”
BackgroundSelf-citation
Bardoxolone Methyl Prevents Fat Deposition and Inflammation in Brown Adipose Tissue and Enhances Sympathetic Activity in Mice Fed a High-Fat Diet
Dinh, C. H. L., Szabo, A., Yu, Y., Camer, D., Zhang, Q., Wang, H., & Huang, X. (2015) · Nutrients · doi:10.3390/nu7064705 · Cited by 20
Cell‐specific insulin resistance: implications for atherosclerosis
Rajwani, A., Cubbon, R. M., & Wheatcroft, S. B. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2336 · Cited by 20
“normalisation of insulin sensitivity [49].”
Macrophage Populations in Visceral Adipose Tissue from Pregnant Women: Potential Role of Obesity in Maternal Inflammation
Bravo-Flores, E., Mancilla‐Herrera, I., y Sosa, S. E., Ortiz-Ramirez, M. A., Flores-Rueda, V., Ibargüengoitia-Ochoa, F., Ibáñez, C. A., Zambrano, E., Solis‐Paredes, J. M., Perichart‐Perera, O., et al. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041074 · Cited by 22
“Some reports have focused on the role of CD11c in adipose tissue, showing that pro-inflammatory adipose tissue macrophages expressing high CD11c levels are associated with inflammation and insulin resistance [31,32].”
Background
Loss of transglutaminase 2 sensitizes for diet-induced obesity-related inflammation and insulin resistance due to enhanced macrophage c-Src signaling
Sághy, T., Köröskényi, K., Hegedűs, K., Antal, M., Bankó, C., Bacsó, Z., Papp, A., Stienstra, R., & Szondy, Z. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1677-z · Cited by 21
Clcn3 deficiency ameliorates high-fat diet-induced obesity and adipose tissue macrophage inflammation in mice
Ma, M.-M., Jin, C., Huang, X., Sun, L., Zhou, H., Wen, X., Huang, X., Du, J.-Y., Sun, H., Ren, Z., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0229-5 · Cited by 20
Myeloid-specific Asxl2 deletion limits diet-induced obesity by regulating energy expenditure
Zou, W., Rohatgi, N., Brestoff, J. R., Moley, J. R., Li, Y., Williams, J. W., Alippe, Y., Pan, H., Pietka, T., Mbalaviele, G., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci128687 · Cited by 22
“In fact, ablation of CD11c- expressing cells normalizes insulin sensitivity in obese mice (3).”
Background
4-Hydroxyisoleucine Alleviates Macrophage-Related Chronic Inflammation and Metabolic Syndrome in Mice Fed a High-Fat Diet
Yang, J., Ran, Y., Yang, Y., Song, S., Wu, Y., Qi, Y., Gao, Y., & Li, G. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.606514 · Cited by 21
RASSF6 Expression in Adipocytes Is Down-Regulated by Interaction with Macrophages
Sanada, Y., Kumoto, T., Suehiro, H., Nishimura, F., Katô, N., Hata, Y., Sorisky, A., & Yanaka, N. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061931 · Cited by 21
“Additionally, conditional ablation of macrophages using the CD11c promoter resulted in a significant reduction of macrophage accumulation in the adipose tissue of obese mice on a high fat diet, accompanied by the normalization of insulin sensitivity [12].”
Background
Fatty acids induce leukotriene C4 synthesis in macrophages in a fatty acid binding protein-dependent manner
Long, E. K., Hellberg, K., Foncea, R. E., Hertzel, A. V., Suttles, J., & Bernlohr, D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.04.004 · Cited by 20
Blocking the SIRPα-CD47 axis promotes macrophage phagocytosis of exosomes derived from visceral adipose tissue and improves inflammation and metabolism in mice
Lin, Y., Pan, Y., Jiang, T., Chen, Y., Shang, T., Xu, M., Feng, H.-B., Ma, Y., Tan, Y., Wang, H., et al. (2025) · Journal of Biomedical Science · doi:10.1186/s12929-025-01124-y · Cited by 21
“ATMs have proven to be the primary executors responsible for the development of IR since the main source of proinflammatory cytokines in AT is ATMs [20].”
Chromatin accessibility analysis identifies the transcription factor ETV5 as a suppressor of adipose tissue macrophage activation in obesity
Hu, R., Zhang, W., Li, L., Zuo, Z.-Q., Ma, M., Ma, J.-F., Yin, T., Gao, C., Yang, S., Zhao, Z., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04308-0 · Cited by 18
Adiponectin administration prevents weight gain and glycemic profile changes in diet-induced obese immune deficient Rag1 −/− mice lacking mature lymphocytes
Liu, X., Perakakis, N., Gong, H., Chamberland, J. P., Brinkoetter, M. T., Hamnvik, O. R., & Mantzoros, C. S. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.003 · Cited by 19
“Depletion of M1 macrophages in humans and mice has been associated with improvement of insulin resistance and glucose profile (34).”
Background
Cell Type-Specific Immunomodulation Induced by Helminthes: Effect on Metainflammation, Insulin Resistance and Type-2 Diabetes
Aravindhan, V., & Anand, G. (2017) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.17-0236 · Cited by 22
“Selective depletion of the CD11c classically activated macrophages (CAM), reduced AT inflammation, and improved IS without having a significant impact on obesity.(40)”
Background
A porcine placental extract prevents steatohepatitis by suppressing activation of macrophages and stellate cells in mice
Xu, L., Nagata, N., Nagashimada, M., Zhuge, F., Ni, Y., Chen, G., Kamei, J., Ishikawa, H., Komatsu, Y., Kaneko, S., et al. (2018) · Oncotarget · doi:10.18632/oncotarget.24587 · Cited by 19
“In fact, specific ablation of M1-like macrophages restores insulin sensitivity and liver lipid levels in dietinduced obese mice [38], while deleting Pparδ, which promotes M2 polarization, thereby predisposing lean mice to develop insulin resistance [39].”
Background
DPP-4 Inhibition with Anagliptin Reduces Lipotoxicity-Induced Insulin Resistance and Steatohepatitis in Male Mice
Sakai, Y., Chen, G., Ni, Y., Zhuge, F., Xu, L., Nagata, N., Kaneko, S., Ota, T., & Nagashimada, M. (2020) · Endocrinology · doi:10.1210/endocr/bqaa139 · Cited by 19
Role of antigen presentation in the production of pro-inflammatory cytokines in obese adipose tissue
Majdoubi, A., Kishta, O. A., & Thibodeau, J. (2016) · Cytokine · doi:10.1016/j.cyto.2016.01.023 · Cited by 20
Corrupted adipose tissue endogenous myelopoiesis initiates diet-induced metabolic disease
Luche, É., Robert, V., Cuminetti, V., Pomié, C., Sastourné-Arrey, Q., Waget, A., Arnaud, E., Varin, A., Labit, E., Laharrague, P. F., et al. (2017) · eLife · doi:10.7554/elife.23194 · Cited by 19
“expressing the diphtheria toxin receptor (DTR) under control of the full CD11c promoter (Patsouris et al., 2008), and transplanted into lethally irradiated CD45.”
BackgroundMethod
Prohibitin: A new player in immunometabolism and in linking obesity and inflammation with cancer
Xu, Y. X. Z., Ande, S. R., & Mishra, S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.12.001 · Cited by 20
Adipocyte microRNA-802 promotes adipose tissue inflammation and insulin resistance by modulating macrophages in obesity
Yang, Y. S., Huang, B., Qin, Y., Wang, D., Jin, Y., Su, L., Wang, Q., Pan, Y., Zhang, Y., Shen, Y., et al. (2024) · eLife · doi:10.7554/elife.99162 · Cited by 19
Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity
Subramanian, M., Özcan, L., Ghorpade, D. S., Ferrante, A. W., & Tabas, I. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0135842 · Cited by 18
“A surprising and interesting aspect of the data herein pertain to the absence of changes in VAT inflammation despite the lack of MyD88 in CD11c-expressing cells, which are the major inflammatory cells in VAT [7, 44].”
Background
Classifying the Linkage between Adipose Tissue Inflammation and Tumor Growth through Cancer-Associated Adipocytes.
Song, Y. C., Lee, S. E., Jin, Y., Park, H. W., Chun, K., & Lee, H. (2020) · PubMed · doi:10.14348/molcells.2020.0118 · Cited by 19
“Though the macrophage polarization status M1 (pro-inflammatory) and M2 (anti-inflammatory) could be an over-simplification, macrophages in inflammatory AT generally exhibit more M1 polarized phenotypes (Huh et al., 2014; Nguyen et al., 2007; Patsouris et al., 2008; Quail and Dannenberg, 2019).”
Background
[Retracted] Macrophage‐Derived Exosomes in TLR9‐/‐ Mice Ameliorate Sepsis‐Induced Mitochondrial Oxidative Stress and Apoptosis in Cardiomyocytes
Li, X., Luo, J.-Y., Li, Y., Lu, J. Q., Li, Y., Ye, S., Liu, L., Yu, Y., Lu, Y., & Luan, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5719974 · Cited by 18
“Macrophage-derived exosomes can participate in innate immune response-induced inflammation through synergistic action with toll-like receptors (TLR) [13].”
Retracted
Tumor Progression Locus 2 (Tpl2) Deficiency Does Not Protect against Obesity-Induced Metabolic Disease
Lancaster, G. I., Kowalski, G. M., Estévez, E., Kraakman, M. J., Grigoriadis, G., Febbraio, M. A., Gerondakis, S., & Banerjee, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039100 · Cited by 18
P62 plasmid can alleviate diet-induced obesity and metabolic dysfunctions
Halenova, T., Savchuk, О., Остапченко, Л. І., Chursov, A., Fridlyand, N., Komissarov, A. B., Venanzi, F. M., Kolesnikov, S. I., Sufianov, A. A., Sherman, M. Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19840 · Cited by 18
“Importantly, removal of M1-MF prevents development of diet-induced obesity [6, 7].”
Macrophages in obesity
Pirzgalska, R. M., & Domingos, A. I. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.04.014 · Cited by 18
Elicited soybean extract attenuates proinflammatory cytokines expression by modulating TLR3/TLR4 activation in high−fat, high−fructose diet mice
Atho’illah, M. F., Safitri, Y. D., Nur’aini, F. D., Widyarti, S., Tsuboi, H., & Rifa’i, M. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.01.003 · Cited by 18
“The upregulation of CD11cþ is also followed by increasing TNF amRNA expression around 2-fold or higher [46,47].”
Background
Transcriptional and epigenetic control of adipocyte remodeling during obesity
Barilla, S., Treuter, E., & Venteclef, N. (2021) · Obesity · doi:10.1002/oby.23248 · Cited by 20
“Indeed, selective ablation of CD11c+ cells leads to a decrease in adipose and systemic inflammation during highfat feeding (42).”
Background
The Dual-Specificity Phosphatase 2 (DUSP2) Does Not Regulate Obesity-Associated Inflammation or Insulin Resistance in Mice
Lancaster, G. I., Kraakman, M. J., Kammoun, H. L., Langley, K. G., Estévez, E., Banerjee, A., Grumont, R. J., Febbraio, M. A., & Gerondakis, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111524 · Cited by 19
“Studies in which particular immune cells or pro-inflammatory molecules have been genetically or pharmacologically targeted underscore the important role specific immune cells, and inflammation more generally, play in systemic insulin resistance [3–8].”
Background
Understanding the heterogeneity and functions of metabolic tissue macrophages
Grosjean, A., Venteclef, N., & Dalmas, É. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.09.002 · Cited by 18
Neuroimmune regulation of white adipose tissues
Qian, X., Meng, X., Zhang, S., & Zeng, W. (2021) · FEBS Journal · doi:10.1111/febs.16213 · Cited by 17
Acetylation of PPARγ in macrophages promotes visceral fat degeneration in obesity
Aaron, N., Zahr, T., He, Y., Yu, L., Mayfield, B., Pajvani, U. B., & Qiang, L. (2022) · Life Metabolism · doi:10.1093/lifemeta/loac032 · Cited by 17
“In addition to being the main source of inflammatory cytokines in adipose tissue [5, 6], ATMs participate in the regulation of lipid and glucose metabolism in adipocytes [7, 8].”
Protective role of perivascular adipose tissue in the cardiovascular system
Tong, Y., Zuo, Z., Li, X., Li, M., Wang, Z., Guo, X., Wang, X., Sun, Y., Chen, D., & Zhang, Z. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1296778 · Cited by 17
Western diet increases brain metabolism and adaptive immune responses in a mouse model of amyloidosis
Poxleitner, M., Hoffmann, S. H. L., Berezhnoy, G., Ionescu, T. M., González-Menéndez, I., Maier, F. C., Seyfried, D., Ehrlichmann, W., Quintanilla‐Martínez, L., Schmid, A. M., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03080-0 · Cited by 22
“Further examination of the pro-inflammatory macrophage M1 phenotype using CD11c + [62] displayed higher populations in WD groups.”
Method
Deconstructing metabolic inflammation using cellular systems
Chan, K. L., Boroumand, P., Milanski, M., Pillon, N. J., Bilan, P. J., & Klip, A. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00039.2017 · Cited by 16
Allograft inflammatory factor-1-like is not essential for age dependent weight gain or HFD-induced obesity and glucose insensitivity
Parikh, D., Riascos‐Bernal, D. F., Egaña-Gorroño, L., Jayakumar, S., Almonte, V. M., Chinnasamy, P., & Sibinga, N. E. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-60433-4 · Cited by 17
Effects of a novel polyphenol-rich plant extract on body composition, inflammation, insulin sensitivity, and glucose homeostasis in obese mice
van der Zande, H. J. P., Lambooij, J. M., Chavanelle, V., Zawistowska‐Deniziak, A., Otero, Y. F., Otto, F., Lantier, L., McGuinness, O. P., Joubioux, F. L., Giera, M. A., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00870-x · Cited by 17
Blood glucose regulation in context of infection
Wensveen, F. M., Šestan, M., Wensveen, T. T., & Polić, B. (2021) · Vitamins and hormones · doi:10.1016/bs.vh.2021.06.009 · Cited by 20
The multifaceted role of profilin-1 in adipose tissue inflammation and glucose homeostasis
Pae, M., & Romeo, G. R. (2013) · Adipocyte · doi:10.4161/adip.26965 · Cited by 17
Correction: Neuropeptide Y Is Produced by Adipose Tissue Macrophages and Regulates Obesity-Induced Inflammation
Singer, K., Morris, D. L., Oatmen, K. E., Wang, T., DelProposto, J. L., Mergian, T. A., Cho, K. W., & Lumeng, C. N.-K. (2013) · PLoS ONE · doi:10.1371/annotation/c2432ace-1dd7-4b02-8980-e4e6c085beba · Cited by 17
Capturing the multifaceted function of adipose tissue macrophages
Matz, A. J., Qu, L., Karlinsey, K., Vella, A. T., & Zhou, B. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1148188 · Cited by 16
“While inhibiting infiltration of monocyte-derived macrophages into obese WAT lessened overall tissue inflammation (11, 13, 14), specific inhibition of the Trem2 lipid-laden program of recruited macrophages exacerbates dyslipidemia and adipocyte hypertrophy, worsening overall metabolic health (15).”
Background
Label-free optical metabolic imaging of adipose tissues for prediabetes diagnosis
Chen, L., Qin, G., Liu, Y., Li, M., Li, Y., Guo, L., Du, L., Zheng, W., Wu, P., Chuang, Y.-H., et al. (2023) · Theranostics · doi:10.7150/thno.82697 · Cited by 17
“Some studies demonstrated that adipose tissue inflammation is a trigger of IR [66-68], while other studies asserted that inhibition of inflammation”
Result
Blockade of 4-1BB and 4-1BBL Interaction Reduces Obesity-Induced Skeletal Muscle Inflammation
Ngoc, H. L., Kim, C.-S., Tu, T. H., Choi, H., Kim, B.-S., Kawada, T., Goto, T., Park, T., Park, J. H. Y., & Yu, R. (2013) · Mediators of Inflammation · doi:10.1155/2013/865159 · Cited by 16
Transgenic Mice Overexpressing SREBP-1a in Male ob/ob Mice Exhibit Lipodystrophy and Exacerbate Insulin Resistance
Ohno, H., Matsuzaka, T., Tang, N., Sharma, R., Motomura, K., Shimura, T., Satoh, A., Han, S., Takeuchi, Y., Aita, Y., et al. (2018) · Endocrinology · doi:10.1210/en.2017-03179 · Cited by 16
The Challenge of Obesity Treatment: A Review of Approved Drugs and New Therapeutic Targets
Bonamichi, B. D. S. F., Parente, E. B., dos Santos, R. B., Beltzhoover, R., Lee, J., & Salles, J. E. N. (2018) · Journal of Obesity & Eating Disorders · doi:10.21767/2471-8203.100034 · Cited by 17
“[101,102] demonstrate that obesity induces systemic inflammation by modulating the amount of inflammatory mediators, such as white blood cells, neutrophils and the Ly6 Chi pro-inflammatory monocytes.”
FcγRIIb on CD11c+ cells modulates serum cholesterol and triglyceride levels and differentially affects atherosclerosis in male and female Ldlr mice
Marvin‐Peek, J., Rhoads, J. P., & Major, A. S. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.04.221 · Cited by 16
Do adipose tissue macrophages promote insulin resistance or adipose tissue remodelling in humans?
Heilbronn, L. K., & Liu, B. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0036 · Cited by 19
Myeloid P2Y2 receptor promotes acute inflammation but is dispensable for chronic high-fat diet-induced metabolic dysfunction
Adamson, S. E., Montgomery, G., Seaman, S. A., Peirce, S. M., & Leitinger, N. (2017) · Purinergic Signalling · doi:10.1007/s11302-017-9589-9 · Cited by 16
Adipose tissue dendritic cells in steady‐state
Macdougall, C. E., & Longhi, M. P. (2018) · Immunology · doi:10.1111/imm.13034 · Cited by 18
Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism
Blaszczak, A. M., Wright, V. P., Anandani, K., Liu, J., Jalilvand, A., Bergin, S. M., Nicoloro, S. M. C., Czech, M., Lafuse, W. P., Deng, T., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801470 · Cited by 16
Urtica dioica Whole Vegetable as a Functional Food Targeting Fat Accumulation and Insulin Resistance-a Preliminary Study in a Mouse Pre-Diabetic Model
Fan, S., Raychaudhuri, S., Kraus, O., Shahinozzaman, M., Lofti, L., & Obanda, D. N. (2020) · Nutrients · doi:10.3390/nu12041059 · Cited by 17
“[18] showed that depleting CD11c+ cells results in rapid normalization of insulin sensitivity and leads to a marked decrease gene expression and protein levels of inflammatory markers.”
Background
Immune Regulatory Crosstalk in Adipose Tissue Thermogenesis
Yildiz, R., Ganbold, K., Sparman, N. Z. R., & Rajbhandari, P. (2025) · Comprehensive physiology · doi:10.1002/cph4.70001 · Cited by 17
“Under normal circumstances, dendritic cells can be distinguished by high levels of CD11c and MHCII, but typical, dendritic cell markers can also be expressed by activated macrophages and monocytes in adipose tissue (Patsouris et al. 2008; Stefanovic-Racic et al. 2012).”
Short-chain chlorinated paraffins at environmentally relevant doses disrupt glucose homeostasis and insulin signaling by macrophage-mediated inflammation
Mu, Y.-W., Yao, W.-H., Li, H., Zhang, C., Zhang, Y.-J., Zhang, X., Song, G., Zhao, X., & Zeng, T. (2025) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2025.139144 · Cited by 16
Driving regeneration, instead of healing, in adult mammals: the decisive role of resident macrophages through efferocytosis
Rabiller, L., Robert, V., Arlat, A., Labit, E., Ousset, M., Salon, M., Coste, A., Fernandes, L. D. C., Monsarrat, P., Ségui, B., et al. (2021) · npj Regenerative Medicine · doi:10.1038/s41536-021-00151-1 · Cited by 23
The Proton-Activated Receptor GPR4 Modulates Glucose Homeostasis by Increasing Insulin Sensitivity
Giudici, L., Velić, A., Daryadel, A., Bettoni, C., Mohebbi, N., Suply, T., Seuwen, K., Ludwig, M., & Wagner, C. A. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000356578 · Cited by 15
Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice
Lebrun, V., Molendi‐Coste, O., Lanthier, N., Sempoux, C. L., Cani, P. D., van Rooijen, N., Stärkel, P., Horsmans, Y., & Leclercq, I. A. (2013) · Clinical Science · doi:10.1042/cs20130064 · Cited by 15
High-fat diet-induced splenic, hepatic, and skeletal muscle architecture damage: cellular and molecular players
Asghar, A., Akhtar, T., Batool, T., Khawar, M. B., Nadeem, S., Mehmood, R., & Sheikh, N. (2021) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-021-04190-6 · Cited by 15
“During obesity, there is an increase in macrophage1 (M1) activation in muscle cells [9, 10].”
Background
Deletion of TNF-like weak inducer of apoptosis (TWEAK) protects mice from adipose and systemic impacts of severe obesity
Bennett, G., Strissel, K. J., DeFuria, J., Wang, J., Wu, D., Burkly, L. C., & Obin, M. S. (2014) · Obesity · doi:10.1002/oby.20726 · Cited by 14
“TWEAK was expressed by ATMUs, notably MGL12/CD11c1 ATMUs (Figure 1C, left panel), a subset expressing a mixed M1/M2 phenotype that is recruited to sites of obesity-associated adipocyte death and implicated in the immunopathogenesis of IR (22-24).”
Background
Microarray Evidences the Role of Pathologic Adipose Tissue in Insulin Resistance and Their Clinical Implications
Mathur, S. K., Jain, P., & Mathur, P. (2011) · Journal of Obesity · doi:10.1155/2011/587495 · Cited by 15
“The phenotypic switch from M2 to M1 is possibly an important determinant of insulin resistance [60].”
Background
The activation state of macrophages alters their ability to suppress preadipocyte apoptosis
Molgat, A. S. D., Gagnon, A., Foster, C. E., & Sorisky, A. (2012) · Journal of Endocrinology · doi:10.1530/joe-12-0114 · Cited by 15
A role of the adaptive immune system in glucose homeostasis
Bronsart, L. L., & Contag, C. H. (2016) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2015-000136 · Cited by 15
Genetic Cell Ablation
Grégoire, D., & Kmita, M. (2013) · Methods in molecular biology · doi:10.1007/978-1-60327-292-6_25 · Cited by 16
Post-Effects of Time-Restricted Feeding against Adipose Tissue Inflammation and Insulin Resistance in Obese Mice
Yun, N., Nah, J., Lee, M. N., Wu, D., & Pae, M. (2023) · Nutrients · doi:10.3390/nu15112617 · Cited by 14
“In contrast, the conditional deletion of the CD11c gene in obese mice could reduce metabolic inflammation and normalize insulin sensitivity [26].”
Background
Osteopontin‐driven T‐cell accumulation and function in adipose tissue and liver promoted insulin resistance and MAFLD
Soysouvanh, F., Rousseau, D., Bonnafous, S., Bourinet, M., Strazzulla, A., Patouraux, S., Machowiak, J., Farrugia, M. A., Iannelli, A., Tran, A., et al. (2023) · Obesity · doi:10.1002/oby.23868 · Cited by 14
Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice
Buras, E. D., Yang, L., Saha, P., Kim, J., Mehta, P., Yang, Y., Hilsenbeck, S. G., Kojima, H., Chen, W., Smith, C. W., et al. (2015) · The FASEB Journal · doi:10.1096/fj.15-271452 · Cited by 14
“inflammation in HFD-fed mice (21, 29, 30), we opted to evaluate livers frompost-DT treatment RIP-DTR and iDTR mice.”
BackgroundMethodInfluential
Intermuscular adipose tissue is associated with monocyte chemoattractant protein-1, independent of visceral adipose tissue
Haam, J.-H., Kim, Y., Koo, H. S., Haam, J., Seo, N., Kim, H. Y., Park, K., Park, K., & Kim, M. J. (2015) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2015.12.003 · Cited by 15
“MCP-1 is one of the major adipokines secreted from adipose macrophages, causing the aggregation of monocytes and T lymphocytes and maintaining a proinflammatory status in metabolic dysfunction [28, 29].”
Background
Characterization of circulating leukocytes and correlation of leukocyte subsets with metabolic parameters 1 and 5 years after diabetes diagnosis
Apostolopoulou, M., Menart, B., Ruetter, R., Nowotny, B., Gehrmann, U., Markgraf, D. F., Szendroedi, J., Schloot, N. C., & Roden, M. (2018) · Acta Diabetologica · doi:10.1007/s00592-018-1143-x · Cited by 14
3,5-Diiodo-L-Thyronine (T2) Administration Affects Visceral Adipose Tissue Inflammatory State in Rats Receiving Long-Lasting High-Fat Diet
Petito, G., Cioffi, F., Silvestri, E., Matteis, R. D., Lattanzi, D., de Lange, P., Lombardi, A., Moreno, M., Goglia, F., Lanni, A., et al. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.703170 · Cited by 14
Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages
O'Reilly, M. E., Kajani, S., Ralston, J. C., Lenighan, Y. M., Roche, H. M., & McGillicuddy, F. C. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800713 · Cited by 13

Authors: Patsouris, D., Li, P.-P., Thapar, D., Chapman, J., Olefsky, J. M., & Neels, J. G.
Affiliations: University of California San Diego (US)
Pfizer (United States) (US)
Corresponding author: Neels, Jaap G.
ORCID: Olefsky, Jerrold M.
Neels, Jaap G.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2008-10
Volume: 8
Issue: 4
Pages: 301-309
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2008.08.015
PMC: PMC2630775
OpenAlex: W2011255130
Cited by: 804
References: 34
Citations by year: 2026: 13 · 2025: 24 · 2024: 24 · 2023: 31 · 2022: 29 · 2021: 65 · 2020: 45 · 2019: 47 · 2018: 52 · 2017: 60 · 2016: 62 · 2015: 60 · 2014: 70 · 2013: 70 · 2012: 50
FWCI: 25.07
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1786 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Moores Cancer Center, UC San Diego Health
University of California, San Diego
National Institute of Diabetes and Digestive and Kidney Diseases (DK 074868, DK 033651, R37DK033651, P01DK074868, R01DK033651)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P50HD012303, HD012303, U54HD012303)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: CD11c+ macrophages, obesity, insulin resistance, adipose tissue macrophages, macrophage depletion, diphtheria toxin receptor, inflammation, type 2 diabetes, therapeutic target
MeSH terms: Adipose Tissue, Animals, Glucose, Homeostasis, Humans, Insulin, Insulin Resistance, Liver, Macrophages, Male, Mice, Inbred C57BL, Mice, Transgenic, Obesity, Gene Expression, Cytokines, Chemokines, Chemokine CCL2, Intercellular Signaling Peptides and Proteins, CD11c Antigen, Mice, Heparin-binding EGF-like Growth Factor

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks